ABSTRACT Collaborative attitudes provide comprehensive, shared care, centered on the user, family and community, overcoming fragmented care. The present study aimed to identify collaborative attitudes and associated factors of professionals who work in the Family Health Strategy teams in the Metropolitan Region of São Luís, Maranhão. This was a cross-sectional, analytical and quantitative study. The final sample consisted of 311 participants. Data collection took place through an electronic form and application of the Jefferson Scale of Attitudes Related to Interprofessional Collaboration. Statistical analyzes were performed using the Chi-Square test, considering p < 0.05. The results demonstrated that the professionals presented moderate collaborative attitudes. It was found that the type of specialization (p = 0.008) and working time in the Family Health Strategy teams (p = 0.02) were associated with more collaborative attitudes, reinforcing the importance of teamwork and qualified labor for the development of positive attitudes for collaboration in health.

RESUMO As atitudes colaborativas propiciam o cuidado integral, compartilhado e centralizado no usuário, na família e na comunidade, superando a assistência fragmentada. O presente estudo objetivou identificar atitudes colaborativas e fatores associados dos profissionais que atuam nas equipes da Estratégia Saúde da Família da Região Metropolitana de São Luís, Maranhão. Trata-se de um estudo transversal, analítico e quantitativo. A amostra foi constituída por 311 participantes. A coleta de dados ocorreu por meio de formulário eletrônico e aplicação da Escala Jefferson de Atitudes Relacionadas à Colaboração Interprofissional. As análises estatísticas foram realizadas pelo teste Qui-Quadrado, considerando p < 0,05. Os resultados demonstraram que os profissionais apresentaram atitudes colaborativas moderadas. Verificou-se, ainda, que o tipo de especialização (p = 0,008) e tempo de trabalho nas equipes da Estratégia Saúde da Família (p = 0,02) associaram-se a atitudes mais colaborativas, reforçando a importância do trabalho em equipe e da mão de obra qualificada para o desenvolvimento de atitudes positivas para colaboração em saúde.

RESUMO As atitudes colaborativas propiciam o cuidado integral, compartilhado e centralizado no usuário, na família e na comunidade, superando a assistência fragmentada. O presente estudo objetivou identificar atitudes colaborativas e fatores associados dos profissionais que atuam nas equipes da Estratégia Saúde da Família da Região Metropolitana de São Luís, Maranhão. Trata-se de um estudo transversal, analítico e quantitativo. A amostra foi constituída por 311 participantes. A coleta de dados ocorreu por meio de formulário eletrônico e aplicação da Escala Jefferson de Atitudes Relacionadas à Colaboração Interprofissional. As análises estatísticas foram realizadas pelo teste Qui-Quadrado, considerando p < 0,05. Os resultados demonstraram que os profissionais apresentaram atitudes colaborativas moderadas. Verificou-se, ainda, que o tipo de especialização (p = 0,008) e tempo de trabalho nas equipes da Estratégia Saúde da Família (p = 0,02) associaram-se a atitudes mais colaborativas, reforçando a importância do trabalho em equipe e da mão de obra qualificada para o desenvolvimento de atitudes positivas para colaboração em saúde. integral usuário comunidade fragmentada Luís Maranhão Tratase Trata se transversal quantitativo 31 participantes Interprofissional QuiQuadrado, QuiQuadrado Qui Quadrado, Quadrado Qui-Quadrado 005 0 05 0,05 moderadas Verificouse, Verificouse Verificou se, Verificou-se ainda 0,008 0008 008 0,02 002 02 associaramse associaram saúde 3 00 0,0 0,00 000 0,

ABSTRACT Collaborative attitudes provide comprehensive, shared care, centered on the user, family and community, overcoming fragmented care. The present study aimed to identify collaborative attitudes and associated factors of professionals who work in the Family Health Strategy teams in the Metropolitan Region of São Luís, Maranhão. This was a cross-sectional, analytical and quantitative study. The final sample consisted of 311 participants. Data collection took place through an electronic form and application of the Jefferson Scale of Attitudes Related to Interprofessional Collaboration. Statistical analyzes were performed using the Chi-Square test, considering p < 0.05. The results demonstrated that the professionals presented moderate collaborative attitudes. It was found that the type of specialization (p = 0.008) and working time in the Family Health Strategy teams (p = 0.02) were associated with more collaborative attitudes, reinforcing the importance of teamwork and qualified labor for the development of positive attitudes for collaboration in health. comprehensive care user community Luís Maranhão crosssectional, crosssectional cross sectional, sectional cross-sectional 31 participants Collaboration ChiSquare Chi Square test 005 0 05 0.05 0.008 0008 008 0.02 002 02 health 3 00 0.0 0.00 000 0.

ABSTRACT Women living with human immunodeficiency virus are at an increased risk of developing cancers related to human papillomavirus (HPV). Thus, it is important to combine clinical assessments, serological screening, and HPV data for planning prevention policies. This study aimed to identify HPV and its specific types in the cervical, anal, and oral mucosa of HIV-seropositive women, associating it with viral load and lymphocyte count. Sociodemographic characteristics, health data (CD4+ and CD8+ T cell counts and viral load), and biological samples (cervical, anal, and oral) were collected from 86 HIV-positive women undergoing antiretroviral therapy. Data were classified according to the presence or absence of HPV-DNA, HPV-DNA presence at one or more anatomic sites, and level of oncogenic risk, considering low- and high-risk oncogenic HPV-DNA groups. The presence of HPV in the cervicovaginal site was 65.9%, 63.8% in anal canal, and 4.2% in oral mucosa. A viral load ≥75 HIV copies/mL was associated with the presence of HPV-DNA. There was an association between viral load and the low-risk HPV or high-risk HPV groups. We found a high prevalence of HPV infection in HIV-seropositive women, particularly in the cervical and anal mucosa, with viral load ≥75 HIV copies/mL being associated with HPV-DNA presence. HPV. . (HPV) Thus assessments screening policies HIVseropositive seropositive count characteristics CD4+ CD4 CD (CD4 CD8 load, , load) (cervical 8 HIVpositive positive therapy HPVDNA, HPVDNA DNA, DNA sites low highrisk groups 659 65 9 65.9% 638 63 63.8 canal 42 4 2 4.2 75 ≥7 copiesmL copies mL HPVDNA. DNA. lowrisk (HPV (CD 6 65.9 63. 4. 7 ≥ 65.

ABSTRACT This study aims to investigate the possible association between neutrophil/lymphocyte and platelet/lymphocyte ratio in women with HIV, undergoing antiretroviral treatment, with HPV coinfection. This is a cross-sectional study with HIV positive women; their biological samples were collected for laboratory tests (complete blood count) and oncotic cytology for detection of HPV DNA, by PCR-Nested (PGMY and GP primers). Viral load and CD4 and CD8 T-cells counts were obtained from medical records. The data were analyzed, comparing the two groups: those with coinfection and those without it. From 82 HIV seropositive women, 50% exhibited HPV coinfection and 12.2% of coinfected patients had cervical cell alterations. Quantification of viral load, CD4 and CD8 T-cells count, CD4 / CD8 ratio and neutrophil/lymphocyte (NLR) and platelet/lymphocyte (PLR) ratio presented significant differences between groups (p<0.05). The predicting power of NLR and PLR in differentiating HIV/HPV coinfection which demonstrated differences between groups (AUC of 0.882 and 0.776 for NLR and PLR, respectively). There is a relation between the neutrophil/lymphocyte and platelet/lymphocyte ratio with HIV/HPV coinfection in women undergoing antiretroviral treatment, suggesting a state of greater and persistent systemic inflammation, reflecting as a biomarker for screening and monitoring these patients. neutrophillymphocyte neutrophil lymphocyte plateletlymphocyte platelet treatment crosssectional cross sectional complete count DNA PCRNested PCR Nested PGMY primers. primers . primers) CD Tcells T cells records analyzed it 8 50 122 12 2 12.2 alterations (NLR (PLR p<0.05. p005 p p<0.05 0 05 (p<0.05) HIVHPV AUC 0882 882 0.88 0776 776 0.77 respectively. respectively respectively) inflammation 5 1 12. p00 p<0.0 (p<0.05 088 88 0.8 077 77 0.7 p0 p<0. (p<0.0 08 0. 07 7 p<0 (p<0. p< (p<0 (p< (p

ABSTRACT Objective: MicroRNAs are small non-coding RNAs that are abundantly expressed in various biofluids, making them promising candidates for cancer biomarkers. This review aims to present current evidence on the use of miRNA as biomarkers for the non-invasive diagnosis of bladder cancer. Methods: A systematic literature review, using the Medline database, was performed in July 2022 according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. All articles were required to satisfy the risk-of-bias assessment using the Joanna Briggs Institute Critical Assessment Tools. Data were collected based on miRNA expression, sample type, expression profiles, and accuracy. Results: The initial search retrieved 437 studies, 21 of which were included in the final analysis. Most studies on miRNA expression in human fluids used urine samples for analysis. Conclusion: There is a trend to cluster the expressed miRNAs to build diagnostic panels or use them in association with other diagnostic methods to achieve reasonable accuracy. Prospero database registration: (https://www.crd.york.ac.uk/prospero/) under ID CRD42022351686. Objective noncoding non coding biofluids noninvasive invasive Methods 202 MetaAnalyses Meta Analyses guidelines riskofbias risk bias Tools type profiles accuracy Results 43 2 analysis Conclusion registration https//www.crd.york.ac.uk/prospero/ httpswwwcrdyorkacukprospero https //www.crd.york.ac.uk/prospero/ www crd york ac uk prospero (https://www.crd.york.ac.uk/prospero/ CRD42022351686 CRD 20 4 https//www.crd.york.ac.uk/prospero wwwcrdyorkacukprospero //www.crd.york.ac.uk/prospero (https://www.crd.york.ac.uk/prospero CRD4202235168 CRD420223516 CRD42022351 CRD4202235 CRD420223 CRD42022 CRD4202 CRD420 CRD42 CRD4

INTRODUÇÃO: Estudos têm demonstrado que a obesidade tem sido considerada um fator de risco para o desenvolvimento de doença periodontal e dos eventos cardiovasculares. OBJETIVO: Avaliar o risco às doenças cardiovasculares (DCVs) em pacientes obesos com e sem doença periodontal. MATERIAL E MÉTODO: Participaram do estudo 100 pacientes, os quais foram divididos em quatro grupos: Grupo O - obeso sem periodontite crônica (n=25), Grupo OP - obeso com periodontite crônica (n=25), Grupo NO - não obeso sem periodontite crônica (n=25), Grupo NOP - não obeso com periodontite crônica (n=25). Foram avaliados dados demográficos e laboratoriais (colesterol total, lipoproteína de alta densidade - HDL e de baixa densidade - LDL, triglicérides e glicemia), dados antropométricos (índice de massa corporal - IMC; circunferência abdominal - CA; gordura corporal - GC), pressão arterial e parâmetros periodontais (sangramento à sondagem - SS, profundidade de sondagem - PS e nível de inserção clínico - NIC). O risco cardiovascular foi obtido baseado no escore de PROCAM. A correlação entre obesidade, doença periodontal e risco às DCVs foi verificado pelo teste de Spearman (α =0,05). RESULTADO: O grupo OP apresentou estatisticamente maior quantidade de sítios com PS > 7 mm (11,2±2,03) quando comparado aos outros grupos (p<0,05). Os níveis de triglicérides, colesterol total e LDL foram estatisticamente maiores no grupo OP. O risco às DCVs foi estatisticamente maior no grupo OP (28,1±3,3) quando comparado ao grupo O (16,5±3,5), grupo NOP (12,8±3,9) e grupo NO (7,7±0,9). A obesidade e a doença periodontal estão diretamente relacionadas com um aumento moderado do risco DCVs (r=0,53; p<0,0001 e r=0,62; p<0,0001, respectivamente). CONCLUSÃO: Conclui-se que a obesidade e a doença periodontal aumentam o risco à eventos cardiovasculares.

INTRODUCTION: Studies have shown that obesity is considered a risk factor for the development of periodontal disease and cardiovascular events. OBJECTIVE: The objective was to evaluate the risk for cardiovascular diseases (CVDs) in obese patients with and without periodontal. MATERIAL AND METHOD: One hundred patients were divided into four groups: Group O - obese without chronic periodontitis (n=25); Group OP - obese with chronic periodontitis (n=25); Group NO - non-obese without chronic periodontitis (n=25); and Group NOP - non-obese with chronic periodontitis (n=25). Demographic and laboratorial data (total cholesterol, high-density lipoprotein - HDL and low-density lipoprotein - LDL, triglycerides, and glucose); anthropometric measurements (body mass index - BMI; waist circumference - WC; body fat - BF); blood pressure; and periodontal parameters (bleeding on probing - BOP, periodontal probing depth - PPD, and the clinical attachment level - CAL) were evaluated. Cardiovascular risk was obtained according to the PROCAM's score. The correlation between obesity, periodontal disease and risk for CVD was verified by Spearman's test (α = 0.05). RESULT: The group OP showed a statistically higher rate of PPD > 7 mm (11.2 ± 2.03) when compared with other groups, as well as higher levels of triglycerides, total cholesterol, and LDL (p<0.05). The risk for CVD was statistically higher in the group OP (28.1 ± 3.3) when compared with group O (16.5 ± 3.5), group NOP (12.8 ± 3.9), and group NO (7.7 ± 0.9). Obesity and periodontal disease are directly related to a moderate increase in CVD risk (r = 0.53, p <0.0001 and r = 0.62, p <0.0001, respectively). CONCLUSION: It was concluded that obesity and periodontal disease increases the risk to cardiovascular events.