This study describes and analyses the pharmacist majoring reorientation’s trajectory in Brazil. A qualitative evaluation was used to adequate the Pharmacy course curriculum and the teaching-learning strategies applied at the Centro Universitário Franciscano, UNIFRA-Brazil. In Brazil, the disease-centered assistentialist medicine model has been abandoned in favor of an integrated model that is concerned with actions to enhance health’s prevention and people’s quality of life. This necessarily requires substantial changes in the profile of health care professionals and better support for the Brazilian Universal Health Care System (Sistema Único de Saúde-SUS). The analysis of the results shows that the various actions of reorientation of the university formation can promote the academic professional qualification of ethical and more humanitarian pharmacists, with critical and reflexive profile, who will be able to work in all levels of health care, with a solid scientific and intellectual basis.

Ese trabajo expone y analiza la trayectoria de la reorientación en la formación del farmacéutico en Brasil. Se realizó una evaluación cualitativa de la adaptación del currículo del curso de Farmacia y de las estrategias de enseñanza-aprendizaje adoptadas por el Centro Universitario Franciscano, UNIFRA-Brasil. En Brasil, el modelo médico de asistencia centrado en la enfermedad ha sido relegado en favor del modelo integrado con dirección en las acciones de promoción a la salud y de la calidad de vida de la población. Esto requiere necesariamente de cambios sustanciales en el perfil del profesional de salud y en el fortalecimiento de la atención integral en el Sistema Único de Salud Brasileño (Sistema Único de Saúde-SUS). El análisis de los resultados muestra que las diversas acciones de reorientación en la formación de los profesionales pretenden promover la formación de profesionales farmacéuticos, éticos y humanitarios, críticos y reflexivos para actuar en todos los niveles de atención de salud con base en el rigor científico e intelectual.

Uma nova série de nove 3-fosfato-(4,4,4-trifluor-butil)-carbamatos de etila (compostos fosfato-carbamato), foram obtidos através da reação de (4,4,4-trifluor-3-hidroxibut-1-il)-etil carbamatos com oxicloreto de fósforo seguido de adição de álcoois. Os produtos foram caracterizados por espectroscopia de RMN de ¹H, 13C, 31P e 19F, CG-EM e análise elementar. Todos os compostos sintetizados foram testados para a inibição da enzima acetilcolinesterase (AChE) usando o método de Ellman. Todos os compostos analisados contendo os grupos carbamato e fosfato em sua estrutura, mostraram inibição enzimática, sendo que o composto contendo o grupo dietóxi (2b) apresentou a maior atividade inibitória. Estudos de modelagem molecular foram realizados para obter informações detalhadas entre o sítio ativo da enzima acetilcolinesterase e os compostos candidatos a inibição, obtendo-se valiosas informações estruturais com relação à inibição de enzima acetilcolinesterase.

A series of nine new [3-(disubstituted-phosphate)-4,4,4-trifluoro-butyl]-carbamic acid ethyl esters (phosphate-carbamate compounds) was obtained through the reaction of (4,4,4-trifluoro-3-hydroxybut-1-yl)-carbamic acid ethyl esters with phosphorus oxychloride followed by the addition of alcohols. The products were characterized by ¹H, 13C, 31P, and 19F NMR spectroscopy, GC-MS, and elemental analysis. All the synthesized compounds were screened for acetylcholinesterase (AChE) inhibitory activity using the Ellman method. All compounds containing phosphate and carbamate pharmacophores in their structures showed enzyme inhibition, being the compound bearing the diethoxy phosphate group (2b) the most active compound. Molecular modeling studies were performed to investigate the detailed interactions between AChE active site and small-molecule inhibitor candidates, providing valuable structural insights into AChE inhibition.