RESUMO O conceito de antificção tem sido usado por teóricos como Lejeune e Alberca para explicar a demanda por gêneros não-ficcionais, como o diário e a autobiografia. A proposta do presente estudo é estender o conceito de antificção às estéticas que se definem como romanescas. Entre essas estéticas estão algumas possibilidades da autoficção, como a praticada pelo francês Hervé Guibert. Ou aquela forma romanesca desenvolvida pelo brasileiro Ricardo Lísias, em que o ensaio sobre o presente é categorizado como um gênero ficcional. Os dois autores partem de diários para a elaboração de seus romances. A forma do diário, tornada romance e ainda mantendo o relato de realidade, é uma forma notável do que se pode definir como antificção romanesca. nãoficcionais, nãoficcionais não ficcionais, ficcionais não-ficcionais autobiografia romanescas autoficção Guibert Lísias ficcional romances realidade

ABSTRACT The concept of antifiction has been used by theorists such as Lejeune and Alberca to explain the demand for non-fiction genres such as the diary and autobiography. The purpose of this study is to extend the concept of antifiction to aesthetic manifestations that define themselves as novels. Among these manifestations are some possibilities of autofiction, such as that practiced by Frenchman Hervé Guibert. Or that novel form developed by Brazilian author Ricardo Lísias, in which the essay on the present is categorized as a fictional genre. These two authors depart from diaries to elaborate their novels. The diary form, made into a novel and still retaining the account of reality, is a remarkable form of what might be defined as novelistic antifiction. nonfiction non fiction autobiography novels autofiction Guibert Lísias genre reality

ABSTRACT Iphigenia brasiliensis is a bivalve mollusk exploited as a shellfish and subsistence resource on the Brazilian coast, mainly in the north and northeast regions. Genetic (allozyme electrophoresis revealed eight gene loci) and morphological variations (multivariate morphometry of valves used 13 linear measurements of traditional and 19 Fourier coefficients of geometric morphometry) were studied, considering the geographic (445 km of the southwest tropical Atlantic), environmental (mangroves and channels of communication with the sea of three estuaries in the state of Rio de Janeiro), and temporal dimensions (over two years). I. brasiliensis showed high levels of genetic variation (the average number of alleles per locus ranged from 2.8 to 3.4, and the average heterozygosity ranged from 0.441 to 0.675). Bayesian analysis of population partitioning showed that the highest LnP(D) value was achieved for K = 3. These results indicated mixed ancestry, possibly oscillations in the dispersion dynamics among the different sampling groups, and temporal oscillations in the population sizes due to the anthropogenic influence on the studied estuaries. The results of morphological variation, inferred by the PERMANOVA from the Fourier analysis, indicated that a similar influence might occur in valves (also, the discriminant analysis showed that different groups could be consistently identified). In this sense, the studied populations may be organized in a dynamic of metapopulations. Finally, these are the first data on morphological and genetic variation of the species in the latitudinal, environmental, and temporal dimensions studied simultaneously, thus providing relevant information for the exploration, management, and conservation of this commercially important species.

Abstract The historical domination of the land in Brazil has meant the domination of the territory, control of the state, and its public funds. As a living contradiction, fences curtailed the right to land and gave rise to the struggle for land and for agrarian reform. In the meantime, this article presents the contemporary land structure of the state of Goiás and discusses the historical mediations of its constitution. To that end, bibliographical and documentary research were carried out. The results show that the struggle for land and for agrarian reform, responsible for land regularization and expropriation, culminated in 426 settlements with 23,670 families settled. Latifundia hold 62% of the area in hectares and 6.10% of the rural properties in the state of Goiás. On the other hand, minifundia and small properties control 76.23% of the properties and 17.93% of the real state area.

Resumen El dominio histórico de la tierra en Brasil significó dominio del territorio, control del Estado y de sus fondos públicos. El cerco cercenó el derecho a la tierra, como contradicción viva, también parió la lucha en la tierra y por la reforma agraria. En este ínterin, este artículo presenta la estructura agraria contemporánea de Goiás y diserta sobre las mediaciones históricas de su constitución. Para ello, se utilizó de investigación bibliográfica y investigación documental. Los resultados apuntan que la lucha por la tierra y por la reforma agraria, responsable por regularizaciones agrarias y expropiación de tierras, culminó con la creación de 426 asentamientos con 23.670 familias asentadas. El latifundio detiene 62% del área en hectáreas y 6,10% de las propiedades rurales en Goiás. Ya los minifundios y las pequeñas propiedades controlan 76,23% de las propiedades y 17,93% del área de los inmuebles.

Resumo O domínio histórico da terra no Brasil significou domínio do território e controle do Estado e de seus fundos públicos. A cerca cerceou o direito à terra e, como contradição viva, também pariu a luta na terra e pela reforma agrária. Nesse ínterim, este artigo apresenta a estrutura fundiária contemporânea de Goiás e as mediações históricas de sua constituição. Para isso, valeu-se de pesquisa bibliográfica e pesquisa documental. Os resultados apontam que a luta pela terra e pela reforma agrária, responsável por regularizações fundiárias e desapropriações, culminou na criação de 426 assentamentos, com 23.670 famílias assentadas. O latifúndio detém 62% da área e 6,10% dos imóveis rurais em Goiás. Já os minifúndios e as pequenas propriedades controlam 76,23% das propriedades e 17,93% da área dos imóveis.

Abstract Cotton is an essential worldwide commodity, and Brazil ranks fourth in world production and second in export. The present work aimed to gather the genealogies and estimate the genetic base of 109 Brazilian cotton cultivars released from 1932 to 2021. Twelve of the 68 ancestors identified contributed with 52.03% of the genes, and 33% of the cultivars resulted from the direct selection from landraces or old cultivars, evidencing a narrow genetic base. Over time, especially after 1990, the increases in the number of cultivars released and number of ancestors added to the breeding programs were driven by the need to reduce the cultivars' cycle for coexistence with pests and to make them suitable for mechanized cultivation in the new agricultural frontiers. However, Brazilian cotton cultivars still have a narrow genetic base, with the important participation of the ancestors CNPA SRI3, CKR 100W, C-77 and Express.

BACKGROUND According to the last 2023 Monkeypox (Mpox) Outbreak Global Map from the Centres for Disease Control and Prevention (CDC), more than 100 countries with no Mpox infection report cases. Brazil stands out in this group and is the second country with the highest number of cases in the last outbreak. OBJECTIVE To contribute to knowledge of the virus infection effects in a cellular model, which is important for diagnosis infections not yet included in a provider´s differential diagnosis and for developing viral inhibition strategies. METHODS We describe a virus isolation protocol for a human clinical sample from a patient from Brazil, the viral growth in a cell model through plaque forming units (PFU) assay, reverse transcriptase polymerase chain reaction (RT-PCR) and transmission electron microscopy (TEM). FINDINGS We follow the viral isolation in Vero cell culture from a Mpox positive clinically diagnosed sample and show the infection effects on cellular structures using a TEM. MAIN CONCLUSIONS Understanding the impact of viral growth on cellular structures and its replication kinetics may offer better strategies for the development of new drugs with antiviral properties.

Resumen Los procesos erosivos tienen graves impactos sobre el ambiente, generando importantes pérdidas económicas, sociales y de biodiversidad. Este trabajo tiene como objetivo analizar la fragilidad ambiental asociada a los procesos erosivos en la cuenca del arroyo La Onça, en Coxim, Mato Grosso do Sul-Brasil. La metodologia se sustenta en la cartografia de los suelos, la inclinación de las pendientes, las áreas prioritarias para la conservación de la biodiversidad y la intensidad de la lluvia, con vistas a evaluar la fragilidad potencial que, unida al mapa del uso y cobertura de la tierra por la superposición booleana ponderada, permite obtener la fragilidad ambiental. Para validar este modelo se realizó la identificación de los sitios con erosión, a partir de una imagen de alta resolución y el levantamiento de las áreas llamadas "suelos con exposición extrema" mediante la identificación de áreas que presentan el menor grado de protección del suelo. Los resultados muestran el predominio en la cuenca de las zonas con fragilidad ambiental media (59,61 %) y alta (23,66 %), asociada a una gran concentración de los procesos erosivos en áreas de baja cobertura vegetal, identificadas en el mapa de uso y cobertura de la tierra como áreas de pastos. Ideas destacadas: Articulo de investigación que tiene como premisa el análisis de la fragilidad ambiental asociada a los procesos erosivos dentro de la cuenca del arroyo La Onça (Coxim-Ms). Se utilizaron geotecnologias para el análisis sistémico, estableciendo medidas dirigidas a ayudar en la toma de decisiones para el manejo y conservación del área.

Resumo Os processos erosivos ocasionam severos impactos ao ambiente, gerando perdas económicas, sociais e de biodiversidade. Este trabalho analisa a fragilidade do ambiente a processos erosivos na bacia hidrográfica do córrego da Onça, em Coxim-MS. A metodologia se fundamentou em mapeamentos de solos, declividade, áreas prioritárias à conservação da biodiversidade e na intensidade pluviomètrica para avaliar a fragilidade potencial e no mapeamento de uso e cobertura da terra que, por meio de sobreposição booleana ponderada resultou um mapeamento da fragilidade ambiental. Para validar esse modelo, foram identificados, pontualmente, as feições erosivas a partir de uma imagem de alta resolução e também um levantamento, com enfoque nas áreas nominadas de "solos com exposição extrema", que teve como objetivo a identificação de áreas que apresentam o menor grau de proteção/cobertura do solo. Os resultados apontaram o predominio de média (59,61 %) e alta (23,66 %), associadas a grandes concentrações de processos erosivos em área de "solo com exposição extrema", áreas de baixa cobertura vegetal, classificadas no uso e cobertura da terra com as classes de pastagem. Ideias destacadas: Artigo de investigação que tem como premissa a análise da fragilidade ambiental associada aos processos erosivos na bacia do córrego da Onça (Coxim-MS), empregando-se as geotecnologias para a análise sistêmica do ambiente, estabelecendo medidas propositivas, que auxiliem na tomada de decisões para o manejo e conservação da área.

Abstract Erosive processes cause severe impacts on the environment, causing economic, social, and biodiversity losses. This paper aims to analyze the fragility of the environment to erosive processes in the Onça river basin, in Coxim-MS. The methodology was based on soil mapping, slope, priority areas for biodiversity conservation, and rainfall intensity to evaluate the potential fragility and land use and land cover, that by means of a boolean weighted overlap with the potential fragility resulted in the mapping of the environmental fragility. To validate the environmental fragility model, the erosive features were identified from a high-resolution image and a making, focusing on the areas named "soils with extreme exposure" from a classification, which had as its only aim to identify areas with the lowest degree of protection/ground cover. The results pointed to the predominance of medium (59.61 %) and high (23.66 %) environmental fragility, associated with high concentrations of erosive processes in "soil with extreme exposure" area, which are areas of low vegetation cover, classified by use. and land cover with the pasture classes. Main ideas: Research article that has as premise the analysis of environmental fragility to erosive processes within the watershed of the Onça stream (Coxim-MS), using geotechnologies for the systemic analysis of the environment, establishing propositional measures that assist in taking decisions for the management and conservation of the area.

Abstract Background The long incubation periods of cardiovascular diseases offer opportunities for controlling risk factors. In addition, preventive interventions in childhood are more likely to succeed because lifestyle habits become ingrained as they are repeated. Objective To investigate the effects of recreational physical activities, in combination or not with a qualitative nutritional counseling, in cardiometabolic risk factors of students with dyslipidemia and abdominal obesity. Methods Students (8-14 years old) were randomly divided into three groups (n=23 each): i ) Control; ii ) PANC, students undergoing Physical Activity and Nutritional Counseling, and iii ) PA, students submitted to Physical Activity, only. Blood samples (12-h fasting) were collected for biochemical analysis and anthropometric markers were also assessed. Two-Way RM-ANOVA and Holm-Sidak’s test, and Friedman ANOVA on Ranks and Dunn’s test were applied. P ≤ 0.05 was considered significant. Effect sizes were evaluated by Hedges’ g and Cliff’s δ for normal and non-Gaussian data, respectively. Results Compared to the control group and to baseline values, both interventions caused significant average reductions in total cholesterol (11%; p <0.001), LDL-c (19%; p=0.002), and non-HDL-c (19%; p=0.003). Furthermore, students in the PANC group also experienced a significant decrease in body fat compared to baseline (p=0.005) and to control (5.2%; g=0.541). Conclusions The proposed strategies were effective to reduce cardiometabolic risk factors in children and adolescents. The low cost of these interventions allows the implementation of health care programs in schools to improve the students’ quality of life.

Resumo A história do povo indígena Xukuru do Ororubá, habitante nos municípios de Pesqueira e Poção, no Semiárido pernambucano, é marcada por mobilizações pela afirmação, exigências de reconhecimento e garantias de direitos desde o início da colonização portuguesa na região. Nas reflexões apresentadas em diferentes situações e contextos sociohistóricos, após meados do Século XIX quando o antigo Aldeamento de Cimbres foi oficialmente declarado extinto ocorrendo a legitimação das invasões de fazendeiros e da agroindústria no Século XX, buscou-se evidenciar as narrativas e registros das continuas reivindicações dos indígenas, o que possibilita compreender os significados dessas mobilizações e a importância para a afirmação da identidade indígena e o reconhecimento do território onde habitam.

Abstract The history of the Xukuru of Ororubá indigenous people, who inhabit the municipalities of Pesqueira and Poção, in the semi-arid region of the state of Pernambuco (Brazilian northeast), is marked by mobilizations for affirmation, demands for recognition and guarantees of rights since the beginning of the Portuguese colonization in the region. This article draws a series of reflections considering different situations and socio-historical contexts, specially after the middle of the 19th century when the former Cimbres Village was officially declared extinct and the invasions by farmers and agro-industry in the 20th century were legitimized. We sought to highlight the narratives and records of the continuous claims made by the indigenous people, which makes it possible to understand the meanings of these mobilizations and their importance for the affirmation of indigenous identity and the recognition of the territory where they live.

Resumo O Brasil é um país reconhecido por sua rica biodiversidade, mas também pela rápida perda de parte significativa de seus recursos genéticos in situ. Entre centenas de espécies nativas que apresentam grande potencial de exploração econômica, muitas ainda não são reconhecidas ou ainda não foram descritas. A mangabeira (Hancornia speciosa Gomes) é uma árvore frutífera que se encontra no início do processo de domestificação e possui enorme potencial econômico. No entanto, está sendo afetada pela erosão genética. Neste trabalho, são descritas cinco populações de mangabeira localizadas em distintas unidades de conservação, nas regiões Centro-Oeste e Nordeste do Brasil, onde ocorrem as variedades pubescens (típica) e speciosa. Mostramos que, mesmo em áreas protegidas, plantas de mangabeira não estão nas melhores condições de conservação. Como as áreas estão localizadas em biomas e em condições ambientais diversas, essas populações oferecem oportunidade para aprimorar o conhecimento sobre a espécie e para mapear suas áreas de ocorrência. Destacamos a relevância de manter as populações de mangabeira como reservatórios de recursos genéticos, o que potencializa a utilização da variabilidade genética desta espécie. Essas descrições destacam a importância significativa da manutenção de áreas protegidas como uma estratégia adequada para a conservação in situ.

Abstract Brazil, a recognized country for its rich biodiversity, is also known for the rapid loss of a significant part of its in situ genetic resources. Among hundreds of native species that have great potential for economic exploitation, many are not yet acknowledged or are yet to be described. The mangabeira (Hancornia speciosa Gomes) is a fruit tree at the begging of the domestication process and has enormous economic potential. However, it is being affected by genetic erosion. In this communication, we describe five populations of mangabeira located in distinct protected areas in the Midwest and Northeast regions of Brazil, where the varieties speciosa and pubescens occur. We show that even in protected areas, mangabeira plants are not in the best situation for conservation. The areas are located in diverse biomes and environmental conditions; therefore, such populations provide an opportunity to improve the knowledge about the species and map its areas of occurrence. We highlight the relevance of maintaining mangabeira populations as reservoirs of genetic resources, which leverage the utilization of the genetic variability of this species. These descriptions highlight the significant importance of maintaining protected areas as a suitable strategy for in situ conservation.

Resumo A demarcação de terra interconecta-se com a reprodução social e a saúde dos povos indígenas. Encontra-se desafiada pela economia globalizada e a implantação de grandes empreendimentos desenvolvimentistas nos territórios indígenas. Este artigo objetiva refletir sobre demarcação de terra indígena, saúde e novas territorialidades na implantação da transposição do rio São Francisco, no povo Pipipã, em Floresta-PE. A abordagem teórico-metodológica para o estudo é a reprodução social e a saúde formulada por Juan Samaja. Trata-se de estudo analítico, qualitativo, com a realização de entrevistas, observação participante e oficinas participativas nas aldeias cortadas pelo Eixo Leste da transposição. Evidencia-se meio século de mobilizações dos Pipipã pela demarcação de terra, marcadas por entraves políticos nos âmbitos municipal, estadual e nacional. A demarcação de terra inter-relacionou-se com a saúde e representou o maior sonho dos indígenas. Para vencerem o medo, no contexto da transposição, assumiram compromissos de união, participação e marcação do território com os rituais. A transposição desestruturou relações, inseriu novas territorialidades, ampliou os desafios de demarcação de terra, agravou a saúde indígena e não promoveu o acesso à água transposta, principal objetivo do projeto, configurando uma situação de injustiça ambiental.

Abstract Land demarcation is interconnected with the social reproduction and health of indigenous peoples. It is challenged by the globalized economy and the implementation of large developmental projects in indigenous territories. This article aims to reflect on the demarcation of indigenous land, health and new territorialities in the implementation of the transposition of the São Francisco River, in the Pipipã people, in Floresta-PE. The theoretical-methodological approach to the study is social reproduction and health formulated by Juan Samaja. This is an analytical, qualitative study, with interviews, participant observation and participatory workshops in the villages crossed by the East Axis of transposition. There is evidence of half a century of mobilizations by the Pipipã for land demarcation, marked by political obstacles at the municipal, state and national levels. Land demarcation was interrelated with health and represented the greatest dream of the indigenous people. To overcome fear, in the context of transposition, they assumed commitments of union, participation and marking the territory with rituals. The transposition disrupted relationships, introduced new territorialities, expanded the challenges of land demarcation, worsened indigenous health and did not promote access to transposed water, the main objective of the project, configuring a situation of environmental injustice.

Resumo A demarcação de terra interconecta-se com a reprodução social e a saúde dos povos indígenas. Encontra-se desafiada pela economia globalizada e a implantação de grandes empreendimentos desenvolvimentistas nos territórios indígenas. Este artigo objetiva refletir sobre demarcação de terra indígena, saúde e novas territorialidades na implantação da transposição do rio São Francisco, no povo Pipipã, em Floresta-PE. A abordagem teórico-metodológica para o estudo é a reprodução social e a saúde formulada por Juan Samaja. Trata-se de estudo analítico, qualitativo, com a realização de entrevistas, observação participante e oficinas participativas nas aldeias cortadas pelo Eixo Leste da transposição. Evidencia-se meio século de mobilizações dos Pipipã pela demarcação de terra, marcadas por entraves políticos nos âmbitos municipal, estadual e nacional. A demarcação de terra inter-relacionou-se com a saúde e representou o maior sonho dos indígenas. Para vencerem o medo, no contexto da transposição, assumiram compromissos de união, participação e marcação do território com os rituais. A transposição desestruturou relações, inseriu novas territorialidades, ampliou os desafios de demarcação de terra, agravou a saúde indígena e não promoveu o acesso à água transposta, principal objetivo do projeto, configurando uma situação de injustiça ambiental.

Abstract Land demarcation is interconnected with the social reproduction and health of indigenous peoples. It is challenged by the globalized economy and the implementation of large developmental projects in indigenous territories. This article aims to reflect on the demarcation of indigenous land, health and new territorialities in the implementation of the transposition of the São Francisco River, in the Pipipã people, in Floresta-PE. The theoretical-methodological approach to the study is social reproduction and health formulated by Juan Samaja. This is an analytical, qualitative study, with interviews, participant observation and participatory workshops in the villages crossed by the East Axis of transposition. There is evidence of half a century of mobilizations by the Pipipã for land demarcation, marked by political obstacles at the municipal, state and national levels. Land demarcation was interrelated with health and represented the greatest dream of the indigenous people. To overcome fear, in the context of transposition, they assumed commitments of union, participation and marking the territory with rituals. The transposition disrupted relationships, introduced new territorialities, expanded the challenges of land demarcation, worsened indigenous health and did not promote access to transposed water, the main objective of the project, configuring a situation of environmental injustice.

Abstract The inadequate choice of a diagnostic method or the option for techniques that have low sensitivity and specificity may limit the diagnosis of parasitic agents that affect aquatic mammals. The aim of this study was to evaluate the performance of the FLOTAC technique and compare it with three traditional methods (Willis, sedimentation and centrifugation- flotation) used in the diagnosis of gastrointestinal parasites in aquatic mammals. For this, 129 fecal samples from 12 species were collected. Each sample was submitted to laboratory processing using the Willis, Hoffman techniques, Faust method and FLOTAC. Sensitivity, specificity, real prevalence, estimated prevalence, positive predictive value, negative predictive value, correct classification (accuracy) and incorrect classification were evaluated to compare the different diagnostic methods. The highest frequency of positive samples occurred using FLOTAC (46.51%), compared to Hoffman (23.25%), Faust (10.07%) and Willis techniques (6.97%). In the samples analyzed, the occurrence of Strongylidae eggs and Eimeriidae oocysts was frequently observed. The FLOTAC technique proved to be the most appropriate technique and due to its efficacy, is strongly recommended for coproparasitological evaluations in aquatic mammals.

Abstract Hancornia speciosaGomes, a native fruit tree, plays an important socio-economic role in Brazil's traditional communities. The objective was to estimate the genetic structure of 176 individuals from eight locations in the Cerrado, Caatinga and Atlantic Forest biomes, based on six microsatellite markers. The analyzes revealed the formation of five population groups: A- Pernambuco, Paraíba and Sergipe (Atlantic Forest), B- Maranhão (Cerrado); both, var. speciosa, C- Bahia (Caatinga / Cerrado transition zone) and Ceará (Caatinga), D- Goiás (Cerrado) and E- Minas Gerais (Cerrado,) being groups C, D and E possibly var. pubescens. Most of the genetic variation is within the groups (65.61%, Fst = 0.34, p <0.001). Although group A had the highest Ho (0.66), it had a negative fixation index (f = -0.02), while the other had positive values. Our results revealed high levels of genetic diversity and provide support the development of more efficient conservation strategies for H. speciosa.

RESUMO Pela questão ambiental aumentou-se a procura por materiais que utilizem mais recursos naturais e renováveis, como os polímeros reforçados com fibras naturais. São realizados tratamentos superficiais para a melhor adesão da fibra na matriz polimérica, o mais comum é a merceirização através de solução de NaOH. A fibra de coco foi analisada em quatro condições: variando entre tratadas e não tratadas, seca em estufa e seca naturalmente. Em seguida foram analisadas por ensaio de tração, microscopia eletrônica de varredura (MEV) e tomografia de raio x para estudar as características mecânicas, morfológicas e observar a adesão ao polímero. Após o tratamento químico ocorreu a remoção da lignina e hemicelulose da superfície da fibra. Nas fibras tratadas e secas surgiram microfissuras que podem comprometer as propriedades mecânicas. Através do processamento das imagens das secções transversais da fibra foi obtida uma área efetiva entre 39,6% e 43,3%. Para as fibras abaixo de 300 µm a resistência a tração converge para 20 a 60 MPa e o módulo de elasticidade entre 1 e 3 GPa. Os tratamentos aumentaram a resistência a tração e módulo de elasticidade das fibras, contribuindo para a utilização de fibra de coco como reforço em polímeros.

ABSTRACT Due to the environmental issue, the demand for materials that use more natural and renewable resources increased, such as natural fibers reinforced polymers. Surface treatments are performed for better adhesion of the fiber to the polymer matrix, the most common is mercerization through NaOH solution. Coconut fiber was analyzed under four conditions: varying between treated and untreated, oven dried and naturally dried. Then they were analyzed by tensile test, scanning electron microscopy (SEM) and x-ray tomography to study the mechanical and morphological characteristics and observe the adhesion to the polymer. After the chemical treatment, lignin and hemicellulose were removed from the fiber surface. In the treated and dried fibers, micro-cracks appeared that could compromise the mechanical properties. By processing the images of the fiber cross-sections, an effective area between 39.6% and 43.3% was obtained. For fibers below 300 µm, the tensile strength converges to 20 to 60 MPa and the modulus of elasticity between 1 and 3 GPa. The treatments increased the tensile strength and modulus of elasticity of the fibers, contributing to the use of coconut fiber as reinforcement in polymers.

Abstract The objective of this study is to validate the specific questionnaire for Hepatitis B HBQOL (Hepatitis B Quality of Life Instrument, version 1.0) for the Brazilian version, in addition to testing its applicability in patients with hepatitis B under treatment and comparing the quality of life between patients using first-line drugs (tenofovir and entecavir). For the validation, the back-translation technique was used in a sample of 47 patients. Factor analysis was performed between the items in each domain of the questionnaire and the internal consistency was calculated using Cronbach's α coefficient. In assessing the applicability of the validated questionnaire, interviews were carried out with 124 patients. Sociodemographic and treatment data were collected to characterize the sample and perform correlation analyzes. The results demonstrate that the Brazilian version of the questionnaire was successfully validated. In the analysis carried out among the 124 patients, the domains psychological well-being and stigma obtained the highest scores in quality of life and the lowest level of education conferred better results in these two domains. The comparison between tenofovir and entecavir showed no significant difference in patients' quality of life. The use of this validated instrument can make therapeutic decisions more rational.