ABSTRACT Objectives: to identify, in the scientific literature, the care that should be provided to individuals with drug-resistant tuberculosis by nurses in primary health care. Methods: integrative review, using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses study selection flowchart. Data collection was conducted in November 2022, across ten databases. Results: six studies emphasized that nurses should perform directly observed treatment; two highlighted the importance of integrated care management between tuberculosis and human immunodeficiency virus; two demonstrated comprehensive nursing consultation using the nursing process; one emphasized person-centered care, with discharge planning and improved hospital communication with primary health care services. Final Considerations: the care that nurses should provide to individuals with drug-resistant tuberculosis in primary health care, for care resolution, is evidence-based. Objectives identify literature drugresistant drug resistant Methods review MetaAnalyses Meta Analyses flowchart 2022 databases Results treatment virus process personcentered person centered services Considerations resolution evidencebased. evidencebased evidence based. based evidence-based 202 20 2

RESUMEN Objetivos: identificar, en la literatura científica, los cuidados que deben brindarse a las personas con tuberculosis farmacorresistente por parte de los enfermeros en la atención primaria de salud. Métodos: revisión integradora, utilizando el flujo de selección de estudios del Preferred Reporting Items for Systematic Reviews and Meta-Analyses. La recolección de datos se realizó en noviembre de 2022, en diez bases de datos. Resultados: seis estudios enfatizaron que el enfermero debe llevar a cabo el tratamiento directamente observado; dos resaltaron la importancia de la gestión del cuidado integrado entre la tuberculosis y el virus de la inmunodeficiencia humana; dos evidenciaron la consulta de enfermería comprensiva utilizando el proceso de enfermería; uno destacó los cuidados centrados en la persona, con planificación de alta y una mejor comunicación hospitalaria con los servicios de atención primaria de salud. Conclusiones: los cuidados que deben brindarse por parte de los enfermeros a las personas con tuberculosis farmacorresistente en la atención primaria de salud, para la resolutividad del cuidado, están basados en evidencia científica. Objetivos identificar científica salud Métodos integradora MetaAnalyses. MetaAnalyses Meta Analyses. Analyses Meta-Analyses 2022 Resultados observado humana persona Conclusiones 202 20 2

RESUMO Objetivos: identificar, na literatura científica, os cuidados que devem ser prestados às pessoas com tuberculose drogarresistente pelos enfermeiros na atenção primária à saúde. Métodos: revisão integrativa, utilizando o fluxograma de seleção de estudos Preferred Reporting Items for Systematic Reviews and Meta-Analyses. A coleta de dados foi realizada em novembro de 2022, em dez bases de dados. Resultados: seis estudos enfatizaram que o enfermeiro deve realizar o tratamento diretamente observado; dois trouxeram a importância da gestão do cuidado integrado entre tuberculose e vírus da imunodeficiência humana; dois evidenciaram a consulta de enfermagem abrangente com utilização do processo de enfermagem; um salientou os cuidados centrados na pessoa, com planejamento de alta e melhor comunicação hospitalar com os serviços de atenção primária à saúde. Considerações Finais: os cuidados que devem ser prestados pelos enfermeiros às pessoas com tuberculose drogarresistente na atenção primária à saúde, para resolutividade do cuidado, são baseados em evidências científicas. Objetivos identificar científica saúde Métodos integrativa MetaAnalyses. MetaAnalyses Meta Analyses. Analyses Meta-Analyses 2022 Resultados observado humana pessoa Finais científicas 202 20 2

Tuberculosis (TB) is one of the infectious diseases that contributes most to the morbidity and mortality of millions of people worldwide. Brazil is one of 22 countries that accounts for 80% of the tuberculosis global burden. The highest incidence rates in Brazil occur in the States of Amazonas and Rio de Janeiro. The aim of this study was to describe the temporal distribution of TB in the State of Amazonas. Between 2001 and 2011, 28,198 cases of tuberculosis were reported in Amazonas, distributed among 62 municipalities, with the capital Manaus reporting the highest (68.7%) concentration of cases. Tuberculosis was more prevalent among males (59.3%) aged 15 to 34 years old (45.5%), whose race/color was predominantly pardo (64.7%) and who had pulmonary TB (84.3%). During this period, 81 cases of multidrug-resistant TB were registered, of which the highest concentration was reported from 2008 onward (p = 0.002). The municipalities with the largest numbers of indigenous individuals affected were São Gabriel da Cachoeira (93%), Itamarati (78.1%), and Santa Isabel do Rio Negro (70.1%). The future outlook for this region includes strengthening the TB control at the primary care level, by expanding diagnostic capabilities, access to treatment, research projects developed in collaboration with the Dr. Heitor Vieira Dourado Tropical Medicine Foundation .;Fundação de Medicina Tropical Dr. Heitor Vieira Dourado (FMT-HVD).; and financing institutions, such as the project for the expansion of the Clinical Research Center and the creation of a hospital ward for individuals with transmissible respiratory diseases, including TB.