Abstract Background The incidence of arterial hypotension during induction of general anesthesia is influenced by the method of propofol administration, but there is a dearth of randomized clinical trials comparing bolus injection and target-controlled infusion in relation to arterial hypotension. This study seeks to compare the incidence of arterial hypotension between these two methods of propofol administration. Methods This prospective, randomized, single-center, non-blinded study included 60 patients (aged 35 to 55 years), classified as ASA physical status I or II, who were undergoing non-cardiac surgeries. They were randomly allocated using a computer to two groups based on the method of propofol administration during the induction of general anesthesia: the Target Group, receiving target-controlled infusion at 4 μg.mL−1, and the Bolus Group, receiving a bolus infusion of 2 mg.kg−1. Both groups also received midazolam 2 mg, fentanyl 3 μg.kg−1, and rocuronium 0.6 mg.kg−1. Over the first 10 minutes of anesthesia induction, Mean Arterial Pressure (MAP), Heart Rate (HR), level of Consciousness (qCON), and Suppression Rate (SR) were recorded every 2 minutes. Results Twenty-seven patients remained in the TCI group, while 28 were in the Bolus group. Repeated measure analysis using mixed-effects models could not reject the null hypothesis for the effect of group-time interactions in MAP (p = 0.85), HR (p = 0.49), SR (p = 0.44), or qCON (p = 0.72). The difference in means for qCON (60.2 for TCI, 50.5 for bolus, p < 0.001), MAP (90.3 for TCI, 86.2 for bolus, p < 0.006), HR (76.2 for TCI, 76.9 for bolus, p = 0.93), and SR (0.01 for TCI, 5.5 for bolus, p < 0.001), irrespective of time (whole period means), revealed some significant differences. Conclusion Patients who received propofol bolus injection exhibited a lower mean arterial pressure, a greater variation in the level of consciousness, and a higher suppression rate compared to those who received it as a target-controlled infusion. However, the interaction effect between groups and time remains inconclusive. targetcontrolled target controlled prospective singlecenter, singlecenter single center, center single-center nonblinded non blinded 6 aged 5 years, years , years) II noncardiac cardiac surgeries Group μgmL1 μgmL μg mL 1 μg.mL−1 mgkg1 mgkg mg kg mg.kg−1 μgkg1 μgkg μg.kg−1 06 0 0. MAP, (MAP) HR, (HR) qCON, (qCON) (SR Twentyseven Twenty seven group mixedeffects mixed effects grouptime 0.85, 085 0.85 85 0.85) 0.49, 049 0.49 49 0.49) 0.44, 044 0.44 44 0.44) 0.72. 072 0.72 . 72 0.72) 60.2 602 (60. 505 50 50. 0.001, 0001 0.001 001 0.001) 90.3 903 90 (90. 862 86 86. 0.006, 0006 0.006 006 0.006) 76.2 762 76 (76. 769 9 76. 0.93, 093 0.93 93 0.93) 0.01 01 (0.0 5. whole means, means) differences pressure consciousness However inconclusive μg.mL− mg.kg− μg.kg− (MAP (HR (qCON 08 0.8 8 04 0.4 07 0.7 7 60. (60 000 0.00 00 90. (90 (76 09 0.9 0.0 (0. μg.mL mg.kg μg.kg (6 (9 (7 (0 (