ABSTRACT Objective: To verify the COVID-19 clinical characteristics, associated comorbidities, and outcomes in adolescents. Data source: This is a systematic review study based on articles published between 2020 and 2022 in the United States National Library of Medicine - PubMed (MedLine), Virtual Health Library – VHL (LILACS), Science Direct, Web of Science, and Scopus (Elsevier) databases. The study was registered in the International Prospective Register of Systematic Reviews, under No. CRD42022309108. Data synthesis: A total of 1188 studies were identified. After applying the selection criteria, 13 articles were included. Prevalence was 25%; mild cases were predominant; and fever, cough, headache, anosmia, nasal congestion, and ageusia were frequent. Fever and cough were proportionally higher in hospitalized cases: 81 and 68%, respectively. Dyspnea (odds ratio [OR] 6.3; confidence interval 95%[CI] 2.8–14.3), fever (OR 3.8; 95%CI 2.0–7.4), and cough (OR 3.4; 95%CI 2.0–6.0) were associated with severe cases. Up to 28% required intensive care and 38% required mechanical ventilation. Pre-existing comorbidities increased the risk of hospitalization and death. Severe cases were associated with the risk of death (relative risk [RR] 4.6; 95%CI 2.8–7.5). The black, mixed, and indigenous races/skin colors represented risk groups, as well as residents of poorer regions. Conclusions: The review provided a better understanding of the disease profile and may favor the development of public policies, in addition to contributing to the current literature in the field of adolescent health. Objective COVID19 COVID 19 COVID-1 characteristics adolescents source 202 MedLine, MedLine , (MedLine) LILACS, LILACS (LILACS) Direct Elsevier (Elsevier databases Reviews No CRD42022309108 CRD synthesis 118 identified criteria 1 included 25% 25 predominant headache anosmia congestion frequent 8 68 68% respectively odds OR [OR 6.3 63 6 3 95CI CI 95% 95 95%[CI 2.8–14.3, 28143 2.8–14.3 2 14 2.8–14.3) 3.8 38 2.0–7.4, 2074 2.0–7.4 0 7 4 2.0–7.4) 3.4 34 2.0–6.0 2060 28 ventilation Preexisting Pre existing relative RR [RR 4.6 46 2.8–7.5. 2875 2.8–7.5 . 5 2.8–7.5) black mixed racesskin races skin groups regions Conclusions policies health COVID1 COVID- 20 (MedLine (LILACS CRD4202230910 11 6. 9 2814 2.8–14. 3. 207 2.0–7. 2.0–6. 206 4. 287 2.8–7. CRD420223091 281 2.8–14 2.0–7 2.0–6 2.8–7 CRD42022309 2.8–1 2.0– 2.8– CRD4202230 2.0 2.8 CRD420223 2. CRD42022 CRD4202 CRD420 CRD42 CRD4
RESUMO Objetivo: Verificar as características clínicas, as comorbidades associadas e os desfechos da COVID-19 em adolescentes. Fontes de dados: Trata-se de uma revisão sistemática elaborada com base em artigos publicados entre 2020 e 2022 nas bases de dados United States National Library of Medicine (PubMed), Biblioteca Virtual em Saúde (BVS), Science Direct, Web of Science e Scopus. O estudo foi registrado no International Prospective Register of Systematic Reviews, n° CRD42022309108. Síntese dos dados: Foram identificados 1.188 estudos. Após a aplicação dos critérios de seleção, 13 artigos foram incluídos. A prevalência foi de 25%; os casos leves foram predominantes; e febre, tosse, cefaleia, anosmia, congestão nasal e ageusia foram frequentes. Febre e tosse foram proporcionalmente maiores em casos hospitalizados, com 81 e 68%, respectivamente. Dispneia (OR 6,3; IC95% 2,8–14,3), febre (OR 3,8; IC95% 2,0–7,4) e tosse (OR 3,4; IC95% 2,0–6,0) foram associados a casos graves. Até 28% necessitaram de cuidados intensivos e 38% de ventilação mecânica. A preexistência de comorbidade aumentou o risco de internação e óbito. Os casos graves estão associados ao risco de óbito (risco relativo — RR 4,6; IC95% 2,8–7,5). As raças/cores preta, parda e indígena e os moradores de regiões mais pobres foram grupo de risco. Conclusões: A revisão permitiu conhecer o perfil da doença e poderá favorecer a elaboração de políticas públicas, além de contribuir para a literatura atual no campo da saúde do adolescente. Objetivo clínicas COVID19 COVID 19 COVID-1 adolescentes Tratase Trata se 202 PubMed, PubMed , (PubMed) BVS, BVS (BVS) Direct Scopus Reviews n CRD42022309108 CRD 1188 1 188 1.18 estudos seleção incluídos 25% 25 predominantes cefaleia anosmia frequentes hospitalizados 8 68 68% respectivamente OR 6,3 63 6 3 IC95 IC 2,8–14,3, 28143 2,8–14,3 2 14 2,8–14,3) 3,8 38 2,0–7,4 2074 0 7 4 3,4 34 2,0–6,0 2060 28 mecânica 4,6 46 2,8–7,5. 2875 2,8–7,5 . 5 2,8–7,5) raçascores raças cores preta Conclusões públicas adolescente COVID1 COVID- 20 (PubMed (BVS CRD4202230910 118 18 1.1 6, IC9 2814 2,8–14, 3, 2,0–7, 207 2,0–6, 206 4, 287 2,8–7, CRD420223091 11 1. 281 2,8–14 2,0–7 2,0–6 2,8–7 CRD42022309 2,8–1 2,0– 2,8– CRD4202230 2,0 2,8 CRD420223 2, CRD42022 CRD4202 CRD420 CRD42 CRD4