Plants and essential oils (EOs) have been used for centuries in folk medicine to treat diverse disorders, including analgesic to pain relief. In this context, the antinociceptive activity of EOs has been attracted attention since the management of pain continues being a major challenge for medicine. This review provides an overview of published reports on the antinociceptive activity of EOs and their constituents from 2000 until the first half of 2015. In this review are compiled the data on the antinociceptive activity of 63 EOs and 26 of their constituents with a discussion about the nociception model used to access the analgesic effect. These data were also analyzed in relation to ethnopharmacological and toxicological data available in the literature. As can be seen by the analysis of more than 300 articles, EOs and their constituents show antinociceptive effects in different models and their action mechanism is quite variable. Although there are a few essential oils or their isolated constituents on the phytopharmaceuticals market, this review intends to put in evidence the often-underexploited vast source of natural compounds with therapeutic potential in pain relief.

We describe herein our results on the synthesis and antioxidant properties of 7-chloroquinoline-1,2,3-triazoyl-4-carboxylates. This class of compounds have been synthesized in moderated to excellent yields by the reaction of 4-azido-7-chloroquinoline with a range of β-ketoesters in the presence of a catalytic amount of pyrrolidine (10 mol%). The synthesized compounds ethyl 1-(7-chloroquinolin-4-yl)-5-methyl-1H-1,2,3-triazole-4-carboxylate and ethyl 1-(7-chloroquinolin-4-yl)-5-phenyl-1H-1,2,3-triazole-4-carboxylate were screened for their in vitro antioxidant activity and the results demonstrated that the first compound reduces the lipid peroxidation levels induced by sodium nitroprusside in liver of mice, while the second compound shown nitric oxide scavenging activity. This is an efficient method to produce new heterocyclic compounds with potential antioxidant activities.

In the present study, we describe the synthesis of alkylseleno carbohydrates with different sugar scaffolds and the evaluation of their antioxidant activity profile. A compound possessing a C8 alkyl chain presented the best results in the free radical scavenging activity.