Objective: To determine whether the stigma associated with schizophrenia has also been directed towards people at ultra-high risk of psychosis (UHR), the present review aimed to synthetize the literature to update and extend our understanding of this topic. Methods: A systematic review compliant with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines was conducted in the PubMed, EMBASE, Cochrane, and Web of Science databases for articles published until April 30, 2023, using a combination of search terms describing at-risk mental states for psychosis, stigma, and related terms. Results: Thirty-eight studies were included. Twenty-nine addressed individuals with UHR directly, and nine conducted interviews with non-patients regarding UHR. A total of 2,560 individuals with UHR were assessed, with a mean sample size of 88.3 participants. Most were quantitative non-randomized/observational studies with young adults, 71.4% used the Structured Interview for Psychosis-Risk Syndromes, and 25% used the Comprehensive Assessment of At-Risk Mental States. Overall, the studies mainly involved patients of UHR clinics from high-income Western countries. The described stigma can be grouped into five forms, the most frequently explored of which was perceived public stigma, followed by public stigma, self-stigma/internalized stigma, stigma stress, and associative stigma. Quantitative nonrandomized studies predominated: only one was an interventional study. Most of the results confirmed the presence of stigma toward individuals with UHR. Conclusion: Despite the knowledge gaps and scarcity of research on UHR-related stigma, the results suggest that stigma toward people with UHR exists and that it is already present at early stages of psychosis. Registration number: PROSPERO CRD42022332037. Objective ultrahigh ultra high UHR, , (UHR) topic Methods MetaAnalyses Meta Analyses PubMed EMBASE Cochrane 30 2023 atrisk Results Thirtyeight Thirty eight included Twentynine Twenty directly nonpatients non 2560 2 560 2,56 assessed 883 88 3 88. participants nonrandomized/observational nonrandomizedobservational randomized/observational randomized observational adults 714 71 4 71.4 PsychosisRisk Psychosis Risk Syndromes 25 AtRisk At States Overall highincome income countries forms selfstigma/internalized selfstigmainternalized self stigma/internalized internalized stress predominated study Conclusion UHRrelated number CRD42022332037 CRD (UHR 202 256 56 2,5 8 randomizedobservational 7 71. selfstigma stigmainternalized CRD4202233203 20 5 2, CRD420223320 CRD42022332 CRD4202233 CRD420223 CRD42022 CRD4202 CRD420 CRD42 CRD4