ABSTRACT The Middle Pleistocene (780-130 ka) was a key period in human evolutionary history. The period holds a great diversity of hominin species, technological innovations, in addition to being, after all, when Homo sapiens appeared on the planet. However, Pleistocene populations, as well as the biological relationships between them, remain poorly understood. Here, we bring a brief summary of human evolution with special attention to the Middle Pleistocene issues, advances in the field and the Brazilian contribution to this debate. 780130 780 130 (780-13 ka history species innovations being all planet However populations them understood Here issues debate 78013 78 13 (780-1 7801 7 1 (780- (780 (78 (7 (

RESUMO O Pleistoceno Médio (780-130 mil anos) foi um período-chave na história evolutiva humana. O período abriga uma grande diversidade de espécies hominínias, inovações tecnológicas, além de ser, afinal, quando o Homo sapiens surgiu no planeta. Entretanto, as populações pleistocênicas, bem como as relações biológicas entre elas, permanecem precariamente compreendidas. Aqui, trazemos uma breve síntese da evolução humana com especial atenção às questões do Pleistoceno Médio, os avanços da área e a contribuição brasileira a esse debate. 780130 780 130 (780-13 anos períodochave chave hominínias tecnológicas ser afinal planeta Entretanto pleistocênicas elas compreendidas Aqui debate 78013 78 13 (780-1 7801 7 1 (780- (780 (78 (7 (

ABSTRACT This study aimed to assess an alkaline protease supplemented in diets with and without crude protein (CP) reduction on performance, apparent total tract digestibility (ATTD), blood parameters, and carcass and meat traits in growing-finishing pigs. Forty male pigs (26.2±1.2 kg) were randomly allocated into one of five treatments: negative control (NC, 2% and 1% reduction of CP in grower and finisher phases, respectively, no protease); NC150: NC + 150 mg protease kg−1 diet; NC300: NC + 300 mg protease kg−1 diet; PC: positive control (no CP reduction and protease); and PC300: PC + 300 mg protease kg−1 diet, with eight replicates of one pig/pen. Pigs fed NC showed greater average daily feed intake (ADFI) than pigs fed NC300 or PC and lower ADFI compared to pigs fed NC150. Pigs fed PC had lower ADFI than those fed PC300. Greater average daily gain and gain to feed ratio (G:F) were observed in pigs on NC compared with those on NC300 or NC150 and NC300, respectively. Pigs fed PC showed better G:F than pigs fed PC300. Lower coefficients of ATTD (CTTAD) of dry and organic matter (OM), digestible dry matter (DDM), digestible organic matter (DOM), and digestible protein were observed in growing II pigs fed NC compared with pigs fed NC150 or NC300. Pigs fed NC showed a lower DP compared with PC or NC150. Positive control group showed increased digestible protein compared with NC. Finishing II pigs fed NC showed lower DDM, DOM, CTTAD of OM, and gross energy than pigs fed NC150 or NC300. Pigs fed PC showed greater albumin concentration compared with pigs fed PC300 in finishing II. Pigs fed NC and PC300 showed greater luminosity in the l. thoracis muscle than pigs fed PC. A greater color score was evidenced in the l. thoracis in pigs fed PC compared with pigs fed PC300. The dietary supplementation of isolated alkaline protease and CP-reduced diets improves ATTD without supporting pig performance. (CP performance ATTD, , (ATTD) parameters growingfinishing 26.2±1.2 26212 26 2 1 (26.2±1. kg treatments NC, (NC phases respectively protease) 15 kg1 kg− diet 30 pigpen pen pig/pen (ADFI NC30 GF G F (G:F NC15 (CTTAD OM (OM) DDM (DDM) DOM (DOM) PC30 l CPreduced reduced (ATTD 26.2±1. 2621 (26.2±1 3 NC3 NC1 (OM (DDM (DOM PC3 26.2±1 262 (26.2± 26.2± (26.2 26.2 (26. 26. (26 (2 (

Abstract Sahelanthropus tchadensis has raised much debate since its initial discovery in Chad in 2001, given its controversial classification as the earliest representative of the hominin lineage. This debate extends beyond the phylogenetic position of the species, and includes several aspects of its habitual behavior, especially in what regards its locomotion. The combination of ancestral and derived traits observed in the fossils associated with the species has been used to defend different hypotheses related to its relationship to hominins. Here, the cranial morphology of Sahelanthropus tchadensis was assessed through 16 linear craniometric measurements, and compared to great apes and hominins through Principal Component Analysis based on size and shape and shape information alone. The results show that S. tchadensis share stronger morphological affinities with hominins than with apes for both the analysis that include size information and the one that evaluates shape alone. Since TM 266-01-060-1 shows a strong morphological affinity with the remaining hominins represented in the analysis, our results support the initial interpretations that S. tchadensis represents an early specimen of our lineage or a stem basal lineage more closely related to hominins than to Panini. 2001 behavior locomotion Here 1 measurements alone S 266010601 266 01 060 266-01-060- Panini 200 26601060 26 0 06 266-01-060 20 2660106 2 266-01-06 266010 266-01-0 26601 266-01- 2660 266-01 266-0 266-

ABSTRACT Objective: To verify the relationship between the presence of proteinuria as a renal injury marker in elderly without history of systemic arterial hypertension and cardiovascular diseases. A cross-sectional study was developed from January 2014 to December 2019, through kidney disease prevention campaigns promoted by the Federal University of Ceará in the city of Fortaleza. Methods: The sample consisted of 417 elderlies. A questionnaire was used to characterize individuals and assess previous diseases, and urinalysis reagent strips were used to assess proteinuria. Results: Statistically significant differences (p < 0.05) and moderate effect sizes were found for blood pressure levels (CI 0.53-0.93), systolic blood pressure, and diastolic blood pressure (CI 0.21-0.61). Significant differences in capillary glycemia were also found between groups (p = 0.033), but with a low effect size (0.02–0.42). The group with comorbidities was 2.94 times more likely to have proteinuria than those without comorbidities (OR 2.94, CI 1.55-4.01; p < 0.05). In the group without cardiovascular disease/high blood pressure, a statistically significant association was found for previous diabetes and proteinuria (p = 0.037), presenting 2.68 times higher risk of proteinuria in those with diabetes mellitus (OR 2.68, CI 1.05-6.85). Significant association was also found between age groups, with the older group having 2.69 times higher risk of developing proteinuria (75 to 90 compared to 60 to 74 years) (CI 1.01-7.16; p = 0.045). Conclusion: Even without systemic arterial hypertension or cardiovascular disease, diabetes and older age can be considered high risk factors for proteinuria. Objective diseases crosssectional cross sectional 201 2019 Fortaleza Methods 41 elderlies Results 0.05 005 0 05 0.530.93, 053093 0.53 0.93 , 53 93 0.53-0.93) 0.210.61. 021061 0.21 0.61 . 21 61 0.21-0.61) 0.033, 0033 0.033 033 0.033) 0.02–0.42. 002042 0.02–0.42 02 42 (0.02–0.42) 294 2 94 2.9 OR 1.554.01 155401 1.55 4.01 1 55 4 01 1.55-4.01 0.05. diseasehigh 0.037, 0037 0.037 037 0.037) 268 68 2.6 1.056.85. 105685 1.05 6.85 6 85 1.05-6.85) 269 69 75 (7 9 7 years 1.017.16 101716 1.01 7.16 16 1.01-7.16 0.045. 0045 0.045 045 0.045) Conclusion 20 0.0 00 530 0.530.93 05309 053 0.5 093 0.9 5 0.53-0.93 210 0.210.61 02106 021 0.2 061 0.6 0.21-0.61 003 0.03 03 00204 0.02–0.4 (0.02–0.42 29 2. 554 1.554.0 15540 155 1.5 401 4.0 1.55-4.0 26 056 1.056.85 10568 105 1.0 685 6.8 8 1.05-6.85 ( 017 1.017.1 10171 101 716 7.1 1.01-7.1 004 0.04 04 0. 0.530.9 0530 09 0.53-0.9 0.210.6 0210 06 0.21-0.6 0020 0.02–0. (0.02–0.4 1.554. 1554 15 1. 40 4. 1.55-4. 1.056.8 1056 10 6. 1.05-6.8 1.017. 1017 71 7. 1.01-7. 0.530. 0.53-0. 0.210. 0.21-0. 002 0.02–0 (0.02–0. 1.554 1.55-4 1.056. 1.05-6. 1.017 1.01-7 0.530 0.53-0 0.210 0.21-0 0.02– (0.02–0 1.55- 1.056 1.05-6 1.01- 0.53- 0.21- 0.02 (0.02– 1.05- (0.02 (0.0 (0. (0

Resumo Objetivo: Verificar a relação entre a presença de proteinúria como marcador de lesão renal em idosos sem histórico de hipertensão arterial sistêmica e doenças cardiovasculares. Um estudo transversal foi desenvolvido de Janeiro de 2014 a Dezembro de 2019, por meio de campanhas de prevenção a doenças renais promovidas pela Universidade Federal do Ceará, na cidade de Fortaleza. Métodos: A amostra foi composta por 417 idosos. Um questionário foi usado para caracterizar indivíduos e avaliar doenças prévias, e foram utilizadas tiras reagentes de urinálise para avaliar proteinúria. Resultados: Diferenças estatisticamente significativas (p < 0,05) e tamanhos de efeito moderados foram encontrados para níveis de pressão arterial (IC 0,53-0,93), pressão arterial sistólica e pressão arterial diastólica (IC 0,21-0,61). Também foram encontradas diferenças significativas na glicemia capilar entre grupos (p = 0,033), mas com um tamanho de efeito baixo (0,02–0,42). O grupo com comorbidades apresentou 2,94 vezes mais probabilidade de ter proteinúria do que aqueles sem comorbidades (OR 2,94; IC 1,55-4,01; p < 0,05). No grupo sem doença cardiovascular/hipertensão, foi encontrada uma associação estatisticamente significativa para diabetes anterior e proteinúria (p = 0,037), apresentando risco 2,68 vezes maior de proteinúria naqueles com diabetes mellitus (OR 2,68; IC 1,05-6,85). Também foi encontrada uma associação significativa entre faixas etárias, com o grupo mais velho apresentando risco 2,69 vezes maior de desenvolver proteinúria (75 a 90 em comparação com 60 a 74 anos) (IC 1,01-7,16; p = 0,045). Conclusão: Mesmo sem hipertensão arterial sistêmica ou doença cardiovascular, o diabetes e a idade avançada podem ser considerados fatores de alto risco para proteinúria. Objetivo cardiovasculares 201 2019 Ceará Fortaleza Métodos 41 prévias Resultados 0,05 005 0 05 0,530,93, 053093 0,53 0,93 , 53 93 0,53-0,93) 0,210,61. 021061 0,21 0,61 . 21 61 0,21-0,61) 0,033, 0033 0,033 033 0,033) 0,02–0,42. 002042 0,02–0,42 02 42 (0,02–0,42) 294 2 94 2,9 OR 1,554,01 155401 1,55 4,01 1 55 4 01 1,55-4,01 0,05. cardiovascularhipertensão cardiovascular cardiovascular/hipertensão 0,037, 0037 0,037 037 0,037) 268 68 2,6 1,056,85. 105685 1,05 6,85 6 85 1,05-6,85) etárias 269 69 75 (7 9 7 anos 1,017,16 101716 1,01 7,16 16 1,01-7,16 0,045. 0045 0,045 045 0,045) Conclusão 20 0,0 00 530 0,530,93 05309 053 0,5 093 0,9 5 0,53-0,93 210 0,210,61 02106 021 0,2 061 0,6 0,21-0,61 003 0,03 03 00204 0,02–0,4 (0,02–0,42 29 2, 554 1,554,0 15540 155 1,5 401 4,0 1,55-4,0 26 056 1,056,85 10568 105 1,0 685 6,8 8 1,05-6,85 ( 017 1,017,1 10171 101 716 7,1 1,01-7,1 004 0,04 04 0, 0,530,9 0530 09 0,53-0,9 0,210,6 0210 06 0,21-0,6 0020 0,02–0, (0,02–0,4 1,554, 1554 15 1, 40 4, 1,55-4, 1,056,8 1056 10 6, 1,05-6,8 1,017, 1017 71 7, 1,01-7, 0,530, 0,53-0, 0,210, 0,21-0, 002 0,02–0 (0,02–0, 1,554 1,55-4 1,056, 1,05-6, 1,017 1,01-7 0,530 0,53-0 0,210 0,21-0 0,02– (0,02–0 1,55- 1,056 1,05-6 1,01- 0,53- 0,21- 0,02 (0,02– 1,05- (0,02 (0,0 (0, (0

RESUMEN: Las proteínas S100 pertenecen al grupo de proteínas fijadoras de calcio y están presentes en actividades reguladoras fisiológicas intracelulares y extracelulares, como la diferenciación celular, y actúan en procesos patológicos inflamatorios y neoplásicos. Recientemente, sus expresiones en el sistema nervioso han sido ampliamente estudiadas, buscando dilucidar su acción a nivel del tálamo: una estructura del sistema nervioso central que forma parte de importantes circuitos, como el somatosensorial, conductual, de memoria y cognitivo, así como además de ser responsable de la transmisión y regulación de la información a la corteza cerebral. Este artículo es una revisión integradora de la literatura científica, que analizó 12 estudios presentes en Pubmed. El análisis mostró que la relación de las proteínas S100 y el tálamo ha sido descrita en procesos neoplásicos, trastornos mentales, hipoxia, trauma, estrés, infección, enfermedad de Parkinson y epilepsia. En resumen, es posible concluir que esta familia de proteínas es relevante como marcador en procesos de lesión talámica, requiriendo más estudios para comprender mejor su significado clínico, preclínico y su valor pronóstico.

SUMMARY: S100 proteins belong group of calcium-binding proteins and are present in physiological intracellular and extracellular regulatory activities, such as cell differentiation, and act in inflammatory and neoplastic pathological processes. Recently, its expressions in the nervous system have been extensively studied, seeking to elucidate its action at the level of the thalamus: A structure of the central nervous system that is part of important circuits, such as somatosensory, behavioral, memory and cognitive, as well as being responsible for the transmission and regulation of information to the cerebral cortex. This article is an integrative review of scientific literature, which analyzed 12 studies present in Pubmed. The analysis showed that the relationship of S100 proteins and the thalamus has been described in neoplastic processes, mental disorders, hypoxia, trauma, stress, infection, Parkinson's disease and epilepsy. In summary, it is possible to conclude that this protein family is relevant as a marker in processes of thalamic injury, requiring further studies to better understand its clinical, preclinical meanings and its prognostic value.

ABSTRACT In this study, we evaluated how guanidinoacetic acid (GAA) addition in diets with various metabolizable energy (ME) contents affects the performance of broiler chickens. We also estimated the equivalence of GAA in ME. We distributed 1,280 one-day-old broilers in a completely randomized design with eight treatments, eight replicates, and twenty birds per experimental unit. Treatments were based on ME levels (2,775-2,875-2,975 kcal/kg; 2,850-2,950-3,050 kcal/kg; 2,925-3,025-3,125 kcal/kg; or 3,000-3,100-3,200 kcal/kg, from 1 to 7, 8 to 21, and 22 to 42 days of age) and the inclusion of GAA (0 or 600 mg/kg). Supplementation of GAA increased weight gain in broilers at an energy level of 2,908 kcal/kg and improved feed conversion ratio (FCR) at energy levels of 2,908 and 2,983 kcal/kg. There was a linear reduction in feed intake and an improvement in FCR of broilers with increasing levels of energy in diets, with and without GAA addition. Solving the equivalence equation, by applying each of the weighted average energy levels studied. indicates the GAA equivalence of 133, 103, 74, and 44 kcal/kg of diet. In conclusion, GAA supplementation improves broilers’ efficiency of energy use; the average ME equivalence of 600 mg/kg of GAA is 88.5 kcal/kg. study (GAA (ME chickens 1280 280 1,28 onedayold one day old treatments replicates unit 2,7752,8752,975 277528752975 2,775 2,875 2,975 2 775 875 975 (2,775-2,875-2,97 kcalkg kcal kg 2,8502,9503,050 285029503050 2,850 2,950 3,050 850 950 3 050 2,850-2,950-3,05 2,9253,0253,125 292530253125 2,925 3,025 3,125 925 025 125 2,925-3,025-3,12 3,0003,1003,200 300031003200 3,000 3,100 3,200 000 100 200 3,000-3,100-3,20 7 21 4 age 0 ( 60 mg/kg. mgkg . mg mg/kg) 2908 908 2,90 (FCR 2983 983 2,98 equation studied 133 103 74 diet conclusion use 885 88 5 88. 128 28 1,2 7752 8752 2,7752,8752,97 27752875297 2775 2,77 2875 2,87 2975 2,97 77 87 97 (2,775-2,875-2,9 8502 9503 2,8502,9503,05 28502950305 2850 2,85 2950 2,95 3050 3,05 85 95 05 2,850-2,950-3,0 9253 0253 2,9253,0253,12 29253025312 2925 2,92 3025 3,02 3125 3,12 92 02 12 2,925-3,025-3,1 0003 1003 3,0003,1003,20 30003100320 3000 3,00 3100 3,10 3200 3,20 00 10 20 3,000-3,100-3,2 6 290 90 2,9 298 98 13 1, 2,7752,8752,9 2775287529 277 2,7 287 2,8 297 9 (2,775-2,875-2, 2,8502,9503,0 2850295030 285 295 305 3,0 2,850-2,950-3, 2,9253,0253,1 2925302531 292 302 312 3,1 2,925-3,025-3, 3,0003,1003,2 3000310032 300 310 320 3,2 3,000-3,100-3, 29 2, 2,7752,8752, 277528752 27 (2,775-2,875-2 2,8502,9503, 285029503 30 3, 2,850-2,950-3 2,9253,0253, 292530253 31 2,925-3,025-3 3,0003,1003, 300031003 32 3,000-3,100-3 2,7752,8752 27752875 (2,775-2,875- 2,8502,9503 28502950 2,850-2,950- 2,9253,0253 29253025 2,925-3,025- 3,0003,1003 30003100 3,000-3,100- 2,7752,875 2775287 (2,775-2,875 2,8502,950 2850295 2,850-2,950 2,9253,025 2925302 2,925-3,025 3,0003,100 3000310 3,000-3,100 2,7752,87 277528 (2,775-2,87 2,8502,95 285029 2,850-2,95 2,9253,02 292530 2,925-3,02 3,0003,10 300031 3,000-3,10 2,7752,8 27752 (2,775-2,8 2,8502,9 28502 2,850-2,9 2,9253,0 29253 2,925-3,0 3,0003,1 30003 3,000-3,1 2,7752, (2,775-2, 2,8502, 2,850-2, 2,9253, 2,925-3, 3,0003, 3,000-3, 2,7752 (2,775-2 2,8502 2,850-2 2,9253 2,925-3 3,0003 3,000-3 (2,775- 2,850- 2,925- 3,000- (2,775 (2,77 (2,7 (2, (2

Abstract The origins of the genus Homo have been a focus of much debate in the paleoanthropological literature due to its importance in understanding the evolutionary trajectories that led to the appearance of archaic humans and our species. On the level of taxonomic classification, the controversies surrounding the origins of Homo are the result of lack of clear classification criteria that separate our genus from australopiths, given the general similarities observed between fossils ascribed to late australopiths and early Homo. The challenge in finding clear autapomorphies for Homo has even led to debates about the classification of Homo habilis and Homo rudolfensis as part of our genus. These debates are further complicated by the scarcity of fossils in the timeframe of appearance of our genus, making any fossils dated to between 3.0 and 2.5 Ma of particular relevance in the context of this discussion. The Ledi-Geraru mandible is one such fossils, which has called the attention of researchers due to its combination of primitive traits seen in Australopithecus and derived traits observed in later Homo. Despite being fragmented and poorly preserved, it is one of the key fossil specimens available from the period mentioned above. species 30 3 0 3. 25 2 5 2. discussion LediGeraru Ledi Geraru preserved above

Resumen El piebaldismo se caracteriza por la ausencia de melanina en regiones del cuerpo, debido a la falta de melanocitos como resultado de mutaciones genéticas, y que ocurre sólo localmente. El presente trabajo reporta el primer registro de piebaldismo para Eptesicus taddeii, una especie de murciélago endémica de la Mata Atlántica en la Región Sur de Brasil.

Abstract Piebaldism is characterized by the absence of melanin in certain areas of the body due the lack of melanocytes as a result of genetic mutations, and which occurs only locally. This study reports the first record of piebaldism for Eptesicus taddeii, a species of bat, endemic to the Atlantic Forest in the South Region of Brazil.

Resumo: Esta introdução apresenta os eixos que inspiraram a organização do dossiê e como os diferentes artigos contribuem para avançar na discussão por nós proposta. Uma primeira seção apresenta em linhas gerais a história da formação da história ambiental como um campo disciplinar, considerando suas potencialidades e limites. Em um segundo momento, discutimos alguns dos principais usos do conceito de capitalismo nas ciências sociais e as possibilidades abertas quando buscamos pensar o sistema de uma perspectiva ambiental. Na sequência, recolocamos os temas anteriores a partir do mundo colonial, com atenção para seu papel na história do capitalismo global. Finalmente, encerramos com algumas questões relacionadas às cronologias sobrepostas do capitalismo, do colonialismo, e da própria crise ambiental contemporânea.

Abstract: This introduction presents the axes of analysis that inspired the organization of this dossier, and how the different articles gathered together here push forward research along these lines of inquiry. First, we offer the general contours of the formation of environmental history as a field of study, weighing its potentials and limitations. Then, we discuss some of the principal uses of the concept of capitalism in the social sciences, and the possibilities that are opened up by examining its historical system through an environmental lens. We then apply these considerations to the colonial world and its role in the history of global capitalism. Finally, we conclude with a series of questions centered on the relationship between the overlapping chronologies of capitalism, colonialism, and the contemporary ecological crisis.

ABSTRACT The objective of the present study was to evaluate the effects of cooling systems by negative pressure versus directed ducts on the performance of lactating sows and their litter. The experiment was conducted in a tropical climatic region in Brazil. Ninety-four lactating sows during 26.2±1.7 days of lactation were included with their 1,236 piglets. Sows were distributed using a completely randomized block design into two treatments: a negative pressure cooling (NPC) system and a directed duct cooling (DDC) system. We adopted sow parity as blocking criterion. During the experimental period, environmental temperatures inside the farrowing rooms were 22.9±1.5 and 25.4±2.5 °C, respectively, using the NPC and DDC systems. Sow daily feed intake, litter weight at weaning, piglet weight at weaning, litter daily weight gain, piglet daily gain, and daily milk production per sow were greater in the NPC system than in the DDC system. The type of cooling system did not affect piglet weight after standardization, mortality, number of piglets weaned per sow, and estrus return. The use of an NPC system can reduce the effects of higher environmental temperatures better than the DDC system. The NPC system allowed for greater feed intake, piglet and litter weight gain, weight of piglets and litter at weaning, and milk production compared with the DDC system.

RESUMO Objetivo: Comparar profilaxia farmacológica e não farmacológica em cirurgia eletiva da coluna vertebral, a fim de determinar os riscos de TVP, TEP e hematoma epidural (HE) em ambos os grupos, bem como a respectiva eficácia do tratamento. Métodos: Revisão sistemática e metanálise com base em artigos sistematicamente pesquisados, usando combinações de termos MESH relacionados à quimioprofilaxia e à não quimioprofilaxia para prevenção de trombose venosa profunda e embolia pulmonar em cirurgia eletiva da coluna vertebral. Pacientes adultos foram elegíveis para inclusão no estudo, exceto aqueles com trauma, lesão medular, neoplasias e aqueles que usavam filtros de veia cava. Resultados: Cinco estudos foram incluídos para fazer parte desta revisão sistemática e metanálise: três estudos retrospectivos, um prospectivo e um série de casos. A análise dos dados mostrou que 4,64% dos pacientes tratados com quimioprofilaxia tiveram um resultado desfavorável em relação à TVP, enquanto esse resultado ocorreu em 1,14% dos pacientes não tratados com quimioprofilaxia (p = 0,001). Entre os pacientes em uso de quimioprofilaxia, apenas 0,1% desenvolveram hematoma epidural (HE) e 0,38% desenvolveram TEP. Entre aqueles em profilaxia não medicamentosa, 0,04% apresentaram HE (p = 0,11) e 0,42% tiveram TEP (p = 0,45). Conclusões: Não foram encontrados benefícios para a quimioprofilaxia quando comparada à não quimioprofilaxia na prevenção da TVP em cirurgia eletiva da coluna vertebral, assim como não foi verificado aumento do risco de hematoma epidural ou eventos tromboembólicos fatais. Nível de evidência III; Estudos terapêuticos - Investigação dos resultados do tratamento.

ABSTRACT Objective: To compare pharmacological and non-pharmacological prophylaxis in elective spine surgery to determine the risks of DVT, PTE, and epidural hematoma (EH) in both groups, as well as their respective treatment effectiveness. Methods: Systematic review and meta-analysis based on systematically searched articles, using combinations of MeSH terms related to chemoprophylaxis and non-chemoprophylaxis for prevention of deep vein thrombosis and pulmonary embolism in elective spine surgery. Adult patients were eligible for inclusion in the study, except for those with trauma, spinal cord injury, neoplasms, or those using vena cava filters. Results: Five studies were selected for this systematic review and meta-analysis: 3 retrospective studies, 1 prospective study, and 1 case series. Data analysis showed that 4.64% of patients treated with chemoprophylaxis had an unfavorable outcome regarding DVT, while this outcome occurred in 1.14% of patients not treated with chemoprophylaxis (p=0.001). Among patients using chemoprophylaxis, only 0.1% developed epidural hematoma and 0.38% developed PTE. Among those on non-pharmaceutical prophylaxis, 0.04% had EH (p=0.11) and 0.42% had PTE (p=0.45). Conclusions: No benefits were found for chemoprophylaxis as compared to non-chemoprophylaxis in preventing DVT in elective spine surgery, nor was there an increased risk of epidural hematoma or fatal thromboembolic events. Level of evidence III; Therapeutic studies; Investigation of treatment results.

RESUMEN Objetivo: Comparar la profilaxis farmacológica y no farmacológica en la cirugía de columna electiva para determinar los riesgos de TVP, TEP y hematoma epidural (HE) en ambos grupos, así como la respectiva eficacia del tratamiento. Métodos: Revisión sistemática y metanálisis basados en artículos buscados sistemáticamente, utilizando combinaciones de términos MESH relacionados con quimioprofilaxis y no quimioprofilaxis para la prevención de trombosis venosa profunda y embolia pulmonar en cirugía electiva de columna. Se eligieron pacientes adultos para su inclusión en el estudio, excepto aquellos con traumatismos, lesión medular, neoplasias y aquellos que usan filtros de vena cava. Resultados: Se incluyeron cinco estudios para formar parte de esta revisión sistemática y metanálisis: 3 estudios retrospectivos, 1 prospectivo y 1 serie de casos. El análisis de los datos reveló que el 4,64% de los pacientes tratados con quimioprofilaxis tuvieron un resultado desfavorable con respecto a la TVP, mientras que este resultado se produjo en el 1,14% de los pacientes no tratados con quimioprofilaxis (p = 0,001). Entre los pacientes que recibieron quimioprofilaxis, sólo el 0,1% desarrolló hematoma epidural (HE) y el 0,38% desarrolló TEP. Entre los que recibieron profilaxis no farmacológica, el 0,04% desarrolló HE (p = 0,11) y el 0,42% desarrolló TEP (p = 0,45). Conclusiones: No se encontraron beneficios para la quimioprofilaxis en comparación con la no quimioprofilaxis para prevenir la TVP en la cirugía de columna electiva, así como tampoco un mayor riesgo de hematoma epidural o eventos tromboembólicos fatales. Nivel de evidencia - III; Estudios terapéuticos – Investigación de los resultados del tratamiento.

Resumo Objetivo: Verificar a relação entre a presença de proteinúria como marcador de lesão renal em idosos sem histórico de hipertensão arterial sistêmica e doenças cardiovasculares. Um estudo transversal foi desenvolvido de Janeiro de 2014 a Dezembro de 2019, por meio de campanhas de prevenção a doenças renais promovidas pela Universidade Federal do Ceará, na cidade de Fortaleza. Métodos: A amostra foi composta por 417 idosos. Um questionário foi usado para caracterizar indivíduos e avaliar doenças prévias, e foram utilizadas tiras reagentes de urinálise para avaliar proteinúria. Resultados: Diferenças estatisticamente significativas (p < 0,05) e tamanhos de efeito moderados foram encontrados para níveis de pressão arterial (IC 0,53-0,93), pressão arterial sistólica e pressão arterial diastólica (IC 0,21-0,61). Também foram encontradas diferenças significativas na glicemia capilar entre grupos (p = 0,033), mas com um tamanho de efeito baixo (0,02–0,42). O grupo com comorbidades apresentou 2,94 vezes mais probabilidade de ter proteinúria do que aqueles sem comorbidades (OR 2,94; IC 1,55-4,01; p < 0,05). No grupo sem doença cardiovascular/hipertensão, foi encontrada uma associação estatisticamente significativa para diabetes anterior e proteinúria (p = 0,037), apresentando risco 2,68 vezes maior de proteinúria naqueles com diabetes mellitus (OR 2,68; IC 1,05-6,85). Também foi encontrada uma associação significativa entre faixas etárias, com o grupo mais velho apresentando risco 2,69 vezes maior de desenvolver proteinúria (75 a 90 em comparação com 60 a 74 anos) (IC 1,01-7,16; p = 0,045). Conclusão: Mesmo sem hipertensão arterial sistêmica ou doença cardiovascular, o diabetes e a idade avançada podem ser considerados fatores de alto risco para proteinúria.

ABSTRACT Objective: To verify the relationship between the presence of proteinuria as a renal injury marker in elderly without history of systemic arterial hypertension and cardiovascular diseases. A cross-sectional study was developed from January 2014 to December 2019, through kidney disease prevention campaigns promoted by the Federal University of Ceará in the city of Fortaleza. Methods: The sample consisted of 417 elderlies. A questionnaire was used to characterize individuals and assess previous diseases, and urinalysis reagent strips were used to assess proteinuria. Results: Statistically significant differences (p < 0.05) and moderate effect sizes were found for blood pressure levels (CI 0.53-0.93), systolic blood pressure, and diastolic blood pressure (CI 0.21-0.61). Significant differences in capillary glycemia were also found between groups (p = 0.033), but with a low effect size (0.02–0.42). The group with comorbidities was 2.94 times more likely to have proteinuria than those without comorbidities (OR 2.94, CI 1.55-4.01; p < 0.05). In the group without cardiovascular disease/high blood pressure, a statistically significant association was found for previous diabetes and proteinuria (p = 0.037), presenting 2.68 times higher risk of proteinuria in those with diabetes mellitus (OR 2.68, CI 1.05-6.85). Significant association was also found between age groups, with the older group having 2.69 times higher risk of developing proteinuria (75 to 90 compared to 60 to 74 years) (CI 1.01-7.16; p = 0.045). Conclusion: Even without systemic arterial hypertension or cardiovascular disease, diabetes and older age can be considered high risk factors for proteinuria.

RESUMO Objetivou-se com este estudo avaliar os efeitos da restrição temporária de lisina na dieta sobre o desempenho e viabilidade econômica de leitões em fase de creche. Foram utilizados 144 leitões, distribuídos em blocos ao acaso, com dois tratamentos e 12 repetições. Os tratamentos foram controle-lis, nível de lisina recomendado dos 21 aos 32 e 32 aos 42 dias de idade e baixa-lis, 90% do nível de lisina das dietas controle-lis. Dos 42 aos 62 dias, todos os animais receberam dieta controle. De 21 a 32 dias, leitões alimentados com baixa-lis tiveram pior ganho médio diário (GMD), conversão alimentar e peso corporal aos 32 dias (P≤0,05). Dos 32 aos 42 dias, leitões alimentados com baixa-lis apresentaram menor consumo médio de ração diário, GMD e peso aos 42 dias (P≤0,05). Dos 21 aos 62 dias, leitões alimentados com baixa-lis apresentaram GMD e peso corporal final menores (P≤0,05) quando comparados aos alimentados com controle-lis. At 27 and 29 days of age, pigs fed the low-lys diet had a higher (P≤0.05) incidence of diarrhea Aos 27 e 29 dias, leitões alimentados com baixa-lis apresentaram maior (P≤0.05) indicência de diarreia. O menor custo de alimentação e o maior índice de eficiência econômica foram registrados para baixa-lis. No entanto, os suínos alimentados com controle-lis apresentaram rentabilidade 3,9% maior. Como conclusão, a restrição temporária de lisina nas dietas de leitões piora o desempenho e diminui a viabilidade econômica.

ABSTRACT To evaluate the effects of temporary dietary lysine restriction on nursery pigs’ growth performance and its economic viability compared to control diets, 144 piglets (21-d-old) were assigned to randomized blocks, with two treatments and twelve replicates. The treatments were control-lys: lysine level as recommended from 21-32 and 32-42 days and low-lys: 90% of the lysine level of the control-lys diets. From 42 to 62 days, all animals received a control diet. From 21 to 32 days, pigs fed low-lys had worse average daily gain (ADG), feed conversion, and 32-d body weight (BW; P ≤ 0.05). From 32 to 42 days, pigs fed low-lys had lower average daily feed intake, ADG, and 42-d BW (P ≤ 0.05). From 42 to 62 days, pigs had similar performance (P > 0.05). Overall (21 to 62 days), pigs fed the low-lys had lower (P <0.05) ADG and final BW. At 27 and 29 days, pigs fed the low-lys diet had a higher (P≤0.05) incidence of diarrhea. The lowest feed cost and the highest economic efficiency index were recorded for the low-lys treatment. However, pigs fed the control-lys presented a 3.9% higher profitability. In conclusion, a temporary reduction of lysine in the diets of nursery pigs followed by an unrestricted diet in the subsequent period led to worse growth performance and lower economic viability.

Abstract Background Stroke management require rapid identification, assessment, and transport of patients to qualified health care centers. However, there is little description in the literature on the multiple challenges associated with the pre-hospital transport of suspected stroke patients. Objective To characterize the pre-hospital care provided to suspected stroke patients by the Brazilian Emergency Medical Service (SAMU in Portuguese), by means of a descriptive case study. Methods This is a descriptive study of a series of cases. Data from the SAMU regarding the responses to emergency calls from suspected stroke patients were collected. Independent reviewers confirmed the diagnostic hypothesis and all discordances were assessed using kappa statistics. Clinical data and transport times were described as frequency and proportion or central tendency and dispersion measures. Normality of continuous variable distribution was assessed using the Kolmogorov-Smirnov test. The Mann-Whitney U test was used for comparison of medians, with a 5% significance level. Results During the studied period, 556 suspected stroke patients were treated. The kappa index was 0.82 (95% CI 0.737 to 0.919) CI. In 74.7% of the cases, the symptom onset time was not recorded. The median time elapsed between the call for emergency services and the ambulance arrival was 18 minutes, and the median transport time was 38 minutes. A total of 34% of the patients were taken to referral hospitals for stroke. Conclusion This study revealed a low level of knowledge regarding the need to determine the exact time of symptom onset of suspected stroke patients. Also, the study showed the low rate of patients taken to referral hospitals. (Int J Cardiovasc Sci. 2021; [online].ahead print, PP.0-0)

Resumo: Introdução: A prevenção e o combate da Covid-19 são de extrema importância. Nesse contexto, a importância do uso de ferramentas de telemedicina tem crescido, incluindo teleconsultas, telemonitoramento epidemiológico, diagnóstico remoto, suporte e treinamento de profissionais de saúde. Objetivo: Este trabalho tem como objetivo relatar os resultados de um curso de treinamento a distância que abordou aspectos relacionados ao Sars-CoV-2 e à Covid-19. Método: Analisaram-se os seguintes aspectos: adesão ao curso, perfil dos alunos, índice de proficiência pré e pós-teste e satisfação com o curso.Trata-se de um estudo transversal que avaliou os dados do curso sobre o Sars-CoV-2 e a Covid-19. Os dados foram analisados em termos de distribuição e comparação de médias e frequências. Um teste t pareado foi usado para comparar as notas do pré e do pós-teste. O valor de p < 0,05 foi considerado significativo.Coletaram-se os dados na plataforma de ensino Moodle, sem identificação dos participantes. Resultado: De 23 de março a 14 de maio de 2020, o curso foi oferecido a 1.008 estudantes de Medicina e profissionais de saúde. A maioria era de Minas Gerais, alguns de outros estados brasileiros e de Moçambique. A maioria concluiu o curso com 89,8% de adesão. As avaliações referentes ao curso, aos tutores, ao grau de satisfação e à segurança para o desempenho profissional após o curso obtiveram pontuação máxima. A comparação entre as séries pré e pós-teste mostrou ganho de proficiência (p < 0,0001). Conclusão: O curso tem contribuído para a formação de estudantes de Medicina e profissionais de saúde do Brasil e de Moçambique. A comissão organizadora conseguiu capacitar alunos e profissionais de saúde com dificuldade de acesso a boas informações técnicas e baseadas em evidências. Após a capacitação, os alunos foram selecionados para atuar em projetos universitários com o objetivo de apoiar prefeituras, secretarias de saúde e comunidade.

Abstract: Introduction: Preventing and fighting COVID-19 are of the utmost importance. In this context, the importance of using telemedicine tools has grown, including teleconsultations, epidemiological telemonitoring, remote diagnosis, support, and training of health professionals. Objective: This article aims to report the results of a distance-training course on SARS-CoV-2 and COVID-19. We analyze the course adherence, the students’ profile, pre, and post-test proficiency index and satisfaction with the course. Methods: This is a cross-sectional study that evaluated data from the course on SARS-CoV-2 and COVID-19. The data were analyzed in terms of distribution and comparisons of means and frequencies. A paired t-test was used to compare the pre and post-test grades. A p-value <0.05 was considered significant. Data were collected from the Moodle teaching platform, without identifying the participants. Results: From March 23 to May 14, the course was offered to 1,008 medical students and health care providers. Most were from the state of Minas Gerais, some from other Brazilian states, and Mozambique. The majority completed the course, with an 89.8% adherence. The evaluations related to the course, the tutors, the degree of satisfaction, and the security for the professional performance after the course obtained maximum scores. The comparison between the pre and post grades showed proficiency gain (p<0.0001). Conclusion: The course has contributed to the training of medical students and health professionals from Brazil and Mozambique. The organizing committee was able to prepare students and provide knowledge to professionals with difficulty to access good technical and evidence-based information. After the training, the students were selected to work on university projects aiming at supporting city halls, health departments, and the community.