Abstract Background: In transthyretin amyloid cardiomyopathy (ATTR-CM), the assessment of functional capacity is of great importance. A distance < 300m covered in the 6-minute walk test (6MWT) is linked to a poorer prognosis in heart failure (HF) patients. However, in ATTR-CM, this association is not well-established, particularly among its various presentations and variants. Objectives: To evaluate functional capacity and, the prognostic value of the 6MWT in patients with ATTR-CM and to identify their clinical characteristics according to the type of ATTR-CM. Methods: This was a retrospective, single-center study that included patients with a confirmed diagnosis of ATTR-CM who performed the 6MWT. Median follow-up was 19 months (8 – 29). The significance level was set at P < 0.05. Results: A total of 32 patients were analyzed; 59.4% had the hereditary form (ATTRh), of which 63.2% were Val142Ile. Mean left ventricular ejection fraction (LVEF) was lower in the ATTRh group when compared to the wild-type form (ATTRwt) [42 ±11 versus 52± 9 %; p = 0.029]. Median distance walked in the 6MWT was 328 m (269 – 397; IQR) in ATTRwt and 304 m (246 – 387; IQR) in ATTRh, with no difference between groups (p = 0.833). In patients with a distance <300 m in the 6MWT, survival was lower (28.8 vs 36.3 months; p = 0.041). Conclusions: A distance <300 m walked in the 6MWT was linked to shorter event-free survival in patients with ATTR-CM. Functional capacity of most patients was very low, and no differences were observed in the distance covered between the wild-type form and the hereditary form of ATTR. Background ATTRCM, ATTRCM ATTR CM , (ATTR-CM) importance 6minute minute 6 MWT (6MWT HF (HF However CM, wellestablished, wellestablished well established, established well-established variants Objectives ATTRCM. CM. Methods retrospective singlecenter single center followup follow up 1 8 ( 29. 29 . 29) 005 0 05 0.05 Results 3 analyzed 594 59 4 59.4 (ATTRh) 632 63 2 63.2 Val142Ile ValIle Val Ile LVEF (LVEF wildtype wild (ATTRwt 42 [4 11 ±1 52 % 0.029. 0029 0.029 029 0.029] 269 (26 397 IQR 30 246 (24 387 0.833. 0833 0.833 833 0.833) 300 <30 28.8 288 28 (28. 363 36 36. 0.041. 0041 0.041 041 0.041) Conclusions eventfree event free low (ATTR-CM 00 0.0 5 59. (ATTRh 63. [ ± 002 0.02 02 26 (2 39 24 38 083 0.83 83 <3 28. (28 004 0.04 04 0. 08 0.8

ABSTRACT Giant cell arteritis (GCA) is a type of chronic vasculitis that affects medium and large-caliber arteries, frequently related to aortic involvement and, consequently, to aneurysm formation. However, associated valvulitis with giant cells is uncommon. We describe the case of a 50-year-old female patient with aortic aneurysm and valvular insufficiency, whose anatomopathological examination revealed giant-cell aortic valvulitis associated with giant cell aortitis. GCA (GCA largecaliber large caliber arteries consequently formation However uncommon 50yearold yearold 50 year old insufficiency giantcell aortitis 5