Abstract Background: The European Society of Cardiology guidelines recommend an LDL-cholesterol (LDL-C) < 55 mg/dL for patients with established cardiovascular disease. While the Friedewald equation to estimate LDL-C is still widely used, the newer Martin-Hopkins equation has shown greater accuracy. Objectives: We aimed to assess: A) the proportion of patients reaching LDL-C goal and the therapies used in a tertiary center; B) the impact of using the Martin-Hopkins method instead of Friedewald’s on the proportion of controlled patients. Methods: A single-center cross-sectional study including consecutive post-myocardial infarction patients followed by 20 cardiologists in a tertiary hospital. Data was collected retrospectively from clinical appointments that took place after April 2022. For each patient, the LDL-C levels and attainment of goals were estimated from an ambulatory lipid profile using both Friedewald and Martin-Hopkins equations. A two-tailed p-value of < 0.05 was considered statistically significant for all tests. Results: Overall, 400 patients were included (aged 67 ± 13 years, 77% male). Using Friedewald’s equation, the median LDL-C under therapy was 64 (50-81) mg/dL, and 31% had LDL-C within goals. High-intensity statins were used in 64% of patients, 37% were on ezetimibe, and 0.5% were under PCSK9 inhibitors. Combination therapy of high-intensity statin + ezetimibe was used in 102 patients (26%). Applying the Martin-Hopkins method would reclassify a total of 31 patients (7.8%). Among those deemed controlled by Friedewald’s equation, 27 (21.6%) would have a Martin-Hopkins’ LDL-C above goals. Conclusions: Less than one-third of post-myocardial infarction patients had LDL-C within the goal. Applying the Martin-Hopkins equation would reclassify one-fifth of presumably controlled patients into the non-controlled group. Background LDLcholesterol LDL cholesterol LDLC C (LDL-C 5 mgdL mg dL disease MartinHopkins Martin Hopkins accuracy Objectives assess center B Friedewalds s Methods singlecenter single crosssectional cross sectional postmyocardial post myocardial 2 hospital 2022 patient equations twotailed two tailed pvalue p value 005 0 05 0.0 tests Results Overall 40 aged 6 1 years 77 male. male . male) 5081 50 81 (50-81 Highintensity High intensity 37 0.5 PCSK inhibitors highintensity high 10 26%. 26 26% (26%) 3 7.8%. 78 7.8% 7 8 (7.8%) 21.6% 216 21 (21.6% Conclusions onethird one third onefifth fifth noncontrolled non group 202 00 0. 4 508 (50-8 (26% 7.8 (7.8% 21.6 (21.6 (50- (26 7. (7.8 21. (21. (50 (2 (7. (21 (5 ( (7

Resumo Fundamento: As diretrizes da Sociedade Europeia de Cardiologia recomendam um nível de colesterol LDL (LDL-C) < 55 mg/dL para pacientes com doença cardiovascular estabelecida. Embora a fórmula de Friedewald ainda seja amplamente utilizada para estimar o LDL-C, a fórmula mais recente de Martin-Hopkins mostrou maior precisão. Objetivos: Nosso objetivo foi avaliar: A) a proporção de pacientes que atingiram a meta de LDL-C e as terapias utilizadas em um centro terciário; B) o impacto da utilização do método de Martin-Hopkins em vez do método de Friedewald na proporção de pacientes controlados. Métodos: Estudo transversal monocêntrico, incluindo pacientes consecutivos pós-infarto do miocárdio, acompanhados por 20 cardiologistas, em um hospital terciário. Os dados foram coletados retrospectivamente de consultas clínicas realizadas após abril de 2022. Para cada paciente, os níveis de LDL-C e o atingimento das metas foram estimados a partir de um perfil lipídico ambulatorial, utilizando as fórmulas de Friedewald e Martin-Hopkins. Um valor-p bicaudal < 0,05 foi considerado estatisticamente significativo para todos os testes. Resultados: Foram incluídos 400 pacientes (com 67 ± 13 anos, 77% do sexo masculino). Utilizando a fórmula de Friedewald, a mediana de LDL-C sob terapia foi de 64 (50-81) mg/dL, e 31% tinham LDL-C dentro da meta. Estatinas de alta intensidade foram usadas em 64% dos pacientes, 37% estavam em uso de ezetimiba e 0,5% estavam em uso de inibidores de PCSK9. A terapia combinada de estatina de alta intensidade + ezetimiba foi utilizada em 102 pacientes (26%). A aplicação do método de Martin-Hopkins reclassificaria um total de 31 pacientes (7,8%). Entre aqueles considerados controlados pela fórmula de Friedewald, 27 (21,6%) teriam LDL-C estimado por Martin-Hopkins acima da meta. Conclusões: Menos de um terço dos pacientes pós-infarto do miocárdio apresentaram LDL-C dentro da meta. A aplicação da fórmula de Martin-Hopkins reclassificaria um quinto dos pacientes presumivelmente controlados no grupo de pacientes não controlados. Fundamento LDLC C (LDL-C 5 mgdL mg dL estabelecida LDLC, C, MartinHopkins Martin Hopkins precisão Objetivos avaliar terciário B Métodos monocêntrico pósinfarto pós infarto 2 cardiologistas 2022 paciente ambulatorial MartinHopkins. Hopkins. valorp valor p 005 0 05 0,0 testes Resultados 40 6 1 anos 77 masculino. masculino . masculino) 5081 50 81 (50-81 37 0,5 PCSK9 PCSK 10 26%. 26 26% (26%) 3 7,8%. 78 7,8% 7 8 (7,8%) 21,6% 216 21 (21,6% Conclusões 202 00 0, 4 508 (50-8 (26% 7,8 (7,8% 21,6 (21,6 (50- (26 7, (7,8 21, (21, (50 (2 (7, (21 (5 ( (7

Abstract The present work aimed to develop a new method for assessing the content of mixtures of polymorphic forms I and II of the drug Efavirenz (EFV) by vibrational spectroscopic techniques such as Middle (MIR) and Near (NIR) infrared and Raman, using multivariate calibration models. Benchtop and handheld instruments were used for NIR and Raman and a benchtop instrument for MIR. In addition, VIP scores and iPLS, variable selection methods were employed. The infrared techniques showed the best models, with Root Mean Squares Error (RMSE) around 5% (w/w). When MIR and portable NIR instruments were used, this value was lowered to 4% (w/w) with selection of variables by iPLS. Raman spectroscopy showed higher error, even with selection of variables, possibly due to the spot laser size used by instruments and the lack of uniformity of the particle size in the samples. The infrared methods developed were shown to be effective in quantifying polymorphic mixtures of EFV. Given the ease of use of handheld instruments, they may be applied as tools of process analytical technology for monitoring quality control during industrial processing. EFV (EFV (MIR (NIR models addition iPLS employed RMSE (RMSE 5 w/w. ww w/w . w 4 (w/w error samples processing

ABSTRACT The recognition of self-determination has also become evident in the field of Intellectual and Developmental Disability (IDD), as the person must assume him/herself as an active agent and decision-maker in his/her own life. Learning self-determined skills is fundamental given their contextual transversality and should not be restricted to the period of adolescence. In Portugal, evidence is scarce and based on the previous model. Therefore, the aim of this study was to identify the self-determination profile, in the light of the causal agent theory, of adults with IDD, in order to analyze the variables that influence it. The Portuguese version of the Self-Determination Inventory was applied to 44 participants aged between 21-73 years old (40.77±12.07), 20 females and 24 males. Half of the sample were participants with IDD, all institutionalized. Internal consistency was acceptable (α=.65). The comparative analysis by diagnosis, gender, age, academic qualifications, professional status and place of residence showed a tendency towards similar profiles (p>.05). The differences found are associated with more self-determined profiles of adults with ID, inferring the greater weight of involvement characteristics than individual ones (diagnosis). People with IDD recognize self-determination as relevant and present decision-making skills. Recommendations for research and practice will be advanced. selfdetermination self determination , (IDD) himherself him herself decisionmaker decision maker hisher his her life selfdetermined determined adolescence Portugal model Therefore profile theory it SelfDetermination Self Determination 4 2173 21 73 21-7 40.77±12.07, 40771207 40.77±12.07 40 77 12 07 (40.77±12.07) 2 males institutionalized α=.65. α65 α α=.65 . 65 (α=.65) diagnosis gender age qualifications p>.05. p05 p p>.05 05 (p>.05) ID diagnosis. (diagnosis) decisionmaking making advanced (IDD 217 7 21- 4077120 40.77±12.0 1 0 (40.77±12.07 α6 α=.6 6 (α=.65 p0 p>.0 (p>.05 (diagnosis 407712 40.77±12. (40.77±12.0 α=. (α=.6 p>. (p>.0 40771 40.77±12 (40.77±12. α= (α=. p> (p>. 4077 40.77±1 (40.77±12 (α= (p> 407 40.77± (40.77±1 (α (p 40.77 (40.77± 40.7 (40.77 40. (40.7 (40. (40 (4 (

RESUMO O reconhecimento da autodeterminação tem vindo a ser evidente também no campo da Dificuldade Intelectual e Desenvolvimental (DID), visto que a pessoa deve assumir-se como agente ativo e decisor na própria vida. A aprendizagem das competências autodeterminadas é fundamental dada a sua transversalidade contextual, não se devendo restringir apenas à adolescência. Em Portugal, as evidências são escassas e baseadas no anterior modelo. Assim sendo, o objetivo deste estudo foi identificar o perfil de autodeterminação, à luz da teoria do agente causal, de adultos com DID, no intuito de analisar as variáveis que o influenciam. A versão portuguesa do Inventário de Autodeterminação foi aplicada a 44 participantes entre os 21-73 anos (40.77±12.07), 20 do género feminino e 24 do masculino. Metade da amostra eram participantes com DID, todos institucionalizados. A consistência interna foi aceitável (α=.65). A análise comparativa pelo diagnóstico, género, idade, habilitações académicas, situação profissional e local de residência apontou a tendência para perfis semelhantes (p>.05). As diferenças encontradas estão associadas a perfis mais autodeterminados de adultos com DID, inferindo-se o maior peso das características envolvimentais do que individuais (diagnóstico). As pessoas com DID reconhecem a autodeterminação como relevante e apresentam as habilidades para a decisão. Recomendações para a investigação e para a prática serão avançadas. , (DID) assumirse assumir vida contextual adolescência Portugal modelo sendo causal influenciam 4 2173 21 73 21-7 40.77±12.07, 40771207 40.77±12.07 40 77 12 07 (40.77±12.07) 2 masculino institucionalizados α=.65. α65 α α=.65 . 65 (α=.65) diagnóstico idade académicas p>.05. p05 p p>.05 05 (p>.05) inferindose inferindo diagnóstico. (diagnóstico) decisão avançadas (DID 217 7 21- 4077120 40.77±12.0 1 0 (40.77±12.07 α6 α=.6 6 (α=.65 p0 p>.0 (p>.05 (diagnóstico 407712 40.77±12. (40.77±12.0 α=. (α=.6 p>. (p>.0 40771 40.77±12 (40.77±12. α= (α=. p> (p>. 4077 40.77±1 (40.77±12 (α= (p> 407 40.77± (40.77±1 (α (p 40.77 (40.77± 40.7 (40.77 40. (40.7 (40. (40 (4 (

Abstract: The aim of this study was to estimate genetic parameters and select superior mango genotypes using the mixed-models approach. The 16 genotypes, varieties and hybrid selections, were evaluated regarding physical and physical-chemical traits of the fruit using the REML/BLUP methodology. Mango fruit weight and pulp weight can be selected indirectly based on fruit length and diameter, which are more easily evaluated. The hybrids CPAC 26394, Lita, and Rosa 46 stand out in regard to fruit size. The genotypes R12P09, CPAC 2293, Roxa, Omega, Alfa, and Lita have better quality fruit than the Tommy Atkins variety that is widely used in commercial orchards. The Roxa variety has pulp with little or no fiber, a trait that is of great importance to consumers and for industrial processing. The genotypes Alfa, CPAC 5895, Ômega, R10P08, R12P09, R13P10, Rosa 2, Rosa 36, and Rosa 46 have pulp free of internal breakdown. The varieties and hybrid selections of mango show variability regarding fruit traits, and the REML/BLUP methodology is efficient for selection of genotypes with desirable fruit traits in mango. Abstract mixedmodels mixed models approach 1 physicalchemical chemical REMLBLUP REML BLUP diameter 26394 4 size R12P09 RP R P 2293 Omega Alfa orchards fiber processing 5895 Ômega R10P08 R13P10 2 36 breakdown 2639 R12P0 229 589 R10P0 R13P1 3 263 R12P 22 58 R10P R13P 26 5

Resumo: Objetivou-se estimar parâmetros genéticos e selecionar genótipos superiores de mangueira, utilizando a abordagem de modelos mistos. Os 16 genótipos, variedades e seleções híbridas, foram avaliados quanto aos caracteres físicos e físico-químicos do fruto, utilizando a metodologia REML/BLUP. A massa do fruto e a massa da polpa de mangueira podem ser selecionadas indiretamente com base no comprimento e no diâmetro do fruto, que são mais facilmente avaliados. Os híbridos CPAC 26394, Lita e Rosa 46 destacam-se quanto ao tamanho do fruto. Os genótipos R12P09, CPAC 2293, Roxa, Omega, Alfa e Lita apresentam frutos de melhorqualidade do que a variedade Tommy Atkins, bastante utilizada em pomares comerciais. Avariedade Roxa apresenta polpa com pouca ou nenhuma fibra, característica muito requisitadapor consumidores e para processamento industrial. Já os genótipos Alfa, CPAC 5895, Ômega, R10P08, R12P09, R13P10, Rosa 2, Rosa 36 e Rosa 46 apresentam polpa livre de colapso interno. Resumo Objetivouse Objetivou se mistos 1 híbridas físicoquímicos físico químicos REMLBLUP REML BLUP REML/BLUP 26394 4 destacamse destacam R12P09 RP R P 2293 Omega Atkins comerciais fibra industrial 5895 Ômega R10P08 R13P10 2 3 interno 2639 R12P0 229 589 R10P0 R13P1 263 R12P 22 58 R10P R13P 26 5

With clear and objective language, this article invites the reader to reflect on the relationship between autism and Brazilian Chemical Education. Here, we begin with approaches to autism in legal terms, which allow the reader to understand how autistic people and their families have their rights guaranteed by law, especially in the school. We also present the point of view of the teacher who trains the graduate and the one who receives an autistic student in the classroom, with reflections about their training curricula that are imperfect in terms of inclusion, which generates situations of discomfort and frustration in their work. We continue to discuss how inclusive education strategies adopted by professors in the area of chemistry aimed at autistic students have stood out, even in the midst of a scarce bibliographic reference. Finally, we turn our attention to one of the main places where inclusion takes place: the school, with valuable discussions about the role that it has played in the inclusion of the autistic student. language Education Here law school classroom work out reference Finally place

Abstract The scope of the study was to investigate the relationship between maternal sociodemographic, obstetric and lifestyle characteristics and the habitual consumption of ultra-processed foods. It included a cross-sectional study of n = 784 pregnant women attended by the Unified Health System. Diet was estimated using two 24-hour recall surveys, using the multiple-pass method. Ultra-processed foods were classified using the UN NOVA food classification and their habitual consumption was expressed as the contribution to the total energy percentage. Adjusted linear regression models were used to investigate the relationship between maternal characteristics and the percentage of energy (%E) derived from ultra-processed foods. The %E of ultra-processed foods in the diet was 32.1%. Maternal age (-0.45[-0.62; -0.29] p < 0.001), economic bracket D+E in relation to A+B (-2.95[-5.59; -0.32] p = 0.03) and energy underreporting (-6.95[-8.86; -5.04] p < 0.001) were inversely associated with the %E of ultra-processed foods, whereas the pre-pregnancy Body Mass Index (BMI) (0.41[0.22; 0.60] p < 0.001) was directly associated. This would suggest that maternal age, economic status, energy underreporting and pre-gestational anthropometric status are associated with the consumption of ultra-processed foods during pregnancy. sociodemographic ultraprocessed ultra processed crosssectional cross sectional 78 System 24hour hour 24 surveys multiplepass multiple pass method Ultraprocessed Ultra E (%E 321 32 1 32.1% 0.450.62 045062 0.45 0.62 0 45 62 (-0.45[-0.62 0.29 029 29 -0.29 0.001, 0001 0.001 , 001 DE D AB A B 2.955.59 295559 2.95 5.59 2 95 5 59 (-2.95[-5.59 0.32 032 -0.32 0.03 003 03 6.958.86 695886 6.95 8.86 6 8 86 (-6.95[-8.86 5.04 504 04 -5.04 prepregnancy pre pregnancy BMI (BMI 0.410.22 041022 0.41 0.22 41 22 (0.41[0.22 0.60 060 60 pregestational gestational 7 3 32.1 450 0.450.6 04506 045 0.4 062 0.6 4 (-0.45[-0.6 0.2 02 -0.2 000 0.00 00 955 2.955.5 29555 295 2.9 559 5.5 9 (-2.95[-5.5 0.3 -0.3 0.0 958 6.958.8 69588 695 6.9 886 8.8 (-6.95[-8.8 5.0 50 -5.0 410 0.410.2 04102 041 022 (0.41[0.2 06 32. 0.450. 0450 0. (-0.45[-0. -0. 2.955. 2955 2. 55 5. (-2.95[-5. 6.958. 6958 69 6. 88 8. (-6.95[-8. -5. 0.410. 0410 (0.41[0. 0.450 (-0.45[-0 -0 2.955 (-2.95[-5 6.958 (-6.95[-8 -5 0.410 (0.41[0 (-0.45[- - (-2.95[- (-6.95[- (0.41[ (-0.45[ (-2.95[ (-6.95[ (0.41 (-0.45 (-2.95 (-6.95 (0.4 (-0.4 (-2.9 (-6.9 (0. (-0. (-2. (-6. (0 (-0 (-2 (-6 ( (-

Resumo O objetivo do estudo foi investigar a relação entre as características sociodemográficas, obstétricas e de estilo de vida maternas e o consumo usual de alimentos ultraprocessados. Estudo transversal, n = 784 gestantes, assistidas pelo Sistema Único de Saúde. A dieta foi estimada utilizando dois inquéritos recordatórios de 24 horas, pelo método de passagens múltiplas. Os alimentos ultraprocessados foram classificados empregando-se a classificação NOVA e seu consumo usual foi expresso como a contribuição no percentual energético total. Modelos de regressão linear ajustados foram empregados para investigar a relação entre as características maternas e o percentual energético proveniente (%E) de ultraprocessados. O %E de ultraprocessados na dieta foi de 32,1%. A idade materna (-0,45 [-0,62; -0,29] p < 0,001), estrato econômico D+E em relação a A+B (-2,95 [-5,59; -0,32] p = 0,03) e sub-relato energético (-6,95 [-8,86; -5,04] p < 0,001) foram inversamente associados ao %E de ultraprocessados, enquanto o índice de massa corporal (IMC) pré-gestacional (0,41 [0,22; 0,60] p < 0,001) foi diretamente associado. Sugere-se que a idade materna, o estrato econômico, a subnotificação energética e o estado antropométrico pré-gestacional estejam associados ao consumo de alimentos ultraprocessados durante a gestação. sociodemográficas transversal 78 gestantes Saúde 2 horas múltiplas empregandose empregando se total E (%E 321 32 1 32,1% 0,45 045 0 45 (-0,4 0,62 062 62 [-0,62 0,29 029 29 -0,29 0,001, 0001 0,001 , 001 DE D AB B 2,95 295 95 (-2,9 5,59 559 5 59 [-5,59 0,32 032 -0,32 0,03 003 03 subrelato sub relato 6,95 695 6 (-6,9 8,86 886 8 86 [-8,86 5,04 504 04 -5,04 IMC (IMC prégestacional pré gestacional 0,41 041 41 (0,4 0,22 022 22 [0,22 0,60 060 60 associado Sugerese Sugere gestação 7 3 32,1 0,4 4 (-0, 0,6 06 [-0,6 0,2 02 -0,2 000 0,00 00 2,9 9 (-2, 5,5 55 [-5,5 0,3 -0,3 0,0 6,9 69 (-6, 8,8 88 [-8,8 5,0 50 -5,0 (0, [0,2 32, 0, (-0 [-0, -0, 2, (-2 5, [-5, 6, (-6 8, [-8, -5, (0 [0, (- [-0 -0 [-5 [-8 -5 ( [0 [- - [

Abstract Anthropogenic interventions have had a compromising effect on environmental health, intensifying the degradation of ecosystems, and the quantity of chemical pollutants released into nature. Therefore, research areas within the scope of environmental assessments and monitoring such as ecotoxicology have contributed to the determination of the toxic potential of contaminants. A small cyprinid known as the zebrafish (Danio rerio), the use of which has exponentially grown, is an alternative vertebrate model for scientific research, mainly in the assessment of environmental risks. The species exhibits several advantages for breeding in a laboratory, in addition to presenting multi-biomarkers of environmental toxicity. Thus, this review aims to present the main characteristics and advantages of working with this species, as well as show studies related to ecotoxicology involving biomarkers of toxicity in zebrafish. The results show a progressive trend towards employing the species in environmental risk analyses, it is an increasingly recommended species in the assessment of the toxicity level of a range of chemical pollutants. The development of future technologies must contribute to scientific advancement, rendering the potential application of this model organism an even more widespread one, which will certainly help in bridging knowledge gaps in various areas of study. health ecosystems nature Therefore contaminants Danio rerio, rerio , rerio) grown risks laboratory multibiomarkers multi Thus analyses advancement one study

Resumen: Los síntomas de ansiedad y depresión en la infancia son ampliamente investigados en la actualidad. Los estudios demuestran que los síntomas son multifactoriales, de los cuales los factores ambientales y las características de funcionamiento de la familia están en el centro de la atención de los investigadores. Por lo tanto, este estudio evaluó la correlación y el poder predictivo de los factores de la parentalidad y de la coparentalidad en los síntomas clínicos de ansiedad y depresión en los niños. Los participantes, 50 individuos que conviven con su pareja y tienen al menos un hijo, de entre 7 y 11 años, completaron una herramienta que se compone de seis escalas que evaluaban la crianza, la coparentalidad y la sintomatología en sus hijos. Los resultados indicaron correlaciones bajas y moderadas entre los factores de la parentalidad y de la coparentalidad y los síntomas emocionales y conductuales de los niños. El conflicto familiar coparental y la supervisión del comportamiento fueron predictores del 16% de los síntomas de ansiedad generalizada en la descendencia y la triangulación familiar del 17% de los síntomas de depresión. Esto coincide con la literatura al indicar que los niños son susceptibles a la calidad del funcionamiento de los subsistemas parental y coparental. Resumen actualidad multifactoriales investigadores tanto participantes 5 hijo 1 años crianza hijos 16 17

Abstract: Anxiety and depression symptoms in the early childhood have been investigated extensively in current times. Studies have point out that these symptoms have a multifactorial nature, with environment factors, such as the characteristics of the familiar functioning, as the researchers’ target. Therefore, this study evaluated the correlation and the predictive power of parenting and co-parenting factors on clinical symptoms of anxiety and depression in the children. The participants, 50 individuals who lived in cohabitation with their partners and that had at least one child aged between 7 and 11 years old, filled in a form composed of six scales; which evaluated the parenting, the coparenting, and the offspring symptomatology. The results revealed low and moderate correlations between the parenting and coparenting variables and the emotional and behavioral symptoms of the children. The coparental familiar conflict and the behavior monitoring were predictors of 16% of the generalized anxiety symptom in the offspring, and the familiar triangulation of 17% of the depression symptoms. It shows, as the literature suggests, that the children are vulnerable to the quality of the functioning of the parental and coparental subsystems. Abstract times nature researchers target Therefore co participants 5 1 old scales symptomatology 16 17 shows suggests subsystems

Resumo: Sintomas de ansiedade e depressão na infância têm sido amplamente investigados na atualidade. Os estudos apontam que esses sintomas têm natureza multifatorial, sendo os fatores ambientais, como as caraterísticas do funcionamento familiar, alvo de atenção dos pesquisadores. Por isso, este estudo avaliou a correlação e o poder preditivo dos fatores da parentalidade e da coparentalidade em sintomas clínicos de ansiedade e depressão nos filhos. Os participantes, 50 indivíduos que vivem em coabitação com o parceiro e têm pelo menos um filho com idade entre 7 e 11 anos, preencheram um instrumento composto por seis escalas, que avaliaram a parentalidade, a coparentalidade e a sintomatologia na prole. Os resultados indicaram correlações baixas e moderadas entre os fatores da parentalidade e da coparentalidade e os sintomas emocionais e comportamentais dos filhos. O conflito familiar coparental e a supervisão do comportamento foram preditores de 16% dos sintomas de ansiedade generalizada na prole e a triangulação familiar de 17% dos sintomas de depressão. Evidencia-se, como indica a literatura, que os filhos são suscetíveis à qualidade do funcionamento dos subsistemas parental e coparental. Resumo atualidade multifatorial ambientais pesquisadores isso participantes 5 1 anos escalas 16 17 Evidenciase, Evidenciase Evidencia se, se Evidencia-se literatura

Abstract Ancylostoma spp. are found worldwide. Infected dog and cat feces can contaminate soil in public places. Despite prophylactic measures being available, studies on direct remediation of Ancylostoma-contaminated soils are scarce. This study aimed to determine the impact of heat treatment and liming on the viability of Ancylostoma spp. eggs in artificially contaminated sandy soil. Sterilized sand samples were contaminated with Ancylostoma spp. eggs extracted from infected dogs’ feces. Samples were heated (trial I) to 70 °C or 80 °C, then sieved after 24 hours (212, 90, 38, and 25 µm). Larval cultures were assessed for larval development following heat treatment. Five quicklime concentrations (trial II; 50, 30, 20, 10 and 5%) were used to treat sand. The effect of liming on larval cultures was assessed by measuring embryonic development. Filariform larvae were exposed to 20% quicklime (25 °C and 37 °C, 20 min). Heat treatment destroys Ancylostoma spp. eggs and prevents in vitro larval development. Liming at 50, 30, and 20% concentrations made embryonic development impossible. However, filariform larvae treated with 20% lime solution retained their motility. Heating at 70 °C and liming at 20% were sufficient to make Ancylostoma spp. egg embryogenesis impossible in experimentally contaminated sand samples. spp worldwide places available Ancylostomacontaminated scarce dogs trial I 7 C 8 2 212, 212 (212 90 38 µm. µm . µm) II 50 30 1 5% 5 (2 3 min. min min) However motility 21 (21 9 (

Resumo Ancylostoma spp. são nematódeos que infectam cães e gatos e podem contaminar locais públicos. Apesar da existência de medidas profiláticas, estudos sobre tratamento do solo são escassos. No presente estudo, foi avaliado o efeito do tratamento térmico e caleação na viabilidade de ovos de Ancylostoma spp., em solo arenoso estéril. Amostras de solo foram contaminadas com ovos de Ancylostoma spp. obtidos de fezes de cães naturalmente infectados, aquecidas a 70°C ou 80°C, e filtradas em tamises metálicas (212, 90, 38 e 25 µm) após 24 horas (Teste I). Cultivos de larvas foram realizadas para a avaliação do desenvolvimento larval. Na caleação (Teste II), cinco concentrações (50, 30, 20, 10 e 5%) de cal virgem foram utilizadas. O efeito da caleação foi avaliado com observação do desenvolvimento larval nos cultivos. Ainda, larvas foram expostas (20 minutos) ao leite de cal (20% a 25°C e 37°C). O tratamento térmico foi capaz de degenerar ovos de Ancylostoma spp. e impedir o desenvolvimento larval, enquanto a caleação (50, 30, e 20%) impossibilitou o desenvolvimento larval. Entretanto, as larvas filariformes, expostas ao leite de cal (20%) mantiveram motilidade. O aquecimento (70°C) e caleação (20%) impediram o embrionamento de ovos de Ancylostoma spp. em solo experimentalmente contaminado. spp públicos profiláticas escassos estudo estéril infectados 70C C 70 80C 80 80°C 212, 212 (212 90 3 2 µm Teste I. I . I) II, II , II) 50, 50 (50 30 20 1 5% 5 utilizadas cultivos Ainda (2 minutos 20% 25C 37°C. 37C 37°C 37 37°C) Entretanto filariformes motilidade (70°C contaminado 7 8 21 (21 9 (5 (

Resumo Tendo como base a proposta para o Dossiê III: O Papel da Unirila nos Desafios da Integração na Rota Bioceânica (Brasil, Paraguai, Argentina E Chile), este artigo tem como objetivo conceituar, identificar e analisar a importância do Patrimônio Cultural de Mato Grosso do Sul- MS e sua relevância no contexto da Rota bioceânica já que o corredor rodoviário cruzará parte deste território, ligando o Porto de Santos, no Brasil, com portos chilenos, passando pelo Paraguai e Argentina. Esta implantação certamente abrirá possibilidades econômicas em vários aspectos na região ao passo que considerar e identificar a cultura local poderá agregar valor e incorporar à temática cultural nas ações de turismo, desenvolvimento local, bem como nas políticas públicas. Este trabalho apresenta uma metodologia por meio de pesquisas documentais e bibliográficas e buscas de informações sobre o patrimônio cultural de Mato Grosso do Sul- MS, junto aos órgãos competentes na identificação e preservação da cultura de MS. Com isso, espera-se que este artigo contribua com informações para estas ações de planejamento e desenvolvimento regionais, na mesma medida em que também possa fortalecer a conscientização da comunidade local, a partir da valorização de suas práticas. III Brasil (Brasil Chile, Chile , Chile) conceituar Sul território Santos chilenos turismo públicas isso esperase espera se regionais práticas

Abstract Based on the proposal for the Dossier: The Role of Unirila in the Challenges of Integration in the Biooceanic Route (Brazil, Paraguay, Argentina and Chile), this article aims to conceptualize, identify and analyze the importance of the Cultural Heritage of Mato Grosso do Sul-MS and its relevance in the context of the biooceanic route since this road corridor crosses part of this territory, causing socioeconomic and cultural impact. The biooceanic corridor is a project started in 2000 with the purpose of building a network of infrastructure works such as waterways, ports, energy and communications interconnections and road corridors to connect the Port of Santos, in Brazil, with Chilean ports, passing through Paraguay and Argentina. This event will certainly open economic possibilities in various aspects in the region and, considering and identifying the local culture can add value and incorporate the cultural theme in tourism actions, local development as well as in public policies. This work presents a methodology through documentary and bibliographical research and searches for information about the cultural heritage of Mato Grosso do Sul-MS, together with the competent bodies in the identification and preservation of the culture of MS. With this, it is expected that this article contributes with information for these developmental actions and to increase the self-esteem of the community that belongs to this place. Dossier Brazil (Brazil Chile, Chile , Chile) conceptualize SulMS Sul MS territory impact 200 waterways ports Santos policies SulMS, MS, selfesteem self esteem place 20 2

Resumen Basado en la propuesta del Dossier: El Papel de Unirila en los Desafíos de la Integración en la Ruta Biooceánica (Brasil, Paraguay, Argentina y Chile), este artículo tiene como objetivo conceptualizar, identificar y analizar la importancia del Patrimonio Cultural de Mato Grosso do Sul-MS y su relevancia en el contexto de la ruta biooceánica, ya que este corredor vial atraviesa parte de este territorio, causando impacto socioeconómico y cultural. El corredor biooceánico es un proyecto iniciado en el año 2000 con el propósito de construir una red de obras de infraestructura como hidrovías, puertos, interconexiones de energía y comunicaciones y corredores viales para conectar el Puerto de Santos, en Brasil, con puertos chilenos, pasando por Paraguay y Argentina. Este evento sin duda abrirá posibilidades económicas en varios aspectos de la región y, considerando e identificando la cultura local puede agregar valor e incorporar el tema cultural en acciones turísticas, desarrollo local y políticas públicas. Este trabajo presenta una metodología a través de la investigación documental y bibliográfica y busca información sobre el patrimonio cultural de Mato Grosso do Sul-MS, junto con los organismos competentes en la identificación y preservación de la cultura de la EM. Con esto, se espera que este artículo contribuya con información para estas acciones de desarrollo y para aumentar la autoestima de la comunidad que pertenece a este lugar. Dossier Brasil (Brasil Chile, Chile , Chile) conceptualizar SulMS Sul MS biooceánica territorio 200 hidrovías Santos chilenos turísticas públicas SulMS, MS, EM esto lugar 20 2

Resumo As diretivas antecipadas de vontade são consideradas um componente fundamental do planejamento de cuidados de saúde, recurso comumente empregado por equipes de cuidados paliativos. Dada a importância da rede de cuidado para o paciente com doença incurável e que ameaça sua vida, este estudo tem o objetivo investigar a compreensão que profissionais da saúde, pacientes e cuidadores têm da temática, além de apreender como o tema é conceituado, identificar convergências e divergências nos discursos e discutir como essas noções podem influenciar na qualidade do cuidado. Optou-se pela revisão integrativa da literatura científica, em que foram selecionados e analisados oito artigos. Com isso, priorizou-se dividir a discussão em três tópicos descritivos e analisá-los criticamente. Desse modo, fica evidente a necessidade de continuar a debater essa temática a fim de garantir o desenvolvimento de condutas centradas no paciente, que contemplem suas condições socioeconômicas e seus valores pessoais. saúde paliativos vida conceituado Optouse Optou se científica artigos isso priorizouse priorizou analisálos analisá los criticamente modo pessoais

Abstract Advance directives are considered a fundamental component of health care planning, a resource commonly used by palliative care teams. Given the importance of the care network for patients with incurable and life-threatening diseases, this study aims to investigate the understanding that health professionals, patients, and caregivers have of the subject, in addition to understanding how the subject is conceptualized, identifying convergences and divergences in the discourses and how these notions can influence the quality of care. We opted for an integrative review of the scientific literature, in which eight articles were selected and analyzed. Priority was given to dividing the discussion into three descriptive topics and analyzing them critically. Thus, the need to continue debating this topic is evident in order to ensure the development of patient-centered behaviors that take into account their socioeconomic conditions and personal values. planning teams lifethreatening life threatening diseases professionals conceptualized literature analyzed critically Thus patientcentered patient centered values

Resumen Las directivas anticipadas se consideran fundamentales en la planificación de la atención de la salud, un recurso comúnmente utilizado por los equipos de cuidados paliativos. Dada la importancia de la red de atención para pacientes con enfermedad incurable y potencialmente mortal, este estudio pretende investigar la comprensión que los profesionales de salud, pacientes y cuidadores tienen sobre el tema, además de comprender cómo se conceptualiza el tema, identificar convergencias y divergencias en los discursos y discutir cómo estas nociones pueden influir en la calidad de la atención. Se realizó una revisión integradora de la literatura científica, en la que se seleccionaron y analizaron ocho artículos. Así, se dio prioridad a dividir la discusión en tres temas descriptivos y analizarlos críticamente. Se evidencia la necesidad de seguir debatiendo este tema para garantizar el desarrollo de comportamientos centrados en el paciente, que incluyan sus condiciones socioeconómicas y valores personales. salud paliativos mortal científica artículos Así críticamente paciente personales

ABSTRACT Women living with human immunodeficiency virus are at an increased risk of developing cancers related to human papillomavirus (HPV). Thus, it is important to combine clinical assessments, serological screening, and HPV data for planning prevention policies. This study aimed to identify HPV and its specific types in the cervical, anal, and oral mucosa of HIV-seropositive women, associating it with viral load and lymphocyte count. Sociodemographic characteristics, health data (CD4+ and CD8+ T cell counts and viral load), and biological samples (cervical, anal, and oral) were collected from 86 HIV-positive women undergoing antiretroviral therapy. Data were classified according to the presence or absence of HPV-DNA, HPV-DNA presence at one or more anatomic sites, and level of oncogenic risk, considering low- and high-risk oncogenic HPV-DNA groups. The presence of HPV in the cervicovaginal site was 65.9%, 63.8% in anal canal, and 4.2% in oral mucosa. A viral load ≥75 HIV copies/mL was associated with the presence of HPV-DNA. There was an association between viral load and the low-risk HPV or high-risk HPV groups. We found a high prevalence of HPV infection in HIV-seropositive women, particularly in the cervical and anal mucosa, with viral load ≥75 HIV copies/mL being associated with HPV-DNA presence. HPV. . (HPV) Thus assessments screening policies HIVseropositive seropositive count characteristics CD4+ CD4 CD (CD4 CD8 load, , load) (cervical 8 HIVpositive positive therapy HPVDNA, HPVDNA DNA, DNA sites low highrisk groups 659 65 9 65.9% 638 63 63.8 canal 42 4 2 4.2 75 ≥7 copiesmL copies mL HPVDNA. DNA. lowrisk (HPV (CD 6 65.9 63. 4. 7 ≥ 65.

Abstract Cancer is a complex and multifactorial disease characterized by uncontrolled cell growth and is one of the main causes of death in the world. This work aimed to evaluate a small series of 10 different indole-thiosemicarbazone compounds as potential antitumor agents. This is a pioneering study. For this, the antioxidant and cytotoxic capacity against normal and tumor cells was evaluated. The results showed that the compounds were able to promote moderate to low antioxidant activity for the ABTS radical scavenging assay. ADMET in silico assays showed that the compounds exhibited good oral bioavailability. As for toxicity, they were able to promote low cytotoxicity against normal cells, in addition to not being hemolytic. The compounds showed promising in vitro antitumor activity against the T47D, MCF-7, Jurkat and DU-145 strains, not being able to inhibit the growth of the Hepg2 strain. Through this in vitro study, it can be concluded that the compounds are potential candidates for antitumor agents. world 1 indolethiosemicarbazone indole thiosemicarbazone agents study evaluated assay bioavailability toxicity hemolytic T47D TD T D MCF7, MCF7 MCF 7, 7 MCF-7 DU145 DU 145 DU-14 strains Hepg strain MCF- DU14 14 DU-1 DU1 DU-

Abstract Thiosemicarbazones are promising classes of compounds with antitumor activity. For this study, six 2,4-dihydroxy-benzylidene-thiosemicarbazones compounds were synthesized. These compounds were submitted to different assays in silico, in vitro and in vivo to evaluate the toxicological, antioxidant and antitumor effects. The in silico results were evaluated by the SwissADME and pkCSM platforms and showed that all compounds had good oral bioavailability profiles. The in vitro and in vivo toxicity assays showed that the compounds showed low cytotoxicity against different normal cells and did not promote hemolytic effects. The single dose acute toxicity test (2000 mg/kg) showed that none of the compounds were toxic to mice. In in vitro antioxidant activity assays, the compounds showed moderate to low activity, with PB17 standing out for the ABTS radical capture assay. The in vivo antioxidant activity highlighted the compounds 1, 6 and 8 that promoted a significant increase in the concentration of liver antioxidant enzymes. Finally, all compounds showed promising antitumor activity against different cell lines, especially MCF-7 and DU145 lines, in addition, they inhibited the growth of sarcoma 180 at concentrations lower than 50 mg/kg. These results showed that the evaluated compounds can be considered as potential antitumor agents. study 2,4dihydroxybenzylidenethiosemicarbazones 24dihydroxybenzylidenethiosemicarbazones dihydroxybenzylidenethiosemicarbazones 2,4 dihydroxy benzylidene thiosemicarbazones 2 4 synthesized toxicological effects profiles 2000 (200 mg/kg mgkg mg kg mice PB PB1 assay 1 enzymes Finally lines MCF7 MCF 7 MCF- DU DU14 addition 18 5 agents 4dihydroxybenzylidenethiosemicarbazones 24 2, 200 (20 DU1 20 (2 (

ABSTRACT This paper analyzes the offer of teacher education programs in the state of São Paulo after the expansion of campuses at the the Federal Institute of São Paulo (IFSP). The objective was to examine the growth of teacher education programs in the IF model and its reach in this state in comparison to other higher education institutions. The paper is a result of a research in which data and official documents were analized and also inteviews were conducted with government managers, about the Federal Institutes (IFs) project. It is observed that there was a concentration of teacher education programs in metropolitan regions, mainly via private HEIs, and a notable presence of public institutions in inland regions. Also, data about evaluation of undergraduate courses taught in São Paulo, are included by means of the Preliminary Course Concept (CPC), an indicator of the National Higher Education Assessment System (Sinaes). It is concluded that the opening of new IFSP degrees took place mainly in the interior of São Paulo allowing the expansion of teacher education with quality standards in some regions that previously lacked public institutions. Finally, the institution was highlighted in the offer, mainly, of degrees in Physics, Chemistry and Mathematics. IFSP. . (IFSP) managers IFs (IFs project HEIs Also CPC, CPC , (CPC) Sinaes. Sinaes (Sinaes) Finally Physics Mathematics (IFSP (CPC (Sinaes

RESUMO O artigo analisa o oferecimento de licenciaturas no estado de São Paulo após a ampliação de campi do Instituto Federal de São Paulo (IFSP). Tem como objetivo examinar o crescimento dos cursos destinados à formação de professores no modelo de IF e o seu alcance nesse estado em comparação às demais instituições de educação superior (IES). O texto é resultado de estudo que analisou dados estatísticos, documentos e entrevistas semiestruturadas. As entrevistas foram realizadas com gestores que participaram da elaboração do projeto de desenvolvimento dos Institutos Federais (IFs) em âmbito governamental. Verificou-se a concentração de cursos de licenciatura nas regiões metropolitanas, sobretudo via IES privadas, mas também se revelou a presença mais notável na atuação das instituições públicas em regiões do interior. Engloba, ainda, um balanço da avaliação de cursos de licenciatura ministrados em São Paulo, tomando-se como base o Conceito Preliminar de Curso (CPC), indicador do Sistema Nacional de Avaliação da Educação Superior (Sinaes). A abertura de novas licenciaturas do IFSP ocorreu sobretudo no interior paulista, o que permitiu a expansão da formação docente com padrão de qualidade referenciada em algumas regiões antes carentes de instituições públicas. Por fim, constatou-se destaque da instituição na oferta, principalmente, de licenciaturas em Física, Química e Matemática. IFSP. . (IFSP) IES. (IES) estatísticos semiestruturadas IFs (IFs governamental Verificouse Verificou metropolitanas privadas Engloba ainda tomandose tomando CPC, CPC , (CPC) Sinaes. Sinaes (Sinaes) paulista fim constatouse constatou oferta principalmente Física Matemática (IFSP (IES (CPC (Sinaes