Resumo Quase 90% dos casos de coccigodínia podem ser tratados por meio de tratamento clínico conservador; os 10% restantesprecisam de outras modalidades invasivas para o alívio da dor, como o bloqueio do gânglio ímpar (BGI) ou ablação por radiofrequência (ARF) do gânglio ímpar. Com o objetivo de avaliara eficácia do BGI e ARF do gânglio ímpar no controle da dor em pacientes com coccigodínia, foi realizada uma pesquisa sistemática no PubMed, MEDLINE eGoogle Scholar, a fim de identificar estudos que relatam o alívio da dor, em termos de Escala Visual Analógica (EVA) ou dos seus homólogos, após o BGI ou ARFem pacientes com coccigodínia por 2 autores diferentes, de acordo com as diretrizes PRISMA. Foram definidos sete estudos com um total de 189 pacientes (104 no grupo BGI e 85 no grupo ARF). No grupo BGI, a média da pontuação EVA melhorou de 7,83 no início do estudo para 3,11 no acompanhamento de curto prazo, 3,55 no acompanhamento de médio prazo e 4,71 no acompanhamento de longo prazo. No grupo ARF, amédia da pontuação EVA melhorou de 6,92 no início do estudo, 4,25 no acompanhamento de curto prazo e 4,04 no acompanhamento de longo prazo. No grupo BGI foram relatadas 13,92% de falhas (11/79) e complicações de 2,88% (3/104), enquanto que no grupo ARF foram relatadas 14,08% de falhas (10/71) e nenhuma complicação (0%). A taxa total de êxito foi > 85% em qualquer uma das modalidades. O BGI e ARF do gânglio ímpar fornecem um método confiável e provavelmente excelente no controle da dor, em pacientes com coccigo- dínia que não respondem ao tratamento médico conservador. No entanto, deve ser estabelecido um limite entre os que responderam, os que não responderam e aqueles não respondedores tardios, sendo necessários estudos mais amplos com acompanhamento mais longo (> 1 ano).

Resumo Objetivo Determinar os fatores de risco modificáveis associados à gravidade da fasciíte plantar e formular um sistema objetivo de pontuação para indexação da doença na população não atlética. Métodos Estudo observacional prospectivo. A principal medida de desfecho foi a associação de um fator de risco modificável, mensurada pelo valor de R (coeficiente de Pearson) e pelo nível de significância de p < 0,05. Resultados Em uma amostra de 50 pacientes, o índice de massa corporal (IMC) e calçados com amortecimento inadequado foram associados de maneira significativa à dor na fasciíte plantar. Todos os demais fatores de risco eram não modificáveis ou não apresentaram associação significativa. Conclusão Com base nos dados à disposição e sua interpretação, um índice, denominado Índice de Ranjeet-Kunal de Pontuação da Fasciíte Plantar (RKISP, em inglês) , foi formulado e utilizado com sucesso não apenas na classificação da fasciíte plantar, mas também na determinação do prognóstico de seu tratamento conservativo, auxiliando a escolha da modalidade terapêutica.

Abstract Objective To determine the modifiable risk factors associated with severity of plantar fasciitis and to formulate an objective scoring system for indexing plantar fasciitis in the non-athletic population. Methods This was a prospective observational study. The main outcome measure was the association of a modifiable risk factor, which was measured with the Pearson coefficient (R-value) and the level of significance, which was kept as p < 0.05. Result In a sample size of 50 patients, the body mass index (BMI) and ill-cushioned shoes were found to be significantly associated with pain in plantar fasciitis. All the other risk factors were either non-modifiable or had no significant association. Conclusion Based on available data and further interpretation, an index was be formulated, named as Ranjeet-Kunal Index for Scoring Plantar fasciitis (RKISP), which can be successfully used for not only grading plantar fasciitis but also prognosticating the conservative management of the same, thus deciding the modality of treatment.

RESUMO Introdução: Uma pandemia foi declarada pela Organização Mundial de Saúde em 30 de janeiro de 2020. A doença do Coronavírus (COVID-19) surgiu, e levou à paralisação da Odontologia e da Ortodontia. Descrição: A COVID-19 é uma doença muito multivariante. Afeta de muitas formas diferentes; e seus sintomas mais relatados assemelham-se muito aos de uma gripe sazonal. Os doentes sentem febre crescente, tosse seca e falta de ar. Há duas maneiras de lidar com eles, sendo o primeiro guiar e ajudar os pacientes remotamente com a ajuda das telecomunicações; e segundo, preparar a clínica, seguindo todos os protocolos de sanitização e manter a clínica aberta apenas para esses pacientes. A utilização de agentes de proteção ambiental, máscaras N95, kits EPI e filtros HEPA são algumas das coisas básicas a serem feitas. Conclusão: Com a mudança contínua do cenário da COVID-19, deve-se seguir um acompanhamento meticuloso da situação local, observando as últimas instruções dadas pela OMS e pelo Ministério da Saúde.

ABSTRACT Introduction: A pandemic was declared by the World Health Organization on 30th January 2020, the coronavirus disease (COVID-19) emerged, and led to standstill of Dentistry and Orthodontics. Description: The COVID-19 is a very multivariant disease. It affects in many different ways; the most reported symptoms resemble very much to that of a seasonal flu. Patients feel rising fever, dry cough and shortness of breath. There are two ways to handle them, the first being remotely guiding and helping them with aid of telecommunication, and second you can prepare the clinic by following all sanitization protocols and keep the clinic open only for such patients. Usage of Environment Protection agents, N95 masks, PPE kits and HEPA filters are some of the basic things to go about. Conclusion: With the non-stop change of scenario of the COVID-19, meticulous monitoring of the local situation and one eye on the latest instructions given by the WHO and Health ministry should be followed.

Abstract: Semantic Role Labeling (SRL) is a well researched area of Natural Language Processing. State-of-the-art lexical resources have been developed for SRL on formal texts that involve a tedious annotation scheme and require linguistic expertise. The difficulties increase manifold when such complex annotation scheme is applied on tweets for identifying predicates and role arguments. In this paper, we present a simplified approach for annotation of English tweets for identification of predicates and corresponding semantic roles. For annotation purpose, we adopted the 5W1H (Who, What, When, Where, Why and How) concept which is widely used in journalism. The 5W1H task seeks to extract the semantic information in a natural language sentence by distilling it into the answers to the 5W1H questions: Who, What, When, Where, Why and How. The 5W1H approach is comparatively simple and convenient with respect to the ProbBank Semantic Role Labeling task. We report an the performance of our annotation scheme for SRL on tweets and show that non-expert annotators can produce quality SRL data for tweets. This paper also reports the difficulties and challenges involved with semantic role labeling on twitter data and propose solutions to them.

ABSTRACT Prostatic utricle cyst is a rare congenital anomaly. Symptomatic cysts require treatment. Surgical excision is the treatment of choice, but is challenging due to close proximity to vas deferens, ejaculatory ducts, bladder, prostate, rectum and pelvic nerves. Complications include rectal injury, ureteral injury, impotence, infertility and faecal incontinence. We here report a rare complication in which bladder was accidentally removed during laparoscopic excision of prostatic utricle cyst. To best of our knowledge such a complication has never been reported previously. We also describe the possible cause of this accident and suggest ways to prevent this disastrous complication.

Abstract Social media has become almost ubiquitous in present times. Such proliferation leads to automatic information processing need and has various challenges. The nature of social media content is mostly informal. Additionally while talking about Indian social media, users often prefer to use Roman transliterations of their native languages and English embedding. Therefore Information retrieval (IR) on such Indian social media data is a challenging and difficult task when the documents and the queries are a mixture of two or more languages written in either the native scripts and/or in the Roman transliterated form. Here in this paper we have emphasized issues related with Information Retrieval (IR) for Code-Mixed Indian social media texts, particularly texts from twitter. We describe a corpus collection process, reported limitations of available state-of-the-art IR systems on such data and formalize the problem of Code-Mixed Information Retrieval on informal texts.

Abstract This study was conducted to isolate an acid-producing, alkaliphilic bacterium to reduce the alkalinity of cement industry waste (cement kiln dust). Gram-positive isolate KG1 grew well at pH values of 6–12, temperatures of 28–50 °C, and NaCl concentrations of 0–16% and thus was further screened for its potential to reduce the pH of an alkaline medium. Phenotypic characteristics of the KG1 isolate were consistent with those of the genus Bacillus, and the highest level of 16S rRNA gene sequence similarity was found with Bacillus halodurans strain DSM 497 (94.7%). On the basis of its phenotypic characteristics and genotypic distinctiveness from other phylogenetic neighbors belonging to alkaliphilic Bacillus species, the isolated strain was designated B. halodurans strain KG1, with GenBank accession number JQ307184 (= NCIM 5439). Isolate KG1 reduced the alkalinity (by 83.64%) and the chloride content (by 86.96%) of cement kiln dust and showed a potential to be used in the cement industry for a variety of applications.

La endomicroscopia confocal láser basada en probes (Cellvizio de Mauna Kea Technologies, París) es una nueva tecnología que permite, durante cualquier procedimiento endoscópico, realizar análisis histológicos en tiempo real (biopsia óptica), mejorando el diagnóstico y ayudando a definir el tratamiento de múltiples patologías digestivas. Es de resaltar, para nuestro medio, su utilidad en patologías de difícil diagnóstico como son las estenosis biliares indeterminadas y las neoplasias quísticas pancreáticas, cuyo diagnóstico temprano y exacto es muy difícil con las técnicas actualmente disponibles, y que es necesario para definir la realización o la exclusión de tratamientos quirúrgicos de alta morbimortalidad y alto costo, como por ejemplo, la cirugía de Whipple. En esta revisión se muestran los aportes actuales de esta tecnología, ya disponible en nuestro medio, para el diagnóstico y estudio de las patologías digestivas

Probe based confocal laser endomicroscopy (Cellvizio Mauna Kea, Paris) is a new technology that allows performance of histological analysis (optical biopsy) during any endoscopic procedure. This improves diagnosis and helps define the treatment needed for multiple digestive diseases. Its utility for diseases that are difficult to diagnose such as indeterminate biliary strictures and pancreatic cystic neoplasms is noteworthy. Early and accurate diagnoses can be very difficult with currently available techniques, but they are exactly what are needed to determine whether or not expensive surgical treatments with great potential morbidity, for example the Whipple procedure, need to be performed. This review looks at the contribution that this technology can make in our country where it is now available for the diagnosis and study of digestive diseases

O objetivo desse trabalho de pesquisa foi planejar, desenvolver e otimizar sistema de liberação de fármaco auto-microemulsificante(SMEDDS) de felodipino (FL) em cápsulas de gelatina dura revestidas com polímero, a fim de obter liberação rápida após tempo desejado no manejo da hipertensão. A microemulsão é composta de FL, lauroglilcol FCC, Transcutol P e Cremophor EL. A proporção ótima de tensoativo e de co-tensoativo foi de 2:1. As microemulsões resultantes têm tamanho de partícula na faixa de 65-85 nm com potencial zeta de -13,71 mV. A liberação de FL foi ajustada adequadamente, utilizando-se polímero independente de pH, como etilcelulose com ftalato de dibutila como plastificante. A influência das variáveis da formulação, como viscosidade do polímero, tipo de plastificante e ganho percentual de peso do revestimento foi investigada para caracterizar o intervalo de tempo de liberação. A formulação de cápsulas de FL SMEDDS revestidas com etilcelulose mostrou intervalo de tempo de liberação de 5 a 7 horas, o que é desejável para uma aplicação cronoterapêutica.

The objective of this research work was to design, develop and optimize the self micro-emulsifying drug delivery system (SMEDDS) of Felodipine (FL) filled in hard gelatine capsule coated with polymer in order to achieve rapid drug release after a desired time lag in the management of hypertension. Microemulsion is composed of a FL, Lauroglycol FCC, Transcutol P and Cremophor EL. The optimum surfactant to co-surfactant ratio was found to be 2:1. The resultant microemulsions have a particle size in the range of 65-85 nm and zeta potential value of -13.71 mV. FL release was adequately adjusted by using pH independent polymer i.e. ethyl cellulose along with dibutyl phthalate as plasticizer. Influence of formulation variables like viscosity of polymer, type of plasticizer and percent coating weight gain was investigated to characterize the time lag. The developed formulation of FL SMEDDS capsules coated with ethyl cellulose showed time lag of 5-7 h which is desirable for chronotherapeutic application.

Cerebral malaria is the most severe and rapidly fatal neurological complication of Plasmodium falciparum infection and responsible for more than two million deaths annually. The current therapy is inadequate in terms of reducing mortality or post-treatment symptoms such as neurological and cognitive deficits. The pathophysiology of cerebral malaria is quite complex and offers a variety of targets which remain to be exploited for better therapeutic outcome. The present review discusses on the pathophysiology of cerebral malaria with particular emphasis on scope and promises of curcumin as an adjunctive therapy to improve survival and overcome neurological deficits.

Since the introduction of varicella vaccination in India, surveillance of circulating VZV strains has gained significance. Differentiating wild-type VZV strains from the Oka vaccine strain can be achieved only by molecular genotyping methods. The development of PCR methods for VZV strain differentiation has been hampered by the fact that the VZV genome is highly conserved. We used VZV ORF 62 PCR-RFLP analysis to identify and differentiate wild-type VZV strains in India from the Oka vaccine strain. Digestion of VZV ORF 62 amplicons with SmaI, enabled accurate strain differentiation; the Oka strain was positive for three SmaI sites, compared to two SmaI sites in the wild-type VZV strains that we tested.