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Juvenile hormone (JH III) is an important example of a chemical signaling derived from the terpene biosynthetic pathway. Because of its impact on many species’ reproductive and developmental processes, analytical approaches must be developed to accurately identify and measure it in biological samples. In this technical note, we explored the gas-phase dissociative behavior of JH III using tandem mass spectrometry combined with electrospray ionization to provide diagnostic fragment-ions for quantitative purposes.

https://doi.org/10.21577/0100-4042.20230091

Long-term oncological and surgical outcomes after Video Endoscopic Inguinal Lymphadenectomy (VEIL) in patients with penile cancer
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Tobias-Machado, Marcos

; Ornellas, Antonio A.

; Hidaka, Alexandre K.

; Medina, Luis G.

; Mattos, Pablo A. L.

; Besio, Ruben S.

; Abreu, Diego

; Castro, Pedro R.

; Nishimoto, Ricardo H.

; Astigueta, Juan

; Dourado, Aurus

; Machado, Roberto D.

; Magnabosco, Wesley J.

; Corona-Montes, Victor

; Villoldo, Gustavo M.

; Zampolli, Hamilton C.

; Taha, Anis

; Auad, Pericles R.

; Faria, Eliney F.

; Arantes, Paulo B. O.

; Tavares, Alessandro

; Nascimento, Francisco S. M. S.

; Brazão Jr., Eder S.

; Rocha, Maurício M.

; Costa, Walter H.

; Panico, Vinicius

; Reis, Leonardo O.

; Almeida-Carrera, Roberto J.

; Silva, Rafael C.

; Zequi, Stênio C.

; Calixto, José R. R.

; Sotelo, Rene

International braz j urol

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Out 2023, Volume 49 Nº 5 Páginas 580 - 589

Resumo: En | Texto: En | PDF: En

ABSTRACT Objective: To report outcomes from the largest multicenter series of penile cancer patients undergoing video endoscopic inguinal lymphadenectomy (VEIL). Materials and Methods: Retrospective multicenter analysis. Authors of 21 centers from the Penile Cancer Collaborative Coalition-Latin America (PeC-LA) were included. All centers performed the procedure following the same previously described standardized technique. Inclusion criteria included penile cancer patients with no palpable lymph nodes and intermediate/high-risk disease and those with non-fixed palpable lymph nodes less than 4 cm in diameter. Categorical variables are shown as percentages and frequencies whereas continuous variables as mean and range. Results: From 2006 to 2020, 210 VEIL procedures were performed in 105 patients. Mean age was 58 (45-68) years old. Mean operative time was 90 minutes (60-120). Mean lymph node yield was 10 nodes (6-16). Complication rate was 15.7%, including severe complications in 1.9% of procedures. Lymphatic and skin complications were noted in 8.6 and 4.8% of patients, respectively. Histopathological analysis revealed lymph node involvement in 26.7% of patients with non-palpable nodes. Inguinal recurrence was observed in 2.8% of patients. 10y- overall survival was 74.2% and 10-y cancer specific survival was 84.8%. CSS for pN0, pN1, pN2 and pN3 were 100%, 82.4%, 72.7% and 9.1%, respectively. Conclusion: VEIL seems to offer appropriate long term oncological control with minimal morbidity. In the absence of non-invasive stratification measures such as dynamic sentinel node biopsy, VEIL emerged as the alternative for the management of non-bulky lymph nodes in penile cancer.

https://doi.org/10.1590/s1677-5538.ibju.2023.0065

Larvicidal Activity of Calcium Alginate Microcapsules Containing Clove Essential Oil Obtained by Microfluidics
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Condé, Débora T.

; Mendes, Luiza A.

; Ramos, Guilherme P.

; Silva, Rafael R. A.

; Teixeira, Alvaro V. N. C.

; Teixeira, Róbson Ricardo

; Martins, Gustavo F.

; Cerceau, Cristiane I.

; Lopes, Renata P.

Journal of the Brazilian Chemical Society

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Ago 2023, Volume 34 Nº 8 Páginas 1166 - 1174

Resumo: En | Texto: En | PDF: En

Essential oils (EO) have diverse applications, such as antibacterial and antifungal activity. However, they are susceptible to oxidation in the presence of air, light, and moisture. In addition, they are thermally unstable. In this sense, it is necessary to develop techniques to increase the lifespan of EO. In this work, EO was obtained from cloves and characterized by different techniques. The major compounds found were eugenol (83%), eugenol acetate (9%), and β-caryophyllene (8%). The EO was encapsulated by extrusion using a microfluidic device. The sodium alginate was used as wall material, and the CaCl2 solution was used as a crosslinking agent. The microcapsule presented sizes of 164.7 ± 0.3 μm, with an encapsulation yield of 64 ± 14%. Functional characteristic groups of EO were observed in the microcapsule by infrared and Raman spectroscopies. The microcapsule increased the thermal decomposition of the EO from 162 to 230 °C. Release kinetics of the capsule was performed, with an equilibrium time of 72 h and release of 54% of the EO. Finally, the pure EO and encapsulated EO-microcapsules were applied in the Aedes aegypti larvae control, showing mean lethal concentration necessary to eliminate 50% (LC50) values of 74.4 and 96.9 μg mL-1 and lethal concentration necessary to eliminate 90% (LC90) of 106.2 and 133.3 μg mL-1 for pure EO and encapsulated EO, respectively. Therefore, it was concluded that these microcapsules have the potential for application in the Aedes aegypti larvae control.

https://doi.org/10.21577/0103-5053.20230029

Educação Não Formal: Representatividade Comunicacional de Sujeitos Surdos Negros e suas Contribuições Políticas
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Silva, Rafael Dias

Revista Internacional em Língua Portuguesa

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Jun 2023, Volume 43 Páginas 139 - 146

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract Racial issues and their struggles find a parallel with issues related to people with disabilities, when we think about their struggles, the lack of representation, of opportunities make up a context of discrimination present in many societies. The black deaf community has been politically organizing as a minority, drawing attention to its guidelines with the aim of increasing communicational accessibility to non-formal education spaces, such as museums. The non-formal education spaces have a high representation to deconstruct the integration system that insists on permanence in our society. As a goal, we need to defend inclusive education, aimed at welcoming and quality learning for all, and we must always be vigilant so that the accessibility policy in our country is on the government agenda, ensuring that inclusion takes place in our society. Nothing about us without us enters the agenda of discussions and reflections in the area of human sciences, strengthening the foundations of modem society in order to transform an excluding modus operandi through new paradigms and representations of the “other” marked by its cultural and cultural plurality. identity.

Resumo Questões raciais e suas lutas encontram um paralelo com as questões relacionadas às pessoas com deficiência, quando pensamos em suas lutas, a falta de representatividade, de oportunidades compõem um contexto de discriminação presente em muitas sociedades. A comunidade surda negra vem se organizando politicamente enquanto minoria, chamando a atenção para as suas pautas com o objetivo de aumentar a acessibilidade comunicacional aos espaços de educação não-formais, como exemplo, os museus. Os espaços de educação não formais possuem uma representatividade elevada para desconstruirmos o sistema de integração que insiste na permanência em nossa sociedade. Como meta, precisamos defender a educação inclusiva, voltada para um acolhimento e aprendizagem para todas(os) de qualidade e devemos estar sempre vigilantes para que a política de acessibilidade em nosso país esteja na pauta governamental, garantindo que a inclusão se concretize em nossa sociedade. Nada sobre nós sem nós entra na pauta de discussões e reflexões na área das ciências humanas fortalecendo os alicerces da sociedade dos tempos modernos, a fim de transformar um modus operandi excludente através de novos paradigmas e representações do “outro” marcado pela sua pluralidade cultural e de identidade.

https://doi.org/10.31492/2184-2043.rilp2023.43/pp.139-146

Impact of COVID-19 pandemic on prostate cancer outcomes at an uro-oncology referral center
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Andrade, Guilherme Miranda

; Sesconetto, Lucas

; Silva, Rafael Benjamim Rosa da

; Santos, Gabriela Guimarães Rodrigues dos

; Kayano, Paulo Priante

; Baccaglini, Willy

; Bezerra, Murilo Borges

; Bianco, Bianca

; Lemos, Gustavo Caserta

; Carneiro, Arie

International braz j urol

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Abr 2023, Volume 49 Nº 2 Páginas 233 - 242

Resumo: En | Texto: En | PDF: En

ABSTRACT Introduction To evaluate the possible effects of the coronavirus disease 2019 (COVID-19) pandemic on the oncologic results of patients with prostate cancer regarding clinical staging, presence of adverse pathological outcomes, and perioperative complications. Materials and methods This retrospective study included patients who underwent radical prostatectomy. The time between biopsy and surgery, staging tests, final histopathological evaluation after surgery, lymphadenectomy rate, postoperative complications, and prostatic specific antigen (PSA) levels (initial and 30 days after surgery) were analyzed and compared in a group of patients before and during the pandemic period. Results We included 226 patients: 88 in the pre-pandemic period and 138 during the pandemic period. There was no statistically significant difference in mean age, body mass index, ASA, pathological locally advanced disease, the proportion of patients who underwent lymphadenectomy, and ISUP grade in the biopsy between the groups. Positive surgical margins, prostatic extracapsular extension, and PSA levels at 30 days were also similar between the groups. The mean time between medical consultation and surgery was longer in the pandemic period than in the pre-pandemic (124 vs. 107 days, p<0.001), and the mean time between biopsy and medical consultation (69.5 days vs. 114 days, p<0.001) and between biopsy and surgery (198.5 days vs. 228 days, p=0.013) was shorter during the pandemic. The incidence of severe early and late perioperative complications was similar between the periods. Conclusions There was no delay between diagnosis and treatment at our institution during the COVID-19 pandemic period. No worsening of the prostate cancer features was observed.

https://doi.org/10.1590/s1677-5538.ibju.2022.0393

Green Synthesis of Cellulose-Based Biofilms Doped with AgNPs with Antibacterial Activity
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Pereira, Arthur B. D.

; Silva, Rafael R. A.

; Marques, Clara S.

; Nascimento, Mayra Aparecida

; Soares, Nilda de Fatima F.

; Lopes, Renata P.

Journal of the Brazilian Chemical Society

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Mar 2023, Volume 34 Nº 3 Páginas 366 - 376

Resumo: En | Texto: En | PDF: En

In this work, cellulose-based composite biofilms doped with silver nanoparticles (AgNPs) have been produced by eco-friendly process. The AgNPs were synthesized from Ilex paraguariensis with an average size of 45 nm, a characteristic plasmon band at 450 nm and zeta potential of -23 mV. The biofilm has been synthesized by casting method, using different volumes of AgNPs suspension with glycerol plasticizing agent (T6-T10) or not (T1-T5). The AgNPs were successfully incorporated into the biofilms, which was confirmed by scanning electron microscopy. The mechanical and optical structural and the antimicrobial properties of the biofilms have been determined. In the presence of AgNPs, the mechanical properties, thermal stability and water vapor barrier of the biofilms have not been altered. However, the addition of glycerol decreased the tensile strength and the modulus of elasticity, in addition to increasing the elongation of the biofilms and the water vapor barrier. The biofilm T10 showed a transmittance of ca. 10%, with high potential to be used as a UV light blocker. Finally, the biofilms doped with AgNPs showed activity against the bacterium Pseudomonas fluorescens. Given the above, this work presented a new biofilm with activity against the bacterium Pseudomonus fluorescens obtained by eco-friendly process.

https://doi.org/10.21577/0103-5053.20220114

Weed interference periods in cowpea crop
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Campos, Marcos L. de

; Lacerda, Marlon L.

; Aspiazú, Ignacio

; Carvalho, Abner J. de

; Silva, Rafael F.

Revista Caatinga

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Mar 2023, Volume 36 Nº 1 Páginas 1 - 8

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

ABSTRACT Cowpea is one of the pulse crops that present the highest potential for growing in the Semiarid region of Brazil. Lowcost vegetable protein source, it has resilience to adverse conditions, however, in competition with weeds, its productivity can be strongly compromised. To overcoming this situation, it is essential for integrated management programs to determine the critical period for preventing interference. Thus, the objective of this work was to determine weed interference periods and the effect of coexistence periods on cowpea grain yield in the Semiarid region of the state of Minas Gerais, Brazil. The treatments were arranged in a 2×9 factorial scheme, as follows: cultivation in coexistence with weeds and cultivation under weed control, for nine crescent periods (0-7, 0-14, 0-21, 0-28, 0-35, 0-42, 0-49, 0-56 and 0-63 days after crop emergence), in a randomized experimental block design with four replications. The weed community was studied through phytosociological survey and evaluation of dry matter production and cowpea was evaluated for dry matter production, 100-grain mass and grain yield. The interference periods were determined using a non-linear logistic regression model. The weed community found was composed of 70% dicotyledonous and 30% monocotyledon plants, distributed in seven families and ten species. The coexistence with weeds results in losses of up to 90% in cowpea grain yield. The critical period of weed control in cowpea crop in the Semiarid region of the state of Minas Gerais, Brazil, is 11 to 36 days after crop emergence.

RESUMO O feijão-caupi é uma das culturas de pulses com maior potencial de cultivo no semiárido brasileiro. Fonte de proteína vegetal de baixo custo, apresenta resiliência a condições adversas, entretanto, em competição com plantas daninhas, pode ter sua produtividade fortemente comprometida. Para superar essa situação, é indispensável aos programas de manejo integrado determinar o período crítico de prevenção à interferência. Assim, objetivou-se com este trabalho determinar os períodos de interferência de plantas daninhas e o efeito dos períodos de convivência sobre a produtividade do feijão-caupi no semiárido mineiro. Os tratamentos foram arranjados em esquema fatorial 2×9, da seguinte forma: cultivo em convivência com plantas daninhas e cultivo sob controle de plantas daninhas, por nove períodos crescentes (0-7, 0-14, 0-21, 0-28, 0-35, 0-42, 0-49, 0-56 e 0-63 dias após a emergência da cultura), em delineamento experimental de blocos casualizados com quatro repetições. A comunidade infestante foi estudada por meio de levantamento fitossociológico e avaliação da produção de matéria seca e o feijão-caupi foi avaliado quanto à produção de matéria seca, massa de 100 grãos e rendimento de grãos. Os períodos de interferência foram determinados adotando um modelo de equação não linear logístico. A comunidade infestante foi composta por 70% de plantas eudicotiledôneas e 30% de monocotiledôneas, distribuídas em sete famílias e dez espécies. A convivência com plantas daninhas resulta em até 90% de perdas na produtividade do feijão-caupi. O período crítico de controle de plantas daninhas no feijão-caupi no semiárido mineiro é de 11 a 36 dias após a emergência da cultura.

https://doi.org/10.1590/1983-21252023v36n101rc

Adjusting Experimental Parameters to Modify Corn Starch with Glycidyl Methacrylate to Tune Specific Properties
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Pellá, Michelly C. G

; Simão, Andressa R

; Maurício, Marcos R

; Dragunski, Douglas C

; Silva, Rafael da

; Rubira, Adley F

Journal of the Brazilian Chemical Society

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Fev 2023, Volume 34 Nº 2 Páginas 263 - 275

Resumo: En | Texto: En | PDF: En

Chemical modification reactions are viable alternatives for improving the properties of starch because they allow the insertion of molecules that change the original behavior of the polymer. Glycidyl methacrylate (GMA) is an example of a vinylic molecule added to starch to decrease its hydrophilicity and improve mechanical properties. This modification reaction is affected by parameters like the volume of the modifier, time, and temperature. Furthermore, the correlation between these parameters might change the response of an individual parameter on the degree of substitution (DS), crystallinity (Xc), and molecular-weight-related parameters. This work evaluated how these effects and their correlations would affect DS, Xc, molecular weight, and polydispersity index (PDI) of starch. The results suggested that, while higher volumes of GMA and temperatures decreased the DS and Xc, the correlation between them increased the DS by 2.47, and Xc by 1.25. On the other hand, higher temperatures also favored the occurrence of hydrolysis. Also, although none of the parameter correlations had a significant effect on the assessed properties (at 95%), the statistical analysis confirmed that the correlation between two parameters changed the effect of individual parameters.

https://doi.org/10.21577/0103-5053.20220105

A guerra do agronegócio contra a saúde coletiva: entrevista com Allan Rodrigo de Campos Silva
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Silva, Rafael Afonso da

Interface - Comunicação, Saúde, Educação

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2023, Volume 27 elocation e220488

Resumo: Pt | Texto: Pt | PDF: Pt

https://doi.org/10.1590/interface.220488

10.

Brazilian Miocene crabs I. Taxonomic review of Cyclocancer tuberculatus Beurlen, 1958 and Hepatella amazonica Beurlen, 1958 (Pancrustacea, Decapoda, Brachyura)
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Lima, Daniel

; Silva, Rafael Costa da

; Aguilera, Orangel

; Pinheiro, Allysson Pontes

; Santana, William

Papéis Avulsos de Zoologia

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2023, Volume 63 elocation e202363012

Resumo: En | Texto: En | PDF: En

Abstract In describing Cyclocancer to accommodate his new species C. tuberculatus, Beurlen highlighted that his new genus was a cancroid intermediate in form between Atelecyclus and Cancer, but with enough characters to be placed in a new genus. Examination of C. tuberculatus type material revealed that Cyclocancer is a junior synonym of Hepatus. Therefore, C. tuberculatus is herein transferred into Hepatus as H. beurleni nomen novum because H. tuberculatus (Beurlen, 1958) is a junior homonym of H. tuberculatusSaussure (1858), a junior synonym of Hepatus pudibundus (Herbst, 1785). Miohepatus gen. nov., comb. nov. is proposed here to accommodate Hepatella amazonica Beurlen from the Pirabas Formation, Neogene, Pará, Brazil, based on new morphological evidence from the type material.

https://doi.org/10.11606/1807-0205/2023.63.012

11.

CARE TECHNOLOGY PROTOTYPE FOR FLUSHING PRACTICE IN INTRAVENOUS CATHETER MAINTENANCE
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Ribeiro, Gabriella da Silva Rangel

; Campos, Juliana Faria

; Parreira, Pedro Miguel Santos Dinis

; Silva, Rafael Celestino da

Texto & Contexto - Enfermagem

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2023, Volume 32 elocation e20220302

Resumo: En Es Pt | Texto: En Es Pt | PDF: En | PDF: Es | PDF: Pt

ABSTRACT Objective: to elaborate, based on the assessment of the nursing team’s flushing practice, a care technology prototype aimed at promoting good practices in intravenous catheter maintenance in intensive care. Method: a technology elaboration study, developed in three stages: flushing practice assessment through a questionnaire completed by 108 nursing professionals working in intravenous catheter maintenance in intensive care settings of a public hospital located in the city of Rio de Janeiro, Brazil. Data collection took place from November 2019 to January 2020, with descriptive and inferential data analysis; analysis of this practice regarding the existence of errors according to the main guidelines and scientific evidence, with classification of types of errors in the light of the conceptual framework of patient safety; and technology prototype development. Results: 88% of participants perform flushing in their practice; 49.5% apply the continuous pressure technique on the syringe plunger; 22% perform flushing before, between and after medication administration; predominance of use of volume and syringes with gauges of 5 ml and 10 ml. Variables related to knowledge were associated with not performing flushing. There were active and latent errors that guided the technology prototype construction. Conclusion: a care guide was built that aims to increase nursing team’s knowledge about good flushing practices and is configured as a barrier to error recurrence.

RESUMEN Objetivo: elaborar, a partir de la evaluación de la práctica de flushing del equipo de enfermería, un prototipo de tecnología asistencial con el objetivo de promover buenas prácticas en el mantenimiento de catéteres intravenosos en cuidados intensivos. Método: estudio de elaboración de tecnología, desarrollado en tres etapas: evaluación de la práctica de flushing a través de un cuestionario completado por 108 profesionales de enfermería que actúan en el mantenimiento de catéteres intravenosos en Unidades de Cuidados Intensivos de un hospital público ubicado en la ciudad de Río de Janeiro, Brasil. La recolección de datos ocurrió de noviembre de 2019 a enero de 2020, con análisis de datos descriptivo e inferencial; análisis de esta práctica en cuanto a la existencia de errores según las principales guías y evidencias científicas, con clasificación de tipos de errores a la luz del marco conceptual de seguridad del paciente; y desarrollo del prototipo tecnológico. Resultados: el 88% de los participantes realizan flushing en su consulta; el 49,5% aplica la técnica de presión continua sobre el émbolo de la jeringa; el 22% realiza flushing antes, entre y después de la administración de medicamentos; hubo predominio del uso de volumen y jeringas con calibres de 5 ml y 10 ml. Las variables relacionadas con el conocimiento se asociaron con no realizar el flushing. Existieron errores activos y latentes que orientaron la construcción del prototipo tecnológico. Conclusión: se elaboró una guía de atención que tiene como objetivo aumentar el conocimiento del equipo de enfermería sobre las buenas prácticas de flushing y se configura como una barrera para la recurrencia de errores.

RESUMO Objetivo: elaborar, com base na avaliação da prática do flushing da equipe de enfermagem, um protótipo de tecnologia de cuidado voltado a promover as boas práticas na manutenção dos cateteres intravenosos em terapia intensiva. Método: estudo de elaboração de tecnologia, desenvolvido em três etapas: avaliação da prática do flushing através de questionário preenchido por 108 profissionais de enfermagem atuantes na manutenção dos cateteres intravenosos em cenários de terapia intensiva de um hospital público localizado no município do Rio de Janeiro, Brasil. A coleta de dados ocorreu de novembro de 2019 a janeiro de 2020, com análise descritiva e inferencial dos dados; análise dessa prática quanto à existência de erros segundo as principais diretrizes e evidências científicas, com classificação dos tipos de erros à luz do referencial conceitual da segurança do paciente; e elaboração do protótipo da tecnologia. Resultados: 88% dos participantes realizam o flushing na sua prática; 49,5% aplicam a técnica de pressão contínua no êmbolo da seringa; 22% realizam o flushing antes, entre e após a administração de medicamentos; predomínio da utilização do volume e de seringas com calibres de 5 ml e 10 ml. Variáveis relacionadas ao conhecimento associaram-se à não realização do flushing. Houve erros ativos e latentes que orientaram a construção do protótipo da tecnologia. Conclusão: construiu-se um Guia de Cuidado que objetiva ampliar o conhecimento da equipe de enfermagem sobre as boas práticas do flushing e se configura como uma barreira à recorrência dos erros.

https://doi.org/10.1590/1980-265x-tce-2022-0302en

12.

Effects of local and remote ischemic postconditioning methods on ischemiareperfusion injury in a young animal model of acute mesenteric ischemia
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Abreu, Mateus Souza

; Tannuri, Ana Cristina Aoun

; Rodrigues, Rafael Felipe Gonçalves

; Silva, Rafael José da

; Gonçalves, Josiane de Oliveira

; Serafini, Suellen

; Tannuri, Uenis

Acta Cirúrgica Brasileira

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2023, Volume 38 elocation e381323

Resumo: En | Texto: En | PDF: En

ABSTRACT Purpose: Acute mesenteric ischemia (AMI) is a condition in pediatric surgery that ranges from intestine necrosis to death. Ischemic postconditioning (IPoC) methods were developed to reduce the damage caused by revascularization. This study aimed to evaluate the efficacy of these methods in an experimental weaning rat model. Methods: Thirty-two 21-day-old Wistar rats were allocated into four groups according to the surgical procedure performed: control, ischemia-reperfusion injury (IRI), local (LIPoC) and remote IPoC (RIPoC). At euthanasia, fragments of the intestine, liver, lungs, and kidneys were submitted to histological, histomorphometric, and molecular analyses. Results: In the duodenum, intestines, and kidneys histological alterations promoted by IRI were reversed by remote postconditioning method. In the distal ileum, the histomorphometric alterations could be reversed by the postconditioning methods with more evident effects promoted by the remote method. The molecular analysis found that the levels of expression of Bax (proapoptotic) and Bcl-XL (antiapoptotic) genes in the intestine were increased by IRI. These alterations were equally reversed by the postconditioning methods, with more evident effects of the remote method. Conclusions: IPoC methods positively reduced the damage caused by IRI in weaning rats.

https://doi.org/10.1590/acb381323

13.

Development of inclusion complex based on cyclodextrin and oxazolidine derivative
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Silva, Rafael Ramos

; Amorim, Cézar Augusto da Cruz

; Lima, Maria do Carmo Alves

; Rabello, Marcelo Montenegro

; Hernandes, Marcelo Zaldini

; Rêgo, Moacyr Jesus Barreto de Melo

; Pitta, Maira Galdino da Rocha

; Oliveira, Maria Danielly Lima de

; Andrade, César Augusto Souza de

Brazilian Journal of Pharmaceutical Sciences

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2023, Volume 59 elocation e22009

Resumo: En | Texto: En | PDF: En

Abstract Oxazolidine derivatives (OxD) have been described as third-line antibiotics and antitumoral agents. The inclusion complexes based on cyclodextrin could improve the solubility and bioavailability of these compounds. A novel synthetic OxD was used, and its inclusion complexes were based on 2-hydroxy-beta-cyclodextrin (2-HPβCD). We conducted an in silico study to evaluate the interaction capacity between OxD and 2-HPβCD. Characterization studies were performed through scanning electron microscopy (SEM), Fourier-transformed infrared (FTIR), nuclear magnetic resonance spectroscopy (1H-NMR), X-ray diffraction (XRD), and thermal analyses. A kinetic study of the OxD was performed, including a cytotoxicity assay using peripheral blood mononuclear cells (PBMCs). The maximum increment of solubility was obtained at 70 mM OxD using 400 mM 2-HPβCD. SEM analyses and FTIR spectra indicated the formation of inclusion complexes. 1H-NMR presented chemical shifts that indicated 1:1 stoichiometry. Different thermal behaviors were obtained. The pharmacokinetic profile showed a short release time. Pure OxD and its inclusion complex did not exhibit cytotoxicity in PBMCs. In silico studies provided a foremost insight into the interactions between OxD and 2-HPβCD, including a higher solubility in water and an average releasing profile without toxicity in normal cells.

https://doi.org/10.1590/s2175-97902023e22009

14.

A guerra do agronegócio contra a saúde coletiva: entrevista com Allan Rodrigo de Campos Silva coletiva
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Silva, Rafael Afonso da

Interface - Comunicação, Saúde, Educação

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2023, Volume 27 elocation e220488

Resumo: Pt | Texto: Pt | PDF: Pt

https://doi.org/10.1590/interface.220488

15.

Do anti-VEGFs used in the ophthalmic clinic cause Müller glial cell stress? antiVEGFs anti VEGFs stress
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Silva, Rafael André da

; Ferreira, Luiz Philipe de Souza

; Roda, Vinicius Moraes de Paiva

; Soares Junior, José Maria

; Simões, Manuel de Jesus

; Regatieri, Caio Vinicius Saito

Clinics

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2023, Volume 78 elocation 100161

Resumo: En | Texto: En | PDF: En

https://doi.org/10.1016/j.clinsp.2022.100161

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