Resumo O estudo objetiva descrever o processo de validação do modelo lógico (ML) da Política de Educação Permanente em Saúde (PEPS) nos Centros de Atenção Psicossocial (CAPS) no município de Barreiras, Bahia, Brasil. Trata-se de um estudo de avaliabilidade, com especialistas distribuídos no quadrilátero para formação da área da saúde, incluindo gestão, ensino/pesquisa, serviço e controle social, por meio da técnica de consenso Delfos, realizada em duas rodadas. Os itens foram consensuados quando alcançaram mais de 80% de concordância entre os participantes, confirmados pela análise da mediana e do intervalo entre o primeiro e o terceiro quartis. Os resultados refletem o conteúdo validado do ML em cinco componentes técnicos: planejamento, articulação política, coordenação, qualificação técnica e trabalho vivo na produção do cuidado. A estrutura e os processos necessários para a realização das ações de EPS nos CAPS, bem como os resultados esperados em curto, médio e longo prazos, foram descritos no ML. A validação de funcionamento da intervenção contribui para a organização e a adoção de critérios de operacionalidade e fecundidade em uma avaliação formativa que visa fortalecer as práticas de uma política educativa em saúde mental na direção do cuidado integral.

Abstract The study aims to describe the validation process of the Continuing Health Education Policy (PEPS) logical model in the Psychosocial Care Centers (CAPS) in Barreiras, Bahia, Brazil. In two rounds, this evaluability study on specialists distributed in the health training four-square model, including management, education/research, service, and social control, was conducted through the Delphi consensus technique. The items were consensual when they reached more than 80% of agreement among the participants, confirmed by the analysis of the median and the interval between the first and the third quartiles. The results reflect the validated logical model content in five technical components: Planning, Political Articulation, Coordination, Technical Qualification, and Live Work in Care Production. The structure and processes required to carry out the EPS actions at the CAPS and the expected results in the short, medium, and long terms were described in the logical model. Validating the operational aspect of the intervention contributes to organizing and adopting operability and fertility criteria in a formative assessment that aims to strengthen the practices of an educational policy in mental health toward comprehensive care.

Abstract The study aims to describe the validation process of the Continuing Health Education Policy (PEPS) logical model in the Psychosocial Care Centers (CAPS) in Barreiras, Bahia, Brazil. In two rounds, this evaluability study on specialists distributed in the health training four-square model, including management, education/research, service, and social control, was conducted through the Delphi consensus technique. The items were consensual when they reached more than 80% of agreement among the participants, confirmed by the analysis of the median and the interval between the first and the third quartiles. The results reflect the validated logical model content in five technical components: Planning, Political Articulation, Coordination, Technical Qualification, and Live Work in Care Production. The structure and processes required to carry out the EPS actions at the CAPS and the expected results in the short, medium, and long terms were described in the logical model. Validating the operational aspect of the intervention contributes to organizing and adopting operability and fertility criteria in a formative assessment that aims to strengthen the practices of an educational policy in mental health toward comprehensive care.

Resumo O estudo objetiva descrever o processo de validação do modelo lógico (ML) da Política de Educação Permanente em Saúde (PEPS) nos Centros de Atenção Psicossocial (CAPS) no município de Barreiras, Bahia, Brasil. Trata-se de um estudo de avaliabilidade, com especialistas distribuídos no quadrilátero para formação da área da saúde, incluindo gestão, ensino/pesquisa, serviço e controle social, por meio da técnica de consenso Delfos, realizada em duas rodadas. Os itens foram consensuados quando alcançaram mais de 80% de concordância entre os participantes, confirmados pela análise da mediana e do intervalo entre o primeiro e o terceiro quartis. Os resultados refletem o conteúdo validado do ML em cinco componentes técnicos: planejamento, articulação política, coordenação, qualificação técnica e trabalho vivo na produção do cuidado. A estrutura e os processos necessários para a realização das ações de EPS nos CAPS, bem como os resultados esperados em curto, médio e longo prazos, foram descritos no ML. A validação de funcionamento da intervenção contribui para a organização e a adoção de critérios de operacionalidade e fecundidade em uma avaliação formativa que visa fortalecer as práticas de uma política educativa em saúde mental na direção do cuidado integral.

Resumo A prescrição farmacêutica é uma experiência em expansão em alguns países desenvolvidos, com diferentes sistemas de saúde. Conhecer a contribuição que essa atividade pode desempenhar no processo de assistência à saúde e investigar sua aceitação é de fundamental interesse para os países que a regularam. Este estudo de revisão de literatura, portanto, objetivou desenhar o estado da arte da investigação acadêmica sobre percepção, opiniões e atitudes no contexto da prática da prescrição farmacêutica em países que a adotaram. Para isso, realizou-se investigação nas bases de dados MEDLINE, Scopus, Embase, SciELO e LILACS, resultando na seleção de 17 estudos. Da análise dos artigos, emergiram três categorias de discussão: “compreensão da prática e benefícios percebidos”; “aceitação e adesão à prática”; “barreiras à prática”. Os resultados mostraram aceitação e percepções variáveis nos diferentes públicos, dependendo, entre outras questões, do nível de conhecimento e experiência dos pacientes e dos profissionais de saúde, do perfil do farmacêutico ou da modalidade de prescrição. Este estudo aponta alguns desafios envolvidos na prática da prescrição farmacêutica e seus achados podem ser úteis para sugerir caminhos para o fortalecimento da prática.

Abstract Pharmacist prescribing is a growing reality in some developed counties, with varied health systems. Understanding the contribution that this activity can offer in the healthcare process, and investigating its acceptance is of utmost importance for the countries that implement and regulate this type of system. This literature review aimed to design a state-of-the-art academic investigation on the perception, opinions, and attitudes in the context of pharmacist prescribing practices in countries that have adopted this system. To achieve this, the present study conducted an investigation of the Medline, Scopus, Embase, SciELO, and Lilacs databases, resulting in the selection of 17 studies. From the analysis of the articles, three categories of discussion arose: “understanding of the practice and perceived benefits”, “acceptance and adherence to the practice, and “hindrances to the practice”. The results showed varied acceptance and perceptions among the different publics, depending, among other questions, on the level of knowledge and experience of the patients and health professionals, on the profile of the pharmacists, or on the prescribing modality. This study highlights some challenges involved in the practice of pharmacist prescribing, and its findings can be useful in suggesting a means through which to strengthen the practice.

Abstract Pharmacist prescribing is a growing reality in some developed counties, with varied health systems. Understanding the contribution that this activity can offer in the healthcare process, and investigating its acceptance is of utmost importance for the countries that implement and regulate this type of system. This literature review aimed to design a state-of-the-art academic investigation on the perception, opinions, and attitudes in the context of pharmacist prescribing practices in countries that have adopted this system. To achieve this, the present study conducted an investigation of the Medline, Scopus, Embase, SciELO, and Lilacs databases, resulting in the selection of 17 studies. From the analysis of the articles, three categories of discussion arose: “understanding of the practice and perceived benefits”, “acceptance and adherence to the practice, and “hindrances to the practice”. The results showed varied acceptance and perceptions among the different publics, depending, among other questions, on the level of knowledge and experience of the patients and health professionals, on the profile of the pharmacists, or on the prescribing modality. This study highlights some challenges involved in the practice of pharmacist prescribing, and its findings can be useful in suggesting a means through which to strengthen the practice.

Resumo A prescrição farmacêutica é uma experiência em expansão em alguns países desenvolvidos, com diferentes sistemas de saúde. Conhecer a contribuição que essa atividade pode desempenhar no processo de assistência à saúde e investigar sua aceitação é de fundamental interesse para os países que a regularam. Este estudo de revisão de literatura, portanto, objetivou desenhar o estado da arte da investigação acadêmica sobre percepção, opiniões e atitudes no contexto da prática da prescrição farmacêutica em países que a adotaram. Para isso, realizou-se investigação nas bases de dados MEDLINE, Scopus, Embase, SciELO e LILACS, resultando na seleção de 17 estudos. Da análise dos artigos, emergiram três categorias de discussão: “compreensão da prática e benefícios percebidos”; “aceitação e adesão à prática”; “barreiras à prática”. Os resultados mostraram aceitação e percepções variáveis nos diferentes públicos, dependendo, entre outras questões, do nível de conhecimento e experiência dos pacientes e dos profissionais de saúde, do perfil do farmacêutico ou da modalidade de prescrição. Este estudo aponta alguns desafios envolvidos na prática da prescrição farmacêutica e seus achados podem ser úteis para sugerir caminhos para o fortalecimento da prática.

Resumo O objetivo deste artigo é verificar os fatores associados à realização de atividades educativas relacionadas à saúde bucal durante o acompanhamento pré-natal na Região Metropolitana da Grande Vitória-ES, Brasil. Estudo transversal com 1.035 puérperas em maternidades públicas ou conveniadas ao SUS, em 2010. Executou-se análise descritiva das principais informações educativas e regressão logística binomial associando-se variáveis individuais e contextuais com o desfecho “recebimento de atividade educativa por meio de reuniões e/ou grupo de gestante na unidade de saúde e/ou por meio de visita domiciliar”. A informação mais recebida durante o pré-natal foi: “vantagem da amamentação exclusiva até os seis meses de vida” (52,0%) e a menos recebida foi “a importância do uso do flúor na saúde” (18,9%). Ter atendimento pela Estratégia Saúde da Família (OR=1,94), ter condições externas de moradia adequadas (OR=1,73) e aumento de 1 consulta pré-natal (OR=1,08) aumentaram a chance de realização de atividade educativa no pré-natal. Número elevado de consultas pré-natal, cobertura dos serviços de saúde nos moldes da ESF e condições externas de moradia adequadas foram fatores que se associaram positivamente às atividades educativas durante o pré-natal.

Abstract The scope of this article is to verify the factors associated with providing educational guidance related to oral health during prenatal care in the Metropolitan Region of Greater Vitória - ES, Brazil. It involved a cross-sectional study of 1,035 postpartum women in public or affiliated private hospitals in the SUS in 2010. A descriptive analysis of the main educational information and binomial logistic regression was conducted to test the association between individual and contextual variables and “receiving educational guidance through meetings and/or pregnant mother groups in the health unit and/or through home visits”. The information given most during prenatal care was “the advantage of exclusive breastfeeding until six months of life” (52.0%) and least was “the importance of fluoride use in health” (18.9%). Being attended by the Family Health Strategy (FHS) (OR=1.94), having adequate living conditions for women and children (OR=1.73) and an additional prenatal visit (OR=1.08), increased the chance of providing educational guidance in prenatal care. Frequent pre-natal visits, coverage of health services in line with the FHS, and adequate conditions of housing were factors that were positively associated with educational guidance during prenatal care.

Resumo O objetivo deste artigo é verificar os fatores associados à realização de atividades educativas relacionadas à saúde bucal durante o acompanhamento pré-natal na Região Metropolitana da Grande Vitória-ES, Brasil. Estudo transversal com 1.035 puérperas em maternidades públicas ou conveniadas ao SUS, em 2010. Executou-se análise descritiva das principais informações educativas e regressão logística binomial associando-se variáveis individuais e contextuais com o desfecho “recebimento de atividade educativa por meio de reuniões e/ou grupo de gestante na unidade de saúde e/ou por meio de visita domiciliar”. A informação mais recebida durante o pré-natal foi: “vantagem da amamentação exclusiva até os seis meses de vida” (52,0%) e a menos recebida foi “a importância do uso do flúor na saúde” (18,9%). Ter atendimento pela Estratégia Saúde da Família (OR=1,94), ter condições externas de moradia adequadas (OR=1,73) e aumento de 1 consulta pré-natal (OR=1,08) aumentaram a chance de realização de atividade educativa no pré-natal. Número elevado de consultas pré-natal, cobertura dos serviços de saúde nos moldes da ESF e condições externas de moradia adequadas foram fatores que se associaram positivamente às atividades educativas durante o pré-natal.

Abstract The scope of this article is to verify the factors associated with providing educational guidance related to oral health during prenatal care in the Metropolitan Region of Greater Vitória - ES, Brazil. It involved a cross-sectional study of 1,035 postpartum women in public or affiliated private hospitals in the SUS in 2010. A descriptive analysis of the main educational information and binomial logistic regression was conducted to test the association between individual and contextual variables and “receiving educational guidance through meetings and/or pregnant mother groups in the health unit and/or through home visits”. The information given most during prenatal care was “the advantage of exclusive breastfeeding until six months of life” (52.0%) and least was “the importance of fluoride use in health” (18.9%). Being attended by the Family Health Strategy (FHS) (OR=1.94), having adequate living conditions for women and children (OR=1.73) and an additional prenatal visit (OR=1.08), increased the chance of providing educational guidance in prenatal care. Frequent pre-natal visits, coverage of health services in line with the FHS, and adequate conditions of housing were factors that were positively associated with educational guidance during prenatal care.

RESUMO Objetivo Avaliar o papel da tomografia computadorizada de tórax em pacientes com COVID-19 que apresentaram reação em cadeia da polimerase via transcriptase reversa (RT-PCR) inicial falsamente negativa. Métodos Estudo retrospectivo de centro único que avaliou 39 pacientes com RT-PCR negativa para COVID-19, submetidos à tomografia computadorizada de tórax e que tiveram diagnóstico final clínico ou serológico de COVID-19. A classificação tomográfica visual foi avaliada de acordo com o Consenso da Radiological Society of North America e o software desenvolvido com inteligência artificial para detecção automática de achados e estimativa de probabilidade de COVID-19. Resultados Na análise tomográfica visual, somente um deles (3%) apresentou tomografia computadorizada classificada como tendo resultado negativo, 69% foram classificados como típicos e 28% como indeterminados. Na avaliação com uso de software, somente quatro (cerca de 10%) tiveram probabilidade de COVID-19 <25%. Conclusão A tomografia computadorizada pode desempenhar papel importante no manejo de casos suspeitos de COVID-19 com RT-PCR inicialmente negativa, principalmente levando-se em consideração os pacientes que estão fora da janela ideal para coleta de amostra para RT-PCR.

ABSTRACT Objective To evaluate the role of chest computed tomography in patients with COVID-19 who presented initial negative result in reverse transcriptase-polymerase chain reaction (RT-PCR). Methods A single-center, retrospective study that evaluated 39 patients with negative RT-PCR for COVID-19, who underwent chest computed tomography and had a final clinical or serological diagnosis of COVID-19. The visual tomographic classification was evaluated according to the Consensus of the Radiological Society of North America and software developed with artificial intelligence for automatic detection of findings and chance estimation of COVID-19. Results In the visual tomographic analysis, only one of them (3%) presented computed tomography classified as negative, 69% were classified as typical and 28% as indeterminate. In the evaluation using the software, only four (about 10%) had a probability of COVID-19 <25%. Conclusion Computed tomography can play an important role in management of suspected cases of COVID-19 with initial negative results in RT-PCR, especially considering those patients outside the ideal window for sample collection for RT-PCR.

OBJECTIVE: To determine the correlation between the two tomographic classifications for coronavirus disease (COVID-19), COVID-19 Reporting and Data System (CORADS) and Radiological Society of North America Expert Consensus Statement on Reporting Chest Computed Tomography (CT) Findings Related to COVID-19 (RSNA), in the Brazilian population and to assess the agreement between reviewers with different experience levels. METHODS: Chest CT images of patients with reverse transcriptase-polymerase chain reaction (RT-PCR)-positive COVID-19 were categorized according to the CORADS and RSNA classifications by radiologists with different levels of experience and who were initially unaware of the RT-PCR results. The inter- and intra-observer concordances for each of the classifications were calculated, as were the concordances between classifications. RESULTS: A total of 100 patients were included in this study. The RSNA classification showed an almost perfect inter-observer agreement between reviewers with similar experience levels, with a kappa coefficient of 0.892 (95% confidence interval [CI], 0.788-0.995). CORADS showed substantial agreement among reviewers with similar experience levels, with a kappa coefficient of 0.642 (95% CI, 0.491-0.793). There was inter-observer variation when comparing less experienced reviewers with more experienced reviewers, with the highest kappa coefficient of 0.396 (95% CI, 0.255-0.588). There was a significant correlation between both classifications, with a Kendall coefficient of 0.899 (p<0.001) and substantial intra-observer agreement for both classifications. CONCLUSION: The RSNA and CORADS classifications showed excellent inter-observer agreement for reviewers with the same level of experience, although the agreement between less experience reviewers and the reviewer with the most experience was only reasonable. Combined analysis of both classifications with the first RT-PCR results did not reveal any false-negative results for detecting COVID-19 in patients.

OBJECTIVE: To investigate the relationship between lung lesion burden (LLB) found on chest computed tomography (CT) and 30-day mortality in hospitalized patients with high clinical suspicion of coronavirus disease 2019 (COVID-19), accounting for tomographic dynamic changes. METHODS: Patients hospitalized with high clinical suspicion of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in a dedicated and reference hospital for COVID-19, having undergone at least one RT-PCR test, regardless of the result, and with one CT compatible with COVID-19, were retrospectively studied. Clinical and laboratory data upon admission were assessed, and LLB found on CT was semi-quantitatively evaluated through visual analysis. The primary outcome was 30-day mortality after admission. Secondary outcomes, including the intensive care unit (ICU) admission, mechanical ventilation used, and length of stay (LOS), were assessed. RESULTS: A total of 457 patients with a mean age of 57±15 years were included. Among these, 58% presented with positive RT-PCR result for COVID-19. The median time from symptom onset to RT-PCR was 8 days [interquartile range 6-11 days]. An initial LLB of ≥50% using CT was found in 201 patients (44%), which was associated with an increased crude at 30-day mortality (31% vs. 15% in patients with LLB of <50%, p<0.001). An LLB of ≥50% was also associated with an increase in the ICU admission, the need for mechanical ventilation, and a prolonged LOS after adjusting for baseline covariates and accounting for the CT findings as a time-varying covariate; hence, patients with an LLB of ≥50% remained at a higher risk at 30-day mortality (adjusted hazard ratio 2.17, 95% confidence interval 1.47-3.18, p<0.001). CONCLUSION: Even after accounting for dynamic CT changes in patients with both clinical and imaging findings consistent with COVID-19, an LLB of ≥50% might be associated with a higher risk of mortality.

Resumo O estudo comparativo de complexos coacervados entre albumina sérica bovina (BSA) e diferentes polissacarídeos, pectina (PEC) e goma acácia (GA), foi realizado avaliando-se a influência de diferentes razões (proteína:polissacarídeo) e concentrações de cloreto de sódio (NaCl) na turbidez e no potencial zeta. Os complexos BSA:PEC foram formados na proporção 10:1, enquanto os de BSA:GA, na proporção 3:1. O pH de complexação apresentou comportamento diferenciado, complexos BSA:PEC exibiram máxima turbidez em uma ampla faixa de pH (4,9 a 1,5), enquanto complexos BSA:GA tiveram turbidez máxima em pH 3,5. O aumento da concentração de NaCl influenciou negativamente a complexação, com a concentração de NaCl de 0,40 mol L-1 capaz de suprimir a interação em BSA:PEC (10:1) e reduzir a faixa de formação de BSA:GA (3:1). A espectroscopia de infravermelho com transformada de Fourier (FTIR) demonstrou a participação não apenas de interações eletrostáticas, mas também de ligações de hidrogênio na complexação. Este estudo inicial elucidou aspectos fundamentais sobre a formação de complexos coacervados entre BSA:GA/PEC que ajudam a direcionar sua aplicação em produtos alimentícios, especialmente em matrizes ácidas e com baixa concentração de sais, tendo em vista o pH máximo de formação (pH ~ 4,0) e a sensibilidade ao NaCl. Esses complexos podem ser adicionados diretamente em produtos, a fim de agregar valor nutricional ou ainda serem utilizados como uma nova matriz para o encapsulamento de compostos bioativos.

Abstract The comparative study regarding complexes coacervated between Bovine Serum Albumin (BSA) and different polysaccharides, Pectin (PEC) and Gum Acacia (GA), was carried out by evaluating the influence of different ratios (protein:polysaccharide) and sodium chloride (NaCl) concentrations on turbidity and zeta potential. The BSA:PEC complexes were formed in a 10:1 ratio whereas BSA:GA at 3:1. The complexation pH showed different behavior, BSA: PEC complexes exhibited maximum turbidity in a wide pH range (4.9 to 1.5), while BSA: GA had maximum turbidity at pH 3.5. The increase in the concentration of NaCl negatively influenced the complexation. The NaCl concentration of 0.40 mol L-1 suppressed the interaction in BSA:PEC (10:1) and reduced the range formation of BSA:GA (3:1). The Fourier Transform Infrared (FTIR) demonstrated the participation not only of electrostatic interactions, but also of hydrogen bonds in the complexation. This initial study elucidated fundamental aspects about the formation of coacervate complexes between BSA:GA/PEC that assist in directing its application in food products especially, in acidic matrices (pH~4.0) as well as with low concentration of salts, in view of the effect of pH on maximum formation and sensitivity to NaCl. These complexes can be added directly to products in order to add nutritional value or even be used as a new matrix for the encapsulation of bioactive compounds.

RESUMO Este estudo objetivou compreender a apropriação da Educação Permanente em Saúde (EPS) no contexto dos Centros de Atenção Psicossocial (Caps), e suas iniciativas no Brasil, por meio de uma revisão integrativa da literatura. Buscaram-se textos em português, inglês e espanhol, publicados no Brasil entre 2007 e 2019, que abordassem o conceito de EPS, cujos objetivos se referiam a iniciativas desenvolvidas nos Caps, e que versassem sobre as percepções quanto à mudança da prática profissional a partir dessas iniciativas. Foram selecionados 28 estudos. A análise de conteúdo temática identificou quatro categorias empíricas: 1. Concepções de EPS nos Caps; 2. Produção do cuidado e a aproximação com a EPS nos Caps; 3. Fatores intervenientes e características da EPS nos Caps; e 4. Fatores facilitadores e dispositivos de EPS nos Caps. A compreensão de EPS por profissionais e gestores aproxima-se do conceito de Educação Continuada, embora reconheçam que a primeira possibilita a reflexão e a problematização das práticas. As ações de formação desenvolvidas ainda estão distantes das transformações desejadas no âmbito da saúde mental. Considera-se necessário fortalecer a relação entre profissionais, gestores, comunidade e instituições de ensino para que essa política se torne eficaz no modelo de atenção psicossocial.

ABSTRACT This study aimed to understand the appropriation of Permanent Health Education (EPS) in the context of the Psychosocial Care Centers (Caps), and their initiatives in Brazil, through an integrative literature review. We searched for texts published in Portuguese, English and Spanish, published in Brazil, between 2007 and 2019, which addressed the concept of EPS, whose objectives referred to initiatives developed at Caps, and which discussed the perceptions regarding the change in professional practice based on these initiatives. 28 studies were selected. Thematic content analysis identified four empirical categories: 1. Conceptions of EPS at Caps; 2. Production of care and approximation with EPS at Caps; 3. Intervening factors and characteristics of EPS at Caps; and 4. Enabling factors and EPS devices in the Caps. The understanding of EPS by professionals and managers comes close to the concept of Continuing Education, although they recognize that EPS allows reflection and problematization of practices. The training actions developed are still far from the desired transformations in the scope of mental health. It is considered necessary to strengthen the relationship between professionals, managers, community and educational institutions so that this policy becomes effective in the model of psychosocial care.

RESUMO Este estudo objetivou compreender a apropriação da Educação Permanente em Saúde (EPS) no contexto dos Centros de Atenção Psicossocial (Caps), e suas iniciativas no Brasil, por meio de uma revisão integrativa da literatura. Buscaram-se textos em português, inglês e espanhol, publicados no Brasil entre 2007 e 2019, que abordassem o conceito de EPS, cujos objetivos se referiam a iniciativas desenvolvidas nos Caps, e que versassem sobre as percepções quanto à mudança da prática profissional a partir dessas iniciativas. Foram selecionados 28 estudos. A análise de conteúdo temática identificou quatro categorias empíricas: 1. Concepções de EPS nos Caps; 2. Produção do cuidado e a aproximação com a EPS nos Caps; 3. Fatores intervenientes e características da EPS nos Caps; e 4. Fatores facilitadores e dispositivos de EPS nos Caps. A compreensão de EPS por profissionais e gestores aproxima-se do conceito de Educação Continuada, embora reconheçam que a primeira possibilita a reflexão e a problematização das práticas. As ações de formação desenvolvidas ainda estão distantes das transformações desejadas no âmbito da saúde mental. Considera-se necessário fortalecer a relação entre profissionais, gestores, comunidade e instituições de ensino para que essa política se torne eficaz no modelo de atenção psicossocial.

ABSTRACT This study aimed to understand the appropriation of Permanent Health Education (EPS) in the context of the Psychosocial Care Centers (Caps), and their initiatives in Brazil, through an integrative literature review. We searched for texts published in Portuguese, English and Spanish, published in Brazil, between 2007 and 2019, which addressed the concept of EPS, whose objectives referred to initiatives developed at Caps, and which discussed the perceptions regarding the change in professional practice based on these initiatives. 28 studies were selected. Thematic content analysis identified four empirical categories: 1. Conceptions of EPS at Caps; 2. Production of care and approximation with EPS at Caps; 3. Intervening factors and characteristics of EPS at Caps; and 4. Enabling factors and EPS devices in the Caps. The understanding of EPS by professionals and managers comes close to the concept of Continuing Education, although they recognize that EPS allows reflection and problematization of practices. The training actions developed are still far from the desired transformations in the scope of mental health. It is considered necessary to strengthen the relationship between professionals, managers, community and educational institutions so that this policy becomes effective in the model of psychosocial care.

Abstract Soft-tissue calcifications are extremely common. Because the imaging findings are nonspecific, soft-tissue calcifications are often problematic for radiologists, sometimes prompting unnecessary interventions. In addition, the nomenclature is quite confusing. Classically, soft-tissue calcifications are divided into four categories, by mechanism of formation-dystrophic, iatrogenic, metastatic, and idiopathic-depending on the clinical and biochemical correlation. However, it is also possible to classify such calcifications by compartment, and that classification can be quite useful in the radiological diagnostic assessment. In this article, we illustrate the main causes of soft-tissue calcifications, organizing them according to their anatomical and pathophysiological aspects, thus narrowing the differential diagnosis.

The emergence of antibiotic resistance among microbial pathogens is a serious public health problem, resulting in a constant need of discovering new antibiotics. For this purpose, we synthetized and determined the antimicrobial activity of copper (Cu), cobalt (Co), and tin (Sn) complexes coordinated with scorpionate ligand in a tridentate mode against microorganisms of clinical importance. New complexes with the sodium hydrotris(2-mercaptothiazolyl)borate ligand were characterized by physicochemical and spectroscopic techniques (UV-vis, IR, 1H and 13C NMR). Moreover, their antimicrobial activity was evaluated using microdilution broth method. Cytotoxicity was determined in Vero cells and the selectivity index (SI) was calculated. The coordination with metals increased the ligand antimicrobial activity, which showed no activity when evaluated alone (MIC>1,080 µM). Cu-complex (1) had activity against Candida albicans and C. krusei, with MICs of 130 and 66 µM, respectively. The compounds had low toxicity on Vero cells and chemo-informatics assays corroborated a low systemic toxic effect. The SI revealed that the compound 1 was 16 times more selective for C. krusei and 8 times more selective for C. albicans in relation to Vero cells. The Cu-complex stands out as a potential prototype for the development of new antifungal agents.