Abstract Euphorbia mosaic virus isolated from the Yucatan Peninsula is a bipartite begomovirus with a wide range of experimental hosts, including species of economic importance, such as bean, chilli and tomato, among others. This virus produced severe symptoms on Nicotiana benthamiana leaves, leaf blade deformations, loss of tissue and cell identity, as well as changes in the mesophyll structure. Unlike other bipartite begomoviruses, EuMV-YP induced cell proliferation at the mesophyll; it also positively regulated the expression of cycA1, cycA2 and cdkB2.2, genes involved in the G2/M transition of the mitotic cell cycle, and localized at the mesophyll. This is the first example of a bipartite begomovirus capable of inducing cell proliferation.

Resumen Euphorbia mosaic virus aislamiento Yucatan Peninsula es un begomovirus bipartita con una amplia gama de hospedantes experimentales, que incluyen especies de importancia económica, como frijol, chile y tomate, entre otras. Este virus provocó síntomas severos en hojas de Nicotiana benthamiana, pérdida de identidad celular y tisular, deformaciones de la lámina foliar y de la nervadura central, cambios en la estructura del mesófilo y proliferación celular, a diferencia de otros begomovirus bipartitas. Activó la expresión de los genes cycA1, cycA2 y cdkB2.2, implicados en la transición G2/M del ciclo celular mitótico y se localizó en el mesófilo de las hojas. EuMV-YP es el primer ejemplo de un begomovirus bipartita capaz de inducir la proliferación celular.

OBJETIVO: Comparar entre os hospitais públicos e privados de Niterói o perfil epidemiológico, sócio-econômico, aspectos clínicos, etiologia, tempo de internação e a mortalidade dos pacientes internados por insuficiência cardíaca descompensada. MÉTODOS: Estudo transversal prospectivo e multicêntrico (julho a setembro/ 2001), incluindo todos os pacientes internados com diagnóstico primário de insuficiência cardíaca, maiores de 18 anos, e com pontuação 8 ou superior pelos critérios de Boston. RESULTADOS: Incluídos 203 pacientes: 98 públicos, 50% eram homens, média de idade de 61,1± 11,3 anos, 65% negros, 57% recebiam até 1 salário mínimo, 56% eram analfabetos, 66% tinham cardiopatia isquêmica; tempo médio de internação de 12,6 dias e a taxa de mortalidade ajustada para a idade de 5,23; 105 privados, 49% eram homens, média de idade de 72 ± 12,7 anos, 20% negros, 58% recebiam mais de 6 salários mínimos, 11% eram analfabetos, 62% eram isquêmicos; o tempo médio de internação hospitalar de 8 dias e a taxa de mortalidade ajustada para idade de 2,94. A distribuição das co-morbidades e fatores de risco similar entre os pacientes, à exceção do tabagismo, mais freqüente no serviço público. CONCLUSÃO: Além de assimetrias sócio-econômicas, o tempo de internação hospitalar e a taxa mortalidade ajustada para idade foram maiores no serviço público de saúde.

OBJECTIVE: To compare the epidemiological and socioeconomic profiles, clinical features, etiology, length of hospitalization, and mortality of patients with decompensated heart failure admitted to public and private hospitals in the city of Niterói. METHODS: We carried out a prospective, multicenter study (from July to September 2001) comprising all patients older than 18 years with the primary diagnosis of heart failure and admitted to hospitals in the city of Niterói, whose scores according to the Boston criteria were 8 or above. Proportions were compared using the chi-square and Fisher exact tests. RESULTS: The sample comprised 203 patients as follows: 1) 98 patients from public hospitals: 50% were men, their mean age was 61.1±11.3 years, 65% were black, 57% had an income of 1 minimum wage or less, 56% were illiterate, 66% had ischemic heart disease, their mean length of hospitalization was 12.6 days, and the mortality rate adjusted for age was 5.23; 2) 105 patients from private hospitals: 49% were men, their mean age was 72±12.7 years, 20% were black, 58% had an income greater than 6 minimum wages, 11% were illiterate, 62% had ischemic heart disease, their mean length of hospitalization was 8 days, and the mortality rate adjusted for age was 2.94. The distribution of comorbidities and risk factors was similar among the patients of the 2 hospital systems, except for the smoking habit, which was more frequent among patients from public hospitals. CONCLUSION: In addition to the socioeconomic asymmetries, the hospitalization length and the mortality rate adjusted for age were greater in patients in the public health system.