ABSTRACT Background: The inflammatory response in gout disease is induced by the activation of NLR family pyrin domain-containing 3 (NLPR3) signaling pathway mediated by IL-1β release. Objective: The objective of the study was to determine the association between single nucleotide polymorphisms (SNPs) within NLRP3 inflammasome genes and gout susceptibility. Methods: Mexican patients with gout from the National Rehabilitation Institute and General Hospital of Mexico were enrolled. A healthy control group was also included. We analyzed the frequency and allelic distribution of eight SNPs from seven different genes within the NLRP3 inflammasome signaling pathway: TLR4 rs2149356, CD14 rs2569190, NLRP3 rs3806268, NLRP3 rs10754558, CARD8 rs2043211, IL-1β rs1143623, P2RX7 rs3751142, and PPARGC1B rs45520937 SNPs. Results: We found that the SNP rs45520937 of PPARGC1B was associated with the risk of developing gout when it was analyzed using the dominant model (Odds ratio [OR] = 2.30; 95% confidence interval [CI]: 1.09-4.86; p = 0.030), and it is proposed that the adaptor molecule CD14 rs2569190 polymorphism could be associated with a lower risk of gout under an additive model (OR= 0.41;95% CI: 0.16-1.05; p = 0.064). No significant associations were identified for the remaining SNPs. Conclusion: Our findings suggest that the PPARGC1B rs45520937 SNP is associated with gout susceptibility.

INTRODUÇÃO: Com a crescente procura pelo acompanhamento psicológico de pacientes com doenças crônicas e indicações clínicas para o monitoramento de suas capacidades físicas e psíquicas, existe a necessidade de instrumentos que possibilitem essa avaliação. A artrite reumatoide é uma doença que vem sendo amplamente estudada para que novas drogas e tratamentos sejam desenvolvidos, porém instrumentos psicométricos desenvolvidos para essa população específica ainda são raros. OBJETIVO: Descrever a adaptação transcultural, para o português brasileiro, da Recent-Onset Arthritis Disability (ROAD) index. MÉTODOS: O processo envolveu duas traduções e retrotraduções realizadas por quatro tradutores independentes, a avaliação das versões fornecidas, seguida da elaboração de uma versão sintética por especialistas no assunto. O processo foi finalizado com a aplicação experimental do instrumento. RESULTADOS: Todas as etapas do processo são descritas. Não foram percebidas dificuldades de compreensão na autoaplicação da escala, que foi realizada por grupos de diferentes níveis de instrução, compreendendo desde ensino fundamental até nível universitário completo. CONCLUSÃO: Ao final do estudo, é apresentada a versão final da ROAD em português brasileiro. O instrumento adaptado foi considerado adequado e correspondente ao instrumento original.

INTRODUCTION: The increasing search for the psychological treatment of patients with chronic diseases and with clinical indications for the control of physical and psychological capacities has revealed a need for instruments aimed at assessing these patients. Rheumatoid arthritis is a condition that has been widely studied with a focus on the development of new drugs and treatment approaches. However, psychometric instruments developed for this specific population are still rare. OBJECTIVE: To describe the translation and cross-cultural adaptation into Brazilian Portuguese of the Recent-Onset Arthritis Disability (ROAD) index. METHODS: The process involved two translations and back-translations performed by four independent translators, the assessment of all versions obtained, followed by the development of a synthetic version by specialists in the field. The process was completed with an experimental application of the instrument. RESULTS: All stages of the translation/adaptation process are described. No comprehension difficulties were reported by the participants, who had different education levels, ranging from elementary school to university level. CONCLUSION: At the end of the study, the final version of the ROAD index in Brazilian Portuguese is presented. The adapted instrument was considered adequate and equivalent in meaning to the original instrument.