Resumo:
En
|
Texto:
En
|
PDF:
En
ABSTRAT: Feline injection-site sarcomas in felines account for more than 40% of cutaneous and subcutaneous neoplasms in felines. The present study aimed to describe the macroscopic and histomorphological findings of feline application/injection sarcomas. Samples from 31 feline tumors with a history of feline application/inflammation sarcoma were re-evaluated regarding histological subtype, mitotic index and score, depth of tissue invasion, and presence of inflammation considering the location, intensity and predominant cell types. Of the 31 samples from felines diagnosed with sarcoma at the application/inflammation site, 87.15% were cats with no defined breed (NDB), with a mean age of 8.5 years. The predominant anatomical sites were the back and flank/abdomen, both with 29% (9/31), and the prevalent histological subtype was fibrosarcoma at 77.4% (24/31), followed by anaplastic giant cell sarcoma at 12.9% (4/31) and myxosarcoma 9.6% (3/31). The histological grade with the highest number of cases was III (51.6%), followed by Grade II (35.4%) and I (12.9%). The mean of the longest axis measurements varied between the different tumor grades without being significant, with the average being 2.5±2.79cm in Grade I tumors and 3.2±2.28cm in Grade II tumors. and 4.68±2.07cm in Grade III tumors. Necrosis was observed in 74.2% of tumors. The tissue inflammation score was mild to moderate in 58% of cases and severe in 32.2%, with lymphocytic and lymphoplasmacytic infiltrates being prevalent, with 25.8% each, followed by lymphoplasmohistiocytic with 22.6%. The infiltration depth was 38.7% in muscle tissue, followed by 32.2% in the subcutaneous tissue. Pleomorphism was accentuated in 51.6%. Desmoplasia was moderate in 45.1%. Satellite nodules were present in 29% of cases, and 19.4% had macrophages with intracytoplasmic content suggestive of adjuvants. Surgical margins were infiltrated (M1) in 48.4% and narrowed in 25.8% (M2). The anatomical locations observed were different from those recommended by the Vaccine-Associated Feline Sarcoma Task Force (VAFST); in most cases, the adjuvanted macrophage was not present. From this data, we can suggest that sarcomas in felines are not only correlated to the vaccine application, corroborating the hypothesis that any material, whether liquid or solid, and any chronic inflammatory process in the subcutaneous tissue of cats can induce the entity if they are predisposed to do so. The detailed histomorphological data evaluated in this study were key points and provided important information about tumor behavior, being a tool for clinical-oncological decision-making. ABSTRAT injectionsite injection site 40 applicationinjection application 3 applicationinflammation reevaluated re invasion location types 8715 87 15 87.15 NDB, NDB , (NDB) 85 8 5 8. years flankabdomen flank abdomen flank/abdomen 29 9/31, 931 9/31 9 (9/31) 774 77 4 77.4 24/31, 2431 24/31 24 (24/31) 129 12 12.9 4/31 431 (4/31 96 6 9.6 3/31. 331 3/31 . (3/31) 51.6%, 516 51.6% 51 (51.6%) 35.4% 354 35 (35.4% 12.9%. (12.9%) significant 25279cm cm 2 79cm 32228cm 28cm 468207cm 68 07cm 742 74 74.2 58 322 32 258 25 25.8 each 226 22 22.6% 387 38 7 38.7 32.2 451 45 1 45.1% 194 19 19.4 adjuvants M1 M (M1 484 48 48.4 M2. M2 (M2) VaccineAssociated Vaccine Associated VAFST (VAFST) material solid so behavior clinicaloncological clinical oncological decisionmaking. decisionmaking decision making. making decision-making 871 87.1 (NDB 93 9/3 (9/31 77. 243 24/3 (24/31 12. 4/3 43 (4/3 9. 33 3/3 (3/31 51.6 (51.6% 35.4 (35.4 (12.9% 74. 25. 22.6 38. 32. 45.1 19. (M 48. (M2 (VAFST 87. 9/ (9/3 24/ (24/3 4/ (4/ 3/ (3/3 51. (51.6 35. (35. (12.9 22. 45. (9/ (24/ (4 (3/ (51. (35 (12. (9 (24 ( (3 (51 (12 (2 (5 (1