A series of biologically active N-acylamino amides were synthesized from readily available amino acids and common fatty acids from oil seeds, including the pharmacophoric group in the family of herbicides propanil, linuron, and diuron. The esterification followed by N-acylation with long-chain fatty acids was carried out with O-(benzotriazole-1-yl)-N,N,N’,N’-tetramethyluronium tetrafluoroborate (TBTU) as activating agent. The N-acylamino esters were synthesized and isolated in good yields (70-98%), which after the hydrolysis step, provided the N-acylamino acids. Finally, new N-acylamino amides were obtained from the reaction with 3,4-dichloroaniline in the presence of TBTU and N,N-diisopropylethylamine (DIPEA), in yields between 24-83%. Bioassays were conducted against arthropod strawberry pests Chaetosiphon fragaefolii, Duponchelia fovealis, and Drosophila suzukii, without any registered compound for use in strawberry crops in Brazil. The bioassay studies showed promising results, with mortality percentages ranging from 20-80%, and the best relative mortality by N-oleyl glycinamide, suggesting a possible fatty chain-amino acid synergistic bioactivity. Overall, this study provides an efficient and sustainable method for synthesizing biologically active N-acylamino amides from abundant natural sources, with potential applications in the development of ecofriendly agrochemicals. Nacylamino N acylamino seeds propanil linuron diuron Nacylation acylation longchain long chain Obenzotriazole1ylN,N,N,Ntetramethyluronium Obenzotriazole1ylNNNNtetramethyluronium ObenzotriazoleylNNNNtetramethyluronium O benzotriazole 1 yl N,N,N ,N tetramethyluronium (TBTU agent 7098%, 7098 70 98% , 98 (70-98%) step Finally 3,4dichloroaniline 34dichloroaniline dichloroaniline 3,4 3 4 N,Ndiisopropylethylamine NNdiisopropylethylamine N,N diisopropylethylamine DIPEA, DIPEA (DIPEA) 2483%. 2483 24 83%. 83 24-83% fragaefolii fovealis suzukii Brazil results 2080%, 2080 20 80%, 80 20-80% Noleyl oleyl glycinamide chainamino bioactivity Overall sources agrochemicals Obenzotriazole1ylN Ntetramethyluronium Obenzotriazole ylN ylNNNNtetramethyluronium NNN 7098% 709 7 9 (70-98% 4dichloroaniline 34 3, Ndiisopropylethylamine NN (DIPEA 2483% 248 2 83% 8 24-83 2080% 208 80% 20-80 ObenzotriazoleylN (70-98 24-8 20-8 (70-9 24- 20- (70- (70 (7 (

ABSTRACT Purpose Present the step of evidence of validity based on the responses to procedures of the MMBGR Protocol Infants and Preschoolers: Instructional and Orofacial Myofunctional Clinical History. Methods Study developed according to phonoaudiologic tests validations recommendations. Validity analysis performed based on the process of instrument response. Ten speech therapists, that work on phonoaudiology clinic and/or orofacial myofunctional research on the population with age between 6 to 71 months, participated and applied the MMBGR Protocol Infants and Preschoolers: Instructional and Orofacial Myofunctional Clinical History with those responsible for the children. The speech therapists appraised the instrument applicability via Google®️ electronic forms, containing dichotic and/or multiple-choice questions, and likert scale with space to justify negative answers. The data was tabulated on Microsoft Excel 2016®️ worksheets and analyzed by the content validity index (CVI). The software R Core Team 2022 (Versão 4.2.2) was used. Results All items from the MMBGR Protocol Infants and Preschoolers: Instructional and Orofacial Myofunctional Clinical History were valid when applied to real contexts. Orofacial Myofunctional Clinic history protocol- IVC 100% in terms of ease of application and filling and usage in professional practice; IVC 90% in terms of usefulness for phonoaudiology clinic. The instructional got IVC 80% in terms of clinic usefulness and 70% regarding to the prior reading necessity to fill the MMBGR Protocol Infants and Preschoolers. Conclusion The Instrucional and Orofacial Myofunctional Clinical History, in the MMBGR Protocol Infants and Preschoolers had its validity proven based on the processes of responses to the usage on phonoaudiology clinic. recommendations response andor or 7 months children Google Google® forms multiplechoice multiple choice questions answers 2016 2016® CVI. CVI . (CVI) 202 Versão 4.2.2 422 4 2 used contexts protocol 100 practice 90 80 70 201 (CVI 20 4.2. 42 10 9 8 4.2 1 4.

RESUMO Objetivo Apresentar a etapa da evidência de validade baseada nos processos de respostas do Protocolo MMBGR Lactentes e Pré-escolares: Instrutivo e História Clínica Miofuncional Orofacial. Método Estudo desenvolvido conforme recomendações para validação de testes em Fonoaudiologia. Realizada análise da validade baseada nos processos de resposta do instrumento. Participaram dez fonoaudiólogos, que atuam em clínica e/ou pesquisa da Motricidade Orofacial com população entre 6 e 71 meses de idade, que aplicaram o Protocolo MMBGR Lactentes e Pré-escolares: Instrutivo e História Clínica Miofuncional Orofacial junto aos responsáveis pelas crianças. Os fonoaudiólogos emitiram apreciação sobre aplicabilidade do instrumento via formulário eletrônico do Google®, contendo questões dicóticas e/ou múltipla escolha, e escala likert com espaço para justificar respostas negativas. Os dados foram tabulados em planilhas Microsoft Excel 2016® e analisados pelo Índice de Validade de Conteúdo (IVC). Utilizado software R Core Team 2022 (Versão 4.2.2). Resultados Todos os itens do Protocolo MMBGR Lactentes e Pré-escolares: Instrutivo e História Clínica Miofuncional Orofacial foram válidos na aplicação em contexto real. Protocolo de História Clínica Miofuncional Orofacial - IVC 100% quanto à facilidade de aplicação e preenchimento, e uso na prática profissional; e IVC 90% quanto à utilidade para clínica fonoaudiológica. O Instrutivo obteve IVC 80% quanto à utilidade e 70% referente à necessidade de leitura prévia para preenchimento do Protocolo MMBGR Lactentes e Pré-escolares. Conclusão O Instrutivo e o Protocolo História Clínica Miofuncional Orofacial, pertencentes ao protocolo MMBGR – Lactentes e Pré-escolares tiveram comprovada validade baseada nos processos de resposta, para uso na clínica fonoaudiológica. Préescolares Pré escolares Fonoaudiologia eou ou 7 idade crianças Google Google® escolha negativas 2016 IVC. . (IVC) 202 Versão 4.2.2. 422 4.2.2 4 2 4.2.2) real 100 profissional 90 fonoaudiológica 80 70 Préescolares. escolares. 201 (IVC 20 42 4.2. 10 9 8 4.2 1 4.

Abstract Energy efficiency in the industrial sector aims to produce goods with lower energy consumption, using efficient practices and technologies throughout the production process, bringing economic, environmental, and social benefits. Taking this into consideration, the objective of this study was to evaluate energy efficiency in a furniture industry, employing the production of a dresser made of wood as the object of analysis. Data were collected through on-site measurements and records in the company's database. Voltage and current measurements were utilized to calculate the electrical energy consumption of each machine in the production of a dresser. Electric energy consumption was analyzed at each stage of the production process, and fractions of consumed energy, mechanical power, and operation time for each machine were determined. Utilizing energy efficiency indicators, energy consumption was compared with similar studies, and strategies were proposed to improve energy efficiency. The results showed that the CNC Machining Center machine is the one that consumes the most energy, representing 58% of the total energy, and that the specific energy consumption (SEC) indicator can be reduced from 143.71 MJ to 99.91 MJ if the suggested strategies are adopted in the production of the dresser. This research introduced the Economic Indicator (EC) as a measure directly related to SEC, in this sense, strategies were proposed that result in savings of R$5.93 per dresser produced. By emphasizing the cumulative impact of adopting multiple energy efficiency strategies and quantifying potential energy savings, this research underscores the importance of such endeavors. process economic environmental benefits consideration industry analysis onsite on site companys company s database power determined indicators studies 58 SEC (SEC 14371 143 71 143.7 9991 99 91 99.9 EC (EC sense R593 R 5 93 R$5.9 produced endeavors 1437 14 7 143. 999 9 99. R59 R$5. 1 R5 R$5 R$

RESUMO Objetivo Identificar a prevalência da Síndrome da Fragilidade em idosos e suas relações com o risco para quedas. Método Estudo clínico descritivo, transversal e analítico. Cento e um voluntários com mais de 60 anos, foram submetidos à avaliação audiológica, Dynamic Gait Index – Brazilian brief (DGI), Timed Up and Go(TUG) e Escala de Fragilidade de Edmonton (EFE) que determinaram, respectivamente, os limiares auditivos, síndrome da fragilidade, equilíbrio funcional e dinâmico e risco para quedas. Utilizou-se a distribuição percentual simples, o teste de Wilcoxon e de Correlação Bivariada com coeficiente de Pearson para a análise estatística. Foram adotados limites iguais inferiores a 1,0 e 5,0%. Resultados A EFE identificou 22,8% dos voluntários como frágeis e 22,8% como vulneráveis. O DGI e o TUG classificaram 34,6 e 84,1% de riscos para quedas. Ocorreu correlação significativa entre a EFE e o DGI (p<0,01), a EFE e o TUG (p<0,01) e o DGI e TUG (p<0,01). O coeficiente de Pearson entre EFE e o DGI, entre o EFE e o TUG e DGI e TUG foram -0,26, -0,41 e 0,46 respectivamente. Ocorreu associação entre DGI e TUG e idade (p<0,01). Não houve correlação entre a EFE com sexo e idade. Conclusão A fragilidade e pré-fragilidade foi identificada em uma parcela expressiva dos voluntários, sobretudo nos mais longevos. O equilíbrio funcional e o dinâmico se correlacionaram moderamente com fragilidade, o que demonstrou que a Síndrome da fragilidade aumenta o risco para quedas.

ABSTRACT Purpose To identify the prevalence of Frailty Syndrome in the elderly and the relationship with risk of falling. Methods Descriptive, cross-sectional, and analytical clinical study. One hundred and one volunteers over 60 years old were submitted to audiological evaluation, Dynamic Gait Index - Brazilian brief (DGI), Timed Up and Go (TUG) and Edmonton Fragility Scale (EFE) that verified, respectively, hearing thresholds, frailty syndrome, functional and dynamic balance, and risk of falling. The simple percentual distribution, the Wilcoxon´s test and the Bivariate Correlation with Pearson's coefficient were used for statistical analysis. Limits equal to or less than 1.0 and 5.0% were adopted. Results EFE identified 22.8% of volunteers as fragile and 22.8% as vulnerable. DGI and TUG found 34.6% and 84.1% of at risk for falls, respectively. Significant correlations between EFE and DGI (p <0.01), EFE and TUG (p <0.01), and DGI and TUG (p <0.01) were observed. Pearson's coefficient between EFE and DGI, EFE and TUG, and DGI and TUG were -0.26, -0.41, and 0.46, respectively. An association between DGI and TUG and age (p <0.01) was identified. No correlation between EFE and sex or age was found. Conclusion Frailty and pre-frailty were identified in a significant segment of the volunteers, especially in the oldest subjects. Functional and dynamic balance were moderately correlated with frailty, which demonstrated that frailty syndrome increases the risk of falls.

RESUMO Objetivo identificar, coletar e analisar, na literatura científica, evidências da existência de protocolos fonoaudiológicos de levantamento da história clínica, conforme classificação de risco, especialmente para distúrbios oromiofuncionais, em lactentes e pré-escolares. Estratégia de pesquisa foram selecionados estudos publicados, sem delimitação temporal, nas bases de dados eletrônicas LILACS, SciELO e PubMed e na literatura cinza (Google Acadêmico). Critérios de seleção estudos disponíveis na íntegra nas línguas portuguesa e inglesa, que identificassem protocolos fonoaudiológicos de história clínica aplicáveis a lactentes (6 a 23 meses de vida) e pré-escolares (24 a 71 meses de vida). Foram excluídas as revisões narrativas e de literatura (integrativa, sistêmica e escopo). Resultados foram encontradas 1371 publicações brasileiras no período de 1980 a 2022. Destas, foram identificadas apenas cinco que tratavam de protocolos fonoaudiológicos para levantamento de dados pregressos a partir da história clínica da faixa etária de 6 a 71 meses. Apenas um desses protocolos possuía classificação de risco para distúrbios fonoaudiológicos, distribuídos na área de linguagem e fluência. Os outros três eram da área de motricidade orofacial (MO) e não continham classificação de risco para distúrbio miofuncional orofacial. Conclusão existem poucos protocolos fonoaudiológicos para levantamento da história clínica de lactentes e pré-escolares que contenham, ou não, classificação de risco, publicados em revistas de acesso aberto e que passaram por processos completos de validação, sendo necessário ampliar estudos e publicações desses instrumentos, inclusive na área de MO.

ABSTRACT Purpose to identify, collect and analyze in the scientific literature evidence of the existence of speech therapy protocols for collecting clinical history, according to risk classification, especially for oromyofunctional disorders, in infants and preschoolers. Research Strategy We selected published studies, without temporal delimitation, in the electronic databases LILACS, SciELO and PUBMED; and in the gray literature (Google Academic). Selection criteria available in full in Portuguese and English, which identify speech-language pathology protocols of clinical history applicable to infants (6 to 23 months of age) and preschoolers (24 to 71 months of age). Narrative and literature reviews (integrative, systemic, and scope) were excluded. Results 1371 Brazilian publications were found in the period from 1980 to 2022. Of these, only five publications on speech therapy protocols were identified for collecting previous data from the clinical history of the age group between 6 and 71 months. Only two of these protocols have a risk classification for speech-language disorders, distributed in the areas of language and fluency. The other three are from the Orofacial Motricity (OM) area and do not carry a risk classification for orofacial myofunctional disorder. Conclusion There are few speech therapy protocols for surveying the clinical history of infants and preschoolers, whether or not they contain risk classification, published in open access journals that have a complete validation process.Therefore there is a need for more research and publication of these instruments, including in the area of OM.

ABSTRACT Objective: To analyze obstetric variables associated with the birth of moderate and late premature babies in a city in the southern region of Brazil. Method: Cross-sectional study that analyzed the obstetric variables of 151 moderate and late preterm infants from May 2016 to May 2017 resident in Santa Maria/RS. Data were collected by means of their own instrument daily, and subsequently analyzed descriptively and by comparison of frequency and correlation. Results: Twinning (14.6%) was the most frequent feature among late twins when compared to the moderate group (p = 0.019). The other factors showed no significant difference. The higher number of previous premature births has a significant correlation with the lower gestational age at birth (CI = -0.522, p = 0.008). Conclusion: For the two groups of premature infants studied, the reasons did not present significant difference, which suggests homogeneity regarding the obstetric reasons for early birth.

RESUMO Objetivo: Analisar variáveis obstétricas associadas ao nascimento de bebês prematuros moderados e tardios em um município da região sul do Brasil. Método: Estudo transversal que analisou as variáveis obstétricas de 151 neonatos prematuros moderados e tardios no período de maio de 2016 a maio de 2017 residentes em Santa Maria/RS. Os dados foram coletados, por meio de instrumento próprio, diariamente, e posteriormente analisados de forma descritiva e por comparação de frequência e correlação. Resultados: A gemelaridade (14,6%) foi a característica mais frequente entre os tardios, quando comparados ao grupo de moderados (p=0,019). Os demais fatores não apresentaram diferença significativa. O maior número de partos prematuros anteriores possui correlação significativa com a menor idade gestacional ao nascer (IC= -0,522, p=0,008). Conclusão: Para os dois grupos de prematuros estudados, os motivos não apresentaram diferença significativa, o que sugere homogeneidade quanto aos motivos obstétricos de nascimento precoce.

RESUMEN Objetivo: Analizar las variables obstétricas asociadas con el nacimiento de bebés prematuros moderados y tardíos en una ciudad de la región sur de Brasil. Método: Estudio transversal que analizó las variables obstétricas de 151 recién nacidos prematuros moderados y tardíos desde mayo de 2016 hasta mayo de 2017 que residen en Santa Maria/RS. Los datos fueron recolectados, por medio de un instrumento específico, diariamente, y posteriormente analizados de manera descriptiva y por comparación de frecuencia y correlación. Resultados: La gemelaridad (14,6%) fue la característica más frecuente entre los tardíos, en comparación con el grupo de moderados (p = 0,019). Los otros factores no mostraron diferencias significativas. El mayor número de partos prematuros anteriores tiene una correlación significativa con la menor edad gestacional al nacer (IC = -0.522, p = 0.008). Conclusión: Para los dos grupos de recién nacidos prematuros estudiados, los motivos no mostraron ninguna diferencia significativa, lo que sugiere homogeneidad con respecto a los motivos obstétricos para el parto prematuro.

Recently, many studies have evaluated HPV vaccine safety and adverse effects. Two vaccine shave been recently evaluated in randomized controlled trials: the bivalent vaccine for HPV 16 and 18 (Cervarix, GlaxoSmithKline Biologicals, Rixensart, Belgium) and the quadrivalent vaccine for HPV 6, 11, 16, and 18 (Gardasil, Merck and Co., Inc., Whitehouse Station, NJ). We have performed a systematic review of all randomized controlled trials in which HPV vaccines were compared with placebo regarding safety, tolerability and adverse effects. Studies were searched up to March 2013 in the databases: Pubmed, Embase, Scielo and Cancerlit. Odds Ratios (OR) of most incident adverse effects were obtained. Twelve reports, involving 29,540 subjects, were included. In the HPV 16/18 group, the most frequently reported events related to the vaccine were pain (OR 3.29; 95% CI: 3.00–3.60), swelling (OR 3.14; 95% CI: 2.79–3.53) and redness (OR 2.41; 95% CI: 2.17–2.68). For the HPV 6/11/16/18 group the events were pain (OR 2.88; 95% CI: 2.42–3.43) and swelling (OR 2.65; 95% CI: 2.0–3.44). Concerning the HPV 16/18 vaccine, pain was the most common outcome detected. These effects can be due to a possible VLP-related inflammation process. Fatigue was the most relevant general effect observed followed by fever, gastrointestinal symptoms, and headache. In the HPV 6/11/16/18 group, only general symptoms, pain and swelling were observed. Pain and swelling were the most frequent. Comparing HPV 16/18 to HPV 6/11/16/18 vaccines, the former presented more adverse effects, perhaps because there are many more trials evaluating the bivalent vaccine. Other studies are needed to clarify this issue.

Atualmente, compósitos à base de polímero/carga mineral têm sido alvo de grande interesse, tanto em indústrias quanto em pesquisas acadêmicas, devido à melhora significativa nas propriedades dos materiais quando comparadas ao polímero virgem. O carbonato de cálcio (CaCO3) é um dos materiais mais abundantes do planeta e tem sido geralmente usado na obtenção de compósitos poliméricos. As propriedades de suas partículas (tamanho, forma e módulo) podem provocar um efeito significativo, especialmente no comportamento mecânico. As misturas PEAD/CaCO3 são amplamente usadas na indústria automotiva. No presente estudo, o efeito da incorporação de CaCO3 nas propriedades mecânicas e de escoamento destas misturas foi avaliado através de um planejamento fatorial simples de dois níveis, do tipo 2n, com n = 3 fatores: teor de carga; tamanho de partícula e velocidade de rotação da rosca. As variáveis de resposta analisadas foram: módulo de Young e resistência ao impacto e índice de fluidez (MFI). Os resultados mostraram que, dentro dos níveis estabelecidos, o fator que apresentou mais impacto nas variáveis de resposta foi o teor de carga mineral.

In recent years, polymer/mineral filler composites have attracted great interest, both in industries and academic researches, because they often show a remarkable improvement of materials properties when compared to virgin polymers. Calcium carbonate, CaCO3, is one of the most abundant materials on the planet and it has been often used to obtain polymer composites. The properties of its particles (size, shape and modulus) can provoke a significant effect, especially on mechanical behavior. HDPE/CaCO3 compounds are widely used in the automotive industry. In the present study, the effect of CaCO3 addition to the mechanical and flow properties of these compounds was evaluated using a simple 2n factorial design, with n = 3 factors: filler content; particle size and screw speed. The dependent variables analyzed were: Young modulus; impact strength and melt flow index (MFI). The results showed that the greatest impacts on the dependent variables were related to changes on mineral filler content.

OBJETIVO: Relatar a experiência com a técnica da drenagem venosa assistida a vácuo (DVAV) na cirurgia cardíaca com circulação extracorpórea (CEC) e a necessidade de hemotransfusão. MÉTODOS: Estudo retrospectivo em prontuários médicos de 111 pacientes operados com a aplicação da DVAV, no período de outubro de 2006 a fevereiro de 2008, no Hospital Esperança, em Recife, Pernambuco. A necessidade de hemotransfusão foi verificada dentro do único grupo estudado, com o uso da DVAV, comparada às variáveis, sexo, idade e peso dos pacientes nos períodos pré-CEC e transoperatório, com uso do teste Qui-quadrado e t-Student. RESULTADOS: No período pré-CEC, apenas 10% dos pacientes necessitaram de hemotransfusão, contra 12% da amostra no transoperatório. Foi observado que 17% das mulheres receberam sangue, contra apenas 4,7% dos homens no período pré-CEC (P=0,051), assim como 38% das mulheres, contra 9% dos homens no período transoperatório (P<0,001). Os pacientes que foram transfundidos, tanto no período pré-CEC como no transoperatório, apresentaram pesos corporais menores que os não transfundidos (P=0,049 e P=0,001, respectivamente). CONCLUSÕES: A técnica de DVAV vem sendo utilizada de forma segura e satisfatória, facilitando a drenagem venosa durante a CEC, no serviço que realizou a pesquisa. Contudo, são necessárias investigações prospectivas e comparativas com a CEC convencional para melhor elucidar a relação da DVAV com a hemotransfusão..

OBJECTIVE: To report the experience with the vacuum-assisted venous drainage (VAVD) technique in cardiopulmonary bypass (CPBP) and blood transfusion need. METHODS: A retrospective study was made about data from 111 patients who were operated, using VAVD between October 2006 and February 2008, at the Esperança Hospital, Recife, Pernambuco. The necessity of blood transfusion was verified on the single group of patients who underwent VAVD, comparing with sex, age and weigh, before the beginning of the CPBP and during the surgery, using Chi-square test and t-student test. RESULTS: Before the beginning of the CPBP only 10% of patients had need for blood transfusion and 12% during the surgery. It was observed that 17% of women received blood transfusion versus 4.7% of men before the beginning of CPBP (P=0.51), and 38% of women versus 9% of men during the surgery (P<0.001). The weight of patients who received blood transfusion were lower both before the beginning of the CPBP as during the surgery (P=0.049 e P=0.001, respectively). CONCLUSION: The VAVD technique has been used safely and satisfactorily, optimizing venous drainage during CPBP, in the hospital that conducted the study. However, prospective and comparative investigations between conventional drainage and VAVD are needed to better clarify this relation with blood transfusion.