RESUMEN Objetivo: El objetivo principal de este estudio fue comparar los niveles de estrés y ansiedad en niños sometidos a procedimientos quirúrgicos con o sin presencia de los padres en la inducción de la anestesia mediante la medición de los niveles de cortisol salival y la aplicación del mYPAS. Método: Ensayo cuasi-aleatorio con niños de 5 a 12 años, con estado físico ASA I, II o III, sometidos a cirugía electiva. Según la disposición de los padres, se definieron como grupo acompañado o no acompañado. Se utilizaron pruebas de chi-cuadrado, exacta de Fisher, t de Student, Mann-Whitney, Hodges-Lehman y Spearman para los análisis estadísticos. Resultados: Se incluyeron 46 niños; el 63% eran niños en edad preescolar, en su mayoría acompañados por sus madres (80%). La puntuación mYPAS mediana fue de 37,5 (rango intercuartílico, 23,4–51,6) en niños no acompañados y de 55,0 (rango intercuartílico, 27,9–65,0) en niños acompañados, con una diferencia mediana estimada de +11,8 (IC del 95% de 0 a 23,4; p = 0,044). No hubo diferencias significativas en los niveles medios de cortisol salival. Conclusión: El nivel de ansiedad fue mayor en los niños acompañados. No hubo diferencias en los niveles de cortisol salival entre ambos grupos. Registro Brasileño de Ensayos Clínicos (ReBEC):RBR-9wj4qvy. Objetivo Método cuasialeatorio cuasi aleatorio 1 años I III electiva chicuadrado, chicuadrado chi cuadrado, cuadrado chi-cuadrado Fisher Student MannWhitney, MannWhitney Mann Whitney, Whitney Mann-Whitney HodgesLehman Hodges Lehman estadísticos Resultados 4 63 preescolar 80%. 80 80% . (80%) 375 37 37, rango intercuartílico 23,4–51,6 234516 23 51 6 550 55 55, 27,9–65,0 279650 27 9 65 118 11 8 +11, IC 95 23,4 234 0,044. 0044 0,044 044 0,044) Conclusión grupos ReBECRBR9wj4qvy. ReBECRBR9wj4qvy ReBECRBRwjqvy ReBEC RBR 9wj4qvy. 9wj4qvy wj qvy (ReBEC):RBR-9wj4qvy (80% 3 23,4–51, 23451 2 27,9–65, 27965 +11 23, 004 0,04 04 ReBECRBR wjqvy (80 23,4–51 2345 27,9–65 2796 +1 00 0,0 (8 23,4–5 27,9–6 279 + 0, ( 23,4– 27,9– 27,9 27,

ABSTRACT Objective: The main objective of this study was to compare stress and anxiety levels in children undergoing surgical procedures with or without parental presence at induction of anesthesia by measuring salivary cortisol levels and applying the mYPAS. Method: Quasi-randomized trial with children aged 5–12 year, with ASA physical status I, II, or III, undergoing elective surgery. According to parents’ willingness, the pair were defined as accompanied or unaccompanied group. Chi-square, Fisher’s exact tests, Student’s t test, Mann-Whitney, Hodges-Lehman and Spearman’s tests were used for statistical analyzes. Results: We included 46 children; 63% were preschool children mostly accompanied by their mothers (80%). The median mYPAS score was 37.5 (quartile range, 23.4–51.6) in unaccompanied children, and 55.0 (quartile range, 27.9–65.0) in accompanied children, with an estimated median difference of +11.8 (95% CI of 0 to 23.4; p = 0.044). There were no significant differences in the mean salivary cortisol levels. Conclusion: The level of anxiety was higher in accompanied children. There were no differences in salivary cortisol levels between both groups. Brazilian Registry of Clinical Trials (ReBEC):RBR-9wj4qvy. Objective Method Quasirandomized Quasi randomized 512 5 12 5–1 year I II III surgery parents willingness group Chisquare, Chisquare Chi square, square Chi-square Fishers Fisher s Students Student test MannWhitney, MannWhitney Mann Whitney, Whitney Mann-Whitney HodgesLehman Hodges Lehman Spearmans Spearman analyzes Results 4 63 80%. 80 80% . (80%) 375 37 37. quartile range 23.4–51.6 234516 23 51 6 550 55 55. 27.9–65.0 279650 27 9 65 118 11 8 +11. 95% 95 (95 23.4 234 0.044. 0044 0.044 044 0.044) Conclusion groups ReBECRBR9wj4qvy. ReBECRBR9wj4qvy ReBECRBRwjqvy ReBEC RBR 9wj4qvy. 9wj4qvy wj qvy (ReBEC):RBR-9wj4qvy 1 5– (80% 3 23.4–51. 23451 2 27.9–65. 27965 +11 (9 23. 004 0.04 04 ReBECRBR wjqvy (80 23.4–51 2345 27.9–65 2796 +1 ( 00 0.0 (8 23.4–5 27.9–6 279 + 0. 23.4– 27.9– 27.9 27.

RESUMO Objetivo: O principal objetivo deste estudo foi comparar os níveis de estresse e ansiedade em crianças submetidas a procedimentos cirúrgicos com ou sem presença dos pais na indução da anestesia, medindo os níveis de cortisol salivar e aplicando o mYPAS. Método: Ensaio quaserandomizado com crianças de 5 a 12 anos, com estado físico ASA I, II ou III, submetidas a cirurgia eletiva. De acordo com a disposição dos pais, o par foi definido como grupo acompanhado ou não acompanhado. Foram utilizados testes de qui-quadrado, exato de Fisher, t de Student, Mann-Whitney, Hodges-Lehman e Spearman para as análises estatísticas. Resultados: Foram incluídas 46 crianças; 63% delas em idade préescolar, principalmente acompanhadas por suas mães (80%). A pontuação mYPAS mediana foi de 37,5 (intervalo interquartil, 23,4–51,6) em crianças não acompanhadas e de 55,0 (intervalo interquartil, 27,9–65,0) em crianças acompanhadas, com uma diferença mediana estimada de +11,8 (IC de 95% de 0 a 23,4; p = 0,044). Não houve diferenças significativas nos níveis médios de cortisol salivar. Conclusão: O nível de ansiedade foi maior em crianças acompanhadas. Não houve diferenças nos níveis de cortisol salivar entre os dois grupos. Registro Brasileiro de Ensaios Clínicos (ReBEC):RBR-9wj4qvy. Objetivo anestesia Método 1 anos I III eletiva quiquadrado, quiquadrado qui quadrado, quadrado qui-quadrado Fisher Student MannWhitney, MannWhitney Mann Whitney, Whitney Mann-Whitney HodgesLehman Hodges Lehman estatísticas Resultados 4 63 préescolar 80%. 80 80% . (80%) 375 37 37, intervalo interquartil 23,4–51,6 234516 23 51 6 550 55 55, 27,9–65,0 279650 27 9 65 118 11 8 +11, IC 95 23,4 234 0,044. 0044 0,044 044 0,044) Conclusão grupos ReBECRBR9wj4qvy. ReBECRBR9wj4qvy ReBECRBRwjqvy ReBEC RBR 9wj4qvy. 9wj4qvy wj qvy (ReBEC):RBR-9wj4qvy (80% 3 23,4–51, 23451 2 27,9–65, 27965 +11 23, 004 0,04 04 ReBECRBR wjqvy (80 23,4–51 2345 27,9–65 2796 +1 00 0,0 (8 23,4–5 27,9–6 279 + 0, ( 23,4– 27,9– 27,9 27,

Resumo Objetivo Comparar os sintomas de estresse e as estratégias de enfrentamento de cuidadores de pessoas idosas com Doença de Alzheimer em razão das variáveis sociodemográficas, de saúde e de atuação profissional. Método Pesquisa transversal realizada com 126 cuidadores de pessoas idosas com Doença de Alzheimer. Foi utilizado um questionário para avaliação do perfil sociodemográfico e de saúde do cuidador, a Escala de Estresse Percebido e Escala de Modos de Enfrentamento de Problemas. A análise de dados foi realizada pelos testes t de Student independente, Anova One-way e Post-Hoc de Tukey (p<0,05). Resultados As mulheres utilizam mais a estratégia de enfrentamento de busca de suporte social (p=0,013). Os cuidadores que cuidam de mais de uma pessoa idosa utilizam mais a estratégia de enfrentamento focada no problema (p=0,020). Cuidadores que realizam cuidado formal apresentaram maior estresse (p=0,015) e utilizam menos a estratégia focada no problema (p=0,020). Conclusão O perfil sociodemográfico, de saúde e atuação profissional são fatores intervenientes nas estratégias de enfrentamento de estresse de cuidadores de pessoas idosas com Doença de Alzheimer. sociodemográficas 12 cuidador Problemas independente Oneway One way PostHoc Post Hoc p<0,05. p005 p p<0,05 . 0 05 (p<0,05) p=0,013. p0013 p=0,013 013 (p=0,013) p=0,020. p0020 p=0,020 020 (p=0,020) p=0,015 p0015 015 (p=0,015 1 p00 p<0,0 (p<0,05 p001 p=0,01 01 (p=0,013 p002 p=0,02 02 (p=0,020 (p=0,01 p0 p<0, (p<0,0 p=0,0 (p=0,02 (p=0,0 p<0 (p<0, p=0, (p=0, p< (p<0 p=0 (p=0 (p< p= (p= (p

Abstract Objective To compare stress symptoms and coping strategies among caregivers of older adults with Alzheimer's disease according to sociodemographic, health, and professional variables. Method A cross-sectional study was conducted of 126 caregivers of older adults with Alzheimer's disease. A questionnaire assessing caregiver sociodemographic and health profiles, the Perceived Stress Scale, and the Ways of Coping Scale were applied. Data analysis was performed using the independent t-test, one-way ANOVA, and Tukey's post-hoc test (p<0.05). Results Women made greater use of the coping strategy of seeking social support (p=0.013). Caregivers with more than one care recipient made greater use of problem-focused coping strategies (p=0.020). Caregivers engaged in formal care exhibited higher levels of stress (p=0.015) and made less use of problem-focused coping strategies (p=0.020). Conclusion Sociodemographic, health, and professional profiles are factors mediating the stress coping strategies employed by caregivers of older adults with Alzheimer's disease. Alzheimers Alzheimer s variables crosssectional cross sectional 12 applied ttest, ttest t test, t-test oneway way ANOVA Tukeys Tukey posthoc post hoc p<0.05. p005 p p<0.05 . 0 05 (p<0.05) p=0.013. p0013 p=0.013 013 (p=0.013) problemfocused problem focused p=0.020. p0020 p=0.020 020 (p=0.020) p=0.015 p0015 015 (p=0.015 Sociodemographic 1 p00 p<0.0 (p<0.05 p001 p=0.01 01 (p=0.013 p002 p=0.02 02 (p=0.020 (p=0.01 p0 p<0. (p<0.0 p=0.0 (p=0.02 (p=0.0 p<0 (p<0. p=0. (p=0. p< (p<0 p=0 (p=0 (p< p= (p= (p

Abstract The consumption of coals without coking properties in coal blends for coke production is a challenge, precisely because of their lack of coking properties, and in some cases, high contents of macerals from the inertinite group, which are known to contribute to a reduction in the mechanical strength of coke when present in high size dimensions. With the constant search for the use of non-coking coal in the coal blends, the main objective of the study was to investigate the effect of increase inertinite-rich coal content in multi-component coal blends. To achieve this, selective crushing was performed to obtain 1.5 mm as the critical inertinite size for the coke’s mechanical strength, decreasing the amount of microcracks at the boundary between reactive maceral-derived components (RMDC) and inert maceral-derived components (IMDC). The microstructural characterization for the industrial metallurgical coke was studied using optical microscopy associated with image analysis (ImageJ software). It was established that a 25 % content of inertinite-rich coal addition in the blend caused systematic changes in the coke’s microstructural features, decreasing the mechanical strength. Additionally, the segmentation between RMDC and IMDC was studied to achieve better correlation from the coke’s microstructural parameters, predicting mechanical strength (DI150/15). A new equation was proposed describing both microstructural features from reactive and inert components. challenge cases group dimensions noncoking non inertiniterich rich multicomponent multi component this 15 1 5 1. cokes s maceralderived maceral derived (RMDC IMDC. . (IMDC) ImageJ software. software software) 2 Additionally parameters DI150/15. DI15015 DI DI150/15 DI150 (DI150/15) (IMDC DI1501 DI150/1 DI15 (DI150/15 DI150/ DI1 (DI150/1 (DI150/ (DI150 (DI15 (DI1 (DI

Resumo A viuvez é o “estado de uma pessoa depois da morte de seu cônjuge”. É considerada como um dos eventos de vida não normativos, de mais difícil manejo, particularmente em pessoas idosas, dado o conjunto de demandas emocionais, sociais e comportamentais que acarreta. Este estudo teve o objetivo de identificar as variáveis de saúde e/ou psicossociais relacionadas a viuvez em idosos. Foi realizada uma revisão integrativa da literatura por meio de busca nas bases de dados AgeLine, BVS, PsycoInfo, Pubmed e Scielo. Foram selecionados estudos publicados no idioma inglês, espanhol e português, com idosos de 60 anos ou mais, transversais ou longitudinais que incluíram descrições e detalhamentos sobre o processo de viuvez, como resultado primário e/ou secundário. Sintomas depressivos, suporte social, impacto das experiências prévias da relação marital no estado de viuvez, estado e/ou condição nutricional enquanto auto percepção de saúde, bem-estar psicológico, satisfação com a vida, religiosidade e espiritualidade podem atuar como fatores agravantes ou de proteção na viuvez.

Abstract Widowhood is “the state of a person after the death of his or her spouse”. It is considered one of the most difficult non-normative life events to manage, particularly in the elderly, given the set of emotional, social and behavioral demands that it entails. This study aimed to identify health and/or psychosocial variables related to widowhood in the elderly. An integrative literature review was carried out by searching the AgeLine, BVS, PsycoInfo, Pubmed and Scielo databases. Cross-sectional or longitudinal studies published in English, Spanish and Portuguese, with elderly aged 60 years and over, including descriptions and details about the widowhood process, as a primary and/or secondary result, were selected. Depressive symptoms, social support, impact of previous experiences of the marital relationship on the state of widowhood, nutritional state and/or condition as self-perception of health, psychological well-being, satisfaction with life, religiosity and spirituality can act as aggravating or debilitating factors. widowhood protection.

Resumo Este estudo investigou a ansiedade pré-competitiva e os indicativos de burnout de 12 atletas de uma equipe de futsal de Floresta-PR ao longo de uma competição de curta duração. O Inventário de Ansiedade Competitiva no Esporte (CSAI-2) e o Questionário de Burnout para atletas (QBA) foram utilizados como instrumentos. A análise de dados foi conduzida por meio dos testes de Shapiro-Wilk, Anova de Medidas Repetidas e correlação de Pearson (p < 0,05). Os resultados evidenciaram aumento da ansiedade cognitiva (AC) e da exaustão física e emocional (EFE) ao longo da competição. Verificou-se correlação significativa entre a AC e a EFE nos jogos 2 (r = 0,48) e 3 (r = 0,56), e correlação negativa entre a autoconfiança e o reduzido senso de realização esportiva no jogo 3 (r = -0,47). Concluiu-se que a demanda de jogos pode ser considerada fator interveniente na AC e EFE jovens atletas de futsal.

Abstract This study investigated the pre-competitive anxiety and the indications of burnout of 12 athletes of a futsal team from Floresta-PR during a short competition. As instruments, the Competitive Anxiety in Sports Inventory (CSAI-2) and the Burnout Questionnaire for athletes were used. Data analysis was conducted using the Shapiro-Wilk, Repeated Measurement Anova and Pearson correlation tests (p <0.05). The results showed an increase in cognitive anxiety (AC) and physical and emotional exhaustion (EFE) throughout the competition. There was a significant correlation between AC and EFE in games 2 (r = 0.48) and 3 (r = 0.56), and a negative correlation between self-confidence and the reduced sense of sporting accomplishment in game 3 (r = -0.47). It was concluded that the demand for games can be considered an intervening factor in CA and EFE young futsal athletes.

Abstract This cross-sectional study compared the indicative of Muscle dysmorphia in CrossFit athletes. Participants were 276 male and female CrossFit athletes with an average age of 28.56 ± 8.08 years. A questionnaire was used with questions about age, practice time and frequency of Crossfit practice, as well as the questionnaire of the Adonis complex. Data analysis was conducted through Kolmogorov-Smirnov and Mann-Whitney tests, and Spearman correlation (p<0.05). The adopted significance was p<0.05. The results showed that men obtained higher indicative of muscle dysmorphia in comparison to women as well as competitive athletes showed higher score than recreational athletes (p<0.05). It was found significant (p<0.05) and negative correlation of the indicative of muscle dysmorphia with training frequency (Rho=-0.51) among recreational athletes, and positive correlation (Rho=0.19) among competitors. It is concluded that being male and having a competitive profile are actors in the presence of Muscle dysmorphia in CrossFit athletes. crosssectional cross sectional 27 2856 28 56 28.5 808 8 08 8.0 years complex KolmogorovSmirnov Kolmogorov Smirnov MannWhitney Mann Whitney tests p005 p p<0.05 . 0 05 (p<0.05 Rho=0.51 Rho051 Rho Rho= 0.51 51 (Rho=-0.51 Rho=0.19 Rho019 19 (Rho=0.19 competitors 2 285 5 28. 80 8. p00 p<0.0 (p<0.0 Rho=0.5 Rho05 051 0.5 (Rho=-0.5 Rho=0.1 Rho01 1 (Rho=0.1 p0 p<0. (p<0. Rho=0. Rho0 0. (Rho=-0. (Rho=0. p<0 (p<0 Rho=0 (Rho=-0 (Rho=0 p< (p< (Rho=- (Rho= (p (Rho

Resumo Este estudo transversal comparou o indicativo de dismorfia muscular em praticantes de crossfit. Participaram da pesquisa 276 praticantes de CrossFit, de ambos os sexos, com idade média de 28,56 ± 8,08 anos. Utilizou-se um questionário com perguntas sobre idade, tempo e frequência da prática do Crossfit, além do questionário do complexo Adonis. A análise de dados foi conduzida por meio dos testes de Kolmogorov-Smirnov e Mann-Whitney, e a correlação de Spearman (p<0,05). Os resultados evidenciaram que os homens apresentaram maior indicativo de dismorfia muscular em quando comparados às mulheres assim como os competidores apresentaram escores superiores do que os praticantes recreacionais (p<0,05). Verificou-se correlação significativa (p<0,05) e negativa do indicativo de dismorfia muscular com a frequência de treinamento (Rho=-0.51) entre os praticantes recreacionais, e correlação positiva (Rho=0.19) entre os competidores. Concluiu-se que ser homem e ter um perfil competitivo são fatores que podem desencadear a dismorfia muscular em praticantes de crossfit. crossfit 27 CrossFit sexos 2856 28 56 28,5 808 8 08 8,0 anos Utilizouse Utilizou se Crossfit Adonis KolmogorovSmirnov Kolmogorov Smirnov MannWhitney, MannWhitney Mann Whitney, Whitney Mann-Whitney p<0,05. p005 p p<0,05 . 0 05 Verificouse Verificou (p<0,05 Rho=0.51 Rho051 Rho Rho= 0.51 51 (Rho=-0.51 Rho=0.19 Rho019 19 (Rho=0.19 Concluiuse Concluiu 2 285 5 28, 80 8, p00 p<0,0 (p<0,0 Rho=0.5 Rho05 051 0.5 (Rho=-0.5 Rho=0.1 Rho01 1 (Rho=0.1 p0 p<0, (p<0, Rho=0. Rho0 0. (Rho=-0. (Rho=0. p<0 (p<0 Rho=0 (Rho=-0 (Rho=0 p< (p< (Rho=- (Rho= (p (Rho

Abstract We present here the treatment of Clusiaceae for the flora of the state of Espírito Santo, Brazil. Sixteen species are recognized: seven species of Clusia, four species of Tovomita, two species of Garcinia, two species of Tovomitopsis, and one species of Symphonia. A brief history of the Clusiaceae in Espírito Santo is presented, as well as descriptions, illustrations, and taxonomic commentary on the species. Brazil recognized Clusia Tovomita Garcinia Tovomitopsis Symphonia presented descriptions illustrations

Resumo Apresentamos aqui o tratamento de Clusiaceae para a flora do estado do Espírito Santo, Brasil. São reconhecidas dezesseis espécies: sete espécies de Clusia, quatro espécies de Tovomita, duas espécies de Garcinia, duas espécies de Tovomitopsis e uma espécie de Symphonia. É apresentado um breve histórico das Clusiaceae do Espírito Santo, além de descrições, ilustrações e comentários taxonômicos sobre as espécies. Santo Brasil Clusia Tovomita Garcinia Symphonia descrições

Abstract Since bull fertility prediction remains challenging, the identification of potential fertility markers is important considering the economic benefits to the livestock industry. The main goal of this study was to determine the Na/K-ATPase activity and expression in thawed sperm of high (HF)- and low-fertility (LF) Angus bulls. Samples from three different batches/bulls with HF (n = 4) and LF (n = 4) were used. The Na/K-ATPase activity was determined after thawing, whereas sperm kinematics, membrane integrity, and expression of Na/K-ATPase on sperm surface were evaluated immediately post-thaw and after 120 minutes of incubation. Within the same incubation time, there was no difference on sperm membrane integrity, kinematics, and the expression of Na/K-ATPase on the sperm surface between HF and LF bulls. Kinematic parameters of LIN and VCL were not influenced by incubation time in samples from HF and LF, respectively. A tendency (P = 0.06) of higher Na/K-ATPase enzymatic activity for sperm of HF bulls compared to LF bulls was observed (0.49 ± 0.07 and 0.32 ± 0.06, respectively). In conclusion, Na/K-ATPase activity and expression in thawed sperm from Angus bulls are not related to the fertility index after fixed-time artificial insemination. However, sperm kinematics related to hyperactivation might indicate higher sperm cryotolerance for HF bulls. challenging industry Na/KATPase NaKATPase Na/K ATPase Na K (HF) lowfertility low (LF batchesbulls batches n 4 used thawing integrity postthaw post thaw 12 respectively P 0.06 006 0 06 0.49 049 49 (0.4 007 07 0.0 032 32 0.3 . respectively) conclusion fixedtime fixed insemination However KATPase NaK (HF 1 00 0.4 04 (0. 0. 03 3 (0 (

Resumo Introdução o estado nutricional e seus fatores associados assume uma importante função na saúde dos idosos. Objetivo Identificar os fatores associados ao estado nutricional dos idosos da atenção primária à saúde da cidade de Maringá, Paraná. Método Estudo transversal, do qual fizeram parte 654 idosos usuários das Unidades Básicas de Saúde. Como instrumentos foram utilizados um questionário sociodemográfico, o Mini Nutritional Assessment, o Questionário Internacional de Atividade Física. A análise de dados foi conduzida por meio dos testes de Kolmogorov-Smirnov, “U” de Mann-Whitney, qui-quadrado e regressão logística binária (p < 0,05). Resultados Os resultados evidenciaram maior proporção de idosos com percepção de saúde boa, que tomam menos medicamentos, não tiveram quedas e com nível muito ativo/ativo com o estado nutricional normal. Verificou-se que idosos com estado nutricional normal apresentaram maior circunferência de panturrilha (p = 0,01). Destaca-se que idosos com melhor percepção de saúde, maior nível de atividade física e circunferência de panturrilha, nível mais alto de escolaridade e renda mensal de 2,1 a 3 salários mínimos têm mais chances de apresentar estado nutricional normal. Conclusão Concluiu-se que o estado nutricional normal em idosos está associado ao maior nível de escolaridade, maior poder aquisitivo, melhor percepção de saúde e à prática regular de atividade física.

Abstract Background nutritional status and its associated factors play an important role in the health of the elderly. Objective To identify the factors associated with the nutritional status of the elderly in primary health care at the city of Maringá, Paraná. Method A cross-sectional study was carried out with 654 Basic Health Units’ elderly patients. The research instruments included a sociodemographic questionnaire, the Mini Nutritional Assessment, and the International Physical Activity Questionnaire. Data analysis was performed using the Kolmogorov-Smirnov, Mann-Whitney U, Chi-square and Binary Logistic Regression tests (p <0.05). Results The results showed a higher proportion of elderly patients with good health perception, who took less medication, had no falls, and had a high/average activity level with normal nutritional status. It was verified that the elderly with normal nutritional status presented a higher calf circumference (p = 0.01). It should be emphasized that older people with better health perception, higher level of physical activity and calf circumference, higher level of education and monthly income of 2.1 to 3 minimum wages are more likely to present normal nutritional status. Conclusion It was concluded that a normal nutritional status in the elderly population is associated with a higher educational level, greater purchasing power, better health perception and regular practice of physical activity.

Resumo Introdução a interação complexa entre fatores sociais, psicológicos e biológicos, que resultam na depressão, poderá acelerar a diminuição da capacidade funcional e, consequentemente, a qualidade de vida do idoso. Objetivo Esta pesquisa teve como objetivo investigar os fatores associados aos indicativos de sintomas depressivos de idosos da atenção básica à saúde de um município do noroeste paranaense. Método Estudo epidemiológico, de corte transversal e base populacional realizado em 12 Unidades Básicas de Saúde (UBS), com 654 homens e mulheres idosos. Foi utilizado um instrumento para caracterização do perfil sociodemográfico dos participantes, assim como o instrumento Geriatric Depression Scale (GDS), versão curta. Os dados foram analisados pelo teste de Qui-quadrado e da Regressão de Poisson (p<0,05). Resultados Os resultados evidenciaram que parece existir uma associação dos idosos com boa percepção de saúde (p=0,001), que não ingerem medicamentos (p=0,001), que não sofreram quedas nos últimos seis meses (p=0,011) e que não apresentaram comorbidades (p=0,001), com a ausência de sintomas depressivos. Os idosos com autopercepção de saúde regular (RP = 1,733; 95%IC = 1280-2,347) e ruim (RP = 2,222; 95%IC = 1,525-3,237) demonstraram maior razão de prevalência de presença de indicativo de depressão. Conclusão Conclui-se que os idosos com pior autopercepção de saúde demonstraram maior razão de prevalência de apresentar indicativos de depressão.

Abstract Background the complex interaction between social, psychological and biological factors, which result in depression, may accelerate the decrease in functional capacity and, consequently, the quality of life of the older adults. Objective This research aimed to investigate the factors associated with suggestive symptoms of depression in older adults of primary health care in a municipality in northwest Paraná. Method Epidemiological, cross-sectional and population-based study was carried out in 12 basic health units, with 654 older adult men and women. The Geriatric Depression Scale (GDS), short version, as well an instrument to characterize the participants sociodemographic profile. Data were analyzed using Chi-square test and Poisson regression (p <0.05). Results Results showed that there seems to be an association of the older adult with good health perception (p = 0.001), when they did not take medication (p = 0.001), have not suffered falls in the last six months (p = 0.011) and have not presented comorbidities (p = 0.001) in the absence of depressive symptoms. Older adult with self-perceived regular health (PR = 1.733; 95% CI = 1280-2.347) and poor health (PR = 2.222; 95% CI = 1.525-3.237) showed a higher prevalence ratio for the presence of depression. Conclusion Older adult with worse self-perceived health showed a higher prevalence ratio of presenting suggestive symptoms of depression.

CONSTRUCTION, OPTIMIZATION AND MOLECULAR DOCKING OF BIOACTIVE SUBSTANCES IN BIOMACROMOLECULES: A PRACTICAL TUTORIAL. In the last two decades, increasing advances in molecular biology and instrumental analysis for solving macromolecular structures have amplified the applicability of cheminformatics in drug discovery. In particular, molecular docking, an in silico structural-based method, has prospered as an efficient tool for understanding molecular interactions that drives formation of stable receptor-ligand systems. Brazil affords many research groups working hard on this subject; however, there is a lack of material in the Portuguese language, teaching how to apply molecular docking methodologies. Herein, we define and discuss a simple and low-cost workflow for molecular docking evaluation, comprising software installation (supplemental material) and how to use them for construction of small-molecules, perform docking calculations, analysis of the results and the preparation of quality figures. Given that, we have used free software and web-servers, as well as in silico tools supported by national funding agencies.

Alzheimer’s disease has about 9.9 million new cases annually, according to World Health Organization. Due to the increasing incidence of people affected by AD and the absence of an efficient treatment or cure so far, many researchers worldwide are involved in the search for novel promising drugs candidates, through several targets, exploring distinct structural patterns. In this context, we describe herein, focusing the last 20 years, strategic examples of substances with targets related to Alzheimer’s disease derived from natural products, such as alkaloids, chalcones, coumarins and flavonoids, in addition to carbamates and heterocyclic compounds. Furthermore, some cases are discussed where computational chemistry is used to better understand protein-ligand interactions.

Resumo Introdução o estado nutricional e seus fatores associados assume uma importante função na saúde dos idosos. Objetivo Identificar os fatores associados ao estado nutricional dos idosos da atenção primária à saúde da cidade de Maringá, Paraná. Método Estudo transversal, do qual fizeram parte 654 idosos usuários das Unidades Básicas de Saúde. Como instrumentos foram utilizados um questionário sociodemográfico, o Mini Nutritional Assessment, o Questionário Internacional de Atividade Física. A análise de dados foi conduzida por meio dos testes de Kolmogorov-Smirnov, “U” de Mann-Whitney, qui-quadrado e regressão logística binária (p < 0,05). Resultados Os resultados evidenciaram maior proporção de idosos com percepção de saúde boa, que tomam menos medicamentos, não tiveram quedas e com nível muito ativo/ativo com o estado nutricional normal. Verificou-se que idosos com estado nutricional normal apresentaram maior circunferência de panturrilha (p = 0,01). Destaca-se que idosos com melhor percepção de saúde, maior nível de atividade física e circunferência de panturrilha, nível mais alto de escolaridade e renda mensal de 2,1 a 3 salários mínimos têm mais chances de apresentar estado nutricional normal. Conclusão Concluiu-se que o estado nutricional normal em idosos está associado ao maior nível de escolaridade, maior poder aquisitivo, melhor percepção de saúde e à prática regular de atividade física.

Abstract Background nutritional status and its associated factors play an important role in the health of the elderly. Objective To identify the factors associated with the nutritional status of the elderly in primary health care at the city of Maringá, Paraná. Method A cross-sectional study was carried out with 654 Basic Health Units’ elderly patients. The research instruments included a sociodemographic questionnaire, the Mini Nutritional Assessment, and the International Physical Activity Questionnaire. Data analysis was performed using the Kolmogorov-Smirnov, Mann-Whitney U, Chi-square and Binary Logistic Regression tests (p <0.05). Results The results showed a higher proportion of elderly patients with good health perception, who took less medication, had no falls, and had a high/average activity level with normal nutritional status. It was verified that the elderly with normal nutritional status presented a higher calf circumference (p = 0.01). It should be emphasized that older people with better health perception, higher level of physical activity and calf circumference, higher level of education and monthly income of 2.1 to 3 minimum wages are more likely to present normal nutritional status. Conclusion It was concluded that a normal nutritional status in the elderly population is associated with a higher educational level, greater purchasing power, better health perception and regular practice of physical activity.

Abstract Aims: The present study investigated the quality of coach-athlete relationship (CAR) and coping as associated factors stress, anxiety, burnout, and depression symptoms of soccer players in the transition to professional. Methods: Twenty-three athletes from four teams of the 2019 under-20 Bahia State Championship participated in the study. The instruments used were the Coach-Athlete Relationship Questionnaire, the Coping Strategic Athletic Inventory, the Daily Analysis of Life Demands in Athletes, the Competitive State Anxiety Inventory-2R, the Burnout Questionnaire for Athletes, and the Major Depression Inventory. Data analysis was conducted using Generalized Estimation Equations, Pearson’s Correlation, and Linear Multiple Regression (p < 0.05). Results: Our findings show that from the beginning to the end of the season, CAR and coping strategies were predictors of psychic occurrences. For CAR, the symptoms of anxiety associated with self-confidence and stress symptoms were predicted by Proximity and Complementarity, respectively. As for coping strategies, only the symptoms of stress were predicted by the dimension of facing adversity. Conclusion: From the beginning to the end of the season, the magnitude of the predicting factors over some psychopathologies is enhanced in youth soccer players going through a career transition stage.