SUMMARY INTRODUCTION: Improving survival is the objective of intensive care units. Various factors affect long-term outcomes. The objective was to explore survival and the associated factors 1 year after admission to the intensive care unit. METHOD: This is an observational, descriptive, and analytical study in a retrospective cohort of adults admitted to an intensive care unit at a regional hospital during the first semester of 2022. Records of 218 patients from an anonymized database were analyzed. RESULTS: The average age was 61 years, and the average APACHE II score was 15 points (24% expected mortality). Survival 1 year after admission was 57.8%. Factors associated with 1-year survival in the Cox regression model were age and APACHE II. The univariate analysis showed that the cancer was significantly associated with lethality after 1 year (OR 10.55; 95%CI 1.99–55.76). CONCLUSION: One-year survival after intensive care unit decreases by 16.1%. Factors that significantly reduced survival were old age, severity, and oncologic cause at admission. INTRODUCTION units longterm long term outcomes METHOD observational descriptive 2022 21 analyzed RESULTS 6 years 24% 24 (24 mortality. mortality . mortality) 578 57 8 57.8% 1year OR 10.55 1055 10 55 95CI CI 95 1.99–55.76. 1995576 1.99–55.76 99 76 1.99–55.76) CONCLUSION Oneyear One 161 16 16.1% severity 202 2 (2 5 57.8 10.5 105 9 199557 1.99–55.7 7 16.1 20 ( 57. 10. 19955 1.99–55. 16. 1995 1.99–55 199 1.99–5 19 1.99– 1.99 1.9 1.

Background: Syphilis continues to be a common sexually transmitted disease. Aim: To describe the epidemiologic features of patients with syphilis consulting in a Chilean sexually transmitted diseases clinic. Material and Methods: Review of medical records of patients with positive serology for syphilis, who attended a unit of sexually transmitted diseases between 2015 and 2017. Results: Of 266 cases, 61% were male and 74% were aged between 20 and 49 years. The highest incidence was observed in males aged between 20 and 30 years. Eighty five percent of cases were diagnosed in latent phases, 10% of the cases had a co-infection with HIV and 18%, a history of other sexually transmitted disease. The rate of coinfection was significantly higher in men than in women (78 and 28%, respectively; p < 0.01). Only 6.4% reported always using a condom. Men used it with higher frequency than women (72 and 28% respectively; p < 0.01). A low adherence to treatment and faulty follow-up and treatment of sexual contacts was observed. Twenty five percent of women diagnosed with syphilis were pregnant and 27% of them had a premature birth, with one neonatal death. Conclusions: A high incidence of syphilis was observed, especially in men of younger ages. The diagnosis is delayed, the treatment of sexual contacts and the use of condoms are uncommon. Although the treatment of pregnant women is appropriated, some perinatal complications are observed.

Abstract: The objective of the study was to evaluate changes in academic performance and satisfaction of medical students in the environmental and occupational health course. This was performed by incorporating educational improvements consisting of active methodologies and information and communication technologies. A quasi-experimental retrospective study was performed on 450 grade records and 343 perception surveys that were divided in two periods: 1) “before” implementing teaching improvements (2008-2011) and 2) “after” implementing teaching improvements (2012-2016). The average period score showed an upward trend. The “before” period showed no linear variation but the “after” period showed a strong tendency to increase in the qualifications observed. The satisfaction survey presented differences between both periods, increasing significantly in curricular relevance and assistantships. The use of active methodologies contributes to promoting active learning and approval and qualifications of students, especially for lower academic performance students.

Resumen: El objetivo del estudio fue evaluar cambios en rendimiento académico y satisfacción de estudiantes de medicina en la asignatura salud ambiental y ocupacional, al incorporar mejoras docentes, consistentes en metodologías activas y en tecnologías de información y comunicación (TIC). Se efectuó un estudio cuasi experimental retrospectivo utilizando 450 registros de calificaciones y 343 encuestas de percepción divididas en dos periodos: “antes” (2008-2011) y “después” (2012-2016) de implementar las mejoras docentes. La calificación promedio del período tuvo una tendencia ascendente. El periodo antes tuvo casi nula variación lineal y el periodo después tuvo una fuerte tendencia al aumento en las notas. La encuesta de satisfacción presentó diferencias entre ambos períodos, aumentando significativamente en pertinencia curricular y ayudantías. El uso de metodologías activas contribuye a fomentar el aprendizaje activo, mejorando la satisfacción y calificaciones de los estudiantes, especialmente de aquellos con menor desempeño académico.

Introduction. The current context demands to incorporate the management of catastrophe situations in medical education. The original experience utilizing active teaching methodologies in a new course of emergencies and disasters in the medical undergraduate formation is presented. Subjects and methods. The course's didactic plan was designed incorporating the use of collaborative work methodologies (case development, team based learning, role play), use of information and communication technologies, field visit and simulations. For each teaching activity, material and corresponding evaluation guidelines were developed. The course was evaluated with the students' qualifications, their degree of satisfaction and their comments. Additionally, an analysis of strengths and weaknesses was carried out by the teaching team; considering an improvement plan. Results. The course qualifications (scale 1 to 7; n = 58) were highly acceptable (average: 6.1; range: 5.7-6.5). A high degree of satisfaction was observed with the teaching strategies used (valuations between 85-95%). In the opinion of the students, the learning objectives were achieved between 88% (teamwork) and 93% (conceptualization and application). Conclusion. The use of active methodologies motivates and favors learning, resulting in high qualifications and student's satisfaction, as well as a good perception of usefulness regarding their future professional development.

Introducción. El contexto actual demanda incorporar el manejo de situaciones de catástrofes en la formación médica. Se presenta una experiencia original en la enseñanza de emergencias y desastres, en la carrera de medicina, con uso de metodologías didácticas activas. Sujetos y métodos. El plan didáctico del curso se diseñó incorporando el uso de metodologías de trabajo colaborativo (desarrollo de casos, team based learning, juego de roles), uso de tecnologías de información y comunicación, visitas sobre el terreno y simulaciones. Para cada actividad docente, se elaboró material y pautas de evaluación correspondientes. El curso se evaluó con las calificaciones de los estudiantes, su grado de satisfacción y sus comentarios. Adicionalmente, se realizó un análisis de fortalezas y debilidades por parte del equipo docente, planteándose un plan de mejoras. Resultados. Las calificaciones del curso (escala de 1 a 7; n = 58) fueron altas (media: 6,1; rango: 5,7-6,5). Se observó un alto grado de satisfacción con las estrategias docentes utilizadas (valoraciones del 85-95%). Según el parecer de los estudiantes, se lograron los objetivos de aprendizaje en un 88% (trabajo en equipo) y 93% (conceptualización y aplicación). Conclusión. El uso de metodologías activas motiva y favorece el aprendizaje, lo que se traduce en altas calificaciones y grado de satisfacción de los estudiantes, así como una buena percepción de utilidad respecto de su futuro desarrollo profesional.

Abstract It was proposed to know the health vulnerability and health care needs of immigrants in Chile, through a qualitative exploratory study. The findings suggest that their vulnerability would be due to their irregular status, precarious work and low incomes, when they do. Health conditions are common morbidity, mental and reproductive health. Acculturation and a positive attitude towards self-care would be protective factors. An important barrier to access is the illegal status of some immigrants; as the ignorance of the Chilean health system. It is suggested to socialize health policies for migrants and to expand targeted strategies for their health care.

Resumen Se propuso conocer la vulnerabilidad sanitaria y necesidades de salud de personas inmigrantes en Chile, a través de un estudio cualitativo exploratorio. Los hallazgos indican que su vulnerabilidad estaría dada por su condición irregular, trabajo precario y bajos ingresos, cuando lo tienen. Las afecciones de salud son morbilidad común, de salud mental y reproductiva. La aculturación y actitud positiva hacia el autocuidado serían factores protectores. Importante barrera de acceso es la situación ilegal de algunos inmigrantes; y el desconocimiento del sistema sanitario chileno. Se sugiere socializar políticas sanitarias para migrantes y expandir estrategias dirigidas para su atención de salud.

Many new discoveries in Life Sciences cannot be translated into products, services or new applications to improve human health. Translational medicine, defined as “from bench to bedside”, refers to the transfer of results or new knowledge achieved in the laboratory into health innovation. We aim to review the state of art of translational medicine, its relationship with innovation processes and the different perspectives to consider. Finally, we contextualize the situation of Research and Development (R&D) in Chile and the main issues of the biotechnology market in the country.