ABSTRACT Introduction Instruments to manage adverse effects of endocrine therapy with Aromatase inhibitors (AI) may improve adherence and persistence to treatment and Health-Related Quality of Life (HRQL). The 31-item Cervantes Scale (CS-31) is an HRQL questionnaire with particularities of the perimenopausal and postmenopausal period that could be an appropriate instrument to assess HRQL in Breast Cancer (BC) survivors. Objective This study aimed to perform additional validation of the CS-31 for BC survivors undergoing adjuvant endocrine therapy. Methods This prospective study was performed at three time points named T0, T1, and T2: initial, intermediate, and final follow-up period, respectively, totaling 24 months of follow-up. At each time point, the participants completed the CS-31, Functional Assessment of Chronic Illness Therapy - Fatigue (FACIT-F), and Hospital Anxiety and Depression Scale (HADS). The internal consistency, construct validity, responsiveness analyses, and known-group validity of CS-31 were evaluated. Results This study included 89 postmenopausal women diagnosed with hormone receptor-positive early BC in adjuvant endocrine therapy with AI. The internal consistency was good (Cronbach's alpha = 0.89). Construct validity received a positive rating, with 100% of results consistent with prior hypotheses. A prospective improvement in HRQL was identified for the CS-31 Global Score and FACIT-F Total Score and for most of their domains. Furthermore, women with anxiety and depression by HADS presented worse HRQL by CS-31. Conclusion The authors identified that the CS-31 seems to be appropriate for use in oncology medical routine and may help to monitor adverse effects and HRQL of BC survivors during adjuvant endocrine therapy. AI (AI HealthRelated Health Related HRQL. . (HRQL) 31item item 31 CS31 CS (CS-31 (BC CS-3 T0 T T1 T2 initial intermediate followup follow up respectively 2 followup. up. point CS31, 31, FACITF, FACITF FACIT F , (FACIT-F) HADS. (HADS) analyses knowngroup known group evaluated 8 receptorpositive receptor Cronbachs Cronbach s 0.89. 089 0.89 0 0.89) rating 100 hypotheses domains Furthermore CS31. 31. (HRQL 3 CS3 (CS-3 CS- (FACIT-F (HADS 08 0.8 10 (CS- 0. 1 (CS

ABSTRACT BACKGROUND: The Quality of Dying and Death Questionnaire (QoDD) may prove to be an important evaluation tool in the Brazilian context, and, therefore, can contribute to a more precise evaluation of the dying and death process, improving and guiding the end-of-life patient care. OBJECTIVE: To translate and cross-culturally adapt the QoDD into Brazilian Portuguese and measure its validity (convergent and known-groups) and internal consistency DESIGN AND SETTING: A cross-sectional, methodological study was conducted at the Hospital de Câncer de Barretos, Brazil METHODS: A total of 78 family caregivers participated in this study. Semantic, cultural, and conceptual equivalences were evaluated using the content validity index. The construct validity was assessed through convergent validation and known groups analysis [presence of family members at the place of death; feel at peace with dying; and place of death (hospital versus home; hospital versus Palliative Care)]. Internal consistency was evaluated using Cronbach's alpha. RESULTS: The questionnaire was translated into Brazilian Portuguese and presented evidence of a clear understanding of its content. Cronbach's alpha values were ≥ 0.70, except for the domains of treatment preference (α = 0.686) and general concerns (α = 0.599). The convergent validity confirmed a part of the previously hypothesized correlations between the Palliative Care Outcome Scale-Brazil (POS-Br) total scores and the QoDD domain scores. The QoDD-Br domains could distinguish the patients who died in palliative care and general wards. CONCLUSION: The QoDD-Br is a culturally adapted valid instrument, and may be used to assess the quality of death of cancer patients. BACKGROUND (QoDD context therefore process endoflife end life OBJECTIVE crossculturally cross knowngroups known-groups SETTING crosssectional, crosssectional sectional, sectional cross-sectional Barretos METHODS 7 Semantic cultural index presence home Care. . Care)] Cronbachs Cronbach s RESULTS 070 0 70 0.70 α 0.686 0686 686 0.599. 0599 0.599 599 0.599) ScaleBrazil Scale POSBr POS Br (POS-Br QoDDBr wards CONCLUSION instrument Care) 07 0.7 0.68 068 68 059 0.59 59 0. 0.6 06 6 05 0.5 5

ABSTRACT BACKGROUND: People living with life-limiting illnesses and their family caregivers consistently emphasize the importance of preparing for imminent death, with planned funerals being a common aspect of this preparation. Few studies have described the funeral rituals or post-mortem preferences of patients with cancer. OBJECTIVE: To evaluate the percentage of patients with cancer who wish to be cremated and to identify the factors associated with this preference. DESIGN AND SETTING: Cross-sectional study conducted at Barretos Cancer Hospital. METHODS: A total of 220 patients with cancer completed a Sociodemographic and Clinical Questionnaire, the Duke University Religiosity Index, and burial or cremation preferences. Binary Logistic Regression was performed to identify independent variables associated with cremation. RESULTS: Of the 220 patients, 25.0% preferred cremation and 71.4% preferred burial. Talks about death with family or close friends in their daily life (odds ratio, OR = 2.89; P = 0.021), patients that answered “other” (unsure, tends not be true and not true) for religious beliefs are what really lie behind my whole approach to life (OR = 20.34; P = 0.005), and education 9 to 11 years (OR = 3.15; P = 0.019) or ≥ 12 years (OR = 3.18; P = 0.024) were associated with cremation preference. CONCLUSION: Most patients with Cancer in Brazil prefer burial after death. Discussions about death, religious beliefs and involvement, and educational level seem to influence the preference for cremation. A deeper understanding of ritual funeral preferences and their associated factors may guide policies, services, and health teams in promoting the quality of dying and death. BACKGROUND lifelimiting limiting preparation postmortem post mortem OBJECTIVE SETTING Crosssectional Cross sectional Hospital METHODS 22 Questionnaire Index RESULTS 250 25 0 25.0 714 71 4 71.4 odds ratio 2.89 289 2 89 0.021, 0021 0.021 , 021 0.021) other “other unsure, unsure (unsure 20.34 2034 20 34 0.005, 0005 0.005 005 0.005) 1 3.15 315 3 15 0.019 0019 019 3.18 318 18 0.024 0024 024 CONCLUSION involvement policies services 25. 7 71. 2.8 28 8 002 0.02 02 20.3 203 000 0.00 00 3.1 31 0.01 001 01 2. 0.0 20. 3. 0.

Abstract This article interprets the song Lamento Sertanejo starting from a “history from the vanquished point of view”. We interpret the song in dialogue with the works Os Sertões by Euclides da Cunha, and Grande Sertão: Veredas, by Guimarães Rosa. Our hypothesis is that Lamento Sertanejo expresses the country/city duality in another interpretative key, presenting a vision of a nation where these two spaces are connected in a contradictory unity. Bringing the theme of isolation in the big city and the memory, Lamento Sertanejo offers us a panorama of the nation fractured by the conservative modernization process perpetuated by the civil military dictatorship in the 1970s. history view. view . view” Cunha Sertão Veredas Rosa countrycity country key unity memory 1970s s

Resumo Este artigo faz uma interpretação da canção Lamento Sertanejo partindo de uma “história do ponto de vista dos vencidos”. Interpretamos a canção em diálogo com as obras Os Sertões, de Euclides da Cunha, e Grande Sertão: Veredas, de Guimarães Rosa. Nossa hipótese é a de que Lamento Sertanejo expressa a dualidade sertão/cidade, presente nas duas obras, em outra chave interpretativa, apresentando uma visão de país em que esses dois espaços se conectam em uma unidade contraditória. A obra se configura como uma “canção de exílio”. Trazendo o tema do isolamento na cidade grande e da memória, Lamento Sertanejo nos oferece um panorama da nação fraturada pelo processo de modernização conservadora empenhado pela ditadura civil militar nos anos 1970. história vencidos. vencidos . vencidos” Sertões Cunha Sertão Veredas Rosa sertãocidade sertão sertão/cidade interpretativa contraditória exílio. exílio exílio” memória 1970 197 19 1

Abstract This interview with Deisy Ventura, professor at the Faculty of Public Health of the Universidade de São Paulo, discusses the political dimension of the covid-19 pandemic in Brazil. She has become a leading reference on the subject due to her extensive knowledge of international law, with a focus on health. In this interview, Deisy Ventura offers some reflections on global health and discusses the handling of the pandemic in Brazil and its human rights implications. According to Ventura, the Brazilian government had a systematic policy for the spread of the virus, and the pandemic should be treated as a matter of memory, truth, and justice. Paulo covid19 covid 19 covid-1 law implications virus memory truth justice covid1 1 covid-

Resumo Entrevista com Deisy Ventura, professora titular da Faculdade de Saúde Pública da Universidade de São Paulo, que discute a dimensão política da pandemia de covid-19 no Brasil. A pesquisadora se tornou uma das principais referências no assunto por seu amplo conhecimento de direito internacional com foco em saúde. Na entrevista, ela apresenta reflexões relacionadas à saúde global, além de discutir a gestão da pandemia no país e suas implicações para os direitos humanos. De acordo com a pesquisadora, houve no Brasil uma política governamental sistemática de disseminação do vírus, e a pandemia deveria ser tratada como uma questão de memória, verdade e justiça. Ventura Paulo covid19 covid 19 covid-1 entrevista global humanos vírus memória justiça covid1 1 covid-

Abstract This article addresses the Brazilian government’s response to the covid-19 pandemic, particularly the public health surveillance and epidemic intelligence system. It traces the evolution of disease surveillance as a response to the International Health Regulations in the context of global health. Executive orders published in the official gazette, Diário Oficial da União, are analyzed, as well as the actors and groups formed to tackle the pandemic between January 2020 and March 2022. The founding assumption is that epidemic intelligence must be placed at the service of public health. Bureaucratic tension and changes in protagonism among different groups can be observed as these intelligence mechanisms were dismantled. governments government s covid19 covid 19 covid-1 system gazette União analyzed 202 2022 dismantled covid1 1 covid- 20 2

Resumo O artigo aborda a resposta do governo brasileiro à pandemia da covid-19, enfatizando o sistema de vigilância em saúde e de inteligência epidemiológica. Retoma a evolução da vigilância em resposta às normas do Regulamento Sanitário Internacional, no contexto da saúde global. Analisa os atos do Executivo publicados no Diário Oficial da União e se detém nos atores e grupos formados para o enfrentamento da pandemia da covid-19 de janeiro de 2020 até março de 2022. Parte da premissa de que a inteligência epidemiológica deve estar a serviço da saúde pública. Constata-se que certo tensionamento burocrático e a transferência de protagonismo entre grupos marcam o desmonte dos mecanismos de inteligência. covid19, covid19 covid 19, 19 Internacional global covid-1 202 2022 pública Constatase Constata covid1 1 covid- 20 2

ABSTRACT BACKGROUND: The Quality of Dying and Death Questionnaire (QoDD) may prove to be an important evaluation tool in the Brazilian context, and, therefore, can contribute to a more precise evaluation of the dying and death process, improving and guiding the end-of-life patient care. OBJECTIVE: To translate and cross-culturally adapt the QoDD into Brazilian Portuguese and measure its validity (convergent and known-groups) and internal consistency DESIGN AND SETTING: A cross-sectional, methodological study was conducted at the Hospital de Câncer de Barretos, Brazil METHODS: A total of 78 family caregivers participated in this study. Semantic, cultural, and conceptual equivalences were evaluated using the content validity index. The construct validity was assessed through convergent validation and known groups analysis [presence of family members at the place of death; feel at peace with dying; and place of death (hospital versus home; hospital versus Palliative Care)]. Internal consistency was evaluated using Cronbach's alpha. RESULTS: The questionnaire was translated into Brazilian Portuguese and presented evidence of a clear understanding of its content. Cronbach's alpha values were ≥ 0.70, except for the domains of treatment preference (α = 0.686) and general concerns (α = 0.599). The convergent validity confirmed a part of the previously hypothesized correlations between the Palliative Care Outcome Scale-Brazil (POS-Br) total scores and the QoDD domain scores. The QoDD-Br domains could distinguish the patients who died in palliative care and general wards. CONCLUSION: The QoDD-Br is a culturally adapted valid instrument, and may be used to assess the quality of death of cancer patients.

ABSTRACT Objectives: To translate and culturally adapt the Pediatric Intensive Care Unit-Quality of Dying and Death questionnaire into Brazilian Portuguese. Methods: This was a cross-cultural adaptation process including conceptual, cultural, and semantic equivalence steps comprising three stages. Stage 1 involved authorization to perform the translation and cultural adaptation. Stage 2 entailed independent translation from English into Brazilian Portuguese, a synthesis of the translation, back-translation, and an expert panel. Stage 3 involved a pretest conducted with family caregivers and a multidisciplinary team. Results: The evaluation by the expert panel resulted in an average agreement of 0.8 in relation to semantic, cultural, and conceptual equivalence. The pretests of both versions of the questionnaire showed that the participants had adequate comprehension regarding the ease of understanding the items and response options. Conclusion: After going through the process of translation and cultural adaptation, the Pediatric Intensive Care Unit-Quality of Dying and Death caregiver and multidisciplinary team versions were considered culturally adapted, with both groups having a good understanding of the items. The questionnaires include relevant items to evaluate the process of death and dying in the intensive care setting, and suggest changes in care centered on patients and especially family caregivers, given the finitude of their children. Objectives UnitQuality Unit Quality Portuguese Methods crosscultural cross stages backtranslation, backtranslation back back-translation Results 08 0 8 0. options Conclusion adapted setting children

RESUMO Objetivo: Traduzir e adaptar culturalmente o questionário Pediatric Intensive Care Unit-Quality of Dying and Death para o português do Brasil. Métodos: Realizou-se um processo de adaptação transcultural que incluiu equivalências conceitual, cultural e semântica. Esse processo foi composto de três etapas: Etapa 1 - autorização para realização da tradução e adaptação cultural; Etapa 2 - traduções independentes do inglês para o português do Brasil, síntese das traduções, retrotraduções e painel de especialistas; e Etapa 3 - pré-teste realizado com familiares cuidadores e equipe multiprofissional. Resultados: A avaliação pelo painel de especialistas resultou em concordância média de 0,8 em relação à equivalência semântica, cultural e conceitual. Os pré-testes de ambas as versões do questionário mostraram compreensão adequada dos participantes dos itens e opções de respostas. Conclusão: Após o processo de tradução e adaptação cultural da ferramenta Pediatric Intensive Care Unit-Quality of Dying and Death, as versões para cuidador e equipe multiprofissional foram consideradas culturalmente adaptadas, com boa compreensão dos itens por ambos os grupos. Os questionários incluem itens relevantes para avaliar o processo de morte e do morrer no ambiente de terapia intensiva e podem proporcionar mudanças no cuidado centrado no paciente e, principalmente, no familiar cuidador, perante a finitude de seus filhos. Objetivo UnitQuality Unit Quality Brasil Métodos Realizouse Realizou se conceitual semântica etapas préteste pré teste Resultados 08 0 8 0, prétestes testes respostas Conclusão adaptadas grupos principalmente filhos

Resumo Com base em documentos pessoais de Ernesto Geisel e matérias na imprensa, o artigo discorre sobre os bastidores da decisão de o Brasil não participar da Conferência Internacional sobre Atenção Primária à Saúde, realizada em 1978, em Alma-Ata, URSS. Sugere que os ministérios da Saúde e das Relações Exteriores avaliaram de maneiras distintas a importância da reunião no Cazaquistão, resultando em encaminhamentos conflitantes ao presidente da República. Estabelecida a ausência brasileira, o artigo traz contribuições acerca das formas pelas quais os preceitos consolidados na declaração de Alma-Ata foram compartilhados pelos círculos sanitaristas no país das mais distintas posições ideológicas, tendo inclusive orientado a formulação de programas ainda no regime militar e com implicações importantes sobre iniciativas posteriores.

Abstract Drawing on personal documents from Ernesto Geisel and press reports, this article discusses the background to the decision by Brazil not to take part in the International Conference on Primary Health Care held in Alma-Ata, USSR, in 1978. It is suggested that the Ministry of Health and the Ministry of Foreign Affairs had different views on the importance of the meeting in Kazakhstan, resulting in their submitting conflicting recommendations to the president of Brazil. It also investigates how the precepts consolidated in the Declaration of Alma-Ata were shared among Brazilian health specialists of different ideological persuasions, even to the point of serving as a blueprint for programs devised under the dictatorship, with implications for the development of later initiatives.

ABSTRACT BACKGROUND: Burnout is a syndrome that mostly affects professionals working in contact with patients and their caregivers. In oncology care, nursing professionals are constantly required to provide emotional support for patients and their caregivers, throughout the process of becoming ill, suffering and dying. OBJECTIVE: To evaluate the prevalence and factors associated with burnout in a sample of nursing professionals at a cancer hospital. DESIGN AND SETTING: Cross-sectional study conducted at Hospital de Câncer de Barretos. METHODS: The study population comprised 655 nursing professionals. Burnout syndrome was assessed using the Maslach Burnout Inventory Human Service Survey. Univariate analysis and binary logistic regression models were used to identify independent predictors associated with burnout. RESULTS: Among 304 nursing professionals included in the study, 27 (8.9%) were classified as presenting burnout according to the two-dimensional criteria, and four (1.3%) were classified based on the three-dimensional criteria. Workplace characteristics were not associated with burnout, while single marital status (odds ratio, OR = 2.695; P = 0.037), perceived workplace stressors, such as impatience with colleagues (OR = 3.996; P = 0.007) and melancholy (OR = 2.840; P = 0.021) were considered to be predictors of burnout. Nursing professionals who would choose the profession again (OR = 0.214; P = 0.001) were least likely to present burnout. CONCLUSION: Perceived workplace stressors are strongly associated with burnout. Strategies focusing on restructuring of daily work processes and on activities that stimulate positive relationships are important for professionals’ health because motivation to continue working in oncology nursing has a protective effect against burnout.

Resumo O artigo explora ideias e propostas de João de Barros Barreto para o campo da organização dos serviços de saúde no Brasil. A partir da proposição da Reforma Capanema (1937-1941), o texto constrói historicamente o contexto da formulação do chamado modelo distrital em saúde no Brasil, com foco em sua lógica, bases conceituais e teóricas e recursos empregados. Conclui-se que a trajetória profissional de Barros Barreto, contextualizada em um cenário específico de ideias, de agenda de Estado e de perspectivas organizacionais, colaborou decisivamente para a constituição de realizações modeladoras de um arranjo organizacional importante na trajetória da saúde pública brasileira.

Abstract The article explores João de Barros Barreto’s ideas and proposals for the field of the organization of health services in Brazil. Based on the proposal of the Capanema Reform (1937-1941), the text reveals the context of the formulation of the so-called district health model in Brazil historically, focusing on its logic, conceptual and theoretical principles and resources employed. The conclusion drawn is that Barros Barreto’s professional career, contextualized in a specific scenario of ideas, state agenda and organizational perspectives, contributed decisively to the constitution of modeling achievements of relevant organizational arrangements in the trajectory of Brazilian public health.

Resumo A história do Programa Nacional de Serviços Básicos de Saúde (Prev-saúde) se inicia em 1979, na articulação entre os Ministérios da Saúde, da Previdência e Assistência Social, do Interior e da Economia e a Organização Pan-americana da Saúde. Teve como objetivo reorganizar os serviços básicos de saúde em suas conexões com os demais níveis assistenciais. Internacionalmente, inscrevia-se no movimento deflagrado pela Conferência de Alma-Ata, de setembro de 1978. Em termos nacionais, representava tanto um acúmulo de conhecimento sobre organização dos serviços quanto um movimento que se adequava, em parte, à agenda da reforma sanitária brasileira. O Prev-saúde representou um conjunto de proposições para a reorganização da saúde que, naquele contexto, era consenso técnico entre burocracias e lideranças da reforma da saúde.

Abstract The history of the National Basic Health Services Program (Prev-saúde) begins in 1979 with a joint effort involving the Ministries of Health, Social Security and Assistance, Interior, and Economy, as well as the Pan-American Health Organization. The objective was to reorganize basic health services in their connections with other levels of care. Internationally, it was part of the movement sparked by the International Conference on Primary Health Care in Alma-Ata in September 1978. Domestically, the program represented an accumulation of knowledge about the organization of services as well as a movement that was partially adapted to Brazilian health reform agenda. Prev-saúde was a set of health proposals that represented a technical consensus between bureaucracies and leaders of health reform.

Abstract Objective To translate, culturally adapt, and evaluate the psychometric properties of Adolescent Barriers Questionnaire for use in Brazilian adolescents with cancer aged 12 to 18 years, based on the original American Adolescent Barriers Questionnaire which was designed to measure the extent to which adolescents with cancer have concerns about reporting pain and using analgesics. Methods The study analyzed the psychometric properties reliability (internal consistency and test-retest) and validity (known groups and convergent) of Adolescent Barriers Questionnaire in adolescents between 12 and 18 years of age with a diagnosis of cancer who were using or who had used analgesic medication (opioid or not) in a pediatric public health institution. It was estimated 64 adolescents as sample size and the research was conclude with 48. Results Results of pre-test suggest good understanding (content validity index > 0.9). The internal consistency value Cronbach's α was 88%. The convergent validity values ranged between -0.400 and -0.450. Analysis of known groups showed that the instrument discriminated groups of patients with solid vs. hematologic tumors. The intraclass correlation coefficient obtained after retest was 0.863. Conclusion After the process of translations, validations and analysis of psychometric properties, the Brazilian Portuguese version of Adolescent Barriers Questionnaire could be considered culturally adapted, valid, and reliable for the Brazilian adolescent population with cancer aged 12 to 18 years and it can be useful in practical clinic, offering the health professionals the opportunity to understand which barriers the adolescent with cancer can encounter and offer, thus, all the support to overcome them.

Resumo O artigo explora ideias e propostas de João de Barros Barreto para o campo da organização dos serviços de saúde no Brasil. A partir da proposição da Reforma Capanema (1937-1941), o texto constrói historicamente o contexto da formulação do chamado modelo distrital em saúde no Brasil, com foco em sua lógica, bases conceituais e teóricas e recursos empregados. Conclui-se que a trajetória profissional de Barros Barreto, contextualizada em um cenário específico de ideias, de agenda de Estado e de perspectivas organizacionais, colaborou decisivamente para a constituição de realizações modeladoras de um arranjo organizacional importante na trajetória da saúde pública brasileira.

Abstract The article explores João de Barros Barreto’s ideas and proposals for the field of the organization of health services in Brazil. Based on the proposal of the Capanema Reform (1937-1941), the text reveals the context of the formulation of the so-called district health model in Brazil historically, focusing on its logic, conceptual and theoretical principles and resources employed. The conclusion drawn is that Barros Barreto’s professional career, contextualized in a specific scenario of ideas, state agenda and organizational perspectives, contributed decisively to the constitution of modeling achievements of relevant organizational arrangements in the trajectory of Brazilian public health.