Abstract Vascular hypo-responsiveness to vasopressors in patients with obstructive jaundice (OJ) is a common anesthetic event, which leads to perioperative complications and increased mortality. The cause of this clinical issue remains unclear. In this study, we estimated the actin cytoskeleton and arterial protein level in the artery of OJ patients by proteomic analysis. Ten patients with OJ due to bile duct diseases or pancreatic head carcinoma were enrolled, while another ten non-jaundice patients with chronic cholecystitis or liver hemangioma as the control group. Vascular reactivity to noradrenaline was measured before anesthesia on the day of surgery. Artery samples in adjacent tissues of removed tumor were collected and evaluated by 2-dimensional electrophoresis. Proteins with differential expression were detected by MALDI-TOF mass spectrometry with immunoblot confirmation. The results confirmed the phenomenon of vascular hypo-reactivity in OJ patients as suppressed aortic response to noradrenaline were existed in these patients. We also found that actin cytoskeleton and several actin-binding proteins were up- or down-regulated in the artery of OJ patients. These proteins changed in OJ patents might be the basic mechanism of vascular hypo-reactivity, further studies to uncover the role of these proteins in OJ is critical for clinical treatment of these patients.

Abstract To investigate the anxiety, depression, fatigue and insomnia of the entry quarantine personnel during the COVID-19 pandemic, and the influencing factors of psychological status were also explored. The Self-Rating Anxiety Scale (SAS), Self-Rating Depression Scale (SDS), Fatigue severity scale (FSS) and the Insomnia Severity Index (ISI) of 630 entry quarantine personnel were performed and the correlation analysis of the four types of scales was performed. The incidence rates of anxiety, depression, fatigue and insomnia were 4.76%, 20.00%, 48.57% and 22.86%, respectively. There was a positive correlation between the four indicators. Univariate analysis showed that age, education level, occupation, continent and reasons for going abroad were the main influencing factors of psychosomatic status. The lower the age group, the higher the education level, and the healthier the psychosomatic health of the entry quarantine personnel. The psychological status of international students was healthier than that of the staff. The psychological condition of the quarantined people in Asia was healthier than that in other continents. 630 entry quarantine personnel had different degrees of anxiety, depression, fatigue and insomnia, there was a positive correlation between them. Age, education level, occupation, continent and reasons for going abroad were the main influencing factors of psychological status.

Abstract To study the caramel reactions of disaccharides with water, the type I maltose caramel products (MCPs) and sucrose caramel products (SCPs) at three reaction stages were yielded and their reaction rates, UV absorptions, flavor compounds, and antioxidant activities were also detected. It was found that the caramel reactions of sucrose were faster than those of maltose and their reaction rates quickly increased to a high level in the middle stage. UV absorption of SCP in the late stage at 305 nm was much stronger than those of MCPs. Both the MCP and SCP obtained at 180 °C and 4 min had the highest concentrations of 5-hydroxymethylfurfural and total flavor compounds. Moreover, the total flavor concentrations of SCPs were much larger than those of MCPs and the antioxidant effects of SCPs were also stronger. Thus, a preferred condition for both two disaccharide caramel reactions was suggested at 180 °C for 4 min and the sucrose caramels could give better flavors than maltose caramels.

Abstract Polygonum capitatum (Polygonaceae) exists in rural areas of Southwest China and some other Asian countries. Its aerial part or whole herbal plant has been used as a Miao ethnomedicine against urinary system diseases, infections, pyelonephritis, diarrhea, and so on. The progress in phytochemical research on P. capitatum over the past decades is summarized. Two hundred and three chemical constituents that have been isolated and identified from this plant are included in this article, the chemical structures of which include aliphatic hydrocarbons, aliphatic alcohols, aliphatic ketones, aromatic aldehydes, aliphatic acids, glycerides, triterpenic acids, sterols, anthraquinones, chromones and their glycosides, flavonoids and their glycosides, phenols, phenolic acids and their esters, lignanoids, flavonolignans, phenolic glycosides, alcoholic glycosides, amino acids, nucleobases, amides, alkaloids, alkyl glycosides, volatile oils, and polysaccharides.