Abstract Flavonoids are a diverse class of polyphenolic substances largely found in plants including citrus peels and are reported to posess a variety of biological activities. We investigated important flavonoids apigenin, hesperidin, narigin, quercetin and tangeritine against diabetes and associated conditions. In current project drug likeness, ADMET analysis, molecular docking and in vitro assays were performed. The apigenin, quercetin and tanagretin exhibited compliance with Lipinski’s rule of five. The molecular docking analysis showed best fit in transcriptional regulator 3TOP and 1IK3 in all tested compounds. During antioxidant assays, all flavonoids presented excellent activities. In the α-glucosidase assay, quercetin showed highest inhibition (76% at final concentration of 52 µg/ml) followed by tangeritin (73% at final concentration of 52 µg/ml). In case of 15-Lox assay, highest inhibition was seen in case of quercetin (75%) followed by apigenin (53%). In the AGEs assay, the quercetin showed 47% inhbition of protein cross link formation preceeded by the tenegretin exhited 37% inhibition. It was therefore concluded that tested flavonoids have significant activities in both in silico and in vitro models that is mainly due to differences in structural features and polar surface area.

En este artículo, de tipo exponencial generalizado ha sido propuesto con el fin de estimar la varianza poblacional a través de una variables auxiliar en muestreo en dos fases. Algunos casos especiales del estimador medio y el sesgo del estimador generalizado propuesto son derivados. El estimador es comprado teóricamente con otros disponibles en la literatura y las condiciones bajos los cuales éste es mejor. Un estudio empírico es llevado a cabo para comprar la eficiencia de los estimadores propuestos.

In this paper, generalized exponential-type estimator has been proposed for estimating the population variance using mean auxiliary variable in single-phase sampling. Some special cases of the proposed generalized estimator have also been discussed. The expressions for the mean square error and bias of the proposed generalized estimator have been derived. The proposed generalized estimator has been compared theoretically with the usual unbiased estimator, usual ratio and product, exponential-type ratio and product, and generalized exponential-type ratio estimators and the conditions under which the proposed estimators are better than some existing estimators have also been given. An empirical study has also been carried out to demonstrate the efficiencies of the proposed estimators.

Uma nova série de 4-amino-5-aril-3H-1,2,4-triazol-3-tionas, tendo vários grupos metoxibenzila e metoxifenila, foi sintetizada através de refluxo de sais de hidrazina carboditioato de potássio em solução aquosa diluída de hidrato de hidrazina. Estes sais foram formados pela reação de hidrazinas ácidas e dissulfeto de carbono em solução de hidróxido de potássio metanólico a 0-5 ºC. 4-Amino-5-aril-3H-1,2,4-triazol-3-tionas foram condensadas com diferentes ácidos aromáticos substituídos para produzir 1,2,4-triazol[3,4-b]1,3,4-tiodiazols 3,6-disubstituídos. As estruturas dos compostos sintetizados foram caracterizadas pelas espectroscopias no infravermelho (IR) e ressonância magnética nuclear (NMR) de ¹H e 13C, análise elementar e espectrometria de massa (MS). Todos os compostos sintetizados foram examinados com relação as suas atividades de inibição de urease, antioxidante e antibacteriana. Alguns compostos mostraram excelente atividade de inibição de urease, mais do que a droga padrão. Outros compostos apresentaram potente atividade antioxidante. Todos os compostos mostraram atividades antibacterianas significativas em comparação com a droga padrão.

A new series of 4-amino-5-aryl-3H-1,2,4-triazole-3-thiones, bearing various methoxybenzyl- and methoxyphenethyl groups, was synthesized by refluxing potassium hydrazinecarbodithioate salts in dilute aqueous solution of hydrazine hydrate. These salts were formed by the reaction of acid hydrazides and carbon disulfide in methanolic potassium hydroxide solution at 0-5 °C. 4-Amino-5-aryl-3H-1,2,4-triazole-3-thiones were condensed with different substituted aromatic acids to yield 3,6-disubstituted-1,2,4-triazolo[3,4-b]1,3,4-thiadiazoles. The structures of the synthesized compounds were characterized by infrared (IR), ¹H and 13C nuclear magnetic resonance (NMR), elemental analysis and mass spectrometric (MS) studies. All the synthesized compounds were screened for their urease inhibition, antioxidant and antibacterial activities. Some compounds showed excellent urease inhibition activity, more than the standard drug. Others exhibited potent antioxidant activity. All the compounds showed significant antibacterial activities as compared to the standard drug.

The biosorption of Cr(III) and Cr(VI) from synthetic solution using dried untreated and pretreated Rosa gruss an teplitz waste biomass was evaluated in this study. The results showed that initial pH, biosorbent dose, sorbent particle size, initial metal concentration, time and temperature affected chromium uptake capacity of rose biomass. The effect of twenty different pretreatments including gaseous and other reagents on Cr(III) and Cr(VI) uptake capacity of Rosa gruss an teplitz waste biomass was comprehensively described. Uptake capacity of Rosa gruss an teplitz waste biomass was significantly affected after pretreatment. The metal uptake capacity of biomass was not only found related to nature of pretreatment but also found strongly related to oxidation state of chromium. The estimation of the correlation coefficients for Cr(VI) showed that the experimental data fit better to Freundlich model. The Langmuir isotherm provided the best correlation for Cr(III) onto the rose waste biomass. The biosorption phenomenon was dependent on the temperature with máximum adsorption at 30°C. Biosorption of Cr(III) and Cr(VI) ions on to biomass followed pseudo 2ntl order adsorption kinetic model. The results confirmed that rose waste biomass is a potential biomaterial to remove Cr(III) and Cr(VI) ions with a high biosorption capacity 45.03 mg/g and 48.75 mg/g for Cr(III) and Cr(VI) respectively.