Abstract Humankind has always been fascinated by venomous animals, as their toxic substances have transformed them into symbols of power and mystery. Over the centuries, researchers have been trying to understand animal venoms, unveiling intricate mixtures of molecules and their biological effects. Among venomous animals, Latrodectus Walckenaer, 1805 (widow spiders) have become feared in many cultures worldwide due to their extremely neurotoxic venom. The Latrodectus genus encompasses 32 species broadly spread around the globe, 14 of which occur in the Americas. Despite the high number of species found in the New World, the knowledge on these spiders is still scarce. This review covers the general knowledge on Latrodectus spp. from the Americas. We address widow spiders’ taxonomy; geographical distribution and epidemiology; symptoms and treatments of envenomation (latrodectism); venom collection, experimental studies, proteome and transcriptome; and biotechnological studies on these Latrodectus spp. Moreover, we discuss the main challenges and limitations faced by researchers when trying to comprehend this neglected group of medically important spiders. We expect this review to help overcome the lack of information regarding widow spiders in the New World.

RESUMO Objetivo Caracterizar as habilidades pragmáticas de crianças nascidas pré-termo e investigar se existe correlação com a idade gestacional, o gênero e a faixa etária. Métodos Foram avaliadas 42 crianças nascidas pré-termo, com baixo peso ao nascer, de ambos os gêneros, na faixa etária de 2 a 4 anos. A análise do perfil comunicativo foi realizada por meio do Protocolo de Pragmática do ABFW – Teste de Linguagem Infantil nas Áreas de Fonologia, Vocabulário, Fluência e Pragmática. Resultados Quanto à iniciativa na comunicação, houve melhor desempenho das crianças pré-termo moderadas e tardias. Em relação aos atos comunicativos, as crianças não alcançaram os valores de referência propostos pelo teste. Os meios verbais foram mais utilizados, apesar de haver grande ocorrência dos meios gestuais. As funções comunicativas mais observadas foram comentário, narrativa, jogo e pedido de objeto. Conclusão As crianças pré-termo apresentaram desvios nas habilidades pragmáticas, na faixa etária investigada. As variáveis linguísticas descritas neste estudo não apresentaram correlação com idade e gênero.

ABSTRACT Purpose To characterize the pragmatic skills of preterm children and investigate whether it is correlated with gestational age, gender and age group. Methods 42 low-birth-weight preterm infants of both genders, aged 2 to 4 years, were evaluated. The analysis of the communication profile was performed through the Pragmatics Protocol of the ABFW – child language test in the fields of phonology, vocabulary, fluency and pragmatics. Results regarding the communication initiative, there was a better performance of moderate and late preterm children. Regarding the communicative acts, the children did not reach the reference values proposed by the test. The verbal means were the most used, although there was a high occurrence of the gestural means. The most observed communicative functions were commenting, narrative, game and object request. Conclusion The preterm children had deviations in pragmatic skills in the age group investigated. The linguistic variables described in this study were not correlated with age and gender.

RESUMO Objetivo: verificar o uso dos processos fonológicos em crianças nascidas pré-termo. Métodos: a avaliação da Fonologia foi realizada por meio do ABFW - Teste de Linguagem Infantil, em 40 crianças, na faixa etária de dois a quatro anos, sendo 20 crianças nascidas pré-termo e 20 crianças nascidas a termo, pareadas conforme idade, sexo e nível socioeconômico. As crianças nascidas pré-termo foram avaliadas no Centro Estadual de Prevenção e Reabilitação da Pessoa com Deficiência - CEPRED; as crianças nascidas a termo foram selecionadas e avaliadas em uma creche municipal, na cidade de Salvador-BA. Foram aplicados os testes estatísticos pertinentes adotando o nível de significância menor que 0,05%. Resultados: na prova de Fonologia, o número de processos fonológicos produtivos não esperados para a idade cronológica foi estatisticamente significante no grupo pré-termo, destacando-se os processos de redução de sílaba, harmonia consonantal, posteriorização para velar e simplificação de líquida. A alta prevalência da simplificação de encontro consonantal e da simplificação de consoante final, apesar de ainda compatíveis com a idade cronológica, alerta para a necessidade do acompanhamento da aquisição da linguagem dessas crianças, após os quatro anos de idade. Conclusão: os resultados evidenciam a dificuldade encontrada pelas crianças nascidas pré-termo no desenvolvimento das habilidades fonológicas, ressaltando a importância do diagnóstico precoce e do monitoramento fonoaudiológico na aquisição da linguagem.

ABSTRACT Purpose: to check the use of phonological processes in preterm infants. Methods: phonological evaluation was performed through the ABFW Child Language Test in 40 children, aged two to four years, i.e., 20 preterm and 20 full-term children, matched according to age, gender and socioeconomic level. Preterm children were evaluated at the State Center for Prevention and Rehabilitation of People with Disabilities - CEPRED; full-term children were selected and evaluated in a municipal nursery in the city of Salvador, BA, Brazil. The pertinent statistical tests were applied adopting the level of significance lower than 0.05%. Results: in the phonology test, the number of productive phonological processes not expected for the chronological age was statistically significant in the preterm group, especially syllable reduction, consonantal harmony, velar backing and liquid reduction. The high prevalence of cluster reduction and final consonant deletion, though still compatible with chronological age, shows the need to follow up the language acquisition of these children, after the age of four. Conclusion: the results evidenced the difficulty found by preterm infants in the development of phonological skills, emphasizing the importance of early diagnosis and speech-language monitoring in language acquisition.

ABSTRACT Endocochlear, retrocochlear and/or central origin hearing damage may be related to the absence of appropriate levels of thyroid hormone during morphogenesis and/or auditory system development. Hearing disorders related to the thyroid are not well studied, despite speculation on the pathophysiological mechanisms. The objective of this review was to characterize the main pathophysiological mechanisms of congenital hypothyroidism and to evaluate the relationship with central and peripheral hearing disorders. We conducted a literature review using the databases MedLine, LILACS, Cochrane Library, SciELO, Institute for Scientific Information (ISI), Embase, and Science Direct between July and September on 2016. We identified the studies that address hearing disorder mechanisms on the congenital hypothyroidism. Congenital hypothyroidism may have clinical and subclinical manifestations that affect the auditory system and may be a potential risk factor for hearing impairment. Hearing impairment can severely impact quality-of-life, which emphasizes the importance of monitoring and evaluating hearing during the clinical routine of these patients.

Great part of lhe avaiable data about snakes reprodution refers to species coming from subtropical and temperate regions. In Brazil, the data is rather rare and can be found in various works where information is restricted. Results from studies developed with five viviparous snakes - Crotalus durissus cascavella (Wagler, 1824). Bothrops erythromelas(Amaral, 1923), B. leucurus (Wagler, 1824), Helicops leopardinus (Schlegel, 1873) and Thamnodynastes strigilis (Thiinberg, 1787) - which come from the Northeast of Brazil (Bahia) are described. Data about pregnancy and birth, number, sex ratio, length and weight of neonates is given and discussed.