Abstract Objective Early diagnosis of Severity Mycoplasma Pneumoniae Pneumonia (SMPP) has been a worldwide concern in clinical practice. Two cytokines, soluble Triggering Receptor Expressed on Myeloid cells (sTREM-1) and Interferon-Inducible Protein-10 (IP-10), were proved to be implicated in bacterial infection diseases. However, the diagnostic value of sTREM-1 and IP-10 in MPP was poorly known. This study aimed to investigate the diagnostic value of sTREM-1 and IP-10 for SMPP. Methods In this prospective study, the authors enrolled 44 children with MPP, along with their clinical information. Blood samples were collected, and cytokine levels of sTREM-1 and IP-10 were detected with ELISA assay. Results Serum levels of sTREM-1 and IP-10 were positively correlated with the severity of MPP. In addition, sTREM-1 and IP-10 have significant potential in the diagnosis of SMPP with an Area Under Curve (AUC) of 0.8564 (p-value = 0.0001, 95% CI 0.7461 to 0.9668) and 0.8086 (p-value = 0.0002, 95% CI 0.6918 to 0.9254) respectively. Notably, the combined diagnostic value of sTREM-1 and IP-10 is up to 0.911 in children with SMPP (p-value < 0.001, 95% CI 0.830 to 0.993). Conclusions Serum cytokine levels of sTREM-1 and IP-10 have a great potential diagnostic value in children with SMPP. (SMPP practice cytokines sTREM1 sTREM 1 (sTREM-1 InterferonInducible Interferon Inducible Protein10 Protein 10 Protein-1 IP10, IP10 IP , (IP-10) diseases However sTREM- IP-1 known 4 information collected assay addition AUC (AUC 08564 0 8564 0.856 pvalue p 00001 0001 0.0001 95 07461 7461 0.746 0.9668 09668 9668 08086 8086 0.808 00002 0002 0.0002 06918 6918 0.691 0.9254 09254 9254 respectively Notably 0911 911 0.91 001 0.001 0830 830 0.83 0.993. 0993 0.993 . 993 0.993) (sTREM- Protein1 Protein- IP1 (IP-10 IP- 0856 856 0.85 0000 000 0.000 9 0746 746 0.74 0.966 0966 966 0808 808 0.80 0691 691 0.69 0.925 0925 925 091 91 0.9 00 0.00 083 83 0.8 099 0.99 99 (sTREM (IP-1 085 85 074 74 0.7 0.96 096 96 080 80 069 69 0.6 0.92 092 92 09 0. 0.0 08 8 (IP- 07 7 06 6 (IP

Abstract Background and aims The association of blood transfusion with an increase in medium- and short-term mortality in specific populations has been confirmed. However, the correlation between blood transfusion and long-term mortality in the general population remains unclear. This cohort study evaluated the correlation between blood transfusion and overall and cause-specific mortality in the general American adult population. Methods The authors utilized 10 sets of 2-year cycle data (1999-2018) from the National Health and Nutrition Examination Survey on the outcomes of adults who did and did not receive blood transfusions. Propensity score-matching (1:1) was performed based on age, sex, race, education level, marital status, poverty-income ratio, arteriosclerotic cardiovascular disease, cancer, anemia, hypertension, and diabetes status. After controlling for demographic characteristics and clinical risk factors, Cox regression analysis was performed to evaluate the correlation between blood transfusion and all-cause and cause-specific mortality. Results The study included 48,004 adult participants. The risk of all-cause mortality increased by 101 % with blood transfusion, and the risk of cardiovascular mortality increased by 165 %. After propensity score-matching, 6,116 pairs of cases were retained, and the risk of all-cause mortality increased by 84 % with blood transfusion, and the risk of cardiovascular mortality increased by 137 %. The sensitivity analysis results were robust. Conclusions In the general American population, blood transfusion significantly impacts long-term all-cause and cardiovascular mortality and may be an unacknowledged risk factor for death. Thus, the effective management of blood transfusion in the general population may be beneficial. medium shortterm short term confirmed However longterm long unclear causespecific cause 1 2year year 2 19992018 1999 2018 (1999-2018 transfusions scorematching score matching 11 (1:1 age sex race level status povertyincome poverty income ratio disease cancer anemia hypertension factors allcause all 48004 48 004 48,00 participants 16 scorematching, matching, 6116 6 116 6,11 retained 8 13 robust death Thus beneficial 1999201 199 201 (1999-201 (1: 4800 4 00 48,0 611 6,1 199920 19 20 (1999-20 (1 480 0 48, 61 6, 19992 (1999-2 ( (1999- (1999 (199 (19

Silicon catalysts have very low catalytic activity in polyester (PET). However, titanium catalysts have high catalytic activity in polyester. The simultaneous use of titanium and silicon catalysts is effective in reducing the activity of a single titanium catalytic base agent. In addition, the glycol salts of titanium and silicon (Ti-EG and Si-EG) prepared in the present invention for use in the polyester catalytic process can avoid the introduction of other groups of impurities during the polyester catalytic process, which would lead to premature capping of the polyester in the process of polycondensation and chain building and make it difficult to increase the molecular weight, and thus affect the quality of the polyester. It has been verified that the ratio of Ti:Si is 1:1 (mol), and total amount added to the catalyst is 0.15% of the raw material amount, and the polycondensation temperature was 260-280 °C for 60 min. Compared with the single Ti-EG catalyst, the b* value of the synthesized PET was significantly reduced, and the molecular weight and other indexes did not change too much. In addition, at the end of catalysis, the catalyst was uniformly dispersed in the reaction system, which could be used as a matting agent for PET. . (PET) However addition TiEG Ti EG SiEG Si Si-EG TiSi 11 1 1: mol, mol , (mol) 015 0 15 0.15 260280 260 280 260-28 C 6 min b reduced much catalysis system (PET (mol 01 0.1 26028 26 28 260-2 0. 2602 2 260-

The effect of annealing process on the microstructures and mechanical properties of Mg/Al composite plates fabricated by cast-rolling was investigated in this study. The results show that the interfacial transition zone can be divided into three regions: a Mg transition region, an Al transition region, and an intermediate region, respectively. The microhardness of the interfacial transition zone is higher than that of AZ31B and A356.When the annealing temperature is 250 ºC, the thermodynamic and kinetic conditions required for the formation of new intermetallic compounds have been met. While, for an annealing temperature at, or above, 300 ºC, the width of the interfacial transition zone, annealing temperature, and time follow model: ∆ X 2 = 2 . 07 × 10 4 exp − 60407 RT t − 11 . 54 exp 21211 RT. The shear strength reaches a maximum value of 116 MPa when the annealing temperature is 200 ºC. Cleavage fracture occurs at the side of the AZ31B alloy and quasi-cleavage fracture at the side of the A356 alloy.