Abstract Regular exercise is beneficial to health. This study evaluated the effects of moderate and intense physical exercise modalities on intradermal infection by Staphylococcus aureus in a murine model. Mice that practiced moderate exercise had lower bacterial load on lymph nodes and less inflammatory infiltrate in dermis. They presented greater weight, however, less amount of epididymal fat: the weight was increased while they had fat diminished. A positive correlation was observed between lipid content and bacterial load in mice trained at moderate intensity. Animals that were under high intensity exercises presented superior bacterial load on the lymph nodes, increased neutrophil count and circulating lymphocytes, and had leukocyte recruitment to the dermis augmented, when compared to the ones in moderate exercise. These findings suggest that moderate physical activity modulates the immune response in dermal infection caused by S. aureus in a murine model.

Abstract Systemic arterial hypertension (SAH) and type 2 diabetes mellitus (T2DM) compose the two major noncommunicable chronic inflammatory diseases. Physical activity has been shown as a promising complementary approach to control the systemic inflammation. However, it is still unclear whether this modulation is gender-dependent. The objective of this study was evaluate the gender-related influence of physical activity on the inflammatory response and biochemical profile of individuals with SAH and T2DM. An international physical activity questionnaire was applied to 376 individuals diagnosed with SAH and T2DM in order to access their exercises routine and was evaluated the influence of physical activity in biochemical, anthropometrical, and immunological markers involved in these disorders in men and women. Even though active individuals have exhibited lower serum levels of IL-1β, IFN-γ, TNF-α, and IL-17A, the ratios between IL-10 and all inflammatory cytokines were higher in men than in women. Physically active individuals also demonstrated increased HDL/LDL and HDL/VLDL ratios. Moreover, multiple correlations revealed that in active women both IL-10 and TNF-α serum levels positively correlate with fasting glucose levels, and were negatively associated with HDL levels. Our findings suggest that gender-related differences dictate a distinct crosstalk between inflammatory and biochemical markers in physically active individuals.

RESUMO A doença de Chagas, causada pelo Trypanosoma cruzi, possui uma ampla distribuição na América do Sul, e tem como principal método de controle a eliminação de triatomíneos. Apresenta-se aqui a distribuição geográfica e a taxa de infecção natural por T. cruzi de triatomíneos coletados e avaliados de 2008 a 2013, no sudoeste da Bahia. Os triatomíneos foram capturados nas áreas intradomiciliares e peridomiciliares de cinco cidades localizadas no sudoeste da Bahia, identificados e analisados quanto à presença de tripanossomatídeos em suas fezes. Durante o período de estudo o número de pacientes com suspeita de doença de Chagas aguda foi recuperado a partir do Sistema de Informação de Agravos de Notificação (SINAN). 8966 triatomíneos foram capturados e identificados como pertencentes a oito espécies. Vinte e seis apresentaram-se infectados, sendo Triatoma sordida o que mostrou maior percentagem de infecção pelo T. cruzi. Tremedal foi a cidade com o maior número de casos de doença de Chagas aguda relatado pelo SINAN. Todas as cidades apresentaram triatomíneos infectados com o T. cruzi, por isso, existe um risco considerável de transmissão vetorial da doença de Chagas no sudoeste da Bahia, evidenciando a necessidade de programas de controle de vetores de transmissão e medidas de vigilância preventiva.

ABSTRACT Chagas disease, caused by the Trypanosoma cruzi, has a wide distribution in South America, and its main method of control is the elimination of triatomines. It is presented here the geographic distribution and the rate of natural infection by T. cruzi of triatomines collected and evaluated from 2008 to 2013 in southwest of Bahia. Triatomines were captured in the intradomiciliary and peridomiciliary areas of five cities located in the southwest of Bahia state, identified, and analyzed for the presence of trypanosomatids in their feces. During the study period the number of patients suspected for acute Chagas disease was recovered from the Notifiable Diseases Information System (SINAN). 8966 triatomines were captured and identified as belonging to eight species. Twenty-six presented themselves infected, being Triatoma sordida the most abundant and with the highest percentage of infection by T. cruzi. Tremedal was the city with the highest number of cases of acute Chagas' disease reported to SINAN. All cities showed triatomines infected with T. cruzi, so there is considerable risk of vectorial transmission of Chagas disease in the southwestern Bahia state, evidencing the need for vector transmission control programs and preventive surveillance measures.