ABSTRACT The caterpillar Ascia monuste orseis (Godart) (Lepidoptera: Pieridae) stands out as one of the main defoliating pests of brassicas. To mitigate the damage and reduce the impact on human health and the environment that results from the persistent and indiscriminate use of chemical insecticides, it is crucial to consider the use of botanical insecticides as a fundamental alternative for pest control. The aim was therefore to investigate the stimulus-response of the hydroalcoholic crude extract of Ocimum campechianum and of its dichloromethane (DCM) fraction on A. monuste orseis. Leaf consumption (cm2) of caterpillars exposed to the extract, caterpillar mortality in 24 h, total caterpillar mortality, pupal mortality, pupal period duration, and morphological malformation in adults were evaluated. Feeding the caterpillars for eight days with cabbage impregnated with the crude extract and its DCM fraction resulted in decreased caterpillar feeding, increased larval mortality (90%), lengthening of the pupal period (two days), and an increase in adult deformation (50%). Therefore, the crude extract of O. campechianum and its DCM fraction have potential for use in the alternative control of A. monuste orseis. Godart (Godart Lepidoptera (Lepidoptera Pieridae brassicas stimulusresponse stimulus response (DCM A cm2 cm (cm2 2 h duration evaluated feeding 90%, 90 90% , (90%) two days, days) 50%. 50 50% . (50%) Therefore O (cm 9 (90% 5 (50% (90 (50 (9 (5 (

RESUMO A lagarta Ascia monuste orseis (Godart) (Lepidoptera: Pieridae), destaca-se como uma das principais pragas desfolhadoras das brássicas. Para mitigar os danos e reduzir os impactos na saúde humana e no meio ambiente, decorrentes do uso persistente e indiscriminado de inseticidas químicos, é crucial considerar a utilização de inseticidas botânicos como uma alternativa fundamental para seu controle. Deste modo, o objetivo foi investigar o estímuloresposta do extrato bruto hidroalcoólico de Ocimum campechianum e de sua fração diclorometano (DCM) sobre A. monuste orseis. Avaliou-se o consumo foliar (cm2) das lagartas expostas aos extratos, mortalidade de lagartas em 24 h, mortalidade total de lagartas, mortalidade de pupas, duração do período de pupa e malformação morfológica em adultos. A alimentação das lagartas de oito dias, com a couve impregnada com o extrato bruto e sua fração DCM, resultou em diminuição da alimentação das lagartas, aumento da mortalidade larval (90%), alongamento do período pupal (2 dias) e aumento da deformação em adultos (50%). Portanto, o extrato bruto e sua fração DCM de O. campechianum apresentam potencial para uso no controle alternativo de A. monuste orseis. Godart (Godart Lepidoptera (Lepidoptera Pieridae, Pieridae , Pieridae) destacase destaca se brássicas ambiente químicos modo (DCM Avaliouse Avaliou cm2 cm (cm2 extratos 2 h pupas dias 90%, 90 90% (90%) ( 50%. 50 50% . (50%) Portanto O (cm 9 (90% 5 (50% (90 (50 (9 (5

ABSTRACT The objective of this study was to investigate the influence of leaf drying techniques (bench and oven at 35 and 45 °C) on the essential oil (EO) yield of Piper aduncum L., Piper anonifolium Kunth, Piper crassinervium Kunth and Piper hispidinervum C. DC., and to analyze the chemical profile of EOs and the insecticidal potential of these oils against Ascia monuste orseis (Godart), Atta sexdens L., Zabrotes subfasciatus (Boheman), Cryptolestes ferrugineus (Stephens) and Sitophilus zeamais Motschulsky. EO yield was evaluated using four replicates of 100g of dry leaves. The EOs were obtained by hydrodistillation and subjected to GC-MS analysis to assess the chemical composition. Concentrations of 2.60 and 157.25 nL/cm2 were used in the oil toxicity bioassays. EO yield was higher in the species P. aduncum and P. hispidinervum using leaves dried in oven at 45 °C, with average yields of 4.72±0.04% and 2.61±0.26%, respectively. The major constituents present in the EOs of P. hispidinervum and P. aduncum were Safrole (98.80%) and Apiole (90.00%). For P. anonifolium, the major constituents were α-Muurolene (23.11%), y-Muurolene (16.60%) and Cadina-1(10), while for P. crassinervium, they were Viridiflorol (27.70%) and Sabinene (15.50%). It was found that the EOs of P. aduncum, P. anonifolium, P. crassinervium and P. hispidinervum had a toxic effect on insects, except for P. anonifolium and P. crassinervium for S. zeamais. EO yield was higher in the species P. aduncum and P. hispidinervum, and these oils caused a higher mortality rate for the investigated insects. bench 3 4 °C C (EO L L. DC DC. Godart, Godart , (Godart) Boheman, Boheman (Boheman) Stephens (Stephens Motschulsky g GCMS GC MS composition 260 2 60 2.6 15725 157 25 157.2 nLcm2 nLcm nL cm2 cm nL/cm bioassays P 472004 72 0 04 4.72±0.04 261026 61 26 2.61±0.26% respectively 98.80% 9880 98 80 (98.80% 90.00%. 9000 90.00% . 90 00 (90.00%) αMuurolene α Muurolene 23.11%, 2311 23.11% 23 11 (23.11%) yMuurolene y 16.60% 1660 16 (16.60% Cadina110, Cadina110 Cadina 1 10 Cadina-1(10) 27.70% 2770 27 70 (27.70% 15.50%. 1550 15.50% 15 50 (15.50%) insects S (Godart (Boheman 6 2. 1572 157. 47200 7 4.72±0.0 26102 2.61±0.26 98.80 988 9 8 (98.80 900 90.00 (90.00% 231 23.11 (23.11% 16.60 166 (16.60 Cadina11 Cadina-1(10 27.70 277 (27.70 155 15.50 5 (15.50% 4720 4.72±0. 2610 2.61±0.2 98.8 (98.8 90.0 (90.00 23.1 (23.11 16.6 (16.6 Cadina1 Cadina-1(1 27.7 (27.7 15.5 (15.50 472 4.72±0 261 2.61±0. 98. (98. 90. (90.0 23. (23.1 16. (16. Cadina-1( 27. (27. 15. (15.5 47 4.72± 2.61±0 (98 (90. (23. (16 Cadina-1 (27 (15. 4.72 2.61± (9 (90 (23 (1 Cadina- (2 (15 4.7 2.61 ( 4.

RESUMO O objetivo desta pesquisa foi investigar a influência de técnicas de secagem de folhas (bancada e em estufa a 35 e 45 °C) sobre o rendimento do óleo essencial (OE) de Piper aduncum L., Piper anonifolium Kunth, Piper crassinervium Kunth e Piper hispidinervum C. DC.; analisar o perfil químico dos OEs; e o potencial inseticida destes óleos para Ascia monuste orseis (Godart), Atta sexdens L., e para Zabrotes subfasciatus (Boheman), para o besouro Cryptolestes ferrugineus (Stephens) e para Sitophilus zeamais Motschulsky. Avaliou-se o rendimento do OE utilizando quatro repetições de 100g de folhas secas. Os OEs foram obtidos por hidrodestilação e submetidos à análise por CG-EM para a constatação da composição química. Utilizou-se as concentrações 2,60 e 157,25 nL/cm2 nos bioensaios de toxicidade dos óleos. O rendimento dos OEs foi maior nas espécies P. aduncum e P. hispidinervum utilizando folhas secas em estufa a 45 °C, com rendimentos médios de 4,72±0,04% e 2,61±0,26% respectivamente. Os constituintes majoritários presentes nos OEs de P. hispidinervum e P. aduncum, foram o Safrol (98,80%) e Apiole (90,00%). Para P. anonifolium, foram o α-Muuroleno (23,11%), y-Muuroleno (16,60%) e Cadina-1(10), enquanto para P. crassinervium, foram o Viridiflorol (27,70%) e Sabineno (15,50%). Constatou-se que os OEs de P. aduncum, P. anonifolium, P. crassinervium e P. hispidinervum apresentaram efeito tóxico para os insetos, exceto P. anonifolium e P. crassinervium para S. zeamais. O rendimento dos OEs foi maior nas espécies P. aduncum e P. hispidinervum e estes óleos causaram maior taxa de mortalidade para os insetos investigados. bancada 3 4 °C C (OE L L. DC. DC Godart, Godart , (Godart) Boheman, Boheman (Boheman) Stephens (Stephens Motschulsky Avaliouse Avaliou se g CGEM CG EM química Utilizouse Utilizou 260 2 60 2,6 15725 157 25 157,2 nLcm2 nLcm nL cm2 cm nL/cm P 472004 72 0 04 4,72±0,04 261026 61 26 2,61±0,26 respectivamente 98,80% 9880 98 80 (98,80% 90,00%. 9000 90,00% . 90 00 (90,00%) αMuuroleno α Muuroleno 23,11%, 2311 23,11% 23 11 (23,11%) yMuuroleno y 16,60% 1660 16 (16,60% Cadina110, Cadina110 Cadina 1 10 Cadina-1(10) 27,70% 2770 27 70 (27,70% 15,50%. 1550 15,50% 15 50 (15,50%) Constatouse Constatou S investigados (Godart (Boheman 6 2, 1572 157, 47200 7 4,72±0,0 26102 2,61±0,2 98,80 988 9 8 (98,80 900 90,00 (90,00% 231 23,11 (23,11% 16,60 166 (16,60 Cadina11 Cadina-1(10 27,70 277 (27,70 155 15,50 5 (15,50% 4720 4,72±0, 2610 2,61±0, 98,8 (98,8 90,0 (90,00 23,1 (23,11 16,6 (16,6 Cadina1 Cadina-1(1 27,7 (27,7 15,5 (15,50 472 4,72±0 261 2,61±0 98, (98, 90, (90,0 23, (23,1 16, (16, Cadina-1( 27, (27, 15, (15,5 47 4,72± 2,61± (98 (90, (23, (16 Cadina-1 (27 (15, 4,72 2,61 (9 (90 (23 (1 Cadina- (2 (15 4,7 ( 4,

Abstract The antiulcer mechanisms of the dry extract of T. erecta flowers (DETe) were studied here. The acute ulcers induced by acidified ethanol or indomethacin were reproduced in mice pretreated with DETe (3 - 300 mg/kg). The antiulcer activity of DETe was also verified in mice pretreated with NEM, L-NAME, indomethacin, or yohimbine. The antisecretory effect of DETe was verified in rats, and its anti-Helicobacter pylori activity was determined in vitro. DETe (300 mg/kg, p.o) reduced the ethanol- or indomethacin-induced ulcer by 49 and 93%, respectively. The pre-treatment with L-NAME, NEM or yohimbine abolished the gastroprotective effect of DETe. However, DETe did not change the volume, acidity, or peptic activity in rats and did not affect H. pylori. This study expands knowledge about the antiulcerogenic potential of DETe, evidencing the role of nitric oxide, non-protein sulfhydryl groups, α2 adrenergic receptors, and prostaglandins, but not antisecretory or anti-H. pylori properties. T (DETe here 3 ( 30 mg/kg. mgkg mg/kg . mg kg mg/kg) LNAME, LNAME L NAME, NAME L-NAME antiHelicobacter anti Helicobacter vitro (30 p.o po p o indomethacininduced 4 93 93% respectively pretreatment pre treatment However volume acidity H oxide nonprotein non protein groups α receptors prostaglandins antiH. antiH anti-H properties 9

RESUMO Objetivo: Este estudo visa analisar a influência da paixão empreendedora e da criatividade na intenção empreendedora e o papel mediador da autoeficácia empreendedora entre as variáveis pessoais/cognitivas e a intenção empreendedora. Originalidade/valor: Ressaltando a importância das variáveis cognitivas e emocionais que podem influenciar as intenções empreendedoras dos estudantes universitários, tais como a criatividade e a paixão empreendedora, este estudo mostra o importante papel das universidades no desenvolvimento das intenções empreendedoras. De acordo com a Teoria Social Cognitiva (TSC), o ambiente influencia o comportamento do indivíduo, e as universidades deveriam promover um ambiente empreendedor, possibilitando a criação de novos empregos e empresas. Design/metodologia/abordagem: Os dados foram coletados por uma pesquisa feita com estudantes de Administração e de Informática de uma universidade brasileira. Ao todo, foram obtidas 338 respostas válidas, analisadas por meio de modelagem de equações estruturais. Essa coleta foi realizada de maneira transversal e com um método de amostragem não-probabilística. Para investigar as hipóteses e atingir os objetivos deste estudo, todos os conceitos foram adaptados a partir da literatura da área de empreendedorismo. O modelo estrutural foi avaliado em relação ao seu ajuste, permitindo a testagem de hipóteses. Resultados: Os resultados mostraram uma relação positiva direta e indireta entre a paixão empreendedora e a intenção de empreender. A respeito da criatividade, foi possível perceber apenas uma influência indireta desse fator na intenção empreendedora, sendo essa relação mediada por meio da autoeficácia empreendedora. Não foram encontradas diferenças significantes no modelo com relação a idade, gênero, curso de graduação, histórico empreendedor familiar, modelo de comportamento e a renda familiar.

ABSTRACT Purpose: This study aims to analyze the influence of entrepreneurial passion and creativity on entrepreneurial intent. It also examines the mediating role of entrepreneurial self-efficacy between the personal/cognitive variable and entrepreneurial intention. Originality/value: By stressing the importance of cognitive and emotional variables that may influence entrepreneurial intentions among university students (such as creativity and entrepreneurial passion), this study shows the important role that universities have in the development of entrepreneurial intent. According to the Social Cognitive Theory (SCT), the environment influences individual behavior and, therefore, universities should encourage an entrepreneurial environment, enabling the creation of new jobs and companies. Design/methodology/approach: Data were collected through a survey with business and technology students from a Brazilian university. In total, 338 valid responses were obtained, which were analyzed through structural equation modeling. The data were collected in a cross-sectional manner and by a stratified and non-probability sampling method. To address the research hypothesis and to attain the objectives of the study, all constructs were adapted from relevant literature in the field of entrepreneurship. The structural model was examined in relation to the model fit, which enabled the hypothesis to be tested. Findings: Results showed both a direct and indirect positive relationship between entrepreneurial passion on entrepreneurial intention. Regarding the creativity factor, results indicated only an indirect effect of creativity on entrepreneurial intention, this relationship being mediated through entrepreneurial self-efficacy. No significant differences were found in the model regarding age, gender, graduation program, entrepreneurial family background, role models or family income.

Objective: Cocaine use disorders (CUDs) represent a major public health problem in many countries. To better understand the interaction between the environmental modulations and phenotype, the aim of the present study was to investigate the DNA methylation pattern of CUD patients, who had concomitant cocaine and crack dependence, and healthy controls. Methods: We studied DNA methylation profiles in the peripheral blood of 23 CUD patients and 24 healthy control subjects using the Illumina Infinium HumanMethylation450 BeadChip arrays. Results: Comparison between CUD patients and controls revealed 186 differentially methylated positions (DMPs; adjusted p-value [adjP] < 10-5) related to 152 genes, with a subset of CpGs confirmed by pyrosequencing. DNA methylation patterns discriminated CUD patients and control groups. A gene network approach showed that the EHMT1, EHMT2, MAPK1, MAPK3, MAP2K1, and HDAC5 genes, which are involved in transcription and chromatin regulation cellular signaling pathways, were also associated with cocaine dependence. Conclusion: The investigation of DNA methylation patterns may contribute to a better understanding of the biological mechanisms involved in CUD.

O crédito hipotecário marca a provisão da habitação em Portugal a partir do início da década de 1990, constituindo um importante mecanismo de reprodução de desigualdades sociais e territoriais. Com base nos dados dos Censos de 2011, este artigo analisa a relação entre formas de provisão da habitação e heterogeneidade socioterritorial nas Áreas Metropolitanas de Lisboa (AML) e do Porto (AMP). Conclui que a financeirização da habitação é um fenómeno mais significativo na AML, tendo-se verificado nesta área metropolitana uma relação mais intensa entre finança e habitação, associando nova construção e dispersão populacional a crédito hipotecário.

Mortgage credit marks housing provision in Portugal since the beginning of the 1990s, becoming an important mechanism of reproduction of social and territorial inequalities. Based on data from the Census of 2011, this article analyzes the relationship between forms of housing provision and socioterritorial heterogeneity in the Metropolitan Areas of Lisbon and Porto. The article concludes that financialization of housing is mostly a phenomenon of the Metropolitan Area of Lisbon, where a closer relationship was found between finance and housing, associating new construction and population dispersion with mortgage credit.

A same coordination polymer [Zn(aip)(DMSO)] (aip: 5-aminoisophthalate and DMSO: dimethylsulfoxide) was synthesized using the same reactants (ZnSO4, aip and H2O/DMSO) but in different conditions, in which the stoichiometry (1:1-4:1 metal:ligand ratio), temperature (70 and 100 °C) and synthetic method (liquid-liquid diffusion, solvothermal and conventional with stirring) varied. A liquid assisted mechanochemical approach using ZnO as ZnII source instead ZnSO4, but keeping DMSO as milling liquid, also resulted in the same compound. This new coordination polymer was investigated using single-crystal X-ray diffraction technique, revealing a two-dimensional honeycomb-type network formation. The crystal structure was compared with either similar or isostructural compounds reported in the literature. Our studies show that the synthetic method and other synthetic variables do not affect the formation of [Zn(aip)(DMSO)] coordination polymers and probe the high stability (thermodynamic and kinetic) and structural invariance of this structure.

The new generation of innovative projects has led to the use of greater amounts of reinforcement and the development of concrete with specific characteristics. It is necessary to use a material that ensures the uniformity of the cross section, as well as the adherence of the existing reinforcement, and due to this, the self-consolidating concrete becomes an technique alternative has great potential to achieve these properties. The aim of this paper is to analyze the bond behavior of self-consolidating concrete that was obtained by means of the Beam Test performed within a large experimental campaign of characterization. Four types of SCC were studied with two strength levels (40 MPa and 60MPa) and two different types of granular skeletons, using two specimens at each age (3, 7, and 28 days). All specimens were tested with a corrugated steel bar 10 mm in diameter. The results show that the adhesion tension independently of resistance presents a rapidly evolving at 7 days reached 95% of the total adhesion by 28 days.

La necesidad de proyectos innovadores ha conducido al empleo de mayores cuantías de armadura y al desarrollo de concretos con características especiales. Para ello, se hace necesario el empleo de un material que garantice la homogeneidad de la sección transversal, así como, la adherencia de la armadura existente; en este sentido, el concreto autocompactante se torna una alternativa técnica con gran potencial para atender esas propiedades. El objetivo de este trabajo es analizar los resultados de la resistencia de adherencia del concreto autocompactante obtenidos en una amplia campaña experimental. Se ha trabajado con dos niveles de resistencia a la compresión (40 y 60 MPa) y con dos esqueletos granulares distintos. Se ha empleado el ensayo de la viga (UNE 36740: 1998) para medir la tensión de adherencia a 3 edades diferentes (3, 7 y 28 días). Todas las probetas fueron ensayadas con una barra corrugada de acero de 10 mm de diámetro. Los resultados muestran que la tensión de adherencia independientemente de la resistencia, presenta una evolución rápida, alcanzando a los 7 días un 95% del total de la adherencia a los 28 días.

Uma das alternativas para reduzir o uso de agrotóxicos pode ser a utilização de óleos essenciais para o controle de doenças e pragas que afetam a produção agrícola. O objetivo do presente estudo foi verificar o efeito fungicida dos óleos essenciais de Schinus molle L. e Schinus terebinthifolius Raddi, espécies nativas amplamente distribuídas na região. Os óleos foram extraídos por hidrodestilação e analisados por cromatografia gasosa. Os fungos fitopatógenos Alternaria spp., Botrytis spp., Colletotrichum spp. e Fusarium spp., foram isolados a partir de gérberas e rosas com sintomas de doença e os ensaios de atividade antifúngica foram realizados através da técnica de difusão em disco e os dados analisados pelo teste de Tukey e Duncan a 5%. Em geral o óleo essencial de S. molle foi efetivo para os quatro fungos testados, nas quatro diluições utilizadas e para todos os tempos avaliados e o óleo essencial de S. terebinthifolius apresenta efeito fungicida mais pronunciado contra Botrytis spp., a partir de testes in vitro.

One of the alternatives to reduce the use of pesticides may be the use of essential oils to control diseases and pests that affect agricultural production. The purpose of this study was to evaluate the fungicide effect of essential oils of Schinus molle L. and Schinus terebinthifoliusRaddi, native species widely distributed in the region. The oils were extracted by hydro distillation and analyzed by gas chromatography. The phytopathogenic fungi Alternariaspp., Botrytisspp., Colletotrichumspp. and Fusarium spp., were isolated from "gerberas" and roses with symptoms of disease and antifungal activity of the tests were carried out by the technique of spreading disk. The data was analyzed by Tukey and Duncan tests to 5%. In general, the essential oil of S. mollewas effective for the four fungi tested, for the four dilutions used and for all the times evaluated. The essential oil of S. terebinthifolius presents more pronounced fungicide effect against Botrytisspp., from in vitro tests.

This study is a result of undergraduate student participation in the Environmental Chemistry discipline provided by the Chemistry Institute/UFBA. The students were involved in the development of passive samplers, a project of the LAQUAM (Environmental Analytical Chemistry Laboratory). The students' residences and other neighborhoods were used to create a passive sampling network, allowing the measurement of atmospheric levels of pollutants in urban areas and in those under industrial influence. The assembly of the passive samplers, including impregnation of filters and chemical analysis were part of the students' practice tasks. The results were analyzed taking into consideration the Brazilian legislation.

Os óleos essenciais de duas variedades da árvore canforeira (Cinnamomum camphora Nees & Eberm, Lauraceae), conhecidas como Hon-Sho e Ho-Sho cultivadas em canteiros experimentais no sul do Brasil foram estudados. Os óleos essenciais foram obtidos das folhas e ramos de plantas jovens por hidrodestilação. A identificação dos componentes foi feita por GC, GC/MS e índices de retenção nas fases metil silicone e carbowax. Os principais componentes foram linalol no Ho-Sho e cânfora no Hon-Sho.

The essential oils of two varieties of Camphor tree (Cinnamomum camphora Nees & Eberm, Lauraceae), known as Hon-Sho and Ho-Sho cultivated in experimental stands in Southern Brazil were studied. The essential oils were obtained from the leaves and twigs of young plants by hydrodistillation. The identification of the components was performed using GC, GC/MS and retention indexes on methyl silicone and carbowax phases. The main components identified were linalool in the Ho-Sho and camphor in the Hon-Sho.