Aim The aim of the present preliminary case-control study was to test the sensitivity and specificity of salivary pipecolic acid in predicting head and neck squamous cell carcinoma (HNSCC). Methods High-performance liquid chromatography was used for the analysis of non-stimulated saliva samples from 40 individuals: 20 in the case group (recently diagnosed with untreated HNSCC) and 20 in the control group (individuals without cancer). Both groups included patients taking daily oral hypoglycemic drugs (comorbidity). The case and control groups were matched at a proportion of 1:1 for sex and comorbidity. Results Mean salivary levels of pipecolic acid were 169.38 ng/mL in the case group and 114.66 ng/mL in the control group (p<0.001). Individuals who took oral hypoglycemic drugs had higher levels of pipecolic acid in both the case and control groups (p<0.001). The receiver operating characteristic curve analysis revealed 90% sensitivity and 65% specificity for head and neck cancer, with an area under the curve of 0.838 between the case and control groups. Conclusions Pipecolic acid had high sensitivity for the diagnosis of HNSCC but low specificity in the sample analyzed. Our findings suggest that salivary pipecolic acid levels are associated with glucose homeostasis. Studies with larger samples are required to evaluate the specificity of this metabolite. casecontrol HNSCC. . (HNSCC) Highperformance High performance nonstimulated non stimulated 4 individuals 2 recently cancer. cancer cancer) comorbidity (comorbidity) 11 1 1: 16938 169 38 169.3 ngmL ng mL 11466 114 66 114.6 p<0.001. p0001 p p<0.001 0 001 (p<0.001) 90 65 0838 838 0.83 analyzed homeostasis metabolite (HNSCC (comorbidity 1693 16 3 169. 1146 6 114. p000 p<0.00 00 (p<0.001 9 083 83 0.8 p00 p<0.0 (p<0.00 08 8 0. p0 p<0. (p<0.0 p<0 (p<0. p< (p<0 (p< (p

RESUMO: O presente artigo teve como objetivo avaliar os parâmetros vitais, hemogasométricos, valores de cortisol e os achados radiológicos, de cabritos nascidos a termo e prematuros, durante as primeiras 48 horas de vida. Para tanto, foram utilizados 24 cabritos oriundos de 20 cabras, distribuídos nos grupos: grupo I: oito cabritos nascidos por meio de cesarianas realizadas aos 149 dias de gestação; grupo II: oito cabritos nascidos por meio de cesarianas realizadas aos 143 dias de gestação; grupo III: oito cabritos nascidos por meio de cesarianas realizadas aos 143 dias de gestação, cujas mães receberam 20 mg de dexametasona. O grupo I apresentou valores mais baixos de frequência cardíaca quando comparados aos demais grupos aos 60 minutos após o nascimento. Em relação à temperatura, não houve diferença entre os grupos nos momentos avaliados. Os valores de pH apresentaram-se diminuídos logo após o nascimento, vindo a elevar-se nos momentos 24 e 48 horas em todos animais estudados. Em relação à análise dos níveis de cortisol, os valores aumentaram de forma significativa no (M0), com os maiores valores obtidos nos animais do grupo II. Esses valores decresceram às 48 horas após o nascimento nos cabritos avaliados. Os animais pertencentes ao grupo I demonstraram melhores aspectos radiográficos, sendo que, ao longo das 48 horas de avaliação, todos os recém-nascidos possuíam adequada adaptação respiratória. Conclui-se que a dexametasona antenatal realizada aos 143 dias de gestação não exerceu influência sobre a viabilidade neonatal, parâmetros metabólicos e radiográficos. As alterações metabólicas encontradas são condizentes com o período de adaptação extrauterina que animais nessa fase de vida enfrentam.

ABSTRACT: This article evaluated the vital parameters, blood gas measurements, cortisol values and radiological findings of goat kids born at term and prematurely during the first 48 hours of life. For this purpose, 24 kids from 24 goats were used and assigned to groups as follows: Group I, eight kids born through cesarean sections performed at 149 days of gestation; Group II, eight kids born through cesarean sections performed at 143 days of gestation; Group III, eight kids born through cesarean sections performed at 143 days of gestation, whose mothers received 20 mg of dexamethasone. Group I had lower heart rate values than the other groups at 60 minutes after birth. In terms of temperature, there was no difference between the groups. The pH values were reduced shortly after birth, rising at 24 and 48 hours in all animals studied. In terms of the cortisol levels, the values increased significantly at birth (M0), with the highest values obtained in animals in group II. These values decreased at 48 hours after birth in the evaluated goats. The animals belonging to group I showed better radiographic aspects, and throughout the 48 hours of evaluation, all newborns exhibited adequate respiratory adaptation. It can be concluded that antenatal dexamethasone administered at 143 days of gestation did not influence neonatal viability, metabolic or radiographic parameters. The metabolic changes found are consistent with the extrauterine adaptation period that animals in this stage of life.

RESUMO: O estudo teve por objetivo avaliar o índice biespectral (BIS) durante a infusão contínua de propofol associado ou não ao fentanil em bezerros. Foram utilizados oito animais machos entre seis e doze meses de idade, holandeses, com massa corporal média de 123±18kg. Todos os animais participaram de ambos os grupos, respeitando-se sempre um intervalo mínimo de uma semana entre uma anestesia e outra, sendo aleatoriamente distribuídos entre os grupos. A anestesia nos bezerros foi induzida com propofol na dose de 5mg kg-1; intravenoso (IV), grupo controle (GP) ou propofol 4mg kg-1 associado ao fentanil 0,001mg kg-1; IV, grupo fentanil (GF) e posicionados em decúbito lateral direito, onde permaneceram respirando espontaneamente ar ambiente. Ato contínuo, a manutenção anestésica foi realizada pela infusão contínua de propofol na taxa de 0,6mg kg-1 min-1; IV GP, associado ou não à infusão de fentanil 0.001mg kg-1 hora-1 GF. A mensuração das variáveis do BIS, índice de qualidade de sinal (IQS) eletromiografia (EMG), frequência cardíaca (FC), frequência respiratória (f) e dióxido de carbono ao final da expiração (ETCO2) foram avaliadas antes da indução anestésica no momento basal (MB), e 15, 30, 45 e 60 minutos após o início da infusão contínua dos fármacos (M15, M30, M45 e M60, respectivamente); o tempo de recuperação também foi avaliado. Não foram observadas diferenças significativas entre os grupos nas variáveis do BIS e o tempo de recuperação foi maior no GF. A co-administração das infusões de propofol e fentanil, nas doses utilizadas nesse estudo, não alterou os valores do BIS em bezerros, porém, prolongou o tempo de recuperação.

ABSTRACT: The aim of this study was to evaluate the bispectral index (BIS) effects in calves through continuous infusion of propofol with or without fentanyl. Eight Holstein male calves (ages from six to twelve months old) with an average weight of 123±18kg were used. All animals participated in both groups, always keeping a minimum interval of one week between the anesthetic procedures; the calves were randomly distributed between groups. Anesthesia was induced with an intravenous (IV) dose of propofol of 5mg kg-1 in control group (GP) or with propofol (4mg kg-1) associated with IV fentanyl 0.001mg kg-1(GF). All the calves were positioned in right lateral recumbency and were allowed to spontaneously breathe room air. Subsequently, the anesthesia was maintained by continuous infusion of propofol at the rate of 0.6mg kg-1 min-1 IV in GP, and associated with the infusion of fentanyl 0.001mg kg-1 hour-1 in GF. Measurements of BIS, signal quality index (SQI) and electromyography (EMG) were evaluated before anesthesia induction (TB), and at 15, 30, 45 and 60 minutes after the beginning of continuous drugs infusion (T15, T30, T45 and T60, respectively). The heart rate (HR), respiratory rate (f), end-tidal carbon dioxide tension (ETCO2) and recovery times were evaluated as well. No significant differences were observed between the groups in the BIS variables and the recovery time was longer in GF. Co-administration of propofol and fentanyl infusions, at the doses reported here, did not change the values of BIS in cattle, but delayed the recovery time.

PURPOSE: To assess the cardiorespiratory parametes, recovery, gastrointestinal motility and serum cortisol concentrations in horses anesthetized with isoflurane with or without a continuous rate infusion (CRI) of butorphanol for orchiectomy. METHODS: Twelve adult, intact, male horses weighing 332 ± 55 kg were included in the study. Xilazine was administered as premedication. Anesthesia was induced with ketamine and midazolam and maintained with isoflurane. Butorphanol (0.025 mg kg-1 bolus) or an equivalent volume of saline (0.9%) was given intravenously followed by a CRI of butorphanol (BG) (13 µg kg-1 hour-1) or saline (CG). Cardiorespiratory variables were recorded before (T0) and every 15 minutes for 75 minutes after the start of infusion. Serum cortisol concentration was measured at T0 and 60 minutes, and 30 minutes and 19 hours after the horse stood up. Recovery from anesthesia was evaluated using a scoring system. Gastrointestinal motility was evaluated before anesthesia and during 24 hours after recovery. RESULTS: There were no significant differences between groups in cardiopulmonary variables, or recovery scores or serum cortisol concentrations. A reduction in gastrointestinal motility was recorded for 60 minutes in BG. CONCLUSIONS: Continuous rate infusion of butorphanol in horses anesthetized with isoflurane did not adversely affect the cardiopulmonary variables monitored, or recovery scores. A small but statistically significant reduction in gastrointestinal motility occurred in the butorphanol group.

Este artigo discute o desenvolvimento de uma abordagem com métodos mistos para o estudo da mobilidade diária das crianças. O estudo aqui apresentado combinou pesquisa etnográfica com a tecnologia de GPS (Global Positioning System) e um questionário interativo que as crianças completaram via telefone celular. Esta metodologia permitiu produzir uma compreensão mais ampla dos movimentos cotidianos das crianças por meio de um rico conjunto de dados, documentando as experiências subjetivas das crianças, as observações sistemáticas, o mapeamento e levantamento de dados. Conclui-se que o sucesso de uma pesquisa usando métodos mistos requer uma estreita cooperação através do diálogo interdisciplinar e engajamento mútuo e coordenação de atividades e perspectivas.

This article discusses the development of a mixed methods approach to the study of children's everyday mobility. The study presented here combined ethnographic fieldwork with GPS (Global Positioning System) technology and an interactive questionnaire that the children completed via mobile phone. This methodology permitted the researchers to generate a fuller understanding of children's everyday movements through the rich dataset documenting children's subjective experiences, systematic observations, mapping and survey data. We conclude that the success of mixed methods research requires close cooperation through interdisciplinary dialogue and mutual engagement in and coordination of activities and perspectives.

Cet article aborde l'élaboration d'une approche de méthodes mixtes pour l'étude de la mobilité quotidienne des enfants. L'étude présentée ici associe le terrain ethnographique avec la technologie du GPS (Global Positioning System) et un questionnaire interactif que les enfants ont rempli via téléphone portable. Cette méthodologie a permis de produire une compréhension plus complète des mouvements de la vie quotidienne des enfants à travers un riche ensemble de données qui a documenté les expériences subjectives des enfants, des observations systématiques, de la cartographie et des données de survey. On a conclu que le succès de la recherche sur les méthodes mixtes nécessite d'une coopération étroite entre le dialogue interdisciplinaire et l'engagement mutuel et la coordination des activités et les perspectives.

PURPOSE: To assess the hemodynamic changes and bispectral index (BIS) following administration of a continuous rate infusion (CRI) of butorphanol in isoflurane-anesthetized calves.METHODS:Eight calves weighing 110 ± 12 kg were included in the study. Anesthesia was induced with 5% isoflurane in O2 delivered via face mask and maintained with end-tidal concentration of 1.4%. IPPV was set to a peak inspiratory airway pressure of 15 cmH2O and respiratory rate of six breaths minute-1. Forty minutes after the start of anesthetic maintenance, 0.1 mg kg-1butorphanol was administered intravenously, followed by a CRI of 20 µg kg-1 minute-1. Hemodynamic variables and BIS were recorded before butorphanol administration (T0), and at 10, 20, 40 and 80 minutes following the CRI. Anesthesia was discontinued after the last recording and the calves were allowed to recover. The time to sternal recumbency (SRE) and standing (ST) were evaluated.RESULTS:There were no significant differences between the moments in all hemodynamic variables and BIS. The time to SRE and ST was 9 ± 5 and 14 ± 7 minutes, respectively.CONCLUSION:The continuous rate infusion did not produce clinically relevant changes in hemodynamic or bispectral index values compared to baseline in mechanically ventilated and unstimulated calves anesthetized at 1.4% isoflurane.

A cetamina tem demonstrado efeito analgésico em doses subanestésicas, além da manutenção da estabilidade dos parâmetros fisiológicos. O estudo objetivou avaliar os efeitos cardiorrespiratórios e a analgesia pós-operatória da cetamina administrada por via epidural, por infusão intravenosa contínua ou pela associação de ambas, em cães submetidos à osteossíntese de fêmur. Foram utilizadas 25 cadelas, hígidas, distribuídas aleatoriamente em quatro grupos: CEP (2mg kg-1 de cetamina associada à lidocaína 2% via epidural), CIV (lidocaína 2% via epidural e 1mg kg-1 de cetamina IV seguido de infusão contínua IV com 100µg kg min-1 da mesma), CIVEP (2mg kg-1 de cetamina associada à lidocaína 2% via epidural e 1mg kg-1 de cetamina IV, seguido de infusão contínua IV com 100µg kg min-1) e CON (anestesia epidural com lidocaína 2%). Avaliaram-se FC, f, PAS, PAM, PAD, T°C, tempo de bloqueio motor e analgesia pós-operatória por meio de escala analógica visual. Houve elevação da FC no CIV e diminuição desse parâmetro no CEP. As pressões arteriais mantiveram-se dentro dos valores fisiológicos e não foram observadas diferenças na f e T°C. O tempo de duração do bloqueio anestésico foi potencializado nos grupos que receberam cetamina epidural, diferindo significativamente em relação ao controle. O tempo para a analgesia resgate não diferiu entre os grupos. Conclui-se que a administração de cetamina pela via epidural, por infusão contínua intravenosa ou pela associação de ambas promoveu estabilidade cardiorrespiratória no período transcirúrgico, porém não foi capaz de prolongar a duração da analgesia pós-operatória em cães submetidos à osteossíntese de fêmur.

Ketamine has demonstrated analgesic effects in subanesthetic doses, besides the maintenance of stability of physiological parameters. The study aimed to evaluate the cardiorespiratory effects and the post operative analgesia of ketamine via epidural route, intravenous continuous infusion or association of both, in dogs submitted to femoral osteosynthesis. Twenty-five healthy bitches were randomly assigned to four groups: CEP (2mg kg-1 of ketamine associated with lidocaine 2% via epidural route), CIV (lidocaine 2% via epidural route and 1mg kg-1 of ketamine IV, followed by IV continuous infusion of 100µg kg min-1 of ketamine), CIVEP (epidural anesthesia identical to CEP and ketamine infusion as in CIV) and CON (epidural anesthesia with lidocaine 2%). HR, RR, SAP, MAP, DAP and T°C, sensitive blockade time and post operative analgesia measured with visual analog scale were evaluated. There was an increase in HR in CIV and decrease of this parameter in CEP. Arterial pressures kept within physiological values and differences in RR and T°C were not observed. The anesthetic blockade time was augmented in the groups which received epidural ketamine, differing significantly in relation to the control. The time for rescue analgesia did not differ between the groups. It can be concluded the administration of ketamine via epidural route, intravenous continuous infusion or the association of both promoted cardiorespiratory stability during the operative period; however, it was not able to extend the duration of post operative analgesia in dogs submitted to femoral osteosynthesis.

Plato’s word in the Phaedrus about the written logos as an "image" of the living logos of the man who knows (cf. Phaedrus, 276a8-9) has to be referred to his own dialogues: the "man who knows" is the dialectician, who "knows the truth" (cf. ibid., 278c4-5) thanks to the insights he has gained by way of his use of the Theory of Ideas. There are three things, according to Plato, which can be achieved only by the living logos of "the man who knows": his logos can give answers to new questions, can choose the right sort of recipient and remain silent to those who have nothing to do with philosophy, and, in case it should be attacked, it can help its argument with "things of higher importance" (cf. ibid., 275d4-276a9, 278c4-e3). An analyse of these views and concepts of Plato in their context shows that the conventional interpretation, current since almost 200 years, according to which the written Platonic dialogue can do the same three things as the "man who knows", is contrary to the wording of Plato’s "Criticism of Writing" and incompatible with its sense. This result leads to a new orientation regarding the hermeneutics of the Platonic dialogue. We have to acknowledge that Plato did not mean his dialogues (each one by itself, and their entirety as a whole) to be autarchic of self-sufficient literary entities. The dialogues point consistently beyond themselves to Plato’s oral teaching.

La frase sobre el logos escrito como "reflejo" del discurso vivo y animado del que sabe (cf. Fedro, 276a8-9) hay que referirla al diálogo platónico: "el que sabe" es el dialéctico, que gracias a los conocimientos a los que ha accedido por medio de la teoría de las Ideas, "sabe cómo es la verdad" (ibid., 278c4-5). Tres capacidades tiene, según Platón, solo el discurso vivo del "que sabe": puede responder las preguntas que se le planteen, puede buscar el receptor adecuado o quedar en silencio ante aquellos que no tienen que ver con filosofía y, en caso de un ataque, puede acudir en ayuda de su argumento con cuestiones que pertenecen a un nivel superior (cf. ibid., 275d4-276a9, 278c4-e3). El análisis de estas expresiones de Platón en su contexto muestra que la interpretación usual que, desde hace casi 200 años, le atribuye estas capacidades de "el que sabe" al diálogo escrito, no hace justicia al texto de la crítica de la escritura y va en contra de su sentido. Esta constatación exige una orientación radicalmente nueva de la hermenéutica de los diálogos platónicos. Hay que reconocer que Platón concibió sus diálogos (cada uno en particular y todos en conjunto) como unidades literarias y filosóficas que no tienen un carácter autárquico. Los diálogos apuntan consistentemente más allá de ellos mismos hacia la doctrina oral de Platón.