Abstract Background and purpose Intravenous Thrombolysis (IVT) prior to Mechanical Thrombectomy (MT) for Acute Ischaemic Stroke (AIS) due to Large-Vessel Occlusion (LVO) remains controversial. Therefore, the authors performed a meta-analysis of the available real-world evidence focusing on the efficacy and safety of Bridging Therapy (BT) compared with direct MT in patients with AIS due to LVO. Methods Four databases were searched until 01 February 2023. Retrospective and prospective studies from nationwide or health organization registry databases that compared the clinical outcomes of BT and direct MT were included. Odds Ratios (ORs) and 95 % Confidence Intervals (CIs) for efficacy and safety outcomes were pooled using a random-effects model. Results Of the 12 studies, 86,695 patients were included. In patients with AIS due to LVO, BT group was associated with higher odds of achieving excellent functional outcome (modified Rankin Scale score 0-1) at 90 days (OR = 1.48, 95 % CI 1.25-1.75), favorable discharge disposition (to the home with or without services) (OR = 1.33, 95 % CI 1.29-1.38), and decreased mortality at 90 days (OR = 0.62, 95 % CI 0.56-0.70), as compared with the direct MT group. In addition, the risk of symptomatic intracranial hemorrhage did not increase significantly in the BT group. Conclusion The present meta-analysis indicates that BT was associated with favorable outcomes in patients with AIS due to LVO. These findings support the current practice in a real-world setting and strengthen their validity. For patients eligible for both IVT and MT, BT remains the standard treatment until more data are available. (IVT (MT (AIS LargeVessel Large Vessel LVO (LVO controversial Therefore metaanalysis meta analysis realworld real world (BT 0 2023 included ORs (ORs 9 CIs (CIs randomeffects random effects model 1 86695 86 695 86,69 modified 0-1 OR 148 48 1.48 1.251.75, 125175 1.25 1.75 , 25 75 1.25-1.75) services 133 33 1.33 1.291.38, 129138 1.29 1.38 29 38 1.29-1.38) 062 62 0.62 0.560.70, 056070 0.56 0.70 56 70 0.56-0.70) addition validity 202 8669 8 69 86,6 0- 14 4 1.4 251 1.251.75 12517 125 1.2 175 1.7 2 7 1.25-1.75 13 3 1.3 291 1.291.38 12913 129 138 1.29-1.38 06 6 0.6 560 0.560.70 05607 056 0.5 070 0.7 5 0.56-0.70 20 866 86, 1. 1.251.7 1251 17 1.25-1.7 1.291.3 1291 1.29-1.3 0. 0.560.7 0560 05 07 0.56-0.7 1.251. 1.25-1. 1.291. 1.29-1. 0.560. 0.56-0. 1.251 1.25-1 1.291 1.29-1 0.560 0.56-0 1.25- 1.29- 0.56-

Rongalite® promove a clivagem de diarildissulfetos gerando os calcogenolatos correspondentes, que reagem facilmente com N-acilbenzotriazóis na presença de K2CO3, produzindo tioésteres em bons a excelentes rendimentos. As principais características desta metodologia são a não necessidade de catalisdores metálicos ou de reagentes caros e o alto rendimento. É digno de nota que as reações de disseleneto de difenila com N-acilbenzotriazóis são também conduzidas para produzir selenoésteres em bons rendimentos sob condições normais.

Rongalite® promotes cleavage of diaryldisulfides generating the corresponding chalcogenolate anions that then undergo facile reaction with N-acylbenzotriazoles in the presence of K2CO3 to afford thioesters in good to excellent yields. The important features of this methodology are no requirement of metal catalysts, without any expensive reagent and high yields. It is noteworthy that the reactions of diphenyl diselenide with N-acylbenzotriazoles are also conducted to afford selenoesters in good yields under the standard conditions.

Óxido de boro adsorvido sobre alumina (B2O3/Al2O3 ) foi usado como um novo e eficiente catalisador na síntese de β-aminocetonas e ésteres pela enaminação de diferentes aminas primárias e secundárias com compostos carbonílicos sob condições livre de solvente. A importância dessa metodologia congrega grande variedade de substratos, alta eficiência, ausência de catalisador metálico, alta régio- e quimioseletividade em condições amigáveis ao ambiente. Ainda, o catalisador pode ser recuperado facilmente depois das reações e reusado sem perda de atividade.

Boron oxide adsorbed on alumina (B2O3/Al2O3 ) has been found to be a new and highly efficient heterogeneous catalyst for the synthesis of β-enamino ketones and esters by the enamination of various primary and secondary amines with β-dicarbonyl compounds under solvent-free conditions. The important features of this methodology are broad substrate scope, high yield, no requirement of metal catalysts, high regio- and chemoselectivity and environmental friendliness. In addition, the catalyst could be recovered easily after the reactions and reused without evident loss of reactivity.