Abstract This study aimed to evaluate dental implant outcomes and to identify risk factors associated with implant failure over 12 years via dental records of patients attending an educational institution. Dental records of 202 patients receiving 774 dental implants from 2002 to 2014 were analyzed by adopting a more reliable statistical method to evaluate risk factors with patients as the unit [generalized estimating equation (GEE)]. Information regarding patient age at implantation, sex, use of tobacco, and history of systemic diseases was collected. Information about implant location in the arch region and implant length, diameter, and placement in a grafted area was evaluated after 2 years under load. Systemic and local risk factors for early and late implant failure were studied. A total of 18 patients experienced 25 implant failures, resulting in an overall survival rate of 96.8% (2.84% and 0.38% early and late implant failures, respectively). The patient-based survival rate was 91.8%. GEE univariate and multivariate analyses revealed that a significant risk factor for implant failure was the maxillary implant (p = 0.006 and p = 0.014, respectively). Bone grafting appeared to be a risk factor for implant failure (p = 0.054). According to GEE analyses, maxillary implants had significantly worse outcomes in this population and were considered to be a risk factor for implant failure. Our results suggested that implants placed in a bone augmentation area had a tendency to fail.

AbstractNonsyndromic oral clefts are considered a problem of public health in Brazil, presenting a multifactorial etiology that involves genetic and environmental components, such as maternal alcohol consumption. Several candidate genes have been investigated to identify some association with nonsyndromic clefts risk. The epidermal growth factor (EGF) gene is implicated in the normal craniofacial development and its functional +61 A>G polymorphism has been related to cancer susceptibility. It has been suggested that cancer and oral clefts may share the same molecular pathways.Objective Our goal was to evaluate the association between the EGF+61 A>G polymorphism and nonsyndromic oral clefts susceptibility.Material and Methods The case-control study included 218 cleft cases and 253 controls from Brazil. The control group was comprised of individuals without congenital malformations, dental anomalies and family history of clefts. The cleft phenotypes and subphenotypes were determined based on clinical examination. Genomic DNA was extracted from oral mucosa cells obtained by mouthwash. The EGF+61 A>G polymorphism genotype was determined by polymerase chain reaction-restriction fragment length polymorphism.Results We noticed the association between maternal alcohol consumption during pregnancy and cleft occurrence. The A allele and AA genotype were over-represented in cleft cases compared with control group when we considered the bilateral cleft lip with or without cleft palate (CL±P) cases, cleft cases with tooth agenesis and cleft cases presenting family history of cleft, but the differences were not statistically significant. Contradictorily, the G allele was higher in cleft palate only (CP) cases than in control group, showing a borderline p value. Comparing the different cleft phenotypes, we observed statistical differences between CP and CL±P cases. Our data suggest the EGF+61 A>G polymorphism was not related with nonsyndromic oral clefts susceptibility in a Brazilian population, but supported the different genetic background between CL±P and CP. Moreover, we confirmed the potential effect of maternal alcohol intake on cleft risk in our population.

Este trabalho objetiva relatar o caso clínico de um paciente do sexo masculino, nove anos de idade, que compareceu a Clínica da Dor de uma instituição de ensino superior com queixa principal de cefaléia e apertamento dentário em vigília. Ao exame clínico, observou-se facetas de desgaste dentário e transpasse horizontal acentuado. Não foram observadas alterações articulares e/ou musculares. A terapêutica adotada foi à confecção de placa miorrelaxante em resina acrílica termoplastificável com ajustes oclusais em cêntrica realizados a cada quinze dias de forma não prejudicar o crescimento ósseo e a erupção dos dentes permanentes. Após um mês de tratamento o paciente apresentou remissão da dor e foi orientado a reduzir o tempo de uso da placa miorrelaxante. O paciente mantém-se em acompanhamento odontológico e psicológico.

This paper aims to report the case of a 9-year-old male patient presented to the Pain Clinic at the education institution with a severe complaint of headache and clenching. During clinical examination, facets of tooth wear and accentuated overjet were observed. There were no joint and / or muscle anomalies. Therapy adopted was an occlusal splint with occlusal adjustments in centric performed every fifteen days in order not to impair bone growth and eruption of permanent teeth. After one month of treatment, the patient showed pain remission and remained in monitoring of dental and psychological care.