Abstract INTRODUCTION: Among patients with Chagas disease, men have a higher risk of worse pathological symptoms than women. We aimed to explore the role of the Y chromosome in men diagnosed with Chagas disease and assess the relationship between their ancestry and disease status. METHODS In this comparative study, we analyzed 150 men with unrelated non-chagasic disease (nCD) and 150 men with unrelated chagasic disease (CD). We assessed the serological diagnosis of Chagas disease, biochemical parameters, thoracic X-rays, electrocardiogram, and transthoracic echocardiography and determined the haplogroup by analyzing a set of 17 microsatellites from the Y chromosome. We examined the associations between common Y chromosome haplogroups and the clinical parameters of risk by logistic regression. RESULTS For all patients, the most common haplogroups were R1b (43%), G2a (9%), and E1b1b (9%). The R1b and G2a haplogroup was more frequent in men with nCD and CD, respectively. As expected, we observed a high proportion of symptomatic patients in the CD group independent of the haplogroups. Men from both groups classified as having the R1b haplogroup showed less clinical evidence of disease. Multivariate analysis showed that CD patients without R1b were about five times more likely to have a cardio-thorax index >0.5% (OR [odds ratio] = 5.1, 95% CI [confidence interval] = 3.31-8.17). Men without the R1b haplogroup were 2.5 times more likely to show EcoCG alterations (OR = 2.50, 95% CI = 0.16-3.94). CONCLUSIONS: Our results provided evidence that the R1b haplogroup may have a potential protective cardiovascular effect for its carriers.

Abstract Case report: we present an 85-year-old patient with polydipsia, polyuria and severe hypertriglyceridemia of 27 years of evolution, without pancreatitis, resistant to dietary and pharmacological treatments. He was diagnosed of hyperglycerolemia due to glycerol kinase deficiency (GKD) based on: transparent non-lipemic serum, with glycerol increase in plasma and urine, without glycerol 3 phosphate increase, and a deletion, not previously described, in the glycerol kinase gene. Discussion: a correct dietary treatment with frequent meals and rich in complex carbohydrates, without medication, improved the symptomatology.

Resumen Caso clínico: presentamos un paciente varón de 85 años con polidipsia, poliuria e hipertrigliceridemia severa de 27 años de evolución, sin pancreatitis, persistente y resistente a tratamientos dietético y farmacológico. Se diagnosticó de hiperglicerolemia por déficit de glicerol kinasa (GKD) en base a: suero transparente no lipémico, aumento de glicerol en plasma y orina, sin aumento de glicerol 3 fosfato y deleción, no descrita previamente, en el gen de la glicerol kinasa. Discusión: un tratamiento dietético correcto con comidas frecuentes y rico en carbohidratos complejos, sin medicación, mejoró la sintomatología.

Este artículo presenta los resultados de la investigación denominada ""Posición Social del colectivo juvenil La Diáspora en un territorio de doble afectación: pobreza y conflicto armado", la cual fue desarrollada por las autoras en el marco del proceso de formación de la Maestría en Desarrollo Educativo y Social, convenio CINDE - Universidad Pedagógica Nacional dentro de la línea de investigación en Desarrollo Social y Comunitario. El artículo presenta cómo construye su posición social el colectivo juvenil La Diáspora en medio de la doble afectación: pobreza y conflicto armado. Para comprender la posición social de La Diáspora se ubican las posiciones sociales con las que interactúa en el territorio, sus diferencias, sus límites y sus puntos de encuentro; igualmente, presenta el modo en que La Diáspora se mantiene en el tiempo y en relación con la doble afectación.

This article shows the results of the investigation named. "Social position of youth group La Díaspora in a territory of dual affectation: poverty and armed conflict" which was developed by the authors as part of training process of the Master in Educational Development and Social, CINDE convention - National Pedagogical University [Universidad Pedagógica Nacional], within the research line of Social and Community Development. Shows how it builds your social position the youth group "La Diaspora" amid dual affectation: poverty and armed conflict. To understand the social position of "La Diaspora" are located the social positions with which interacts the territory, their differences, their limits and their meeting points, also, shows how "La Diaspora" is maintained over the time and in relation with dual affectation.

Este artigo apresenta os resultados da pesquisa denominada "Posição Social do coletivo juvenil A Diáspora em um território de dupla afetação: pobreza e conflito armado", a qual foi desenvolvida pelas autoras no marco do processo de formação do Mestrado em Desenvolvimento Educativo e Social, convenio CINDE - Universidade Pedagógica Nacional dentro da linha de pesquisa em Desenvolvimento Social e Comunitário. O artigo apresenta como o coletivo juvenil A Diáspora constitui sua posição social no meio da dupla afetação: pobreza e conflito armado. Para compreender a posição social de A Diáspora, são assinaladas as perspectivas sócias com as quais interatua no território, suas diferencias, sus limites e seus pontos de encontro; igualmente, apresenta a maneira em que A Diáspora permanece no tempo e em relação com a dupla afetação.

The ability of first and third-instar Delphacodes kuscheli Fennah (Hemiptera: Delphacidae) nymphs to acquire and transmit Mal de Río Cuarto virus (MRCV), under controlled conditions, was investigated. First and third-instar nymphs were allowed acquisition feeding separately on infected wheat plants for 48 hours. The insects were then placed in groups of three for serial transmissions to healthy wheat plants, using inoculation periods of 24 hours. Both instars of D. kuscheli were demonstrated to acquire and subsequently transmit the virus. Nevertheless, transmission trials showed highest transmission efficiency and shortest latent period when MRCV was acquired by first-instar nymphs.

Se comparó la capacidad de ninfas de primer y tercer estadío de Delphacodes kuscheli Fennah (Hemiptera: Delphacidae) para adquirir y posteriormente transmitir el Mal de Río Cuarto virus (MRCV), bajo condiciones controladas. Ninfas I y III avirulíferas se alimentaron separadamente de plantas de trigo infectadas durante 48 horas, para luego ser colocadas en subgrupos de tres individuos sobre plantas de trigo sanas. Se realizaron transmisiones seriales utilizando períodos de inoculación de 24 horas. Ambos estadií os lograron adquirir y transmitir el MRCV, pero se evidenció una mayor cantidad de subgrupos infectivos cuando la adquisición se efectuó como ninfas I, así como una disminución significativa en la duración del período de latencia del virus respecto de los insectos que adquirieron el MRCV durante el tercer estadio ninfal.