Novas séries de pirazolinas, 3-aril-4,5-diidro-1H-pirazol-1-carbaldeídos (4-6), (aril-4,5-diidro-1H-pirazol-1-il)etanonas (9-11) e 3-aril-4,5-diidro-1H-pirazóis (24 e 25) foram sintetizadas pela reação de chalconas (1-3) com hidrato de hidrazina em ácido fórmico, ácido acético ou etanol, respectivamente. Novos derivados de pirimidina 6-arilpirimidina-2-amina (32-34) também foram sintetizados a partir das mesmas chalconas de partida. As estruturas dos novos compostos sintetizados foram estabelecidas através do estudo dos espectros de IV, ¹H RMN, 13C RMN e análise elementar. Todos os compostos foram avaliados quanto as suas atividades antibacteriana e antifúngica. Dentre estes compostos, três mostraram atividade relevante contra C. albicans e outros também apresentaram atividade contra E. coli.

New series of pyrazoline 3-aryl-4,5-dihydro-1H-pyrazole-1-carbaldehydes (4-6), (aryl-4,5-dihydro-1H-pyrazol-1-yl)ethanones (9-11) and 3-aryl-4,5-dihydro-1H-pyrazoles (24 and 25) were synthesized by reacting chalcones (1-3) with hydrazine hydrate in either formic acid, acetic acid or ethanol, respectively. Also, new 6-arylpyrimidin-2-amine derivatives (32-34) were synthesized from the same chalcones. The structures of the newly synthesized compounds were established on the basis of IR, ¹H NMR, 13C NMR, mass spectral data and elemental analyses. The compounds were evaluated for their antibacterial and antifungal activities. Three heterocycles showed relevant activity against C. albicans and some compounds also showed activity against E. coli.