ABSTRACT Objective: To report the need for cord untethering after prenatal repair of open spina bifida using a unique biocellulose-based technique performed at a later gestational age. Methods: An observational cohort study was conducted to determine the incidence of tethered cord syndrome. Between May 2013 and May 2022, we performed 172 procedures using the percutaneous fetoscopic approach in fetuses at 26-28 weeks of gestation. After placode dissection, a biocellulose patch was placed to cover the placode, a myofascial flap (when possible) was dissected, and the skin was closed. Owing to death or loss to follow-up, 23 cases were excluded. Cord tethering syndrome was defined as symptoms of medullary stretching, and the infants were evaluated and operated on by local neurosurgeons after an magnetic resonance imaging examination. Infants over 30-month had ambulation and neurodevelopment evaluations (PEDI scale). Results: Among 172 cases operated at a median gestational age of 26.7 weeks and delivered at 33.2 weeks, 149 cases were available for postnatal follow-up, and cord untethering was needed in 4.4% of cases (6/136; excluding 13 cases younger than 12 months). Cerebrospinal fluid diversion and bladder catheterization were needed in 38% and 36% of cases, respectively. Of the 78 cases evaluated at 30 months, 49% were ambulating independently, and 94% had normal social function. Conclusion: The biocellulose-based technique was associated with a low rate of cord tethering, wich may be attributed to the lack of the duramater suture during prenatal repair, the formation of a neoduramater and/or later gestational age of surgery. Objective biocellulosebased based Methods 201 2022 17 2628 26 28 26-2 gestation dissection when possible dissected closed followup, followup follow up, up follow-up 2 excluded stretching examination 30month month PEDI scale. scale . scale) Results 267 7 26. 332 33 33. 14 44 4 4.4 6/136 6136 6 136 (6/136 1 months. months months) 38 36 respectively 3 49 independently 94 function Conclusion andor surgery 20 202 262 26- 4. 6/13 613 (6/13 9 6/1 61 (6/1 6/ (6/ (6 (

Objective: To design and validate a Brazilian version of the Animal Empathy Scale, based on the existing Portuguese version. Methods: Content validity assessment was performed by expert judges, and the adapted scale was administered to a sample of 386 participants. Exploratory and confirmatory factor analyses were performed. Results: The bifactorial profile of the scale remained consistent, comprising Empathic Concern for Animals (Cronbach's alpha and McDonald's omega coefficients: 0.75) and Emotional Attachment with Animals (Cronbach's alpha and McDonald's omega coefficients: 0.79). Considering the One Health framework, collaborative, multidisciplinary, and intersectoral approaches are essential for achieving optimal health conditions for people, animals, and the environment given their intricate interconnections. Empathy plays a crucial role in promoting proximity between humans and animals, fostering positive connections that encourage biodiversity conservation. Conclusion: The 13 statements were retained, confirming the validity of the animal empathy scale for use in Brazil, and a Brazilian version of the Animal Empathy Scale was established. Objective Methods judges 38 participants Results consistent Cronbachs Cronbach s McDonalds McDonald coefficients 0.75 075 0 75 0.79. 079 0.79 . 79 0.79) framework collaborative multidisciplinary people animals interconnections conservation Conclusion 1 retained Brazil established 3 0.7 07 7 0.