Abstract Introduction Many patients suffered from rhino-orbital-cerebral mucormycosis during the coronavirus disease 2019 (COVID-19) pandemic in India. Diabetes is a known risk factor of COVID-19 infection and mucormycosis. Objective The present study was done to describe the clinical spectrum and histopathological findings of mucormycosis in COVID-19 patients and their outcomes. Methods A cross-sectional study was done over a period of two and half months. The biopsy samples or scrapings from sinonasal or periorbital tissue of 38 patients were analyzed. Hematoxylin & Eosin (H&E stain) slides were evaluated along with Grocott-Gomori methenamine–silver and Periodic acid–Schiff stains to highlight the fungal elements. Results The male to female ratio was 2.5:1, and the mean age of the subjects was 53 years old. A total of 68.4% (n = 26/38) of the patients had diabetes as a comorbidity, 84.2% (n = 32/38) had a history of steroid intake, and 55.3% (n = 21/38) were given supplemental oxygen during their treatment. The common presentations were nasal blockage, discharge, eye pain, headache, and altered mentation. The sites of biopsy were: nasal cavity 76.3% (n = 29/38), periorbital fat/orbit 21.1% (n = 8/38), maxillary sinus 15.8% (n = 6/38) and ethmoid sinus 13.2% (n = 5/38). In 76.3% (n = 29/38) cases, broad, irregular, nonseptate, and right-angle branching hyphae were seen on H&E-stained tissue sections. Conclusion COVID-19 led to various complications in individuals affected by it. Mucormycosis was one such lethal complication. An early diagnosis and prompt treatment is crucial to control the progression of the disease and improve outcomes. rhinoorbitalcerebral rhino orbital cerebral 201 COVID19 COVID 19 (COVID-19 India COVID-1 outcomes crosssectional cross sectional months 3 analyzed H&E HE H E stain GrocottGomori Grocott Gomori methenaminesilver methenamine silver acidSchiff acid Schiff elements 2.51, 251 2.5 1, 2 5 1 2.5:1 old 684 68 4 68.4 n 26/38 2638 26 comorbidity 842 84 84.2 32/38 3238 32 intake 553 55 55.3 21/38 2138 21 blockage discharge pain headache mentation 763 76 76.3 29/38, 2938 29/38 , 29 fatorbit fat orbit 211 21.1 8/38, 838 8/38 8 8/38) 158 15 15.8 6/38 638 6 132 13 13.2 5/38. 538 5/38 . 5/38) cases broad irregular nonseptate rightangle right angle H&Estained HEstained stained sections it complication 20 COVID1 (COVID-1 COVID- 51 2.51 25 2. 2.5: 68. 26/3 263 84. 32/3 323 55. 21/3 213 7 76. 293 29/3 21. 83 8/3 15. 6/3 63 13. 5/3 Estained (COVID- 26/ 32/ 21/ 29/ 8/ 6/ 5/ (COVID

ABSTRACT Cystic hypersecretory carcinoma (CHC) of the breast is a rare variant of ductal carcinoma, characterized by variably sized cysts lined by micropapillary fronds to proliferative pseudostratified columnar epithelium. It includes a spectrum of morphological features ranging from clearly benign cystic hypersecretory hyperplasia (CHH), CHH with atypia to invasive CHC. Only 20 cases of invasive CHC have been reported to date. We report a case of a 49-year-old female who presented with a palpable breast lump and nipple discharge. Gross examination showed variable-sized cysts lined by solid grey white tumors. On microscopic examination, cysts were lined by micropapillary fronds with eosinophilic colloid-like secretion with a focus of invasion. A diagnosis of invasive CHC was made. Since there are limited case reports, our understanding of its biological behavior, prognostic factors, and genetic basis is limited.