O presente aborda a influência do Transtorno de Estresse Pós Traumáticos (TEPT) diante do cotidiano dos veteranos de guerra. O estudo se faz relevante ao contexto atual mediante a falta de investigação sobre o tema, e em razão da atual conjuntura internacional, em que eventos relacionados aos conflitos bélicos estão presentes dentro da perspectiva micro e macro em uma escala de impacto social. Deste modo, se tem como objetivo embasar futuras buscas de linhas de pesquisas equivalentes ao tema. Tem como método a busca pela literatura na forma de revisão integrativa, que aborde a temática. A partir da estratégia PICo, foi possível formulação da pergunta central, que através da ferramenta DeSC (Descritores em Ciência da Saúde) permitiu a seleção dos descritores, prosseguindo com o desenvolvimento dos dados adquiridos no bibliográfico eletrônico, nas bases LILACS, MEDLINE, PUBMED, SciELO e Google Acadêmico. O TEPT é umas das patologias que atingem em grande escala um número de pessoas envolvidas em conflitos armados, que gera ao individuo sequelas que tornam as relações pessoais atribuladas, afetando não somente ele como também pessoas próximas a ele. Por fim, é evidente que em pleno século XXI, no qual o mundo tem passado por situações de confrontos, atingindo de forma indireta e direta diferentes camadas da sociedade, demostra a necessidade de pesquisas voltadas ao assunto.

This work discusses the influence of Post-Traumatic Stress Disorder (PTSD) in everyday life of war veterans. The study is relevant to the current context through the lack of research on the theme, and due to the current international situation, in that events related to present war conflicts within the micro and macro perspective on a scale of social impact. In this way, it has like objective to contextualize future research on research lines similar to the theme. It has as a method the search for literature in the form of an integrative review that argue about theme. Through from the PICo strategy, it was possible to formulate the central question, which through the DeSC tool (Descriptors in Health Science) allowed the selection of the descriptors, proceeding with the development of the data acquired in the electronic bibliography, in database LILACS, MEDLINE, PUBMED, SciELO and GoogleAcadêmico. PTSD is one of the pathologies that reach large numbers of people involved in armed conflict, which generates to the individual sequels that make personal relationships troubled, affecting not only him but also people close to him. Finally, it is evident that in the 21st century, in which the world has experienced confrontational situations, indirectly and directly reaching different levels of society, it demonstrates the need for research about the subject.

ABSTRACT Objective: To evaluate the candidate genes PAX-8, NKX2-5, TSH-R and HES-1 in 63 confirmed cases of thyroid dysgenesis. Subjects and methods: Characterization of patients with congenital hypothyroidism into specific subtypes of thyroid dysgenesis with hormone levels (TT4 and TSH), thyroid ultrasound and scintigraphy. DNA was extracted from peripheral blood leukocytes and the genetic analysis was realized by investigating the presence of mutations in the transcription factor genes involved in thyroid development. Results: No mutations were detected in any of the candidate genes. In situ thyroid gland represented 71.1% of all cases of permanent primary congenital hypothyroidism, followed by hypoplasia (9.6%), ectopia (78%), hemiagenesis (6.0%) and agenesis (5.5%). The highest neonatal screening TSH levels were in the agenesis group (p < 0.001). Conclusions: Thyroid dysgenesis is possibly a polygenic disorder and epigenetic factors could to be implicated in these pathogeneses.

Objective To search for genetic alteration in NKX2.5 gene in patients presenting both congenital heart disease (CHD) and TD. Subjects and methods Individual phenotypes were carefully analyzed in 86 children with thyroid dysgenesis (TD) using thyroid function tests, scintigraphy, ultrasound and echocardiography. DNA was extracted and NKX2.5 gene coding region was amplified by polymerase chain reaction (PCR) and sequenced. Results CHD were found in 8.1% of patients with TD. The mutation screening revealed two known polymorphisms in patients with isolated TD or TD associated with CHD. None of them are predicted to result in codon change in conserved domain. The c.63A>G polymorphism was detected in 54/86 patients (49 with isolated TD and 5 with TD combined with CHD). There was a significant association of c.63A>G polymorphism with hypoplasia (p < 0.036). The c.541G>A polymorphism was observed in only one patient with isolated thyroid hypoplasia. Conclusion NKX2.5 mutations were not found. The c.63A>G polymorphism might be associated with thyroid hypoplasia.

OBJETIVO: Correlacionar o achado ultra-sonográfico isolado de cisto de cordão umbilical com anomalias fetais, como cromossomopatias e alterações estruturais. Segundo a literatura médica, as implicações clínicas do achado ultra-sonográfico de cisto de cordão nos segundo e terceiro trimestres de gestação estão bem estabelecidas, entretanto, quando no primeiro trimestre, o significado ainda permanece controverso. MATERIAIS E MÉTODOS: Foi realizado estudo retrospectivo de gestantes da população geral, consecutivas, com fetos únicos e vivos, que apresentavam apenas o achado de cisto de cordão umbilical, num período de dez anos (1996-2006). Em todos os casos foram realizados exames ultra-sonográficos para o rastreamento de anomalias fetais após o diagnóstico de cisto de cordão. Os recém-nascidos e o cordão umbilical foram examinados após o parto para se verificar a presença de anomalias. RESULTADOS: Foram estudados nove casos que apresentavam cisto de cordão umbilical como único achado, sem outros marcadores ultra-sonográficos de anomalias fetais. Detectaram-se dois casos no primeiro trimestre de gestação e sete nos segundo e terceiro trimestres. Dois casos foram submetidos a estudo citogenético fetal, por meio de amniocentese. Nenhum recém-nascido apresentou anomalias estruturais ou aneuploidia. CONCLUSÃO: O achado ultra-sonográfico isolado de cisto de cordão umbilical não significou aumento de risco para anomalias estruturais ou aneuploidias.

OBJECTIVE: To correlate the isolated sonographic finding of umbilical cord cyst with fetal anomalies such as chromosomopathies and structural changes. According to the medical literature, the clinical implications of the sonographic finding of umbilical cord cyst in the second and third trimesters of pregnancy are well established; however, the meaning of this finding in the first trimester still remains controversial. MATERIALS AND METHODS: A retrospective study was developed with consecutive, pregnant women with single living fetuses presenting with umbilical cord cyst as an isolated finding, over a 10-year period (1996-2006). Ultrasound studies were performed in all cases for screening of fetal anomalies after the diagnosis of umbilical cord cyst. Neonates and umbilical cords were evaluated after delivery for the presence of abnormalities. RESULTS: Nine cases presenting umbilical cord cyst as a sole finding with no other sonographic marker for fetal abnormality were evaluated. Two cases were detected in the first pregnancy trimester and seven cases in the second and third trimesters. Fetal cytogenetic study was done by means of amniocentesis in two cases. No newborn presented with structural anomalies or aneuploidy. CONCLUSION: Isolated sonographic finding of umbilical cord cyst did not imply increased risk for fetal structural anomalies or aneuploidies.