Resumo O objetivo do presente estudo foi avaliar clinicamente em humanos o efeito antiplaca de Ocimum gratissimum (Og). Quinze adultos saudáveis participaram deste estudo cruzado, duplo-cego, por meio de um modelo de acúmulo de placa parcial de 3 dias. Os voluntários aboliram qualquer método mecânico de higiene oral e foram inicialmente designados para usar os seguintes enxaguatórios bucais: água destilada (solução AD), digluconato de clorexidina a 0,12% (solução CLX) ou 10% Og (solução Og). O índice de placa (IPL) foi registrado em todos os dentes inferiores no final do experimento e os testes estatísticos Kruskal-Wallis (α=0,05) e Mann-Whitney (α=0,05) foram utilizados para estimar a diferença entre os grupos. Os resultados clínicos demonstraram diferença estatisticamente significante entre os três grupos (p<0,05), favorecendo os grupos CLX e Og; entretanto o grupo CLX foi mais efetivo que o grupo Og (p<0,05). Os enxaguatórios bucais contendo digluconato de clorexidina e Og a 10% foram capazes de reduzir a formação de nova placa bacteriana, mas Og mostrou resultados mais limitados em comparação ao digluconato de clorexidina.

Abstract The aim of this study was to evaluate the antiplaque effect of Ocimum gratissimum (Og) by in vivo investigation. Fifteen healthy volunteers participated in a crossover, double-blind clinical study, using a 3-day partial-mouth plaque accumulation model. The participants abolished any method of mechanical oral hygiene and they were randomly assigned to initially use just the following mouthrinses: distilled water (DW solution), 0.12% chlorhexidine digluconate (CLX solution) or 10% Og (Og solution). The plaque index (PLI) was recorded in all mandibular teeth at the end of the trial and the Kruskal-Wallis (α=0.05) and Mann-Whitney (α=0.05) tests were used to estimate the difference among groups. The clinical results showed statistically significant difference among the groups (p<0.05), favoring the CLX solution and Og solution, but the first was more effective (p<0.05). The mouthrinses containing 0.12% chlorhexidine digluconate and 10% Og were able to inhibit plaque re-growth, however Og showed more limited results in comparison to CLX.

OBJECTIVES: The antiplaque and antigingivitis effect of Lippia Sidoides (LS) was evaluated in this in vivo investigation. MATERIAL AND METHODS: Twenty-three subjects participated in a cross-over, double-blind clinical study, using 21-day partial-mouth experimental model of gingivitis. A toothshield was constructed for each volunteer, avoiding the brushing of the 4 experimental posterior teeth in the lower left quadrant. The subjects were randomly assigned initially to use either the placebo gel (control group) or the test gel, containing 10% LS (test group). RESULTS: The clinical results showed statistically significant differences for plaque index (PLI) (p<0.01) between days 0 and 21 in both groups, however only the control group showed statistically significant difference (p<0.01) for the bleeding (IB) and gingival (GI) index within the experimental period of 21 days. On day 21, the test group presented significantly better results than the control group with regard to the GI (p<0.05). CONCLUSIONS: The test gel containing 10% LS was effective in the control of gingivitis.

The effect of Aloe vera on the reduction of plaque and gingivitis was evaluated in a randomized, parallel and double-blind clinical trial. Subjects were randomly allocated to the test group (n=15) - dentifrice containing Aloe vera - or the control group (n=15) - fluoridated dentifrice. Plaque index (PI) and gingival bleeding index (GBI) were assessed at days 0 and 30. Subjects were asked to brush their teeth with the control or test dentifrice, three times a day, during a 30-day period. There was a significant reduction on plaque and gingivitis in both groups, but no statistically significant difference was observed among them (p>0.01). The dentifrice containing Aloe vera did not show any additional effect on plaque and gingivitis control compared to the fluoridated dentifrice.

OBJETIVOS: O efeito antiplaca e antigengivite de um gel contendo extrato de romã a 10% foi avaliado utilizando um modelo de gengivite experimental parcial em humanos. MÉTODOS: 23 indivíduos participaram voluntariamente deste estudo cruzado, duplo-cego, compreendendo dois períodos de 21 dias cada um. Uma moldeira de acrílico foi confeccionada para cada participante, a qual foi utilizada como carreadora dos géis sobre a área a ser avaliada (hemiarco inferior esquerdo). Os sujeitos foram aleatoriamente designados para usar o gel placebo (grupo controle) ou o gel teste (grupo experimental), sendo instruídos a colocar o gel na moldeira e esta sobre os dentes teste, escovando os outros normalmente três vezes ao dia. No dia 0 e dia 21 os índices de placa visível (IPV) e índice de sangramento gengival (ISG) foram registrados. RESULTADOS: Os resultados não demonstraram diferença estatística significante entre os grupos controle e experimental para nenhum dos índices. CONCLUSÕES: O gel contendo extrato de romã a 10% não foi eficiente em evitar a formação de placa bacteriana supragengival e prevenir a inflamação gengival.

OBJECTIVES: The antiplaque and antigingivitis effects of a gel containing 10% Punica granatum Linn extract were evaluated using a 21-day partial-mouth experimental model of gingivitis. METHODS: 23 volunteers participated in this cross-over, double-blind study, carried out in 2 phases of 21 days each. For each period of the experiment, an acrylic toothshield was made for each volunteer to carry the test or placebo gel as well as to avoid brushing of the 4 experimental teeth (posterior teeth in the lower left quadrant). The subjects were randomly assigned to use either the placebo gel (control group) or the test gel (experimental group) and were instructed to brush the remaining teeth normally 3 times a day. On days 0 and 21, the visible plaque index (VPI) and gingival bleeding index (GBI) were recorded. RESULTS: The results did not show statistically significant difference between control and experimental groups for either of the indices (VPI and GBI). CONCLUSION: The gel containing 10% Punica granatum Linn extract was not efficient in preventing supragingival dental plaque formation and gingivitis.