Abstract This study aims to evaluate the anti-cancer-related inflammation activity of Cyperus rotundus bioactive compounds. The component of C. rotundus was analyzed using LC-HRMS. The drug-likeness of all compounds were analyzed using swissADME webserver. In addition, the analysis of inhibition potential of compounds against NF-κB and iNOS were carried out using molecular docking in PyRx software. This study found 1-Nitro-2-phenoxybenzene, ethyl 4-(acetylamino)-3-phenyl-2-thioxo-2,3-dihydro-1,3-thiazole-5-carboxylate, and nootkatone passed all the parameters of drug-likeness including Lipinski, ghose, veber, egan, and muege. Based on molecular docking, verbascoside A and n-Pentyl isopentyl phthalate has the lowest binding affinity against iNOS (-10 and -8.9 kcal/mol, respectively). In addition, verbascoside A and maltopentaose have binding affinity of -7.6 and -6.6 kcal/mol, respectively, for NF-κB. The anti-cancer activity of verbascoside A, maltopentaose, and n-Pentyl isopentyl phthalate, according to PASS analysis were anti-inflammatory, antineoplastic, chemopreventive, and chemoprotectant. The cytotoxic effect prediction showed that these compounds were relatively selective to kill tumor cell but not non-tumor cell. Rat toxicity analysis showed maltopentaose was non-toxic, where n-Pentyl isopentyl phthalate was only toxic (class IV) for intravenous administration. perMM analysis showed verbascoside A and n-Pentyl isopentyl phthalate can translocate and across the cell membrane. anticancerrelated anti cancer related C LCHRMS. LCHRMS LC HRMS. HRMS LC-HRMS druglikeness drug likeness webserver addition NFκB NF κB software 1Nitro2phenoxybenzene, 1Nitro2phenoxybenzene Nitrophenoxybenzene 1 Nitro 2 phenoxybenzene, phenoxybenzene 1-Nitro-2-phenoxybenzene 4acetylamino3phenyl2thioxo2,3dihydro1,3thiazole5carboxylate, 4acetylamino3phenyl2thioxo23dihydro13thiazole5carboxylate acetylaminophenylthioxodihydrothiazolecarboxylate 4 acetylamino 3 phenyl thioxo 2,3 dihydro 1,3 thiazole 5 carboxylate, carboxylate 4-(acetylamino)-3-phenyl-2-thioxo-2,3-dihydro-1,3-thiazole-5-carboxylate Lipinski ghose veber egan muege nPentyl n Pentyl 10 (-1 8.9 89 8 9 -8. kcalmol kcal mol kcal/mol respectively. respectively . respectively) 7.6 76 7 6 -7. 6.6 66 -6. NFκB. κB. anticancer antiinflammatory, antiinflammatory inflammatory, inflammatory anti-inflammatory antineoplastic chemopreventive chemoprotectant nontumor non nontoxic, nontoxic toxic, non-toxic class IV administration membrane 4acetylamino3phenyl2thioxo2 3dihydro1 3thiazole5carboxylate 4acetylamino3phenyl2thioxo2,3dihydro1,3thiazole5carboxylate 23 2, 13 1, (- 8. -8 7. -7 6. -6 acetylaminophenylthioxo 4acetylamino3phenyl2thioxo 3dihydro thiazolecarboxylate ( -

Resumo Este estudo tem como objetivo avaliar a atividade inflamatória relacionada ao câncer de compostos bioativos de Cyperus rotundus. O componente de C. rotundus foi analisado utilizando LC-HRMS. A semelhança com o medicamento de todos os compostos foi analisada usando o servidor web swissADME. Além disso, a análise do potencial de inibição dos compostos contra NF-κB e iNOS foi realizada utilizando docking molecular no software PyRx. Este estudo descobriu que 1-Nitro-2-fenoxibenzeno, etil 4-(acetilamino)-3-fenil-2-tioxo-2,3-di-hidro-1,3-tiazol-5-carboxilato e nootkatone passaram em todos os parâmetros do medicamento-semelhança, incluindo Lipinski, ghose, veber, egan e muege. Com base no acoplamento molecular, o verbascosídeo A e o ftalato de n-pentil isopentil têm a menor afinidade de ligação contra iNOS (-10 e -8,9 kcal/mol, respectivamente). Além disso, o verbascosídeo A e a maltopentaose têm afinidade de ligação de -7,6 e -6,6 kcal/mol, respectivamente, para o NF-κB. A atividade anticancerígena do verbascosídeo A, maltopentaose e ftalato de n-pentil isopentil, de acordo com a análise PASS, foi antiinflamatória, antineoplásica, quimiopreventiva e quimioprotetora. A previsão do efeito citotóxico mostrou que esses compostos eram relativamente seletivos para matar células tumorais, mas não células não tumorais. A análise de toxicidade em ratos mostrou que a maltopentaose não era tóxica, enquanto o n-pentil isopentil ftalato era tóxico apenas (classe IV) para administração intravenosa. A análise perMM mostrou que o verbascosídeo A e o n-pentil isopentil ftalato podem translocar-se através da membrana celular. C LCHRMS. LCHRMS LC HRMS. HRMS LC-HRMS swissADME disso NFκB NF κB PyRx 1Nitro2fenoxibenzeno, 1Nitro2fenoxibenzeno Nitrofenoxibenzeno 1 Nitro 2 fenoxibenzeno, fenoxibenzeno 1-Nitro-2-fenoxibenzeno 4acetilamino3fenil2tioxo2,3dihidro1,3tiazol5carboxilato 4acetilamino3fenil2tioxo23dihidro13tiazol5carboxilato acetilaminofeniltioxodihidrotiazolcarboxilato 4 acetilamino 3 fenil tioxo 2,3 di hidro 1,3 tiazol 5 carboxilato medicamentosemelhança, medicamentosemelhança semelhança, medicamento-semelhança Lipinski ghose veber muege npentil n pentil 10 (-1 8,9 89 8 9 -8, kcalmol kcal mol kcal/mol respectivamente. respectivamente . respectivamente) 7,6 76 7 6 -7, 6,6 66 -6, NFκB. κB. PASS antiinflamatória antineoplásica quimioprotetora tumorais tóxica classe IV intravenosa translocarse translocar se celular 4acetilamino3fenil2tioxo2 3dihidro1 3tiazol5carboxilato dihidro 23 2, 13 1, (- 8, -8 7, -7 6, -6 acetilaminofeniltioxo 4acetilamino3fenil2tioxo 3dihidro tiazolcarboxilato ( -

ABSTRACT. The immediate early gene exhibits activation markers in the nervous system consisting of ARC, EGR-1, and c-Fos and is related to synaptic plasticity, especially in the hippocampus. Immediate early gene expression is affected by physical exercise, which induces direct ARC, EGR-1, and c-Fos expression. Objective: To assess the impact of exercise, we conducted a literature study to determine the expression levels of immediate early genes (ARC, c-Fos, and EGR-1). Methods: The databases accessed for online literature included PubMed-Medline, Scopus, and ScienceDirect. The original English articles were selected using the following keywords in the title: (Exercise OR physical activity) AND (c-Fos) AND (Hippocampus), (Exercise OR physical activity) AND (ARC) AND (Hippocampus), (Exercise OR physical activity) AND (EGR-1 OR zif268) AND (Hippocampus). Results: Physical exercise can affect the expression of EGR-1, c-Fos, and ARC in the hippocampus, an important part of the brain involved in learning and memory. High-intensity physical exercise can increase c-Fos expression, indicating neural activation. Furthermore, the expression of the ARC gene also increases due to physical exercise. ARC is a gene that plays a role in synaptic plasticity and regulation of learning and memory, changes in synaptic structure and increased synaptic connections, while EGR-1 also plays a role in synaptic plasticity, a genetic change that affects learning and memory. Overall, exercise or regular physical exercise can increase the expression of ARC, c-Fos, and EGR-1 in the hippocampus. This reflects the changes in neuroplasticity and synaptic plasticity that occur in response to physical activity. These changes can improve cognitive function, learning, and memory. Conclusion: c-Fos, EGR-1, and ARC expression increases in hippocampal neurons after exercise, enhancing synaptic plasticity and neurogenesis associated with learning and memory. ABSTRACT EGR1, EGR1 EGR 1, 1 cFos c Fos hippocampus Objective (ARC cFos, Fos, EGR1. . EGR-1) Methods PubMedMedline, PubMedMedline PubMed Medline, Medline PubMed-Medline Scopus ScienceDirect title Exercise activity (c-Fos Hippocampus, Hippocampus , (Hippocampus) (EGR- zif268 zif Hippocampus. Results memory Highintensity High intensity Furthermore connections EGR- Overall function Conclusion (Hippocampus (EGR zif26 zif2

RESUMO. O gene precoce imediato (GPI) exibe marcadores de ativação no sistema nervoso constituídos por ARC, EGR-1 e c-Fos e está relacionado à plasticidade sináptica, especialmente no hipocampo. A expressão do GPI é afetada pelo exercício físico, que induz a expressão direta de ARC, EGR-1 e c-Fos. Objetivo: Para avaliar o impacto do exercício físico, realizamos um estudo de literatura para determinar os níveis de expressão dos GPIs (ARC, c-Fos e EGR-1). Métodos: A base de dados utiliza literatura on-line, PubMed-Medline, Scopus e ScienceDirect. O artigo original em inglês usa as seguintes palavras-chave em seu título: (Exercise) AND (c-Fos) AND (Hippocampus), (Exercise) AND (ARC) AND (Hippocampus), (Exercise) AND (EGR-1) AND (Hippocampus). Resultados: O exercício físico pode afetar a expressão de EGR-1, c-fos e ARC no hipocampo, uma parte importante do cérebro envolvida na aprendizagem e na memória. O exercício físico aumenta a expressão do gene c-Fos; sua alta intensidade pode aumentar a expressão de c-Fos, indicando ativação neural. Além disso, a expressão do gene ARC aumentou devido ao exercício físico, onde ARC é um gene que desempenha um papel na plasticidade sináptica e na regulação da aprendizagem e da memória, nas mudanças na estrutura sináptica e no aumento das conexões sinápticas, enquanto o EGR-1 também desempenha um papel na plasticidade sináptica, uma mudança genética que afeta o aprendizado e a memória. De maneira geral, o exercício físico regular pode aumentar a expressão de ARC, c-fos e EGR-1 no hipocampo. Isso reflete as mudanças na neuroplasticidade e na plasticidade sináptica que ocorrem em resposta à atividade física. Essas mudanças podem melhorar a função cognitiva, o aprendizado e a memória. Conclusão: A expressão de c-Fos, EGR-1 e ARC aumenta após o exercício físico nos neurônios do hipocampo, para aumentar a plasticidade sináptica, a neurogênese associada ao aprendizado e à memória. RESUMO (GPI EGR1 EGR 1 EGR- cFos c Fos hipocampo cFos. Fos. Objetivo (ARC EGR1. . EGR-1) Métodos online, online on line, line on-line PubMedMedline, PubMedMedline PubMed Medline, Medline PubMed-Medline ScienceDirect palavraschave palavras chave título Exercise (Exercise (c-Fos Hippocampus, Hippocampus , (Hippocampus) (EGR-1 Hippocampus. Resultados EGR1, 1, cfos fos memória cFos, Fos, neural disso sinápticas geral física cognitiva Conclusão (Hippocampus (EGR- (EGR

Abstract This study examines the influence of family control on firm performance, taking into consideration the moderating variable of the proportion of independent commissioners. The sample for this research consists of manufacturing sector companies listed on the Indonesia Stock Exchange (IDX) for the period 2012-2018, with 477 observations. Ordinary Least Squares (OLS) regression analysis and Moderated Regression Analysis (MRA) techniques were employed to test the hypotheses. The findings of this research indicate that family control has a significant negative impact on firm performance. Additionally, it was found that the proportion of independent commissioners significantly weakens the negative influence of family control on firm performance. performance IDX (IDX 20122018, 20122018 2012 2018, 2018 2012-2018 47 observations OLS (OLS MRA (MRA hypotheses Additionally 2012201 201 2012-201 4 201220 20 2012-20 20122 2 2012-2 2012-

Resumo Esta pesquisa analisa o efeito do controle familiar no desempenho corporativo tendo a proporção de conselheiros independentes como variável moderadora. A amostra desta pesquisa são empresas do setor manufatureiro listadas na Bolsa de Valores da Indonésia para o período 2012-2018, com 477 observações. Este estudo utiliza técnicas de mínimos quadrados ordinários (OLS) e análise de regressão moderada (MRA) para chegar aos resultados. Esta pesquisa descobriu que o controle familiar tem um efeito negativo significativo no desempenho corporativo. O outro resultado concluiu que a proporção de comissários independentes enfraquece significativamente o efeito negativo do controle familiar no desempenho empresarial. moderadora 20122018, 20122018 2012 2018, 2018 2012-2018 47 observações OLS (OLS MRA (MRA resultados empresarial 2012201 201 2012-201 4 201220 20 2012-20 20122 2 2012-2 2012-

Abstract: Introduction: arrhythmia is one of the most common extrapulmonary complications of coronavirus 2019 (COVID-19). Objectives: this study aimed to assess the outcomes of hospitalized COVID-19 patients with and without arrhythmia from asymptomatic to life-threatening disease severity and the predictors of the in-hospital outcomes. Material and methods: a total of 257 patients with confirmed COVID-19 who had at least one electrocardiogram recording from April 01 to December 31, 2021, were enrolled in this cross-sectional study. Results: arrhythmia occurred in 36.6% of patients. The mean age of patients with arrhythmia was 52.48 ± 13.936 years, with a male preponderance (57.4%). The most common arrhythmia was sinus tachycardia (69.1%). Pre-existing atrial fibrillation (AF) and new-onset AF occurred in 10.6% and 2.1% of patients, respectively. Total atrioventricular block occurred in 2.1% of patients. Heart failure (20.2%), previous arrhythmia (10.6%), hypertension (46.8%), diabetes mellitus (DM) (42.6%), and chronic kidney disease (55.3%) were more prevalent in patients with arrhythmia. Patients with arrhythmia had a significantly higher need for Intensive Care Unit (ICU) (50%), need for intubation and mechanical ventilation (MV) (7.4%), hypotension requiring vasopressor (16%), and in-hospital mortality (44.7%) compared to patients without arrhythmia. After multivariate analysis, DM was associated with a higher need for ICU, hypotension requiring vasopressor, and in-hospital mortality. History of stroke/transient ischemic attack (TIA) and thrombocytopenia during admission was associated with a higher need for intubation and MV. Conclusions: the in-hospital outcomes in patients with COVID-19 and arrhythmia are the worst. In patients with arrhythmia, DM is associated with higher need for ICU, hypotension requiring vasopressor, and in-hospital mortality. A history of stroke/TIA and thrombocytopenia during admission are associated with higher need for intubation and MV.

Resumen: Introducción: las arritmias son una de las complicaciones extrapulmonares más comunes del coronavirus 2019 (COVID-19). Objetivos: este estudio se realizó para evaluar la evolución de los pacientes hospitalizados por COVID-19, desde asintomático hasta grave, que presentaban con y sin arritmias, e investigar los predictores de desenlaces hospitalarios. Material y métodos: se hizo un estudio transversal que incluyó un total de 257 pacientes con COVID-19 confirmado y que contaban con al menos un registro de electrocardiograma entre el 1 de abril y el 31 de diciembre del 2021. Resultados: se observaron arritmias en 36.6% de los pacientes. Su edad promedio fue de 52.48 ± 13.93 y predominaron los de género masculino (57.4%). La arritmia más común fue la taquicardia sinusal (69.1%), seguida por fibrilación auricular (FA) preexistente y la FA de reciente aparición, que ocurrieron, respectivamente, en 10.6% y 2.1% de los pacientes. Hubo bloqueo auriculoventricular completo en 2.1%. Las comorbilidades más frecuentes en el grupo de arritmias fueron: la insuficiencia cardiaca (20.2%), arritmia previa (10.6%), hipertensión arterial (46.8%), diabetes mellitus (DM) 42.6% y enfermedad renal crónica (55.3%). Los pacientes con arritmia tuvieron una mayor necesidad de cuidados intensivos (CI) (50%), intubación y ventilación mecánica (VM) (7.4%), vasopresores (16%) y mayor mortalidad hospitalaria (44.7%). El análisis multivariante asoció la DM con mayor necesidad de CI y necesidad de vasopresores y mortalidad hospitalaria. La historia de accidente cerebrovascular o ataque isquémico transitorio (AIT) y trombocitopenia al momento de la admisión se asoció con mayor necesidad de intubación y VM. Conclusión: los resultados intrahospitalarios en pacientes con COVID-19 y arritmia son los peores. Los pacientes con arritmias y DM requirieron con mayor frecuencia de CI, vasopresores y tuvieron mayor mortalidad hospitalaria, aquellos con historia de accidente cerebrovascular y AIT eran más susceptibles de ser intubados y recibir VM.

Abstract Objective The aim of this study is to analyze various rehabilitation protocol and determine which methods will yield a better outcome. Methods The database reports were searched within 1990 until 2020, using PubMed, Cochrane library database, Ovid, Medline, and the other several published trials. A statistical analysis was made from Review Manager and Trial Sequential Analysis (TSA). Result The mean of re-rupture rate is 3.3% (n= 8) in the combination protocol until 8% (n= 48) in CAM protocol. Meta-analyses found no significant difference between Kleinert vs CAM in re-rupture rate. Also no significant difference in Duran vs CAM in rerupture rate. In Trial Sequential Analysis (TSA), the z-curve does not cross both of the trial sequential boundaries, a further trial with larger sample will be required. The TSA of flexion contracture CAM vs Kleinert was indicated that CAM protocol may be superior than Kleinert to reduce the incidence of flexion contracture. For the range of mean flexion contracture 6.6% (n= 18) in CAM to 23.6% (n= 76) in Kleinert protocol. Conclusion Current meta-analysis proposed that the combination technique will result less re-rupture incidence and better functional outcome in flexor zone II injuries than other techniques. The CAM method also results less flexion contracture than others. However, a further meta-analyses with larger sample trials will be required to confirm this review's conclusion. 199 2020 PubMed Ovid Medline TSA. . (TSA) re rupture 33 3 3.3 n= n (n 8 48 Metaanalyses Meta analyses TSA, , zcurve z curve boundaries 66 6 6.6 18 236 23 23.6 76 metaanalysis meta techniques others However metaanalyses reviews review s conclusion 19 202 (TSA 3. 4 6. 1 2 23. 7 20

Resumo Objetivo O objetivo deste estudo é analisar vários protocolos de reabilitação e determinar quais métodos produzem um melhor resultado. Métodos Os relatórios dos bancos de dados foram pesquisados entre 1990 e 2020, usando PubMed, banco de dados da biblioteca Cochrane, Ovid, Medline e vários outros ensaios publicados. Uma análise estatística foi feita a partir do Review Manager e Trial Sequential Analysis (TSA). Resultado A taxa média de re-ruptura é de 3,3% (n = 8) no protocolo combinado, e até 8% (n = 48) no protocolo de Movimento Ativo Controlado (MAC). As metanálises não encontraram diferença significativa entre Kleinert vs MAC na taxa de re-ruptura. Também não há diferença significativa entre Duran e MAC na taxa de re-ruptura. Na Trial Sequential Analysis (TSA), a curva z não cruza ambos os limites sequenciais de ensaio, será necessário um ensaio adicional com amostra maior. A TSA de contratura em flexão MAC vs Kleinert indicou que o protocolo MAC pode ser superior ao Kleinert para reduzir a incidência de contratura em flexão. Para a faixa de contratura média em flexão de 6,6% (n = 18) no MAC a 23,6% (n = 76) no protocolo Kleinert. Conclusão A metanálise atual propôs que a técnica combinada resultará em menor incidência de re-ruptura e melhor resultado funcional em lesões da zona flexora II do que outras técnicas. O método MAC também resulta em menos contratura em flexão do que outros. No entanto, serão necessárias mais metanálises com estudos com amostras maiores para confirmar a conclusão desta revisão. 199 2020 PubMed Cochrane Ovid publicados TSA. . (TSA) reruptura re ruptura 33 3 3,3 n 8 combinado 48 MAC. (MAC) reruptura. ruptura. TSA, , maior 66 6 6,6 18 236 23 23,6 76 técnicas entanto revisão 19 202 (TSA 3, 4 (MAC 6, 1 2 23, 7 20

Abstract Objective The purpose of this meta-analysis is to compare ligament healing on autograft and allograft in anterior cruciate ligament (ACL) reconstruction. Methods The selection of appropriate studies was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We made a statistical analysis using a review manager. Electronic reports were searched using the PubMed, Medline, and Cochrane Library databases. The inclusion criteria were animal studies and cellular histology of both grafts as an outcome. Results The initial search revealed 412 potential articles. After duplicates were removed, 246 articles remained. Then, 14 articles were obtained and screened for relevance and eligibility. The relevant articles were searched manually, checking for eligibility and details in order not to miss included reports. Subsequently, 5 studies were included, with a total of 232 samples, reporting the biopsied results with quantitative histology of ligament healing between allograft and autograft. The biopsy samples in those studies were examined under light or electron microscope, to analyze the cellular distribution area and ligamentization stages in each group. Meta-analyses found significant difference between autograft and allograft (Heterogeneity, I2 = 89%; Mean Difference, 95% confidence interval [CI] =-34.92, -54.90, -14.93; p = 0.0006). There is also a significant difference on both graft in cellular count at over 24 weeks (Heterogeneity, I2 = 26%; Mean Difference, 95% CI = -14.59, -16.24, -12.94; p < 0.00001). Conclusion In the current meta-analysis, autograft shows a significant difference when compared to allograft, with more cellular accumulation and faster remodeling response on the ligamentization process being noticed in the former. However, a larger clinical trial will be needed to emphasize this literature’s result. metaanalysis meta ACL (ACL reconstruction MetaAnalyses Meta Analyses PRISMA (PRISMA guidelines manager PubMed Medline databases outcome 41 removed remained Then 1 manually Subsequently 23 microscope group Metaanalyses analyses Heterogeneity, Heterogeneity (Heterogeneity I 89% 89 Difference 95 [CI =34.92, 3492 34.92, 34 92 =-34.92 54.90, 5490 54 90 -54.90 14.93 1493 93 -14.93 0.0006. 00006 0.0006 . 0 0006 0.0006) 2 26% 26 14.59, 1459 59 -14.59 16.24, 1624 16 -16.24 12.94 1294 12 94 -12.94 0.00001. 000001 0.00001 00001 0.00001) metaanalysis, analysis, former However literatures literature s result 4 8 9 =34.92 349 34.92 3 =-34.9 54.90 549 -54.9 14.9 149 -14.9 0000 0.000 000 14.59 145 -14.5 16.24 162 -16.2 12.9 129 -12.9 00000 0.0000 =34.9 34.9 =-34. 54.9 -54. 14. -14. 0.00 00 14.5 16.2 -16. 12. -12. =34. 34. =-34 54. -54 -14 0.0 16. -16 -12 =34 =-3 -5 -1 0. =3 =- -

Resumo Objetivo O objetivo desta metanálise comparar a cicatrização de ligamentos no autoenxerto e aloenxerto na reconstrução do ligamento cruzado anterior (LCA). Métodos A seleção dos estudos adequados foi realizada de acordo com as diretrizes de Relatórios Preferenciais para Revisões Sistemáticas e Metanálises (Preferred Reporting Items for Systematic Reviews and Meta-Analyses - PRISMA). Uma análise estatística foi feita usando um gerente de revisão. Os relatórios eletrônicos foram pesquisados usando os bancos de dados PubMed, Medline e Cochrane Library. Os critérios de inclusão foram estudos em animais e a histologia celular de ambos os enxertos como desfecho. Resultado A pesquisa inicial revelou 412 artigos potenciais. Após a retirada das duplicatas, restaram 246 artigos. Então, 14 artigos foram obtidos e selecionados pela relevância e elegibilidade. Os artigos relevantes foram pesquisados manualmente, verificando sua elegibilidade e detalhando os estudos para não perder os relatórios incluídos. Posteriormente, foram incluídos 5 estudos, com um total de 232 amostras, relatando os resultados de biópsia com histologia quantitativa de cicatrização de ligamento entre aloenxerto e autoenxerto. As amostras de biópsia nesses estudos foram examinadas sob microscópio leve ou eletrônico, para análise da área de distribuição celular e estágios de ligamentização em cada grupo. As metanálises encontraram diferença significativa entre autoenxerto e aloenxerto (Heterogeneidade, I2 = 89%; Diferença média, 95% intervalo de confiança [IC] =-34,92, -54,90, -14,93; p = 0,0006). Também há uma diferença significativa nosdoisenxertosnacontagem celular de mais de 24 semanas (Heterogeneidade, I2 = 26%; Diferença média, 95% IC = -14,59 , -16,24, -12,94; p < 0,00001). Conclusão Na presente metanálise, o autoenxerto mostra resultados significativos quando comparado ao aloenxerto, com mais acúmulo celular e resposta de remode-lagem mais rápida no processo de ligamentizaçãosendoobservadonoprimeiro.No entanto, será necessário um estudo clínico maior para enfatizar o resultado desta literatura. LCA. LCA . (LCA) Preferred MetaAnalyses Meta Analyses PRISMA. PRISMA PRISMA) revisão PubMed Library desfecho 41 potenciais duplicatas Então 1 manualmente Posteriormente 23 eletrônico grupo Heterogeneidade, Heterogeneidade (Heterogeneidade I 89% 89 média 95 [IC =34,92, 3492 34,92, 34 92 =-34,92 54,90, 5490 54 90 -54,90 14,93 1493 93 -14,93 0,0006. 00006 0,0006 0 0006 0,0006) 2 26% 26 14,59 1459 59 -14,5 16,24, 1624 16 -16,24 12,94 1294 12 94 -12,94 0,00001. 000001 0,00001 00001 0,00001) remodelagem remode lagem ligamentizaçãosendoobservadonoprimeiroNo ligamentizaçãosendoobservadonoprimeiro No entanto literatura (LCA 4 8 9 =34,92 349 34,92 3 =-34,9 54,90 549 -54,9 14,9 149 -14,9 0000 0,000 000 14,5 145 -14, 16,24 162 -16,2 12,9 129 -12,9 00000 0,0000 =34,9 34,9 =-34, 54,9 -54, 14, 0,00 00 -14 16,2 -16, 12, -12, =34, 34, =-34 54, -54 0,0 -1 16, -16 -12 =34 =-3 -5 0, =3 =-

Abstract Objective This study aims to explore in-depth how to apply logotherapy to people with phubbing. Methods The research methodology uses with mixed methods, a sequential approach used in this study for handling the phubbing population is 110 students. Samples taken by purposive sampling with attention to the range aged 10-25 years, and the research sample obtains as many as 16 students. The sample was determined based on the scale analysis results and recommendations from the school – research data from research instruments in observation sheets and qualitative data interviews. A Phubbing scale was used to get quantitative data. Results The results of the study showed that there were better changes as evidenced by changes in phubbing scale scores before and after being given treatment. Conclusion The study’s conclusion shows that Logotherapy Counseling effectively reduces phubbing in Generation Z. indepth depth methods 11 students 1025 10 25 10-2 years 1 interviews treatment studys s Z 102 2 10-

Resumo Objetivo Este estudo tem como objetivo explorar em profundidade como aplicar a logoterapia a pessoas que são praticantes de phubbing. Método A metodologia da pesquisa dispõe de métodos mistos, com uma abordagem sequencial em uma população de 110 estudantes praticantes de phubbing. As amostras foram obtidas por amostragem proposital, respeitando uma faixa etária de 10 a 25 anos, resultando em 16 estudantes. A amostra foi determinada com base nos resultados da análise da escala de phubbing, usada para obtenção de dados quantitativos, e nas recomendações da escola – dados provenientes de instrumentos de pesquisa em fichas de observação e entrevistas de dados qualitativos. Resultados Os resultados do estudo mostraram que houve melhorias, como evidenciado pelas mudanças na pontuação da escala de phubbing antes e depois de receber o tratamento. Conclusão Concluímos que a Logoterapia reduz efetivamente o phubbing na Geração Z. mistos 11 proposital 1 2 anos quantitativos qualitativos melhorias tratamento Z

RESUMO As baixas habilidades fundamentais de movimento, atividade física e diversão dos alunos da era COVID-19 são lacunas neste estudo. Este estudo tem como objetivo examinar os efeitos do exergame nas habilidades fundamentais de movimento, atividade física e diversão em alunos inativos durante a era COVID-19. Pesquisa quantitativa com métodos experimentais foi utilizada neste estudo. Havia 26 crianças alocadas no grupo exergame (n = 13; idade: 7,20 ± 1,30 anos; altura: 1,38 ± 2,38 cm; peso: 31,60 ± 4,50 kg e um grupo controle n = 13; idade: 7,40 ± 1,14 anos; altura : 1,36 ± 3,08 cm; peso: 28,40 ± 3,43 kg). O programa de intervenção durou nove semanas. As crianças com habilidades fundamentais de movimento foram avaliadas usando Test of Gross Motor Development-Third Edition e a atividade física foi medida usando o acelerômetro ActiGraph GT9X Link, enquanto o prazer foi avaliado usando a escala de prazer do currículo de educação física. Os resultados mostraram que a implementação do exergame demonstrou melhorar significativamente as habilidades fundamentais de movimento, atividade física e prazer. No entanto, não houve aumento no grupo controle. Esta pesquisa é uma evidência de que o exergame é uma ferramenta eficaz para melhorar as habilidades fundamentais de movimento, atividade física e diversão em alunos durante a era COVID-19.

ABSTRACT The low fundamental movement skills, physical activity and enjoyment students in the COVID-19 era are gaps in this study. This study aims to examine the effects of exergame on fundamental movement skills, physical activity and enjoyment in among inactive students during the COVID-19 era. Quantitative research with experimental methods was used in this study. There were 26 children allocated to the exergame group (n=13; age: 7.20±1.30 years; height: 1.38±2.38 cm; weight: 31.60±4.50 kg and a control group n=13; age: 7.40±1.14 years; height: 1.36±3.08 cm; weight: 28.40±3.43 kg). The intervention program was conducted for nine weeks. Fundamental movement skills children were assessed using the Test of Gross Motor Development-Third Edition and physical activity was measured using the ActiGraph GT9X Link accelerometer, while enjoyment was assessed using the physical education curriculum enjoyment scale. The results showed that the implementation of exergame was proven to improve fundamental movement skills, physical activity and enjoyment significantly, however there was no increase in the control group. This research is evidence that exergame is an effective tool to improve fundamental movement skills, physical activity and enjoyment in students during the COVID-19 era.

RESUMEN: Introducción: La enfermedad por coronavirus 2019 (COVID-19) es una enfermedad transmisible que ha infectado a millones de personas en muchos países, incluida Indonesia. Los trabajadores comunitarios de la salud (CHW, por sus siglas en inglés) desempeñan un papel fundamental en el apoyo a los programas de los centros de salud primarios, incluso en respuesta a la pandemia de COVID-19. Método: Realizamos entrevistas en profundidad semiestructuradas con 13 CHW en la ciudad de Makassar, Indonesia. Los datos se analizaron mediante análisis temático. Resultados: De las entrevistas surgieron seis temas: (1) automotivación; (2) beneficios valiosos; (3) deberes nobles; (4) desafíos percibidos; (5) apoyo significativo; y (6) camino a seguir. Conclusión: A pesar de los desafíos experimentados por los participantes, la participación de los CHW es crucial para garantizar que la comunidad reciba información correcta y cumpla con los protocolos de salud para romper la cadena de transmisión de COVID-19. Los participantes emprenden la tarea con un fuerte compromiso y el sentimiento de honor ya que cuentan con la confianza del gobierno y la comunidad. La asociación entre el personal de los servicios de salud y los CHW debe fortalecerse brindando suficiente apoyo para que se puedan contener los casos de COVID-19 en la comunidad.

ABSTRACT: Background: Coronavirus disease 2019 (COVID-19) is a communicable disease that has infected millions of people in many countries, including Indonesia. Community health workers (CHWs) play a pivotal role in supporting primary health center programs, including in response to the COVID-19 pandemic. Methods: We conducted semi-structured in-depth interviews with thirteen CHWs in Makassar City, Indonesia. Data were analyzed using thematic analysis. Results: Six themes emerged from the interviews: (1) self-motivation; (2) valuable benefits; (3) noble duties; (4) perceived challenges; (5) meaningful support; and (6) way forward. Conclusions: Despite the challenges experienced by the participants, the involvement of CHWs is crucial to ensure that the community receives correct information and complies with health protocols to break the chain of COVID-19 transmission. The participants undertake the task with strong commitment and the feel of honor as they are trusted by the government and the community. The partnership between health service staffs and CHWs should be strengthened by providing sufficient support so COVID-19 cases in the community can be contained.

Background: Cough is a common symptom for which people frequently present to community pharmacies. Previous articles from developing countries have shown that the provision of self-medication consultation for cough in community pharmacies were suboptimal, with knowledge deficiency being a contributing factor. However, little is known regarding the ability of pharmacy students in handling self-medication consultations in developing countries. Objectives: To measure the competency of Indonesian pharmacy students in providing self-medication consultations for patients with chronic cough and to identify factors associated with the provision of appropriate advice. Method: This study is a cross-sectional study. A simulated patient method using a product and a symptom-based request of chronic cough was used in students from a pharmacy school in Indonesia. The nature and amount of information gathered and advice provided by pharmacy students were noted and audio-recorded. A logistic regression analysis was performed to identify factors associated with the provision of appropriate advice. Results: The information gathered by participating students was not comprehensive. The most common types of information gathered were related to the nature and duration of the cough. Information relating to accompanying symptoms, medications, and allergies was gathered in less than 60% of the participating students for both product and symptom based scenarios. The appropriate advice of direct medical referral was provided in 54% and 56% of the 183 participating students for the product and symptom-based request scenarios respectively. Asking about symptom duration and prior medical conditions were positively associated with the provision of appropriate advice in the symptom and product based requests respectively. Conclusion: Student competency in self-medication consultation for chronic cough needs to be improved. Appropriate information-gathering is a predictor of appropriate advice. Further qualitative research identifying factors affecting students' competence in providing self-medication consultation is required, so that suitable interventions are developed and implemented.

RESUMEN La mano es una de las extremidades más importantes del cuerpo humano que se utiliza para actividades de la vida diaria. El objetivo de esta investigación es desarrollar una mano exoesqueleto suave para ayudar a las personas con la mano deteriorada. El exo-guante desarrollado está hecho de caucho de silicona RTV (vulcanización a temperatura ambiente) de bajo costo con un sistema de accionamiento motor-tendón que produce el movimiento de flexión y extensión. Aquí, el actuador convierte el movimiento de rotación en movimiento lineal del motor de DC, mientras que se utiliza un sensor de potenciómetro para medir el ángulo de rotación en el sistema del actuador, en el que se utiliza el control lógico difuso (FLC) para controlar el movimiento del actuador motor-tendón propuesto. Para validar la función y el mecanismo del exo-guante blando desarrollado se realizaron pruebas para lograr el rendimiento de FLC en la mano humana sana en varias pruebas de agarre de objetos. Según los resultados de la prueba, este estudio muestra que el guante blando se puede implementar en la mano humana como un dispositivo de asistencia.

ABSTRACT A hand is one of the essential limbs on the human body that is used for daily activities. The aim of this research is to develop a soft exoskeleton hand to assist people with hand deterioration. The developed exo-glove is made of low-cost RTV (room-temperature vulcanizing) silicone rubber with a motor-tendon actuation system that produces the flexion and extension motion. Here, the actuator converts rotation motion into linear motion from DC motor, while a potentiometer sensor is utilized to measure the rotation angle on the actuator system, in which fuzzy logic control (FLC) is employed for controlling the motion of the proposed motor-tendon actuator. To validate the function and mechanism of the developed soft exoskeleton glove, testing was conducted towards the FLC performance on the healthy human hand for various object grasping tests. Based on the test results, this study shows that the soft glove can be implemented on the human hand as an assistive device.

Background: The provision of information by pharmacy staff is a key factor to ensure patients’ understanding and quality use of medications, including antibiotics. However, little is known regarding the transmission of information between pharmacy staff and patients in Indonesia. Objective: This study aimed to identify information on antibiotics provided by pharmacy staff and recalled by patients in an Indonesian outpatient setting. Methods: The study was conducted in a hospital outpatient clinic in Malang, Indonesia, in 2019. A checklist was used to obtain the data on information provided by pharmacy staff, while interviews were conducted to determine information recalled by patients (only presenting patients were included); a total of 15 information items - i.e. 14 essential and one secondary - were observed. Descriptive analysis was used to summarise data on the checklists (‘given’ versus ‘not given’) as well as responses from the interviews (‘recalled’ versus ‘missed’). Results: Eleven pharmacy staff (two pharmacists and nine pharmacy technicians) were involved in providing information for patients obtaining oral antibiotics during the study period. Of 14 essential information items, only about half was given by pharmacy staff, with pharmacists significantly providing on average more information items than pharmacy technicians (7.96 versus 7.67 respectively; p<0.001). The most frequently information items provided (>90%) included “antibiotic identification”, “indication”, administration directions (i.e. “dosage”, “frequency”, “hour of administration”, “administration before/after meal”, “route of administration”), and “duration of use”. A total of 230 patients consented to the study, giving 79.9% response rate. The average number of information items recalled by patients was 7.09 (SD 1.45). Almost all patients could recall information on administration directions [i.e. “route of administration” (97.0%), “frequency” (95.2%), “dosage” (92.6%), “hour of administration” (85.7%), “administration before/after meal” (89.1%)] and “duration of use” (90.9%). Fewer patients were able to recall “antibiotic identification” (76.5%) and “indication” (77.0%). Conclusions: Pharmacy staff provided antibiotic information in a limited fashion, while patients showed adequate ability to recall the information given to them. Further study is needed to better understand the effective process of information transmission between pharmacy staff and patients, especially if more information was provided, to better optimise the use of antibiotics in outpatient settings in Indonesia.

Abstract Objective: To identify the occurrence of Veillonella spp. in children using real-time PCR (RT-PCR) and to determine its role as a risk factor for ECC in children aged 2-3 years. Material and Methods: A cross-sectional survey was conducted and samples from 87 children aged 2-3 years, who lived in selected villages in the Bandung City area, Indonesia, were collected. Examination for dental caries was performed using standard checks for decay, missing, and filled surfaces (dfms), and saliva samples were taken. Microbiological examination was performed using RT-PCR with primers consisting of one primary set for Veillonella spp. and one universal primary set for 16S rDNA. We performed statistical testing using the Mann Whitney rank-sum test. Results: A total of 87 children were sampled, and an ECC prevalence of 71.3% was found, with a mean dmfs of 7.1 (± 9.1). The proportion of Veillonella spp. in caries-free children was 2.13 ± 2.30, while in children with ECC, it was 3.29 ± 6.83. Conclusion: The proportion of Veillonella spp. in children with ECC was higher than in caries-free children; therefore, Veillonella spp. may be a risk factor for ECC.

Abstract Background: The introduction of universal healthcare coverage in 2014 has affected the practice of community pharmacies in Indonesia. Studies regarding the practice of pharmacist in the chain community pharmacy setting in Indonesia are very limited. The chain community pharmacies in Indonesia are operated and controlled by the same management. The chain community pharmacies usually show better services compared to independent community pharmacies in Indonesia. Objective: The study aimed to assess the knowledge, attitude and practice (KAP) of pharmacist working in chain community pharmacy towards their current function and performance in delivering pharmacy services Methods: A cross-sectional study using questionnaires was conducted between January and March 2017 in KF, one of the largest chain community pharmacies in Indonesia. The total sampling method was used in the recruitment process. The data were analyzed using descriptive statistics, independent t-Test and one-way ANOVA. The KAP scores were assessed and categorized as “poor”, “moderate” and “good” based on the standardized scoring system. Results: A total of 949 KF’s pharmacists (100% response rate) were participated in the study. The majority of pharmacists showed a good score in terms of knowledge and attitude, which is in contrast to practice as majority only obtained a moderate score. Working experience, age and the availability of standard operating procedures (SOP) for both dispensing and self-medication services were found to be statistically significant (p<0.005) aspects to KAP of pharmacists in delivering pharmacy services. Conclusions: This study identified several important aspects that could affect the KAP of pharmacists working in chain community pharmacies in Indonesia. Specific policies should be conceived to improve the competencies of pharmacist and to ensure the compliance with the SOP and standardization system within pharmacy sector.

ABSTRACT Indonesia is one of the endemic countries for dengue fever, and for the incidents are increasing year by year. Children are the risk population to dengue incidents than the others age groups. Part of the dengue prevention is increasing the knowledge, and also the children’s knowledge. The use of the game is the enjoyable way for learning in children. Aim The aim of the study was to know children's basic knowledge about dengue prevention and develop an educational media for children. This study uses a quasi-experimental design with pre and post-test and using a control group. Method The participants are a school-aged children between the ages of 10-12 years old with total 92 participants who were divided into intervention group and control group. Results The results showed that there are a significantly increasing score at children basic knowledge at intervention group about dengue fever sign and symptom (p=0,001); prevention strategy based on Indonesia Health Ministry guidelines (p=0,001); chemistry agent (p=0,000); biology agent (p=0,000); self-protection (p=0,001); and immune system (p=0,001). There are difference knowledge between intervention and control groups (p=0,000). Conclusion The conclusion of the study is board game can be designed to be an educational media to give a health education about dengue prevention strategy to the children.

RESUMEN Indonesia es uno de los países endémicos del dengue y los incidentes aumentan año tras año. Los niños son la población de mayor riesgo de incidentes de dengue que los demás grupos de edad. Parte de la prevención del dengue es aumentar el conocimiento y también el conocimiento de los niños. El uso del juego es una forma divertida de aprender en los niños. Objetivo El objetivo del estudio fue conocer los conocimientos básicos de los niños sobre la prevención del dengue y desarrollar un medio educativo para los niños. Método Este estudio utiliza un diseño cuasi experimental con pre y post prueba y el uso de un grupo de control. Los participantes son niños en edad escolar de entre 10 y 12 años de edad con un total de 92 participantes que se dividieron en grupos de intervención y control. Resultados Los resultados mostraron que hay un puntaje significativamente creciente en el conocimiento básico de los niños en el grupo de intervención sobre el signo y el síntoma de la fiebre del dengue (valor de p = 0,001); estrategia de prevención basada en las directrices del Ministerio de Salud de Indonesia (valor de p = 0,001); agente químico (valor de p = 0,000); agente de biología (valor de p = 0,000); autoprotección (valor de p = 0,001); y sistema inmune (valor de p = 0,001). Existen diferencias de conocimiento entre los grupos de intervención y control (valor de p = 0,000). Conclusión La conclusión del estudio es que el juego de mesa puede diseñarse para ser un medio educativo que brinde a los niños una educación sanitaria sobre la estrategia de prevención del dengue.