ABSTRACT Objective: To assess the efficacy and safety of the use of midazolam as monotherapy, compared to the associated use of midazolam and hydroxyzine for minimum and moderate sedation of children in dental offices, using data obtained from clinical trials. Material and Methods: A systematic review protocol was developed and registered on PROSPERO (CR42020208633). An electronic search was carried out in Pubmed, Lilacs, Science Direct, Open Gray, Web of Science, and central Cochrane Library. No language restrictions were included. Clinical trials were carried out with children aged 0-12 years, using midazolam as monotherapy compared to the use of midazolam associated with hydroxyzine to verify the effectiveness and safety of oral sedation. The quality of the studies was individually assessed and grouped using the RoB 2 (Revised Cochrane risk-of-bias tool for randomized trials) and GRADE (Grading of Recommendations Assessment, Development and Evaluation) systems, respectively. Results: A total of 749 studies were found. After analyzing the inclusion and removal of duplicates, two studies were analyzed for the quality of evidence. Through this analysis, it was possible to verify the very low level of scientific evidence on the superiority of the efficacy and safety of the combined use of midazolam and hydroxyzine for oral sedation in children in dental offices. Conclusion: The conflicting results and limitations of the studies enabled to establish that there is insufficient evidence to support the use of these drugs combined. There is only evidence for the use of midazolam as monotherapy. Objective offices Methods CR42020208633. CR42020208633 CR . (CR42020208633) Pubmed Lilacs Direct Gray Library included 012 0 12 0-1 years Revised riskofbias risk bias Grading Assessment Evaluation systems respectively Results 74 found duplicates analysis Conclusion CR4202020863 (CR42020208633 01 1 0- 7 CR420202086 (CR4202020863 CR42020208 (CR420202086 CR4202020 (CR42020208 CR420202 (CR4202020 CR42020 (CR420202 CR4202 (CR42020 CR420 (CR4202 CR42 (CR420 CR4 (CR42 (CR4 (CR

Abstract Acquired hemophilia A is an unusual bleeding disorder of autoimmune origin resulting in the formation of autoantibodies directed against coagulation factor VIII. These autoantibodies can act by partially or completely neutralizing the activation or function of the factor, or they can also accelerate its elimination from the circulation. The global incidence of the disease is 1.5 cases per million inhabitants per year. In nearly 50% of cases, an underlying disease that is presumed responsible to produce autoantibodies can be detected. We report a case with acquired hemophilia A, in a patient with Vater’s ampulla adenocarcinoma.

Resumen La hemofilia adquirida A es un desorden hemorrágico inusual de origen autoinmune que resulta en la formación de autoanticuerpos dirigidos contra el factor VIII de la coagulación. Estos autoanticuer pos pueden actuar neutralizando parcial o completamente la activación o función del factor, o también pueden acelerar su eliminación de la circulación. La incidencia mundial de la enfermedad es de 1.5 casos por millón de habitantes por año. En cerca del 50% de los pacientes se puede detectar una enfermedad subyacente que se presume responsable de la producción de los autoanticuerpos. Se presenta el caso de un varón con hemofilia adquirida A, en contexto de adenocarcinoma de la ampolla de Vater.

RESUMO Objetivo: compreender como os estudantes percepcionam o seu envolvimento em atividades de investigação e o contributo para o desenvolvimento de uma prática baseada na evidência. Método: estudo qualitativo, transversal, descritivo e exploratório, realizado em Portugal, em agosto de 2019, que recorreu ao grupo focal, com oito participantes, para responder à questão: “Quais as vantagens da participação dos estudantes de enfermagem em atividades de investigação para o desenvolvimento de conhecimentos, atitudes e competências de utilização da evidência?”. A análise de conteúdo foi realizada com o software NVivo. Resultados: da análise qualitativa dos achados, emergiram cinco categorias e subcategorias: autoaprendizagem, integração teórico-prática, trabalho interdisciplinar, tomada de decisão baseada na evidência e literácia científica. Conclusão: a criação de uma experiência eficaz de aprendizagem ajuda na construção do conhecimento e potencialmente contribui para a saúde da comunidade, os resultados de aprendizagem do estágio e o desenvolvimento de competências essenciais para uma Prática Baseada na Evidência.

ABSTRACT Objective: to understand how students perceive their involvement in investigation activities and how they contribute for the development of evidence-based practices. Method: qualitative, cross-sectional, descriptive, and exploratory study, carried out in Portugal, in August 2019. A focus group of eight participants was formed to answer the question: “What are the advantages of the participation of nursing students in investigations for the development of knowledge, attitudes, and performance in the use of evidence?” The software NVivo was used for a content analysis. Results: five categories and subcategories emerged from the qualitative analysis of findings: self-learning, integration of theory and practice, interdisciplinary work, evidence-based decision making, and scientific literacy. Conclusion: creating an effective learning experience helps building knowledge and can contribute for the health of the community, for improved educational results during the internship, and for the development of the abilities necessary for Evidence Based Practice.

RESUMEN Objetivo: comprender como estudiantes perciben su envolvimiento con actividades investigativas y su contribución para desarrollar una práctica basada en evidencias. Método: estudio cualitativo, trasversal, descriptivo y exploratorio, hecho en Portugal en agosto de 2019, utilizando un grupo focal con ocho participantes para responder a la cuestión: “Cuales las ventajas de la participación de los estudiantes de enfermería en actividades de investigación para desarrollar conocimientos, actitudes y competencias de utilización de la evidencia?” Se hizo al análisis de contenido con el software NVivo. Resultados: el análisis cuantitativo de los datos generó cinco categorías y subcategorías: autoaprendizaje, integración teórico-práctica, interdisciplinariedad, tomada de decisiones basadas en evidencia, y alfabetización científica. Conclusión: la creación de una experiencia eficaz de aprendizaje ayuda en la construcción del conocimiento y potencialmente contribuye para la salud de la comunidad, para los resultados del aprendizaje en la pasantía y para el desarrollo de competencias esenciales para una Práctica Basada en Evidencias.

Cannabis sativa has many promising medicinal applications for the mitigation, or even cure, of chronic diseases. The high bioaccumulation potential of C. sativa enables its use for the phytoremediation and detoxification of soil, may increase the levels of inorganic elements in products such as cannabidiol (CBD) extracts being necessary the evaluation/monitoring of the level of inorganic components, mainly the toxic species in these formulations. An analytical method employing graphite furnace atomic absorption spectrometry (GFAAS) was developed for the quantification of Pb, As, and Cd in commercial CBD extracts and homemade samples. The alkaline solubilization was employed in agreement with the external analytical curve, in a robust method. The limits of quantification were 0.26 (Pb), 0.067 (As), and 0.011 µg g-1 (Cd), with satisfactory accuracy (80-120%) and relative standard deviation (RSD) values < 7%. The CBD extracts presented levels of Pb, As and Cd below the maximum limits established by regulatory agencies.

Resumo: Objetivo Identificar variações sazonais na dieta de jovens que vivem no estuário do Delta do Rio Parnaíba. Métodos Os itens alimentares foram identificados através da análise do conteúdo estomacal, e depois submetidos à análise pelos métodos Frequência de Ocorrência (FO), Frequência Numérica (FN), Frequência gravimétrica (FW) e Índice de Importância Relativa (IRI). Resultados A dieta dos jovens de Elops saurus que habitam as lagoas no delta do Parnaíba foi composta em ordem decrescente de importância por Osteichthyes (Teleostei), Insecta e Crustacea, além de Polychaeta e Nematoda. Também foi registrada elevada frequência de ocorrência de fragmentos de plásticos na dieta. Na estação chuvosa, 17 itens foram registrados na dieta, enquanto que na estação seca apenas 7 itens estavam presentes. O Índice de Importância Relativa evidenciou a importância dos peixes Teleostei (69,93%) na dieta de E. saurus na estação chuvosa, enquanto que, no período Seco destacaram-se os insetos das Famílias Corixidae (43,25%) e Dysticidae (39,16%). Conclusões Com o estudo foi possível identificar que os jovens são carnívoros, especificamente, piscívoros na estação chuvosa quando ocorre maior disponibilidade de presas no ambiente e insetívoros na estação seca, quando reduz a oferta de alimento, evidenciando uma flexibilidade alimentar frente às alterações ambientais.

Abstract: Aim Identify seasonal variations in the diet of juvenile living in the estuary of the Parnaíba River Delta. Methods Food items were identified through analysis of stomach contents, and later submitted to analysis by regular methods for Frequency of Occurrence (FO), Frequency Numerical (FN), Gravimetric Frequency (FW) and Relative Importance Index (IRI). Results Juvenile diet of Elops saurus that inhabit the lagoons in the Parnaíba delta was composed in order decreasing of importance by Osteichthyes (Teleostei), Insecta and Crustacea in addition to Polychaeta and Nematoda. It was also observed a high frequency of occurrence of fragments of plastics in the diet. In the rainy season, 17 items were recorded in the diet, whereas in the dry season only 7 items were present. Relative Importance Index showed high presence of the Teleostei fish (69.93%) on diet of E. saurus during the rainy season, whereas during the dry period the insects of the families Corixidae (43.25%) and Dysticidae (39.16%). Conclusions With the study it was possible to identify that juvenile are piscivorous in the rainy season when there is a higher availability of prey in the environment and insectivores in the dry season when it reduces the supply of food, indicating feeding flexibility to environmental alterations.

Resumo As águas de má qualidade, como os esgotos, têm se tornado uma alternativa para reduzir o consumo de águas de boa qualidade pela irrigação, principalmente em regiões áridas e semiáridas, porém, águas ricas em sais podem causar efeitos deletérios aos sistemas agrícolas. Objetivou-se com essa pesquisa avaliar os impactos da salinidade de águas de diferentes qualidades no desenvolvimento da cultura do girassol e no solo. A pesquisa foi desenvolvida na área da Equipe de Estudos Ambientais (EEA/UEFS), e o delineamento experimental utilizado foi o inteiramente casualizado, constando de quatro tratamentos: água de chuva (0,20 dS m-1), água de poço (1,50 dS m-1), efluente de uma fossa séptica (3,50 dS m-1) e água salobra (5,00 dS m-1), sendo a irrigação feita manualmente e a lâmina calculada com base na evapotranspiração diária. A irrigação com o efluente da fossa promoveu um melhor desenvolvimento da cultura do girassol, e o aumento da salinidade das águas de irrigação nos demais tratamentos, promoveu um decrescimento das fitomassas frescas e secas totais, na altura de planta, diâmetro do caule, número de folhas, área foliar e nos diâmetros interno e externo dos capítulos, no consumo e na eficiência do uso de água. O uso da água de chuva, de poço e do efluente da fossa se mostraram adequadas para irrigação da cultura do girassol, porém, a última solidificou o solo, o que já seria recomendável à aplicação de tratamentos para recuperação dos solos.

Abstract Poor quality water, such as sewage, has become an alternative to reduce the consumption of good quality water by irrigation, especially in arid and semi-arid regions; however, water rich in salts can be harmful to agricultural systems. This research evaluated the impacts of salinity of waters of different qualities on the development of the sunflower culture and on the soil. The research was developed in the area of the Environmental Studies Team (EEA/UEFS), and the experimental design used was completely randomized, consisting of four treatments: rain water (0.20 dS m-1), well water (1.50 dS m-1), cesspool effluent (3.50 dS m-1) and brackish water (5.00 dS m-1), with the irrigation manually done and the blade calculated based on daily evapotranspiration. Irrigation with effluent promoted a better development of the sunflower crop, and the increase in the salinity of the irrigation water in the other treatments promoted a decrease in the total fresh and dry phytomasses, plant height, stem diameter, number of leaves, leaf area, internal and external diameters of the capitula and in the consumption and efficiency of water use. The use of rainwater, well water and cesspool effluent proved to be suitable for irrigation of the sunflower crop; however, the latter sodified the soil, which would already be recommended for the application of treatments for soil recovery.

In order to produce bioactive derivatives of carvacrol and thymol, nine derivatives of each compound were prepared through modifications the phenolic hydroxyl group. The structures of compounds were confirmed by spectral data from MS, IR and NMR. Carvacrol, thymol and derivatives were submitted to the evaluation of the inhibition of the enzyme acetylcholinesterase, using a colorimetric method in which the inhibition of the enzyme is measured by coloration, and larvicidal activity against Aedes aegypti. Derivatives carvacryl acetate-1b and thymyl hexanoate-2b showed the best results for the inhibition of the acetylcholinesterase enzyme, and for the larvicidal activity the derivatives 1a, 1b, 1c, 3h, 2a, 2b, 2c and 4h showed positive results, emphasizing compound thymyl 4-methoxybenzoate-4h which showed LC50 values of 23.60 ppm, considered a very good result.

Na análise das variabilidades espacial e temporal dos fatores inerentes à produtividade agrícola, a geoestatística constitui a base para a aplicação dos conceitos de agricultura de precisão. Assim, este estudo foi desenvolvido com os objetivos de avaliar a variabilidade espacial de atributos físico-hídricos do solo e delimitar zonas homogêneas para o manejo da irrigação em um cultivo de videira, utilizando ferramentas geoestatísticas. Um experimento de campo foi realizado em Petrolina, PE, no Vale do Submédio São Francisco, em um pomar de videira irrigada por microaspersão. Em uma área de 3,2 ha, foram coletadas 160 amostras de solo nas camadas de 0,0-0,20 e 0,20-0,40 m, em quatro transeções, as quais foram utilizadas para as determinações das frações granulométricas (areia total, silte e argila), curva de retenção de água no solo, densidade do solo e porosidade total do solo. Os dados foram submetidos às análises pela estatística descritiva e geoestatística. A variabilidade espacial dos atributos físico-hídricos do solo foi observada; foi realizada a interpolação por krigagem e geração de mapas de contorno para a delimitação de zonas homogêneas. Os atributos de solo analisados apresentaram baixa (densidade do solo, porosidade total e areia total) e média heterogeneidade (silte e argila). O índice de dependência espacial observado foi classificado entre moderado e forte para todos os atributos. A água disponível na camada de 0,2-0,4 m apresentou o maior alcance e foi considerada o atributo para delimitação de três zonas homogêneas, que receberam diferentes volumes de água de irrigação durante dois ciclos de produção da videira, em razão da umidade do solo medido em cada uma dessas zonas.

In analysis of the spatial and temporal variability of the factors inherent to agricultural production, geostatistics is the basis for the application of the concepts of precision agriculture. Thus, this study was developed to evaluate the spatial variability of soil physical and water properties and to delineate homogeneous zones in a vineyard using geostatistical tools. A field experiment was carried out in Petrolina, Pernambuco, Brazil (in the Lower Middle São Francisco Valley) in a grape vineyard, irrigated by microsprinklers. In a 3.2 ha area, 160 soil samples were collected in the 0.0-0.20 and 0.20-0.40 m layers, in four transects, which were used for determination of soil particle size fractions (total sand, silt, and clay), the soil water retention curve, soil bulk density, and total porosity. Data were subjected to descriptive statistical analysis and geostatistical analysis, and spatial variability of the physical and water properties were observed. Interpolation by kriging was then performed, and contour maps were generated to delimit homogeneous soil zones. Soil bulk density, total porosity, and total sand showed low heterogeneity, while silt and clay showed medium heterogeneity. The spatial dependence index observed was classified from moderate to strong for all properties. The water available in the 0.20-0.40 m soil layer showed the greatest range, and it was the property considered for delimitation of three homogeneous zones, which received different amounts of irrigation water throughout two growing seasons in accordance with the soil moisture measured in each one of these zones.