ABSTRACT Huntington's disease (HD) is a hereditary, neurodegenerative disease characterized by motor, cognitive, and behavioral issues. As the disease progresses, people become dependent on their caregivers leading to a significant burden. There is a lack of effective neuropsychological intervention to support this population. Objective: To develop an online neuropsychological intervention and evaluate its effects in decreasing the HD caregiver burden. Methods: This qualitative pilot study was conducted online during the COVID-19 pandemic in Brazil. We selected a convenience sample of five informal caregivers of HD patients (mean 46.2 years old). At baseline, participants were assessed via an individual online neuropsychology interview/screening, covering demographic data. Subsequently, we conducted 20 online 90-minute sessions of the psychological consultation over 12 months. Each session was structured in three stages: 1) Welcoming; 2) Breathing and mindfulness practice; and 3) Discussion of themes about the group's needs based on the main complaints. A second intervention assessment was applied. Results: None of the caregivers were provided with details about HD at the time of diagnosis and later care. The necessity to care for a person with a rare genetic disease was added to caregivers' already-existing working routine and home services, causing a symptom of overload. After the neuropsychological intervention, all participants reported feeling less burdened by caring, improved self-care and conflict resolution with the person with HD through expanding behavioral repertoire focused on emotions and communication. Conclusion: Online neuropsychologic intervention can reduce the burden of HD caregivers. More comprehensive studies should investigate these findings. Huntingtons Huntington s (HD hereditary motor cognitive issues progresses population Objective Methods COVID19 COVID 19 COVID-1 Brazil mean 462 46 2 46. old. old . old) baseline interviewscreening interview screening interview/screening data Subsequently 90minute minute 90 1 months stages Welcoming practice 3 groups group complaints applied Results alreadyexisting already existing services overload caring selfcare self communication Conclusion findings COVID1 COVID- 4 9

RESUMO A doença de Huntington (DH) é hereditária e neurodegenerativa, caracterizada por problemas motores, cognitivos e comportamentais. À medida que avança, os pacientes dependem cada vez mais de cuidadores, gerando uma sobrecarga significativa. Há uma carência de intervenções neuropsicológicas eficazes para apoiar esta população. Objetivo: Desenvolver uma intervenção neuropsicológica online e avaliar seus efeitos na redução da sobrecarga do cuidador em DH. Métodos: Este estudo piloto qualitativo ocorreu online, durante a pandemia de COVID-19 no Brasil. Selecionamos uma amostra de conveniência de cinco cuidadores informais de pacientes com DH (média de 46,2 anos). Inicialmente, realizamos triagens neuropsicológicas online, abrangendo dados demográficos e entrevistas. Subsequentemente, conduzimos 20 sessões de 90 minutos ao longo de 12 meses, estruturadas em: 1) acolhimento, 2) prática de respiração e mindfulness e 3) discussão das necessidades do grupo com base nas principais queixas. Após a intervenção, realizamos uma segunda avaliação. Resultados: Constatamos que os cinco cuidadores não foram adequadamente educados pelos profissionais de saúde sobre a DH após o diagnóstico. A responsabilidade de cuidar da pessoa com DH foi agregada à sua rotina de trabalho e serviços domiciliares, ocasionando um sintoma de sobrecarga. Após a intervenção neuropsicológica online, todos os participantes relataram menos sobrecarga relacionada ao cuidado das pessoas com DH, melhoraram o autocuidado e a resolução de conflitos por meio da ampliação do repertório comportamental focado nas emoções e na comunicação. Conclusão: A intervenção neuropsicológica online pode diminuir a sobrecarga dos cuidadores em DH. Estudos mais abrangentes devem investigar esses resultados. (DH neurodegenerativa motores comportamentais avança significativa população Objetivo Métodos COVID19 COVID 19 COVID-1 Brasil média 462 46 2 46, anos. anos . anos) Inicialmente entrevistas Subsequentemente 9 1 meses acolhimento 3 queixas avaliação Resultados diagnóstico domiciliares comunicação Conclusão resultados COVID1 COVID- 4

Abstract This article, in an essay format, seeks to establish a dialogue between the ethics of care and pediatric palliative care, taking into consideration the fact that moral perceptions are based on a network of relationships, while care is built on intersubjectivity. Four pillars that are referred to as movements are discussed: the ethics of care, as a feminist ethic, in a dialogue with pediatric palliative care, and communication and autonomy as tools of care based on their relational aspects. The conclusion drawn is that considering these aspects from a palliative standpoint can be a way to implement a moral commitment of care. article format relationships intersubjectivity discussed ethic

Resumo Este artigo, sob a forma de ensaio, tem como objetivo fazer uma interlocução entre a ética do cuidado e o cuidado paliativo pediátrico, considerando que as percepções morais são tecidas a partir de uma rede de relações e que o cuidado se constrói na intersubjetividade. Discute-se com base em quatro pilares, a que chamamos de movimentos: a ética do cuidado, como ética feminista, em diálogo com o cuidado paliativo pediátrico, a comunicação e a autonomia como ferramentas de cuidado a partir de suas características relacionais. Conclui-se que considerar esses aspectos na abordagem paliativa pode ser um caminho para exercer um compromisso moral de cuidado. artigo ensaio pediátrico intersubjetividade Discutese Discute pilares movimentos feminista relacionais Concluise Conclui

Abstract Price of iron ore is affected by instabilities of microeconomic balance between supply and demand. Periods of equilibrium adjustment result in huge swings, growth or global recession. They also impact the viability of mineral enterprises and generate consequences to important global economic scenarios. This research aims to evaluate the market variables capable of influencing the price of iron ore through multivariate statistical techniques. Principal component analysis and multiple linear regression, booth multivariate statistical techniques were used. The studied variables were rate export of iron ore and concentrates from Brazil, steel production from China, steel production from Japan, production from Europe, steel production from the United States, steel production from India, steel price, coal price, China’s Construction Gross Domestic Production, United States construction index, oil price and global oil production. First three components explained 89.12% of the variability of the data matrix. Multiple linear regression highlighted the significance of five variables. They are export iron ore from Brazil, steel production from China, price of coal, steel production from India and price of steel. demand swings recession scenarios used Brazil China Japan Europe Chinas s Production index 8912 89 12 89.12 matrix 891 8 1 89.1 89.

ABSTRACT Objective Pronation of the first metatarsal in hallux valgus has recently been discussed among foot and ankle surgeons. This study aimed to evaluate the potential radiographic correction of moderate and severe hallux valgus using the percutaneous Chevron and Akin (PECA) technique. Methods We evaluated 45 feet in 38 patients (mean age 65.3 years old [36 - 83]; 4 men; 34 women; 7 bilateral) who underwent surgical correction using the PECA technique. The radiographic images evaluated were anteroposterior radiographs obtained pre- and postoperatively at least 6 months after surgery, including the metatarsophalangeal angle, the intermetatarsal angle, pronation of the first metatarsal, displacement of the distal fragment, medial sesamoid position and bone union. Results All parameters evaluated showed significant postoperative improvement, including correction of pronation of the first metatarsal (p < .05) and position of the sesamoid (p < .05). There was a union of osteotomies in all feet. No complications were observed, such as screw loosening or necrosis of the first metatarsal head. Conclusion The PECA technique can correct pronation of the first metatarsal in moderate and severe hallux valgus, and other deformity-associated parameters. Level of Evidence IV; Case Series. surgeons (PECA 3 mean 653 65 65. 36 [3 83 83] men women bilateral pre surgery angle fragment improvement p .05 05 .05. . observed head deformityassociated deformity associated IV Series [ 8 .0 0

RESUMO Objetivo A pronação do primeiro metatarso no hálux valgo tem sido um tema de discussão recente entre os cirurgiões de pé e tornozelo. O objetivo deste estudo foi avaliar o potencial de correção radiográfica do hálux valgo moderado e grave utilizando a técnica percutânea de Chevron e Akin (PECA). Métodos Avaliamos 45 pés em 38 pacientes (média de idade 65,3 anos [36 - 83]; 4 homens; 34 mulheres; 7 bilaterais) submetidos à correção cirúrgica pela técnica PECA. As imagens radiográficas avaliadas foram radiografias anteroposteriores obtidas no pré e pós-operatório com no mínimo 6 meses após a cirurgia, incluindo ângulo metatarsofalângico, ângulo intermetatarsal, pronação do primeiro metatarso, deslocamento do fragmento distal, posição do sesamoide medial e união óssea. Resultados Todos os parâmetros avaliados apresentaram melhora significativa no pós-operatório, incluindo correção da pronação do primeiro metatarso (p < 0,05) e posição do sesamoide (p < 0,05). Houve união de osteotomias em todos os pés. Não foram observadas complicações, como soltura do parafuso ou necrose da cabeça do primeiro metatarso. Conclusão A técnica PECA pode corrigir a pronação do primeiro metatarso no hálux valgo moderado e grave, bem como outros parâmetros associados à deformidade. Nível de Evidência IV; Série De Casos. tornozelo . (PECA) 3 média 653 65 65, 36 [3 83 83] homens mulheres bilaterais pósoperatório pós operatório cirurgia metatarsofalângico intermetatarsal distal óssea pósoperatório, operatório, p 0,05 005 0 05 0,05. complicações deformidade IV Casos (PECA [ 8 0,0 00 0,

Abstract This article presents a study of the impacts caused by Fundão dam failure in buildings from Gesteira district, Barra Longa city, Brazil. The analyzed dataset was built using technical reports from surveys carried out in 152 buildings. Principal component analysis was capable of explain the interdependence of data variable and allowed conditions of understand the consequences and evidenced pathologies. Heavy vehicle traffic caused more damage (57% of buildings) to the studied buildings than the contact with the tailing mud (43% of buildings). district city Brazil 15 pathologies 57% 57 (57 43% 43 (43 . 1 5 (5 4 (4 (

Abstract This study assessed the effect of different periods of post-hatch fasting on animal performance and breast and digestive system growth in European quail. Quail chicks were distributed in a completely randomized design, with four fasting periods (0, 24, 36, and 48 hs) and four replications of 40 birds per treatment. In 1 to 14-day-old chicks, weight gain decreased with increasing fasting time. Compensatory gain was observed from 15 days of age onward. Fasted quail had a lower length and relative weight of the digestive system than fed animals for up to 14 days. Histologically, the duodenal villus height was significantly lower in 3-day-old quail fasted for 36 hs than in those fasted for 48 hs, but this effect was not observed at 7 days. Scanning electron microscopy showed no differences in the small intestinal mucosa between fasted and fed birds at 3 days of age. Post-hatch fasting reduced the relative weight of the breast in quail aged 1 to 14 days but did not affect type IIa and IIb fiber diameter at 35 days. On the basis of these results, it is recommended that European quail raised for meat should not be fasted for more than 48 hs post-hatch. posthatch post hatch design 0, 0 (0 24 4 treatment 14dayold dayold day old time onward Histologically 3dayold Posthatch Post results posthatch. hatch. ( 2

ABSTRACT. The goal of this study was to determine the essential fatty acids of the total lipids of the fillet, head and orbital cavity tissue from farmed tambaqui (Colossoma macropomum) fish from a Brazilian Amazon area. The tambaqui were acquired from different fish farms in the Roraima state, located at Western Brazilian Amazon. The meat, the head and the fatty tissue from orbital cavity were dissected for lipid extraction and analysis of fatty acids by gas chromatography. The fatty acids were quantified in mg g-1 of total lipids using C23:0 as an internal standard. The nutritional quality of the lipids was determined by using the atherogenicity and thrombogenicity indices, and also by the ratio between hypocholesterolemic / hypercholesterolemic fatty acids. The orbital cavity tissue had the higher concentration amount of linoleic and α-linolenic acid, whereas the fillet had higher docosahexaenoic acid (DHA). The eicosapentaenoic acid (EPA) concentration was: 1.28, 0.97, 1.71 mg g-1 of total lipids, in the filet, in head, and in orbital cavity tissue, respectively. All essential fatty acids were detected in the three parts analyzed. The nutritional quality of the total lipids from the head and from the orbital cavity tissue was similar to the fillet.

Resumo Este artigo, sob a forma de ensaio, tem como objetivo fazer uma interlocução entre a ética do cuidado e o cuidado paliativo pediátrico, considerando que as percepções morais são tecidas a partir de uma rede de relações e que o cuidado se constrói na intersubjetividade. Discute-se com base em quatro pilares, a que chamamos de movimentos: a ética do cuidado, como ética feminista, em diálogo com o cuidado paliativo pediátrico, a comunicação e a autonomia como ferramentas de cuidado a partir de suas características relacionais. Conclui-se que considerar esses aspectos na abordagem paliativa pode ser um caminho para exercer um compromisso moral de cuidado.

Abstract This article, in an essay format, seeks to establish a dialogue between the ethics of care and pediatric palliative care, taking into consideration the fact that moral perceptions are based on a network of relationships, while care is built on intersubjectivity. Four pillars that are referred to as movements are discussed: the ethics of care, as a feminist ethic, in a dialogue with pediatric palliative care, and communication and autonomy as tools of care based on their relational aspects. The conclusion drawn is that considering these aspects from a palliative standpoint can be a way to implement a moral commitment of care.

Resumo A garantia da Segurança Alimentar e Nutricional (SAN) e do Direito Humano à Alimentação e Nutrição Adequadas (DHANA) à população depende da produção sustentável de alimentos diversificados e saudáveis. A agricultura familiar é o segmento responsável por grande parte dos alimentos destinados ao consumo interno. Políticas públicas como o Programa de Aquisição de Alimentos (PAA) e o Programa Nacional de Alimentação Escolar (PNAE), que possibilitam o acesso de agricultores familiares ao mercado institucional e o fornecimento de alimentos a populações em vulnerabilidade, são de grande relevância à promoção da SAN. O objetivo deste artigo foi analisar quais os efeitos do acesso ao mercado institucional brasileiro na SAN de agricultores familiares do município de Almirante Tamandaré. Para tal, adotou-se como procedimentos metodológicos a revisão integrativa da literatura e o estudo de caso. Para a apresentação e análise dos resultados foi utilizada a análise de conteúdo aliada a uma análise estatística descritiva dos dados. Evidenciou-se que o acesso dos agricultores familiares entrevistados ao mercado institucional impactou positivamente nas suas condições de SAN, ao possibilitar geração e melhoria de renda, garantia de trabalho e escoamento de produção, diversificação produtiva e, consequentemente, maior variedade de alimentos consumidos.

Abstract Ensuring Food and Nutrition Security (SAN) and the Human Right to Adequate Food and Nutrition (DHANA) for the population depends on the sustainable production of diversified and healthy foods. Family farming is the segment responsible for most of the food intended for domestic consumption. Public policies such as the Food Acquisition Program (PAA) and the National School Feeding Program (PNAE), which allow family farmers access to the institutional market and the supply of food to vulnerable populations, are of great relevance to the promotion of SAN. The aim of this study was to analyze the impacts of access to the Brazilian institutional market in the SAN for family farmers in the municipality of Almirante Tamandaré. To this end, the integrative literature review and case study were adopted as methodological procedures. For the presentation and analysis of the results, content analysis combined with a descriptive statistical analysis of the data was used. It was evident that the access of family farmers interviewed to the institutional market had a positive impact on their SAN conditions, by enabling the generation and improvement of income, guarantee of work and production flow, productive diversification and, consequently, a greater variety of consumed foods.

Abstract Growth curves have been described in the quail but with no attention to the muscle composing of the breast. The description of the characteristics of growth curves to body weight and to breast muscle was the aim of this study. Morphological development of Musculus supracoracoideus and Musculus pectoralis in European and Japanese quail was assessed from the final incubation of to 35 days. Gompertz models were adjusted with maximum growth rates to body weight, breast weight, and Musculus pectoralis and supracoracoideus weight at 17.6; 22.2; 23.5, and 21.4 days. The European quail had a higher body and breast weight at maturity. Musculus supracoracoideus developed faster in both subspecies but with larger Musculus pectoralis. Both musculus had a greater number of fibers type IIA and largest fibers IIB, with quadratically increasing in fiber diameter with age in both subspecies and muscles. At 35 days, results of meat quality indicated similarity between genders and subspecies, with darker and redness breast meat in Japanese quail. In conclusion, breast weight gain was a result of type IIA and IIB fiber hypertrophy in both muscles and, despite the difference in size and aptitude, Japanese and European quail showed similar body and muscle growth patterns. study 3 days 17.6 176 17 6 22.2 222 22 2 235 23 5 23.5 214 21 4 21. maturity conclusion aptitude patterns 17. 1 22. 23.

Abstract This work summarizes some considerations related to the process of translation, analysis and commentary on chapter XII of the second volume of the book Exploration of the Valley of The Amazon, written by United States Navy Lieutenant Lardner Arthur Gibbon Arthur, between 1851 and 1852. The historical and political scenarios for the Amazon of that period are also presented and contextualized, to be able to understand more closely the conditions of possibility for the journeys, the compiled reports and opinions of the expeditionary to have taken place as they are known today. At the end of the translation of the chapter, rich in details about the descent from Bolivia to Brazil (especially along the Madeira River), we made 18 notes, in which we sought to cover economic, social and political life aspects of the population in region. We consulted the original text in different editions, in order to present a text in English and in Portuguese as accurate as possible, paying special attention to the units of measurement used at the time. We hope that the bilingual edition of this chapter will contribute to a greater knowledge of the neglected second volume of this exceptional book and of great value for the history of the Brazilian Amazon. 185 1852 contextualized journeys today especially River, River , River) 1 notes economic region editions possible time

Resumo Este trabalho apresenta de forma sintetizada algumas considerações referentes ao processo de tradução, análise e comentário do capítulo XII do segundo volume do livro Exploration of the Valley of The Amazon, escrito pelo tenente da Marinha dos Estados Unidos da América Lardner Arthur Gibbon, entre 1851 e 1852. Também são introduzidos e contextualizados os cenários histórico e político para a Amazônia daquele período, a fim de que se possa compreender com mais precisão as condições de possiblidade para que as viagens, os relatos compilados e opiniões do expedicionário tenham se dado como hoje o sabemos. Ao final da tradução do capítulo rico em detalhes sobre a descida da Bolívia para o Brasil (especialmente pelo Rio Madeira), elaboramos 18 notas, nas quais buscamos compreender aspectos da vida econômica, social e política da população da região. Consultamos o texto original em diferentes edições, para apresentar um texto em inglês e em português o mais preciso possível, dando especial atenção às unidades de medida da época utilizadas. Esperamos que a edição bilíngue deste capítulo contribua para um maior conhecimento do negligenciado segundo volume deste livro excepcional e de grande valor para a história da Amazônia brasileira. Amazon Gibbon 185 1852 período viagens sabemos especialmente Madeira, Madeira , Madeira) 1 notas econômica região edições possível utilizadas brasileira

ABSTRACT Caregivers of people living with dementia (PLwD) have a high burden degree that leads to health issues, including sleep. Objective: This study aimed to analyze the impacts of the caregiving burden on caregiver’s sleep disturbances. Methods: This systematic review involved a qualitative analysis of publications on Web of Science and Pubmed/Medline databases published between February 2018 and August 2022. Results: A total of 27 studies were identified and analyzed. Caregiver’s sleep presents impairments in sleep latency, sleep fragmentation, sleep duration, subjective sleep quality, daytime dysfunction, and insomnia. Caregiver’s distress and depressive symptoms have a dual relationship with sleep problems. Conclusion: Sleep disturbances presented by caregivers are correlated with higher burden levels and lead to more vulnerability to psychiatric symptoms and health issues. PLwD (PLwD issues Objective caregiver s Methods PubmedMedline Pubmed Medline 201 2022 Results 2 analyzed Caregiver latency fragmentation duration quality dysfunction insomnia problems Conclusion 20 202

RESUMO Cuidadores de pessoas com demência possuem alto grau de sobrecarga que impacta de forma objetiva o sono e suas dimensões. Objetivo: Este estudo teve o objetivo de analisar o impacto da sobrecarga nas alterações do sono do cuidador. Métodos: Esta revisão sistemática envolveu a análise de resultados quantitativos e qualitativos de publicações das bases de dados Web of Science e PubMed/ Medical Literature Analysis and Retrieval System Online (Medline) publicadas entre fevereiro de 2018 e agosto de 2022. Resultados: O total de 27 estudos foi identificado e analisado. Cuidadores apresentam prejuízos na latência, fragmentação, duração e qualidade subjetiva do sono, disfunção diurna e insônia. O estresse e sintomas depressivos apresentados pelo cuidador possuem com o sono uma relação bidirecional. Conclusão: Os distúrbios do sono apresentados pelos cuidadores estão correlacionados com o alto nível de sobrecarga e geram maior vulnerabilidade para sintomas psiquiátricos e problemas de saúde. dimensões Objetivo Métodos PubMed Medline (Medline 201 2022 Resultados 2 analisado latência fragmentação insônia bidirecional Conclusão saúde 20 202

Abstract This study described the growth, morphometric, biomechanical, and chemical properties of the femur, tibiotarsus, and tarsometatarsus of European and Japanese quail. Analyses were performed at 13 and 15 days of incubation, at hatch, and at 4, 7, 10, 14, 21, 28, and 35 days post-hatch (n=6/subspecies/period). Bone specimens were analyzed by cone-beam computed tomography, biomechanical assays, chemical analyses, and histomorphometry. Variables were fitted by the Gompertz function and its derivative or assessed using the analysis of variance. Analysis of the derivative of Gompertz curves showed that the growth behavior of the tarsometatarsal bone was similar between quail subspecies, and the femur and tibiotarsus of European quail increased first in width and then in length, whereas the opposite occurred in Japanese quail. There was an interaction between quail subspecies and days of growth on femoral, tarsometatarsal, and tibiotarsal bone densities. Femoral and tibiotarsal cross-sectional areas were influenced by the interaction of quail subspecies and day of growth. Interaction effects were significant for breaking strength and phosphorus percentage. European and Japanese quail have different femoral and tibiotarsal growth patterns, especially in the first few days after hatching, whereas tarsometatarsal growth is similar between subspecies. morphometric 1 incubation hatch 4 7 10 14 21 28 3 posthatch post n=6/subspecies/period. n6subspeciesperiod nsubspeciesperiod n=6/subspecies/period . n 6 period (n=6/subspecies/period) conebeam cone beam tomography assays analyses histomorphometry variance length densities crosssectional cross sectional percentage patterns hatching 2 subspeciesperiod (n=6/subspecies/period

Abstract This work presents, in a synthesized way, some considerations regarding the process of translation, analysis and commentary of chapter XIV of the first volume of the book Exploration of the Valley of The Amazon, written by the lieutenant of the United States Navy of America William Lewis Herndon, between 1851 and 1852. The historical and political scenarios for the Amazon of that period are also introduced and contextualized, in order to understand more closely the conditions of possibility for the journeys, the compiled reports and opinions of the expeditionary to have taken place as we know today. At the end of the translation of the chapter rich in details about the old Manaus (Vila da Barra do Rio Negro), we obtained 45 notes, in which we sought to cover in analysis aspects such as those of the economic, social and political life of the population of the city and the region. Seeking success in this proposal, we consulted the original text in its various editions, in order to present a text in English and in Portuguese as accurate as possible, paying special attention to the specific vocabulary of the region at the time. We hope that the bilingual edition of this chapter will contribute to a greater understanding of this exceptional book and of great value to the history of the Brazilian Amazon. presents way Herndon 185 1852 contextualized journeys today Vila Negro, Negro , Negro) 4 notes economic proposal editions possible time 18 1

Resumo Este trabalho apresenta de forma sintetizada algumas considerações referentes ao processo de tradução, análise e comentário do capítulo XIV do primeiro volume do livro Exploration of the Valley of The Amazon, escrito pelo tenente da Marinha dos Estados Unidos da América William Lewis Herndon, entre 1851 e 1852. Também são introduzidos e contextualizados os cenários histórico e político para a Amazônia daquele período, a fim de se possa compreender com mais proximidade as condições de possiblidade para que as viagens, os relatos compilados e opiniões do expedicionário tenham se dado como hoje o sabemos. Ao final da tradução do capítulo rico em detalhes sobre a antiga Manaus (Vila da Barra do Rio Negro), obtivemos 45 notas, nas quais buscamos abranger em análise aspectos como os da vida econômica, social e política da população da cidade e da região. Almejando êxito nesta proposta, consultamos o texto original em suas várias edições, para se apresentar um texto em inglês e em português o mais preciso possível, dando especial atenção ao vocabulário específico da região para a época. Esperamos que a edição bilíngue deste capítulo contribua para um maior conhecimento deste livro excepcional e de grande valor para a história da Amazônia brasileira. Amazon Herndon 185 1852 período viagens sabemos Vila Negro, Negro , Negro) 4 notas econômica proposta edições possível época brasileira 18 1