Pesquisa | SciELO

RESUMO: Este estudo foi conduzido com o objetivo de avaliar os efeitos da suplementação dietética com selênio e cromo biocomplexados sobre o perfil de ácidos graxos do peito e da coxa de frangos de corte machos e fêmeas da linhagem Label Rouge. O delineamento experimental foi inteiramente casualizado em esquema fatorial 3 x 2 correspondendo a três dietas (controle; 0,40 ppm de cromo; 0,50 ppm de selênio) e dois sexos. Cada tratamento foi composto por três parcelas de cinco frangos de corte. O perfil de ácidos graxos foi avaliado nas amostras de peito e coxa. A adição de selênio biocomplexado na dieta de frangos de corte aumentou o teor de ácidos graxos de cadeia longa das séries ômega 3 e 6 (ácido docosahexaenóico - DHA e araquidônico, respectivamente), o total de ômega 6 e o conteúdo de ácido esteárico no peito (músculo pectoralis major). Além disso, a suplementação com selênio causou redução no teor de ácido oleico e no total de monoinsaturados no mesmo músculo. Os machos apresentaram maiores teores dos ácidos linoléico e linolênico e total de poliinsaturados; e menor conteúdo de ácido oleico, total de monoinsaturados e saturados na coxa. Os frangos suplementados com selênio biocomplexado e os machos apresentaram melhor qualidade lipídica no músculo do peito e coxa, respectivamente.

ABSTRACT: This study was conducted to evaluate the effects of dietary supplementation with biocomplexed selenium and chromium on the fatty acid profile of the breast and thigh of males and females broilers of the Label Rouge lineage. The experimental design was completely randomized arranged in a 3 x 2 factorial scheme corresponding to three diets (control; 0.40 ppm of chromium; 0.50 ppm of selenium) and two sexes. Each treatment consisted of three plots of five broilers. The fatty acid profile was evaluated in the breast and thigh samples. The addition of biocomplexed selenium in the broilers diets increased the content of long chain fatty acid of the omega 3 and 6 series (docosahexaenoic - DHA and arachidonic acids, respectively), the total of omega 6 and the stearic acid content on the breast (pectoralis major muscle). In addition, selenium supplementation caused a reduction in oleic acid content and in total of monounsaturated in the same muscle. Males had higher contents of linoleic and linolenic acids, and total of polyunsaturated; and lower content of oleic acid, total of monounsaturated and saturated in the thigh. The broilers supplemented with biocomplexed selenium and males presented better lipid quality in the muscle by breast and thigh, respectively.

https://doi.org/10.1590/0103-8478cr20210525

Quality of life and psychological comorbidities in patients with migraine and hypertension
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Ribeiro, Thamires Sales

; Almeida, Luciana Salles Branco de

; Rodrigues, Vandilson Pinheiro

; Oliveira, Caio Marcio Barros de

; Moura, Ed Carlos Rey

; Naves, Luciana Maia Moura

; Lima Neto, Lidio Gonçalves

; Moreira, Leonardo Victor Galvão

; Pereira, Emanuel Cabral

; Leal, Plínio da Cunha

Revista da Associação Médica Brasileira

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Set 2022, Volume 68 Nº 9 Páginas 1156 - 1160

Resumo: En | Texto: En | PDF: En

https://doi.org/10.1590/1806-9282.20220724

Carcass characteristics and pork quality of pigs fed diets containing crude glycerin and ractopamine
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BARROS, Imara Guimarães Lima

; GARBOSSA, Cesar Augusto Pospissil

; ALBUQUERQUE, Tatiane Mendonça Nogueira Carneiro de

; COUTO, Claudiana Esteves

; SILVA JUNIOR, Sudário Roberto

; PINTO, Adriana Brasil Ferreira

; FARIA, Peter Bitencourt

; NAVES, Luciana de Paula

Food Science and Technology

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2022, Volume 42 elocation e14921

Resumo: En | Texto: En | PDF: En

Abstract An experiment was conducted to evaluate the effects of increasing concentrations of crude glycerin, with or without ractopamine, in the diet of finishing barrows on carcass characteristics and pork quality. The experimental design was a randomized complete block, in a 4 x 2 factorial scheme, with four concentrations of crude glycerin (0, 100, 150, or 200 g/kg) and two concentrations of ractopamine (0 or 10 mg/kg). There was no interaction between the crude glycerin concentrations and the ractopamine use as well as there was no isolated effect of the dietary crude glycerin concentration for all the evaluated traits. However, the dietary ractopamine increased the hot (p = 0.021) and cold (p=0.020) carcass weight, the hot carcass yield (p = 0.038), the shear force (p = < 0.0001), lightness (L* index) (p = 0.043), hue angle (h*) (p = 0.026), and C16:1 (p = 0.023) concentration in the loin. Moreover, the dietary ractopamine decreased the red content (a* value) (p = 0.043), the activity of C16-C18 elongase (p = 0.037) and the C18:0 (p = 0.021) concentration in the loin. The inclusion of up to 200 g/kg crude glycerin in the diet of finishing pigs may be used as a partial substitute for dietary corn, combined or not with 10 mg/kg ractopamine, without impair the evaluated carcass characteristics and the quality of the loin.

https://doi.org/10.1590/fst.14921

Nutritional evaluation of chia (Salvia hispanica) seeds and oil in broiler diets
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Mendonça, Nicole Batelli de Souza Nardelli

; Sobrane Filho, Sérgio Turra

; Lima, Eduardo Machado Costa

; Oliveira, David Henrique de

; Coelho, Flávio de Aguiar

; Cruz, Fábio Loures

; Bernardes, Laryssa Fernanda

; Moreira, Rennan Herculano Rufino

; Naves, Luciana de Paula

; Rodrigues, Paulo Borges

Revista Brasileira de Zootecnia

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2022, Volume 51 elocation e20220005

Resumo: En | Texto: En | PDF: En

ABSTRACT Two experiments were carried with broilers from 29 to 42 days of age for the nutritional evaluation of dietary chia. Thus, the nitrogen-corrected apparent metabolizable energy (AMEn) and the apparent metabolizability coefficients of gross energy and ether extract of chia seeds and oil, toasted soybean grain (TSG), and soybean oil were determined in the experiment I, by total excreta collection method, using 120 broilers. Each experimental diet (reference diet [RD] and four diets with the tested feedstuffs) was evaluated in eight replicates of three broilers. The TSG and chia seeds replaced the RD in 250 g/kg, whereas soybean and chia oils replaced the RD in 100 g/kg. Simultaneously, a second experiment was carried subdivided into two trials. In the performance trial, we evaluated the dietary feedstuffs effects on performance, carcass and cut yields, blood parameters, and activity of lipogenic enzymes. The nutrient metabolizability coefficients and AMEn were evaluated in the metabolism trial. The AMEn values of 37.49, 37.35, 15.85, and 8.43 MJ/kg of dry matter were determined for chia oil, soybean oil, TSG, and chia seeds, respectively (experiment I). In the second experiment, the best feed conversion was observed in broilers fed diets containing chia oil and TSG. However, the diet formulated with chia seeds worsened broiler feed conversion, exhibited the smaller energy value and apparent metabolizability coefficient of the ether extract, and increased the activity of the malic enzyme and serum total cholesterol level. There was no difference for glucose-6-phosphate dehydrogenase activity and high-density lipoprotein cholesterol level. In general, chia oil showed to be efficient in replacing soybean oil in broiler diets.

https://doi.org/10.37496/rbz5120220005

Management of hypopituitarism: a perspective from the Brazilian Society of Endocrinology and Metabolism
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Garmes, Heraldo Mendes

; Boguszewski, César Luiz

; Miranda, Paulo Augusto Carvalho

; Martins, Manoel Ricardo Alves

; Silva, Silvia Regina Correa da

; Abucham Filho, Julio Zaki

; Musolino, Nina Rosa de Castro

; Vilar, Lucio

; Portari, Luiz Henrique Corrêa

; Gadelha, Mônica Roberto

; Kasuki, Leandro

; Naves, Luciana Ansaneli

; Czepielewski, Mauro Antônio

; Almeida, Tobias Skrebsky de

; Duarte, Felipe Henning Gaia

; Glezer, Andrea

; Bronstein, Marcello Delano

Archives of Endocrinology and Metabolism

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Abr 2021, Volume 65 Nº 2 Páginas 212 - 230

Resumo: En | Texto: En | PDF: En

ABSTRACT Hypopituitarism is a disorder characterized by insufficient secretion of one or more pituitary hormones. New etiologies of hypopituitarism have been recently described, including head trauma, cerebral hemorrhage, and drug-induced hypophysitis. The investigation of patients with these new disorders, in addition to advances in diagnosis and treatment of hypopituitarism, has increased the prevalence of this condition. Pituitary hormone deficiencies can induce significant clinical changes with consequent increased morbidity and mortality rates, while hormone replacement based on current guidelines protects these patients. In this review, we will first discuss the different etiologies of hypopituitarism and then address one by one the clinical aspects, diagnostic evaluation, and therapeutic options for deficiencies of TSH, ACTH, gonadotropin, and GH. Finally, we will detail the hormonal interactions that occur during replacement of pituitary hormones.

https://doi.org/10.20945/2359-3997000000335 625 downloads

Brazilian multicenter study on pegvisomant treatment in acromegaly
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Boguszewski, Cesar L.

; Huayllas, Martha Katherine P

; Vilar, Lucio

; Naves, Luciana Ansaneli

; Ribeiro-Oliveira Junior, Antonio

; Soares, Beatriz Santana

; Czepielewski, Mauro Antonio

; Abucham, Julio

; Correa-Silva, Silvia Regina

; Bronstein, Marcello Delano

; Jallad, Raquel Soares

; Duarte, Felipe Gaia

; Musolino, Nina Rosa

; Kasuki, Leandro

; Gadelha, Monica Roberto

Archives of Endocrinology and Metabolism

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Ago 2019, Volume 63 Nº 4 Páginas 328 - 336

Resumo: En | Texto: En | PDF: En

ABSTRACT Objective Investigate the therapeutic response of acromegaly patients to pegvisomant (PEGV) in a real-life, Brazilian multicenter study. Subjects and methods Characteristics of acromegaly patients treated with PEGV were reviewed at diagnosis, just before and during treatment. All patients with at least two IGF-I measurements on PEGV were included. Efficacy was defined as any normal IGF-I measurement during treatment. Safety data were reviewed. Predictors of response were determined by comparing controlled versus uncontrolled patients. Results 109 patients [61 women; median age at diagnosis 34 years; 95.3% macroadenomas] from 10 Brazilian centers were studied. Previous treatment included surgery (89%), radiotherapy (34%), somatostatin receptor ligands (99%), and cabergoline (67%). Before PEGV, median levels of GH, IGF-I and IGF-I % of upper limit of normal were 4.3 µg/L, 613 ng/mL, and 209%, respectively. Pre-diabetes/diabetes was present in 48.6% and tumor remnant in 71% of patients. Initial dose was 10 mg/day in all except 4 cases, maximum dose was 30 mg/day, and median exposure time was 30.5 months. PEGV was used as monotherapy in 11% of cases. Normal IGF-I levels was obtained in 74.1% of patients. Glycemic control improved in 56.6% of patients with pre-diabetes/diabetes. Exposure time, pre-treatment GH and IGF-I levels were predictors of response. Tumor enlargement occurred in 6.5% and elevation of liver enzymes in 9.2%. PEGV was discontinued in 6 patients and 3 deaths unrelated to the drug were reported. Conclusions In a real-life scenario, PEGV is a highly effective and safe treatment for acromegaly patients not controlled with other therapies.

https://doi.org/10.20945/2359-3997000000159 822 downloads

Relações de comercialização entre compradores e produtores de leite do sul de Minas Gerais
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Bassotto, Leandro Carvalho

; Angelocci, Marina Ariente

; Naves, Luciana de Paula

; Putti, Fernando Ferrari

Interações (Campo Grande)

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Jan 2019, Volume 20 Nº 1 Páginas 207 - 220

Resumo: O objetivo deste estudo foi analisar as relações existentes entre as empresas compradoras de leite e os produtores rurais de oito cidades do Sul de Minas Gerais e verificar a influência dessas relações em diversos fatores de produção nos resultados econômicos provenientes da produção leiteira e outras áreas da atividade necessárias para a produção láctea. Para isso, foram realizadas entrevistas de campo com 115 produtores rurais das cidades de Campestre, Caldas, Elói Mendes, Paraguaçu, Poço Fundo, Poços de Caldas, Ipuiuna e Machado. Após a coleta de dados, foram realizadas análises para verificar a relação existente entre diversos fatores de produção que sofrem impactos a partir das relações de comercialização entre os produtores de leite e as empresas compradoras do produto na região. Os resultados permitem concluir que diversos fatores necessários para o processo produtivo são influenciados pelo relacionamento entre os agentes citados, e o resultado dos processos de comercialização podem impactar não somente os lucros, mas também outras áreas da atividade leiteira necessárias para o processo produtivo.

Abstract: The objective of this study was to analyze the existing correlations of milk buyers with rural producers in eight cities in the South of Minas Gerais and to verify the influence of these relationships on several factors of production in the economic results from dairy production and other areas of activity required for dairy production. For this, field interviews were conducted with 115 rural producers from the cities of Campestre, Caldas, Elói Mendes, Paraguaçu, Poço Fundo, Poços de Caldas, Ipuiuna and Machado. After the data collection, analyzes were carried out to verify the relationship between several factors of production that are impacted by the commercial relations between milk producers and the companies purchasing the product in the region. The results allow us to conclude that several factors necessary for the productive process are influenced by the relationship between the mentioned agents and the result of the commercialization processes can impact not only the economic results but also on other areas of the dairy activity required for the productive process.

Resumen: El objetivo de este estúdio fue analizar las correlaciones existentes de las empresas compradoras de leche com los productores rurales de ocho ciudadesdelsur de Minas Gerais y verificar La influencia de estas relaciones en diversos factores de producción em los resultados económicos provenientes de laproducción lechera y otras áreas de La actividad necesarias para la producción láctea. Para esto, se realizaron entrevistas de campo con 115 productores rurales de lãs ciudades de Campestre, Caldas, Elói Mendes, Paraguaçu, Poço Fundo, Poços de Caldas, Ipuiuna y Machado. Después de La recolección de datos, se realizaron análisis para verificar La relación existente entre diversos factores de producción que sufren impacto a partir de las relaciones de comercialización entre productores de leche y las empresas compradoras Del producto en La región. Los resultados permiten concluir que diversos factores necesarios para El proceso productivo son influenciados por La relación entre los agentes citados y el resultado de los procesos de comercialización pueden impactar no solo los resultados económicos, sino también otras áreas de La actividad lechera necesarias para el proceso productivo.

Résumé: Le but de cette étude était d'analyser la corrélation du lait d'acheter des entreprises avec les agriculteurs de 8 villes dans le sud du Minas Gerais et l'influence de ces relations dans divers facteurs de production dans les résultats économiques de la production de lait et d'autres domaines d'activité nécessaire pour la production laitière. Pour ce faire, des interviews sur le terrain ont été menées auprès de 115 agriculteurs des villes de Campestre, Caldas, Elói Mendes, Paraguaçu, Poço Fundo, Pocos de Caldas, Ipuiúna et Machado. Après la collecte des données, des analyses ont été réalisées pour étudier la relation entre les différents facteurs de production qui sont impactés de la commercialisation des relations entre les producteurs de lait et les sociétés d'achat du produit dans la région. Les résultats suggèrent que plusieurs facteurs nécessaires au processus de production sont influencés par la relation entre les agents ci-dessus et le résultat des processus de marketing peut avoir un impact non seulement économique, mais aussi d'autres secteurs de l'élevage laitier nécessaires au processus de production.

https://doi.org/10.20435/inter.v0i0.1671 966 downloads

Ileal digestibility of calcium and phosphorus in broilers fed diets with different phytases and Ca:available P ratios
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Oliveira, David Henrique de

; Naves, Luciana de Paula

; Nardelli, Nicole Batelli de Souza

; Zangerônimo, Márcio Gilberto

; Rodrigues, Paulo Borges

Pesquisa Agropecuária Brasileira

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Nov 2018, Volume 53 Nº 11 Páginas 1222 - 1229

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo: O objetivo deste trabalho foi determinar a digestibilidade ileal aparente do cálcio e do fósforo em frangos de corte alimentados com rações com diferentes fitases e relações cálcio:fósforo disponível (Ca:Pd). Foram realizados dois experimentos: um com frangos de 22 a 33 dias de idade, e outro com frangos de 35 a 42 dias. As relações Ca:Pd usadas foram de 4,5:1,0, 6,0:1,0 e 7,5:1,0, no primeiro período, e de 3,5:1,0, 5,0:1,0 e 6,5:1,0, no segundo. Todas as dietas foram suplementadas com 1.500 unidades de atividade de fitase por quilograma de seis diferentes fontes de fitase microbiana. Ao final de cada experimento, duas aves por repetição foram abatidas para a coleta do conteúdo ileal. Nas amostras de digestas, foram determinados os teores de Ca e P para posterior cálculo do coeficiente de digestibilidade ileal aparente destes minerais. A relação Ca:Pd influenciou a atividade das fitases, e a maior digestibilidade foi observada nas menores relações, em ambos os experimentos. As fitases que proporcionaram os maiores coeficientes de digestibilidade foram A, D e E. Em ambas as idades avaliadas, a inclusão de fitases às dietas aumentou a digestibilidade de Ca e P, a qual também foi afetada pelo teor de cálcio e pela fonte de fitase utilizada.

Abstract: The objective of this work was to determine the apparent ileal digestibility of calcium and phosphorus in broilers fed diets with different phytases and calcium:available phosphorus (Ca:aP) ratios. Two experiments were carried out: one with broilers with 22 to 33 days of age, and the other with broilers with 35 to 42 days. The Ca:aP ratios used were 4.5:1.0, 6.0:1.0, and 7.5:1.0 in the first period, and 3.5:1.0, 5.0:1.0, and 6.5:1.0 in the second. All diets were supplemented with 1,500 units of phytase activity per kilogram of six different sources of microbial phytase. At the end of each experiment, two broilers per replicate were slaughtered to collect the ileal content. In the samples of digested food, the Ca and P contents were determined for later calculation of the apparent ileal digestibility coefficients of these minerals. The Ca:aP ratio influenced the activity of phytases, and the highest digestibility was observed with lower ratios, in both experiments. The phytases that provided greater digestibility coefficients were A, D, and E. In both ages evaluated, the inclusion of phytases in the feed improved the digestibility of Ca and P, which was also affected by the content of calcium and by the phytase source used.

https://doi.org/10.1590/s0100-204x2018001100004 1070 downloads

Desenvolvimento de Urochloa brizantha adubada com fonolito e inoculada com bactérias diazotróficas solubilizadoras de potássio
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Miranda, Cássia C. B.

; Florentino, Ligiane A.

; Rezende, Adauton V. de

; Nogueira, Denismar A.

; Leite, Rafael F.

; Naves, Luciana P.

Revista de Ciências Agrárias

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Set 2018, Volume 41 Nº 3 Páginas 41 - 50

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Objetivou-se analisar a viabilidade de uso do pó da rocha fonolito em Urochloa brizantha cv. Marandu e se a inoculação com bactérias diazotróficas solubilizadoras de potássio (K) contribui para o maior desenvolvimento e características bromatológicas desta forrageira. O experimento foi conduzido em vasos contendo 15 dm³ de solo, durante três períodos de cortes. Foi utilizado o delineamento em blocos casualizados em esquema fatorial e um tratamento adicional (4x3+1), sendo quatro doses do fonolito (100%, 75%, 50% e 25%) e três variáveis inoculantes (UNIFENAS 100-13, UNIFENAS 100-94 e o controle sem inoculação), além do tratamento adicional com cloreto de potássio (KCl), com quatro repetições por tratamento. Na época de cada corte foram avaliados os parâmetros morfológicos e bromatológicos da forrageira. As diferentes doses de fonolito associadas à inoculação com as estirpes bacterianas não conduziram a diferenças significativas nos parâmetros morfológicos, como largura e comprimento de folha, densidade de perfilhos e matéria seca. No entanto, o fonolito promoveu uma melhoria nas características bromatológicas nos parâmetros de fibra em detergente ácido, hemicelulose, digestibilidade da matéria seca, nutrientes digestíveis totais, energia digestível e metabolizável, contribuindo, portanto, para a melhoria no valor nutricional, indicando o potencial de utilização desta rocha silicatada como fonte alternativa ao cloreto de potássio (KCl).

The objective of this study was to analyze the feasibility of using phonolite rock powder in Urochloa brizantha cv. Marandu and whether the inoculation with potassium solubilizing diazotrophic bacteria (K) contributes to a greater development and bromatological characteristics of this forage. The experiment was conducted in pots containing 15 dm³ of soil, during three cutting periods. A randomized block design in a factorial scheme and an additional treatment (4x3 + 1) were used, with four doses of phonolite (100%, 75%, 50% and 25%) and three inoculant variables (UNIFENAS 100-13, UNIFENAS 100-94 and a control without inoculation), further, was added the additional treatment with potassium chloride (KCl), with four replicates per treatment. At the time of each cut, the morphological and bromatological parameters of the forage were evaluated. The different doses of phonolite associated with inoculation with the bacterial strains showed no significant differences in morphological parameters, such as leaf width and length, tillers density and dry matter. However, phonolite promoted an improvement in the bromatological characteristics in the parameters of acid detergent fiber, hemicellulose, dry matter digestibility, total digestible nutrients, digestible and metabolizable energy, thus contributing to the improvement in nutritional value, indicating the potential of this rock as an alternative source to potassium chloride (KCl).

https://doi.org/10.19084/RCA17011 966 downloads

10.

Controversial issues in the management of hyperprolactinemia and prolactinomas – An overview by the Neuroendocrinology Department of the Brazilian Society of Endocrinology and Metabolism
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Vilar, Lucio

; Abucham, Julio

; Albuquerque, José Luciano

; Araujo, Luiz Antônio

; Azevedo, Monalisa F.

; Boguszewski, Cesar Luiz

; Casulari, Luiz Augusto

; Cunha Neto, Malebranche B. C.

; Czepielewski, Mauro A.

; Duarte, Felipe H. G.

; Faria, Manuel dos S.

; Gadelha, Monica R.

; Garmes, Heraldo M.

; Glezer, Andrea

; Gurgel, Maria Helane

; Jallad, Raquel S.

; Martins, Manoel

; Miranda, Paulo A. C.

; Montenegro, Renan M.

; Musolino, Nina R. C.

; Naves, Luciana A.

; Ribeiro-Oliveira Júnior, Antônio

; Silva, Cíntia M. S.

; Viecceli, Camila

; Bronstein, Marcello D.

Archives of Endocrinology and Metabolism

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Mar 2018, Volume 62 Nº 2 Páginas 236 - 263

Resumo: En | Texto: En | PDF: En

ABSTRACT Prolactinomas are the most common pituitary adenomas (approximately 40% of cases), and they represent an important cause of hypogonadism and infertility in both sexes. The magnitude of prolactin (PRL) elevation can be useful in determining the etiology of hyperprolactinemia. Indeed, PRL levels > 250 ng/mL are highly suggestive of the presence of a prolactinoma. In contrast, most patients with stalk dysfunction, drug-induced hyperprolactinemia or systemic diseases present with PRL levels < 100 ng/mL. However, exceptions to these rules are not rare. On the other hand, among patients with macroprolactinomas (MACs), artificially low PRL levels may result from the so-called “hook effect”. Patients harboring cystic MACs may also present with a mild PRL elevation. The screening for macroprolactin is mostly indicated for asymptomatic patients and those with apparent idiopathic hyperprolactinemia. Dopamine agonists (DAs) are the treatment of choice for prolactinomas, particularly cabergoline, which is more effective and better tolerated than bromocriptine. After 2 years of successful treatment, DA withdrawal should be considered in all cases of microprolactinomas and in selected cases of MACs. In this publication, the goal of the Neuroendocrinology Department of the Brazilian Society of Endocrinology and Metabolism (SBEM) is to provide a review of the diagnosis and treatment of hyperprolactinemia and prolactinomas, emphasizing controversial issues regarding these topics. This review is based on data published in the literature and the authors' experience.

https://doi.org/10.20945/2359-3997000000032 36158 downloads

11.

A review of Cushing's disease treatment by the Department of Neuroendocrinology of the Brazilian Society of Endocrinology and Metabolism
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Machado, Márcio Carlos

; Fragoso, Maria Candida Barisson Vilares

; Moreira, Ayrton Custódio

; Boguszewski, César Luiz

; Vieira Neto, Leonardo

; Naves, Luciana A.

; Vilar, Lucio

; Araújo, Luiz Antônio de

; Musolino, Nina Rosa Castro

; Miranda, Paulo Augusto C.

; Czepielewski, Mauro A.

; Gadelha, Monica R.

; Bronstein, Marcello Delano

; Ribeiro-Oliveira Jr., Antônio

Archives of Endocrinology and Metabolism

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Fev 2018, Volume 62 Nº 1 Páginas 87 - 105

Resumo: En | Texto: En | PDF: En

ABSTRACT The treatment objectives for a patient with Cushing's disease (CD) are remission of hypercortisolism, adequate management of co-morbidities, restoration of the hypothalamic-pituitary-adrenal axis, preservation of fertility and pituitary function, and improvement of visual defects in cases of macroadenomas with suprasellar extension. Transsphenoidal pituitary surgery is the main treatment option for the majority of cases, even in macroadenomas with low probability of remission. In cases of surgical failure, another subsequent pituitary surgery might be indicated in cases with persistent tumor imaging at post surgical magnetic resonance imaging (MRI) and/or pathology analysis of adrenocorticotropic hormone-positive (ACTH+) positive pituitary adenoma in the first procedure. Medical treatment, radiotherapy and adrenalectomy are the other options when transsphenoidal pituitary surgery fails. There are several options of medical treatment, although cabergoline and ketoconazole are the most commonly used alone or in combination. Novel treatments are also addressed in this review. Different therapeutic approaches are frequently needed on an individual basis, both before and, particularly, after surgery, and they should be individualized. The objective of the present review is to provide the necessary information to achieve a more effective treatment for CD. It is recommended that patients with CD be followed at tertiary care centers with experience in treating this condition.

https://doi.org/10.20945/2359-3997000000014 5266 downloads

12.

Supplementation of fungal and/or bacterial phytase in broiler diets formulated with reduced phosphorus level and different calcium contents
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Nardelli, Nicole Batelli de Souza

; Naves, Luciana de Paula

; Oliveira, David Henrique de

; Garcia Junior, Antonio Amandio Pinto

; Lima, Eduardo Machado Costa

; Oliveira, Evelyn Cristina de

; Rodrigues, Paulo Borges

Revista Brasileira de Zootecnia

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2018, Volume 47 elocation e20170297

Resumo: En | Texto: En | PDF: En

ABSTRACT The objective of the current study was to evaluate the effects of three calcium:available phosphorus (Ca:aP) ratios and different supplementation with phytases from different origins on performance and ash, Ca, and P contents in the tibia of broilers. A total of 900 male broilers (22 to 35 days old) were fed ten dietary treatments in a completely randomized design. A 3 × 3 + 1 factorial scheme was used, corresponding to three Ca:aP ratios (4.5:1.0, 6.0:1.0, and 7.5:1.0) and three different supplementations with phytases from different origins (isolated or combined supplementation with bacterial and fungal phytase), plus a control diet. Regardless of the dietary Ca:aP ratio, the isolated use of bacterial phytase provided better feed conversion than the fungal phytase but did not differ from combined supplementation with bacterial and fungal phytase. However, regardless of the supplemented phytase, the 7.5:1.0 Ca:aP ratio decreased the feed conversion. Best results for bone P deposition were observed using diets containing the 4.5:1.0 Ca:aP and fungal phytase or the 4.5:1 and 6.0:1 Ca:aP ratios using the bacterial phytase. In general, when the parameters of feed conversion, bone ash, and P content in tibia are considered together, diets containing a 4.5:1.0 or 6.0:1.0 Ca:aP ratio and 1,500 FTU kg−1 bacterial phytase, or a 4.5:1.0 Ca:aP ratio using fungal phytase and only 1.0 g kg−1 available phosphorus provide better results.

https://doi.org/10.1590/rbz4720170297 1169 downloads

13.

Metabolic and histologic responses of pacu (Piaractus mesopotamicus) fed diets supplemented with increasing concentrations of ractopamine
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Drumond, Mariana Martins

; Naves, Luciana de Paula

; Ribeiro, Paula Adriane Perez

; Oliveira, Marinez Moraes de

; Okamura, Daniel

; Resende, Anaise Emanuele

; Cantarelli, Vinicius de Souza

; Rosa, Priscila Vieira

Revista Brasileira de Zootecnia

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2018, Volume 47 elocation e20160234

Resumo: En | Texto: En | PDF: En

ABSTRACT An experiment was conducted during 60 days with forty pacu males fed diets supplemented with increasing concentrations of ractopamine (0.00, 11.25, 22.50, 33.75, and 45.00 mg kg−1). Eight fish were evaluated for each experimental diet. Performance and survival rate of the fish were measured. At the end of the experiment, blood was collected to determine the levels of cortisol, triacylglycerol, and protein. Moreover, the liver was collected to determine the activities of glucose-6-phosphate dehydrogenase and malic enzymes. The fillets were collected to determine chemical composition, and histologic cuts were analyzed to verify muscle growth and deposition of adipose tissue between muscle fibers. Increasing concentrations of dietary ractopamine did not change feed intake, fillet yield, fillet content of protein and ash, and frequency of relative distribution of muscle fibers. By increasing the dietary ractopamine concentration, the serum cortisol level was elevated. Ractopamine supplementation (45.00 mg kg−1) increased serum levels of triacylglycerol and protein and reduced the activity of hepatic lipogenic enzymes and the survival rate of the fish, probably in response to the high concentration of circulating cortisol. In addition, the higher level of ractopamine supplementation evaluated in this research impaired the weight gain and feed conversion. However, 11.25 mg kg−1 ractopamine reduced the ether extract level determined in the fillet and the fat deposition between muscle fibers, improving the nutritional quality of meat.

https://doi.org/10.1590/rbz4720160234 1211 downloads

14.

Galactorreia após mastoplastia de aumento
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MACEDO, JEFFERSON LESSA SOARES DE

; ROSA, SIMONE CORRÊA

; NAVES, LUCIANA ANSANELI

; MOTTA, LUIZ AUGUSTO CASULARI ROXO DA

; ASCENÇO, ADRIANA SAYURI KUROGI

Revista Brasileira de Cirurgia Plástica

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Mar 2017, Volume 32 Nº 1 Páginas 155 - 156

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

https://doi.org/10.5935/2177-1235.2017rbcp0024

15.

A review on the diagnosis and treatment of patients with clinically nonfunctioning pituitary adenoma by the Neuroendocrinology Department of the Brazilian Society of Endocrinology and Metabolism
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Vieira Neto, Leonardo

; Boguszewski, Cesar L.

; Araújo, Luiz Antônio de

; Bronstein, Marcello D.

; Miranda, Paulo Augusto C.

; Musolino, Nina R. de C.

; Naves, Luciana A.

; Vilar, Lucio

; Ribeiro-Oliveira Júnior, Antônio

; Gadelha, Mônica R.

Archives of Endocrinology and Metabolism

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Ago 2016, Volume 60 Nº 4 Páginas 374 - 390

Resumo: En | Texto: En | PDF: En

ABSTRACT Clinically nonfunctioning pituitary adenomas (NFPA) are the most common pituitary tumors after prolactinomas. The absence of clinical symptoms of hormonal hypersecretion can contribute to the late diagnosis of the disease. Thus, the majority of patients seek medical attention for signs and symptoms resulting from mass effect, such as neuro-ophthalmologic symptoms and hypopituitarism. Other presentations include pituitary apoplexy or an incidental finding on imaging studies. Mass effect and hypopituitarism impose high morbidity and mortality. However, early diagnosis and effective treatment minimizes morbidity and mortality. In this publication, the goal of the Neuroendocrinology Department of the Brazilian Society of Endocrinology and Metabolism is to provide a review of the diagnosis and treatment of patients with NFPA, emphasizing that the treatment should be performed in reference centers. This review is based on data published in the literature and the authors’ experience. Arch Endocrinol Metab. 2016;60(4):374-90

https://doi.org/10.1590/2359-3997000000179 7830 downloads

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