The neutrophil is an important cell in host defense against infections, acting as the first line of microorganism control. However, this cell exhibits dysregulated activity in sepsis and may contribute to the pathogenesis of the disease. This systematic review aimed to highlight the major scientific findings regarding neutrophil activity in sepsis reported in clinical and experimental research published in the last 10 years. The search was conducted in the Virtual Health Library of PAHO-WHO (BVS) and PubMed databases, and articles published between January 2007 and May 2017 in Portuguese, English, and Spanish were eligible. Article selection was carried out independently by two reviewers (CB and IB). A total of 233 articles were found, of which 87 were identified on PubMed and 146 on BVS. Eighty-two articles were duplicates. Of the remaining 151 articles, 19 met the inclusion criteria after title, abstract, and full-text analysis. Overall, research in clinical samples and animal models of sepsis showed reduced capacity of neutrophils to migrate and delayed apoptosis, but there was no consensus on the phagocytic activity of neutrophils in sepsis. Molecules, such as pentraxin 3 (PTX3), have been analyzed as potential diagnostic markers in sepsis but the diversity of soluble molecules detected in blood samples of sepsis patients did not enable further understanding of the correlation of these circulating molecules with neutrophil activity during sepsis. Optimal understanding of the function of neutrophils in sepsis remains a challenge that, if overcome, would eventually allow targeted therapeutic interventions in patients affected by this severe syndrome.

Abstract This work evaluated the feasibility of glycerol as the sole carbon source for nutrient biological removal in an intermittently aerated bioreactor. The reactor operation was divided into two phases: the first one aimed only at removing nitrogen; and the second one aimed at removing nitrogen and phosphorus. In the first operational phase, three C/N (Carbon / Nitrogen) ratios were tested: 1.2, 1.5 and 1.8. For a C/N ratio of 1.8, higher denitrification efficiency was achieved (91 ± 8%). During the second phase, the reactor was subjected to periods of aeration and non-aeration of 2 h and 4 h, respectively, for a C/P (Carbon / Phosphorus) ratio of 10. The biological phosphorus removal in this phase was not significant (12 ± 9%), indicating that there was no development of PAO (Phosphorus Accumulating Organisms), since phosphate release did not occur during the anaerobic phase. This can be explained by the lack of VFA (Volatile Fatty Acids), which should come from the anaerobic degradation of the remaining amount of glycerol after denitrification was completed. The optical microscopy analysis indicated the presence of filamentous bacteria similar to the genusBeggiatoa, which could also have consumed part of the substrates from the glycerol fermentation.

The association of dietary NaCl with arterial hypertension has led to a reduction in the levels of this salt in cheeses. For salting, KCl has been used as a partial substitute for NaCl, which cannot be completely substituted without affecting product acceptability. In this study a sensorially adequate saline solution (NaCl/KCl) was simultaneously diffused during salting of Prato cheese in brine with agitation. The simultaneous multicomponent diffusion during the process was modeled with Fick’s second generalized law. The system of partial differential equations formed was solved by the finite element method (FEM). In the experimental data concentration the deviation for NaCl was of 7.3% and for KCl of 5.4%, both of which were considered acceptable. The simulation of salt diffusion will allow control and modulation of salt content in Prato cheese, permitting the prediction of final content from initial conditions.

Espécies de eucalipto e acácia são amplamente utilizadas em plantios agroflorestais e reflorestamentos. Com o intuito de comparar a reconstituição das camadas orgânicas do solo, i.e., dos horizontes húmicos, estabelecendo-se uma relação com propriedades edáficas, sob plantações de Acacia mangium e Eucalyptus grandis, foram feitas coletas dos horizontes holorgânicos e hemiorgânicos do solo. Os referidos plantios encontravam-se na região de Tabuleiros Terciários no norte do estado do Espírito Santo e pertenciam à Reserva Natural da Vale do Rio Doce. As coletas foram feitas quando os plantios tinham sete anos de idade, em quatro estações. Acacia mangium apresentou maior estoque de folhiço (10 t ha-1, em média), tanto na camada L, de folhas inteiras, como na camada F, de folhas fragmentadas, do que Eucalyptus grandis (5 t ha-1, em média). O material foliar em acácia apresentou menor relação C/N que o de eucalipto, cerca da metade, decorrente dos maiores teores de nitrogênio. Quanto às análises químicas de carbono e nutrientes, no solo sob Acacia mangium, foram observadas, de modo geral, maiores quantidades destes elementos que no solo sob Eucalyptus grandis (e.g., carbono: 1,74 dag kg-1 vs 1,23 dag kg-1 e cálcio: 3,34 cmol c kg-1 vs 2,75 cmol c kg-1). O conjunto destes resultados evidencia que os aportes orgânicos sob Acacia mangium em relação a Eucalyptus grandis foram responsáveis pela maior incorporação de matéria orgânica e nutrientes ao solo. Estes dados, no entanto, comparados aos obtidos em estudos na floresta primária, mostraram que o carbono e os nutrientes do solo, em ambas as plantações, são menores que na floresta, evidenciando que, após sete anos de plantio, os teores de fertilidade e matéria orgânica do subhorizonte A11 não estavam restabelecidos.

Eucalyptus and acacia species are widely used in agrosilviculture and reforestry practices. In order to evaluate the reconstitution of organic soil layers - i.e. the humic horizons -and establish relationships to the soil properties, the holorganic and hemiorganic horizons were sampled under Acacia mangium and Eucalyptus grandis plantations. These plantations lie in the tertiary tableland region in the North of Espírito Santo State, Brazil, and are part of the Natural reservation Area of the Vale do Rio Doce Company. Samples were collected in seven-year-old plantations in four seasons. Acacia mangium presented a higher litter stock (mean of 10 t ha-1) in both the L (undecomposed leaves) and the F layer (fragmented leaves) than Eucalyptus grandis (mean of 5 t ha-1). The foliar material of Acacia also presented smaller C/N ratios than Eucalyptus, almost half as small, due to higher nitrogen contents. In regard to the chemical analyses of carbon and nutrients, higher quantities of the elements were observed in the soil under Acacia mangium than under Eucalyptus grandis (e.g., carbon: 1.74 vs 1.23 dag kg-1 and calcium: 3.34 vs 2.75 cmol c kg-1). This set of results suggests that the organic contribution of Acacia mangium was responsible for higher organic matter and nutrient inputs in the soil than Eucalyptus grandis. However, when these data were compared to those found in studies of primary forest, carbon and nutrient soil contents in both plantations were smaller than in the forest, indicating that after seven years fertility and organic matter of the A11 horizon had not been reestablished in the plantations.

Este estudo é uma contribuição para a conservação e a preservação ex situ e in situ de preguiças, sobretudo nesta fase de dependência de filhotes. Foi detectado, neste estudo, que as interações de aprendizado, sobretudo as de caráter alimentar, e o desenvolvimento físicomotor dependem da transferência de comportamentos da mãe. Esta interação materna com filhotes é, portanto, de fundamental importância para o desenvolvimento dos filhotes. Animais desprovidos desse aprendizado, como é o caso de animais órfãos, são mais susceptíveis a óbito quando são translocados ou reintroduzidos em seu habitat natural.

This study is a contribution to the ex situ and in situ conservation and preservation of Sloths. The behavioral records of the social interaction between mothers and offspring allow the detection of important learning interactions and psychomotor development. The results provide valuable information that may assist in improving management conditions of captive orphan progeny. They also favor a more effective monitoring of released or transferred specimens. Age is of fundamental importance in deciding what is important during the release, transfer, or reintroduction of the species.