RESUMO Objetivo: Resumir as principais descobertas dos RNA não codificantes (ncRNAs) na síndrome de Turner (ST), correlacionando essas biomoléculas com as manifestações clínicas observadas nos pacientes afetados. Fontes de dados: Foram realizadas pesquisas nas bases de dados da Biblioteca Nacional de Medicina dos Estados Unidos (PubMed), Biblioteca Científica Eletrônica Online (SciELO) e ScienceDirect, abrangendo artigos originais em inglês publicados de 2014 a 2023. Os descritores utilizados foram: "lncRNAs e síndrome de Turner", "miRNAs e síndrome de Turner" e "circRNAs e síndrome de Turner". Os estudos incluídos abordaram o papel dos ncRNA nas características clínicas dos pacientes com ST. Os critérios de exclusão compreenderam textos de resumos, relatórios, resenhas e monografias. Síntese dos dados: Identificamos 147 estudos, dos quais sete foram incluídos no estudo. Na análise dos microRNAs, o miR-486-5p e o miR-320a se destacaram, estando associados ao desenvolvimento ovariano; o miR-126-3p e o miR-126-5p foram relacionados a uma maior rigidez aórtica. Com relação aos RNAs, a regulação negativa do XIST indicou disfunções na inativação do cromossomo X. Quanto aos circRNA, circPPP2R3B, circCSF2RA e circPCTN foram associados a funções imunológicas, enquanto circ_0090421, circ_0090392 e circ_0089945 foram vinculados ao desenvolvimento cardíaco. Conclusões: Os dados desses estudos demonstram que essas biomoléculas desempenham papéis cruciais em processos relacionados a características específicas observadas em pacientes com ST. Além de serem sugeridos como biomarcadores potenciais, os quais podem ser úteis na prática clínica. Objetivo ncRNAs (ncRNAs ST, ST , (ST) afetados PubMed, PubMed (PubMed) SciELO (SciELO ScienceDirect 201 2023 lncRNAs Turner, miRNAs circRNAs Turner. . resumos relatórios monografias 14 estudo microRNAs miR4865p miRp miR 486 5p p miR320a miRa 320a destacaram ovariano miR1263p 126 3p miR1265p aórtica RNAs X circRNA circPPP2R3B circPPPRB circPPP R B circCSFRA circCSF RA imunológicas circ0090421 circ 0090421 circ_0090421 circ0090392 0090392 circ_009039 circ0089945 0089945 circ_008994 cardíaco Conclusões potenciais clínica (ST (PubMed 20 202 1 48 12 circ009042 009042 circ_009042 circ009039 009039 circ_00903 circ008994 008994 circ_00899 2 4 circ00904 00904 circ_00904 circ00903 00903 circ_0090 circ00899 00899 circ_0089 circ0090 0090 circ_009 circ0089 0089 circ_008 circ009 009 circ_00 circ008 008 circ00 00 circ_0 circ0 0 circ_

ABSTRACT Objective: The aim of this study was to summarize the main findings of non-coding RNA (ncRNAs) in Turner syndrome (TS), correlating these biomolecules with the clinical manifestations in affected patients. Data source: Searches were conducted in the databases of the United States National Library of Medicine (PubMed), Scientific Electronic Library Online (SciELO), and ScienceDirect, covering original English articles published from 2014 to 2023. Descriptors used included "lncRNAs and Turner Syndrome," "miRNAs and Turner Syndrome," and "circRNAs and Turner Syndrome." The studies that were included addressed the role of ncRNAs in the clinical characteristics of patients with TS. Exclusion criteria comprised texts in abstracts, reports, reviews, and monographs. Data synthesis: We identified 147 studies, of which seven were included. In the analysis of microRNAs, miR-486-5p and miR-320a stood out, being associated with ovarian development; miR-126-3p and miR-126-5p were related to greater aortic stiffness. Regarding long non-coding RNAs, the downregulation of XIST indicated dysfunctions in X chromosome inactivation. Concerning circular RNAs, circPPP2R3B, circCSF2RA, and circPCTN were related to immunological functions, while circ_0090421, circ_0090392, and circ_0089945 were linked to cardiac development. Conclusions: The data from these studies demonstrate that these biomolecules play crucial roles in processes related to specific characteristics observed in TS patients. Besides being suggested as potential biomarkers, they may be useful in clinical practice. Objective noncoding non coding (ncRNAs TS, , (TS) source PubMed, PubMed (PubMed) SciELO, SciELO (SciELO) ScienceDirect 201 2023 lncRNAs Syndrome, Syndrome miRNAs circRNAs Syndrome. abstracts reports reviews monographs synthesis 14 microRNAs miR4865p miRp miR 486 5p p miR320a miRa 320a a out development miR1263p 126 3p miR1265p stiffness RNAs inactivation circPPP2R3B circPPPRB circPPP R B circCSF2RA circCSFRA circCSF RA functions circ0090421 circ 0090421 circ_0090421 circ0090392 0090392 circ_0090392 circ0089945 0089945 circ_008994 Conclusions biomarkers practice (TS (PubMed (SciELO 20 202 1 48 12 circ009042 009042 circ_009042 circ009039 009039 circ_009039 circ008994 008994 circ_00899 2 4 circ00904 00904 circ_00904 circ00903 00903 circ_00903 circ00899 00899 circ_0089 circ0090 0090 circ_0090 circ0089 0089 circ_008 circ009 009 circ_009 circ008 008 circ_00 circ00 00 circ_0 circ0 0 circ_

ABSTRACT Objective: MicroRNAs are small non-coding RNAs that are abundantly expressed in various biofluids, making them promising candidates for cancer biomarkers. This review aims to present current evidence on the use of miRNA as biomarkers for the non-invasive diagnosis of bladder cancer. Methods: A systematic literature review, using the Medline database, was performed in July 2022 according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. All articles were required to satisfy the risk-of-bias assessment using the Joanna Briggs Institute Critical Assessment Tools. Data were collected based on miRNA expression, sample type, expression profiles, and accuracy. Results: The initial search retrieved 437 studies, 21 of which were included in the final analysis. Most studies on miRNA expression in human fluids used urine samples for analysis. Conclusion: There is a trend to cluster the expressed miRNAs to build diagnostic panels or use them in association with other diagnostic methods to achieve reasonable accuracy. Prospero database registration: (https://www.crd.york.ac.uk/prospero/) under ID CRD42022351686. Objective noncoding non coding biofluids noninvasive invasive Methods 202 MetaAnalyses Meta Analyses guidelines riskofbias risk bias Tools type profiles accuracy Results 43 2 analysis Conclusion registration https//www.crd.york.ac.uk/prospero/ httpswwwcrdyorkacukprospero https //www.crd.york.ac.uk/prospero/ www crd york ac uk prospero (https://www.crd.york.ac.uk/prospero/ CRD42022351686 CRD 20 4 https//www.crd.york.ac.uk/prospero wwwcrdyorkacukprospero //www.crd.york.ac.uk/prospero (https://www.crd.york.ac.uk/prospero CRD4202235168 CRD420223516 CRD42022351 CRD4202235 CRD420223 CRD42022 CRD4202 CRD420 CRD42 CRD4

Abstract: INTRODUCTION: Rhinosporidiosis is a chronic infection of the mucous membrane and is caused by Rhinosporidium seeberi, an aquatic mesomycetozoan. The mode of infection is probably transepithelial penetration. The large number of rivers and lakes and the strong presence of riparian populations in the State of Maranhão are strong predisposing factors for rhinosporidiosis. METHODS: A 5-year retrospective study was conducted in a tertiary medical center situated in Maranhão, Northeast Brazil. Twenty-five Maranhense patients diagnosed with rhinosporidiosis were analyzed. RESULTS: Most of the patients were children, adolescents and young adults (age range: 7-24 years, mean age: 14 years). The majority of the participants were male (84%), brown (76%), and students (92%). All lesions involved the entire nasal cavity and presented with a vascular polypoid mass. All patients were treated by surgical excision of the lesions. CONCLUSIONS: Rhinosporidiosis affects younger age groups, especially students from the countryside and the outskirts of urban areas. This study will aid and guide physicians in diagnosing and treating this infection in endemic areas.