Resumo Objetivos: O presente trabalho pretendeu estudar a associação de aspetos relacionados com a qualidade de vida a características sociodemográficas, comportamentos de saúde oral e estado de saúde oral dos jovens de 18 anos da Região de Lisboa e Vale do Tejo, utilizando dados previamente recolhidos no III Estudo Nacional de Prevalência das Doenças Orais (ENPDO). Métodos: A amostra do III ENPDO foi constituída por 157 indivíduos com 18 anos, residentes na região de Lisboa e Vale do Tejo. O III ENPDO recolheu dados através de um questionário e de uma observação intraoral. O questionário recolheu informação sobre a qualidade de vida, dados sociodemográficos e comportamentos de saúde oral. A observação intraoral incluiu o registo de cárie dentária (ICDAS II) e hemorragia gengival (IPC modificado). A análise estatística utilizou os testes de Mann-Whitney e de Kruskal-Wallis (α=0,05). Resultados: De um modo geral, os indivíduos do sexo feminino, com um nível de escolaridade mais baixo, que nunca visitaram um profissional de saúde oral e com presença de cárie ou de hemorragia gengival apresentaram piores resultados (p<0,05). A presença de cárie foi o fator mais frequentemente associado a uma pior qualidade de vida, encontrando-se em 4 das 8 questões consideradas. Conclusões: Foram identificados alguns fatores relacionados com uma pior qualidade de vida. A consideração destes fatores é importante para um reforço das medidas preventivas, particularmente das relacionadas com a melhoria dos comportamentos de saúde oral e com o tratamento precoce das doenças orais.

Abstract Objectives: The present study investigated the association between quality of life and sociodemographic characteristics, oral health behaviors, and oral health status in 18-year-old individuals in the Region of Lisbon and Tagus Valley, using data from the III National Study of the Prevalence of Oral Diseases (NSPOD). Methods: The sample of the III NSPOD consisted of 157 18-year-old individuals living in Lisbon and Tagus Valley region. The III NSPOD collected data by a questionnaire and an intraoral observation. The questionnaire included questions about quality of life, sociodemographic data, and oral-health behaviors. The intraoral observation included recording of dental caries (ICDAS II) and gingival bleeding (modified CPI). Statistical analysis used the Mann-Whitney and Kruskal-Wallis tests (α=0.05). Results: In general, female individuals with a lower level of education who had never visited an oral health professional and had caries or gingival hemorrhage had worse results (p<0.05). The presence of dental caries was the factor most frequently associated with worse quality of life, as found in 4 of the 8 questions considered. Conclusions: Some factors related to a worse quality of life were identified. These factos should be considered to reinforce preventive measures, particularly those related to improving oral health behaviors and the early treatment of oral diseases.

Abstract Pitaya is a rich source of bioactive compounds, such as polyphenols and betalains. Moreover, these compounds has been associated with reduced risk of type 2 diabetes mellitus. The aim of this study is to evaluate the effect of this fruit on glycemia and oxidative stress in aloxan-induced diabetic mice. Thus, considering that In the in vivo assays, the mice were divided into 5 groups (n = 6): (a) healthy group treated with water; (b) diabetic mice treated with metformin at 200 mg/kg body weight diluted in water; (c) untreated diabetic mice; (d) diabetic mice treated with pitaya at 200 mg/kg and (e) diabetic mice treated with pitaya at 400 mg/kg of body weight diluted in water. The results shows that pitaya was able significantly to reduce blood glucose (p < 0.05) (200 mg/kg); significantly reduce cholesterol (200 and 400 mg/kg) and significantly increase HDL-c (400 mg/kg) levels. In the oxidative stress experiment, Malondialdehyde levels in the liver were significantly reduced (p < 0.05) in the groups treated with pitaya, when compared to the other groups, suggesting lower lipid peroxidation. The consumption of pitaya reduced the blood glucose and cholesterol and increase the HDL, in addition, the lipid peroxidation - which is common in diabetic patients, was reduced.

ABSTRACT Objective: To evaluate the influence of maternal pre-pregnancy body mass index (BMI) and gestational weight gain (GWG) on blood glucose levels at diagnosis of gestational diabetes mellitus (GDM) and obstetric/neonatal outcomes. Subjects and methods: Retrospective cohort study including 462 women with GDM and singleton pregnancy delivered in our institution between January 2015 and June 2018 and grouped according to BMI/GWG. Results: The diagnosis of GDM was more likely to be established in the 1st trimester (T) in women with obesity than in normal-weight (55.8% vs 53.7%, p = 0.008). BMI positively and significantly correlated with fasting plasma glucose (FPG) levels in the 1stT (rs = 0.213, p = 0.001) and 2ndT (rs = 0.210, p = 0.001). Excessive GWG occurred in 44.9% women with overweight and in 40.2% with obesity (p < 0.001). From women with obesity, 65.1% required pharmacological treatment (p < 0.001). Gestational hypertension (GH) was more frequent in women with obesity (p = 0.016). During follow-up, 132 cesareans were performed, the majority in mothers with obesity (p = 0.008). Of the 17 large-for-gestational-age (LGA) birthweight delivered, respectively 6 and 9 were offsprings of women with overweight and obesity (p = 0.019). Maternal BMI had a predictive value only for macrosomia [aOR 1.177 (1.006-1.376), p = 0.041]. BMI and GWG positively correlated with birthweight (rs = 0.132, p = 0.005; rs = 0.188, p = 0.005). Conclusion: Maternal obesity is related with a major probability of diagnosis of GDM in 1stT, fasting hyperglycemia in 2ndT and a more frequent need for pharmacological therapy. Pre-gestational obesity is associated with GH, cesarean delivery and fetal macrosomia.

ABSTRACT Objective: To evaluate the influence of maternal pre-pregnancy body mass index (BMI) and gestational weight gain (GWG) on blood glucose levels at diagnosis of gestational diabetes mellitus (GDM) and obstetric/neonatal outcomes. Subjects and methods: Retrospective cohort study including 462 women with GDM and singleton pregnancy delivered in our institution between January 2015 and June 2018 and grouped according to BMI/GWG. Results: The diagnosis of GDM was more likely to be established in the 1st trimester (T) in women with obesity than in normal-weight (55.8% vs 53.7%, p = 0.008). BMI positively and significantly correlated with fasting plasma glucose (FPG) levels in the 1stT (rs = 0.213, p = 0.001) and 2ndT (rs = 0.210, p = 0.001). Excessive GWG occurred in 44.9% women with overweight and in 40.2% with obesity (p < 0.001). From women with obesity, 65.1% required pharmacological treatment (p < 0.001). Gestational hypertension (GH) was more frequent in women with obesity (p = 0.016). During follow-up, 132 cesareans were performed, the majority in mothers with obesity (p = 0.008). Of the 17 large-for-gestational-age (LGA) birthweight delivered, respectively 6 and 9 were offsprings of women with overweight and obesity (p = 0.019). Maternal BMI had a predictive value only for macrosomia [aOR 1.177 (1.006-1.376), p = 0.041]. BMI and GWG positively correlated with birthweight (rs = 0.132, p = 0.005; rs = 0.188, p = 0.005). Conclusion: Maternal obesity is related with a major probability of diagnosis of GDM in 1stT, fasting hyperglycemia in 2ndT and a more frequent need for pharmacological therapy. Pre-gestational obesity is associated with GH, cesarean delivery and fetal macrosomia.

Abstract Malaria is a disease caused by Plasmodium spp. protozoa. The ability of Plasmodium to develop resistance to current antimalarial drugs makes the study of chemotherapeutic alternatives extremely important. This study aimed to evaluate the antimalarial activity of compound 3286938 (1-(3-benzyloxy-4-methoxy-phenyl)-3-(3,4,5-trimethoxy-phenyl)-propan-1-one), which presents in its structure a 3,4,5-trimethoxyphenyl group, in vitro, using the W2 strain of P. falciparum and against circulating strains of P. vivax and P. falciparum from the state of Rondônia. The compound 3286938 obtained an IC50 of 24.4 µM against the W2 strain of P. falciparum, and against the circulating strains, it presented a median (MD)=38.7 µM for P. vivax and MD=6.7 µM for P. falciparum. As for toxicity, 3286938 showed CC50 > 500 µM for VERO and HepG2 strains with a selectivity index greater than 12.9, a ratio calculated for P. falciparum and P. vivax regarding Vero and HepG2 cells. The compound was not considered hemolytic in in vitro assays, thus indicating the specificity of its antiplasmodial action. Based on the results presented, and considering the unprecedented character of the compound, it can be concluded that 3286938 was shown to be promising for complementary in vitro and in vivo studies aiming to produce effective antiplasmodial action.

Resumo Introdução: O pé pendente define-se pela incapacidade em elevar o pé por diminuição da força dos músculos dorsiflexores. Para elaborar um plano de tratamento é necessário determinar a sua etiologia. Cabe, assim, ao médico de família reconhecer as situações em que a gestão desta entidade poderá ser feita exclusivamente em cuidados de saúde primários, diferenciando-as das que poderão exigir avaliação e orientação em meio hospitalar. Descrição do Caso: Homem de 71 anos com hipertensão arterial e dislipidemia, medicado com indapamida. Em consulta com o médico de família referia que, há dois dias, havia permanecido sentado por duas horas com a perna direita cruzada sobre o membro inferior contralateral. Ao levantar-se notou dormência do pé direito, o qual não conseguia elevar. À observação apresentava marcha em steppage, com pé direito pendente e diminuição da sensibilidade do dorso do mesmo. Foi pedida eletromiografia, que documentou acentuada lesão axonal do nervo peroneal comum direito abaixo do colo do perónio, compatível com compressão prolongada. Foi submetido a sessões de fisioterapia, demonstrando resolução completa do quadro após três meses. Comentário: A neuropatia do nervo peroneal comum é a causa principal de pé pendente e a terceira neuropatia focal mais frequente, depois do nervo mediano e nervo cubital. A etiologia mais frequente é a compressiva. O local mais afetado é onde o nervo contorna o colo do perónio, manifestando-se por marcha em steppage, consequente à diminuição da força dos músculos dorsiflexores do pé. Embora o diagnóstico seja habitualmente clínico, a maioria dos pacientes requer eletromiografia. O tratamento inicial costuma ser conservador, sendo comum ocorrer resolução das queixas em três meses. Esta é uma condição que poderá ser pouco frequente na prática clínica em medicina geral e familiar, mas cuja abordagem poderá, muitas vezes, ser feita em cuidados de saúde primários. É importante saber tranquilizar os pacientes quanto à semiologia, abordagem terapêutica e prognóstico.

Abstract Introduction: Foot drop is defined by the inability to elevate the foot due to diminished strength of the dorsiflexor muscles. To elaborate a treatment plan, it is necessary to determine its etiology. Thus, the family doctor must recognize the situations in which the management of foot drop can be done exclusively in primary health care, differentiating from those that may require observation and assessment in-hospital care. Case description: 71-year-old man with arterial hypertension and dyslipidemia, medicated with indapamide. An appointment with the family doctor referred that, two days ago, had remained seated for two hours with the right leg crossed over the contralateral lower limb. By getting up, the patient noticed right foot numbness and inability to elevate the same foot. At the physical examination, he presented a steppage gait, with right foot drop and decreased sensitivity of the back of the foot. It was requested electromyography, which documented severe axonal damage of the right common peroneal nerve below the fibular neck, compatible with prolonged compression. The patient was submitted to physiotherapy sessions, demonstrating complete clinical resolution of foot drop after three months. Comment: The neuropathy of the common peroneal nerve is the main cause of foot drop and the third most frequent focal neuropathy, after the median nerve and cubital nerve. Compression remains the most frequent etiology. The most affected site is at the level of the fibular neck, manifested by steppage gait, consequent to decreased strength of the dorsiflexor muscles of the foot. Even though the diagnosis is usually clinical, most of the patients require electromyography. The initial treatment tends to be conservative, with a frequent resolution of the complaints in three months. This is a condition that may be uncommon in family medicine’s clinical practice, but its approach could be, many times, managed in primary health care. It is important to know how to reassure the patients about the semiology, therapeutic approach, and prognosis.

ABSTRACT OBJECTIVE: To investigate how sociodemographic conditions, political factors, organizational confidence, and non-pharmaceutical interventions compliance affect the COVID-19 vaccine hesitancy in Brazil. METHODS: Data collection took place between November 25th, 2020 and January 11th, 2021 using a nationwide online survey. Subsequently, the researches performed a descriptive analysis on the main variables and used logistic regression models to investigate the factors associated with COVID-19 vaccine hesitancy. RESULTS: Less concern over vaccine side effects could improve the willingness to be vaccinated (probability changed by 7.7 pp; p < 0.10). The current vaccine distrust espoused by the Brazilian president is associated with vaccine hesitancy, among his voter base. Lower performance perception (“Very Bad” with 10.7 pp; p < 0.01) or higher political opposition (left-oriented) regarding the current presidency is associated with the willingness to be vaccinated. Higher compliance with non-pharmaceutical interventions (NPIs) is usually positively associated with the willingness to take the COVID-19 vaccine (+1 score to NPI compliance index is associated with higher willingness to be vaccinated by 1.4 pp, p < 0.05). CONCLUSION: Willingness to be vaccinated is strongly associated with political leaning, perceived federal government performance, vaccine side effects, and compliance with non-pharmaceutical interventions (NPIs).

ABSTRACT OBJECTIVE: To investigate how sociodemographic conditions, political factors, organizational confidence, and non-pharmaceutical interventions compliance affect the COVID-19 vaccine hesitancy in Brazil. METHODS: Data collection took place between November 25th, 2020 and January 11th, 2021 using a nationwide online survey. Subsequently, the researches performed a descriptive analysis on the main variables and used logistic regression models to investigate the factors associated with COVID-19 vaccine hesitancy. RESULTS: Less concern over vaccine side effects could improve the willingness to be vaccinated (probability changed by 7.7 pp; p < 0.10). The current vaccine distrust espoused by the Brazilian president is associated with vaccine hesitancy, among his voter base. Lower performance perception (“Very Bad” with 10.7 pp; p < 0.01) or higher political opposition (left-oriented) regarding the current presidency is associated with the willingness to be vaccinated. Higher compliance with non-pharmaceutical interventions (NPIs) is usually positively associated with the willingness to take the COVID-19 vaccine (+1 score to NPI compliance index is associated with higher willingness to be vaccinated by 1.4 pp, p < 0.05). CONCLUSION: Willingness to be vaccinated is strongly associated with political leaning, perceived federal government performance, vaccine side effects, and compliance with non-pharmaceutical interventions (NPIs).

RESUMO Tendo em vista os diferentes contextos e transições nas vidas dos jovens, este artigo analisa as vulnerabilidades daqueles que se encontram sem trabalhar e sem estudar, a partir de dados empíricos produzidos com jovens de Recife. Com base nisso, o artigo discute como o reconhecimento das diferentes vulnerabilidades pode contribuir para a formulação de políticas públicas mais adequadas para os jovens que se encontram nessa situação.

ABSTRACT In light of the different contexts and transitions in the lives of young people, this article analyzes the vulnerabilities of the group of young people not in education, employment or training (NEETs) based on empirical data produced with young people in Recife. The article discusses how the recognition of different vulnerabilities of this target group can contribute to the formulation of public policies that are more appropriate for their needs.

Resumo A angina de Ludwig apresenta-se como uma celulite grave que envolve o espaço submandibular, de início agudo e evolução rapidamente progressiva. Descreve-se o quadro clínico de um homem de 33 anos com uma tumefação submandibular de agravamento progressivoassociada a obstrução da via aérea e necessidade de ventilação mecânica invasiva. Imagiologicamente, apresentava extenso processo fleimonoso dos tecidos moles do pescoço, com ponto de partida em cáries dentárias homolaterais. Foi instituída a drenagem do abcesso e antibioterapia, sem evidência de melhoria. Careceu de intervenção cirúrgica, com evolução paulatina, mas favorável. Este caso demonstra que o diagnóstico e tratamento precoces são fundamentais para o sucesso terapêutico.

Abstract Ludwig’s angina is a severe cellulitis involving the submandibular space, with acute onset and rapidly progressive evolution. We describe the case of a 33-year-old man with a progressive submandibular swelling associated with an airway obstruction that required mechanical ventilation. Radiologically, the patient presented with an extensive phlegmonous process of the soft tissues of the neck, originating from homolateral dental caries. Abscess drainage and antibiotic therapy were performed, without evidence of improvement. Surgical intervention was required, resulting in slow but favorable evolution. This case shows that successful treatment depends on early diagnosis and treatment.

RESUMO A síndrome de Kounis, enquanto síndrome coronária aguda, ocorre em um contexto de reação de hipersensibilidade, alergia ou anafilaxia, e subdivide-se em três tipos: o espasmo coronário em artérias normais, a instabilidade de placas em artérias coronárias ateroscleróticas e a trombose de stent coronário. Apresenta-se o caso de uma doente de 73 anos que, após administração de amoxicilina/ácido clavulânico, entra em parada cardiorrespiratória, com evidência de supradesnivelamento do segmento ST-T em eletrocardiograma. Realiza coronariografia com ausência de lesões obstrutivas, verificando-se resolução espontânea das alterações eletrocardiográficas. Revisão da anamnese com a família documenta alergia prévia à penicilina. O doseamento de triptase foi fortemente positivo. Foi admitida provável síndrome de Kounis tipo 2, com boa evolução clínica posterior.

ABSTRACT Kounis syndrome, while an acute coronary syndrome, occurs in the context of a hypersensitivity reaction, allergies, or anaphylaxis and is subdivided into three types: coronary spasm in normal arteries, instability of plaques in atherosclerotic coronary arteries, and thrombosis of coronary stents. Herein, the case of a 73-year-old patient who, after administration of amoxicillin/clavulanic acid, went into cardiorespiratory arrest with evidence of ST-T segment elevation on electrocardiogram is reported. Coronarography revealed no obstructive lesions, and spontaneous resolution of electrocardiographic abnormalities was observed. A review of anamnesis with the family revealed a previous allergy to penicillin. The tryptase dosage was strongly positive. Kounis syndrome type 2 was diagnosed, and the clinical outcome was good.

Os principais objetivos deste estudo observacional foram descrever uma malformação pouco reconhecida do ouvido interno designada malformação congénita bilateral dos canais semicirculares; determinar se o grau e padrão de dismorfia dos canais semicirculares e a presença ou ausência de uma cóclea bem formada são preditivos do resultado audiológico, tipo e gravidade da perda auditiva congénita; e investigar se esta malformação surge isoladamente ou em associação a formas sindrómicas já descritas. Foi realizada uma revisão de oito casos de perda auditiva com evidência radiológica de malformação congénita dos canais semicirculares. Foi recolhida informação sobre história clínica, exame físico, estudo imagiológico por tomografia computorizada e audiogramas seriados para todos os doentes. As características analisadas incluíram presença de outras dismorfias sugestivas de síndromes malformativas; avaliação da configuração, gravidade e tipo de perda auditiva nos exames audiométricos; tipo de reabilitação audiológica; e presença de outras anomalias do ouvido interno para além das alterações no sistema vestibular. Entre os oito casos incluídos no estudo, seis apresentavam um síndrome ou anomalia cromossómica conhecida. A perda auditiva foi moderada a profunda em todos os casos. Todos os pacientes apresentavam deformidades dos canais semicirculares bilateralmente, com padrão anatómico geralmente idêntico em cada lado. Dos oito casos, seis apresentavam um desenvolvimento coclear normal; malformações na membrana timpânica e no canal auditivo externo foram encontradas apenas em um caso; alterações na cadeia ossicular foram descritas em três pacientes; o vestíbulo e aqueduto vestibular eram normais na maioria dos casos; anomalias no desenvolvimento da janela oval estavam presentes em dois casos. O presente estudo mostra que é difícil estabelecer uma correlação entre a gravidade e o tipo de perda auditiva e as alterações radiográficas. A perda auditiva associada à displasia do canal semicircular é mais provável devido ao desenvolvimento anômalo do labirinto membranoso, que não é detetável radiologicamente pela tomografia computadorizada.

The main aims of this observational study were to describe a poorly characterized malformation of the inner ear termed bilateral congenital semicircular canal malformation; determine if the degree and pattern of semicircular canal dysmorphology and the presence or absence of a well-formed cochlea predict audiological outcomes, type, and severity of congenital hearing loss; and investigate its relationship with known syndromic forms of hearing loss. Review of eight cases of hearing loss with radiographic evidence of congenital semicircular canal malformation was performed. Information was collected on clinical history, physical examination, computed tomography study and serial audiograms for all patients. Analyzed features included other syndrome-characteristic phenotypic dysmorphologies, audiometric configuration, severity and type of hearing loss, type of audiological rehabilitation, and presence of associated inner ear abnormalities besides those in the vestibular system. Among the eight cases included in the study, six patients had recognized syndromes/chromosomal abnormalities. Hearing loss was moderate to profound in all cases. All patients had bilateral semicircular canal deformities, with usually identical anatomical pattern on each side. Of the eight cases, six had normal cochlear development; malformations in the tympanic membrane and external auditory canal were only found in one; changes in ossicular chain were found in three patients; vestibules and vestibular aqueduct were normal in most cases; and abnormalities of oval window development and hypoplasia were found in two cases. The present study shows that a correlation between the severity and type of hearing loss and radiographic abnormalities is difficult to establish. Hearing loss associated with semicircular canal dysplasia is more likely due to anomalous membranous labyrinth development, which is not radiologically detectable by computerized tomography scan.

RESUMO: O texto aborda uma pesquisa que investigou como o acesso de estudantes com deficiência na educação superior reverbera nas práticas de gestão universitária no que se refere aos direitos desse público. Nesse sentido, buscamos compreender os efeitos da presença de estudantes com deficiência nos programas e políticas institucionais relativas à inclusão. Foram entrevistados gestores atuantes em quatro universidades, localizadas no oeste de Santa Catarina: uma pública federal, uma pública estadual, uma comunitária e uma privada. Por meio de entrevistas narrativas, foram geradas materialidades empíricas, posteriormente analisadas na perspectiva da análise do discurso, com referenciais foucaultianos. O estudo aponta os efeitos dos discursos normativos da inclusão na subjetivação dos gestores e os posicionamentos frente às demandas. Constatamos que as políticas governamentais de inclusão, materializadas, inclusive, nos instrumentos de avaliação dos cursos e das instituições de educação superior aplicados pelo Ministério da Educação, mobilizam os gestores a investirem esforços na inclusão.

ABSTRACT: This text addresses a research that investigated how the access of students with disabilities in college education reverberates in the institution management practices with regard to the rights of this group. In this sense, we seek to understand the effects in programs and institutional policies related to inclusion of disabled students. We interviewed managers who have been working in four colleges located in the west of Santa Catarina: a federal, a state, a community and a private ones. By means of narrative interviews, empirical materialities were generated, later analyzed in the perspective of discourse analysis, under Foucaultian references. The study points out the effects of the normative discourses of inclusion on the subjectivation of the managers and their positioning about requirements. We realize that government inclusion policies, materialized in the evaluation instruments of the courses and institutions of higher education applied by the Ministry of Education, mobilize managers to invest in inclusion.

RESÚMEN: El texto analiza una investigación que abordó la temática de cómo el acceso de los estudiantes con discapacidades a la educación superior repercute en las prácticas de gestión universitaria respecto a los derechos de este grupo. En este sentido, buscamos comprender los efectos de la presencia de estudiantes con discapacidades en programas institucionales y políticas relacionadas con la inclusión. Se entrevistó a gestores activos en cuatro universidades, ubicadas en el oeste de Santa Catarina: una pública federal, un pública provincial, una comunitaria y una privada. A través de entrevistas narrativas se generaron materiales empíricos, luego analizados desde la perspectiva del análisis del discurso, con referencias de Foucault. El estudio señala los efectos de los discursos normativos de inclusión sobre la subjetividad de los gestores y sus posicionamientos en relación con las demandas. Constantamos que las políticas de inclusión del gobierno, materializadas incluso en los instrumentos para evaluar cursos e instituciones de educación superior por el Ministerio de Educación, alientan a los gestores a invertir esfuerzos en implementar las políticas de inclusión.

Resumen Introducción: la sarcoidosis es una granulomatosis sistêmica de etiología desconocida, que se puede manifestar de forma aguda como síndrome de Löfgren en 20 %-50 % de los individuos, la cual, a pesar de tener un curso benigno, exige una vigilancia y acompañamiento cuidadoso de los enfermos. Este síndrome, caracterizado por la triada eritema nodoso, linfadenopatias hilares bilaterales y poliartralgia o poliartritis, no carece de confirmación histológica para el diagnóstico y es más prevalente en mujeres caucasianas hasta los 35 años. Presenta buenos pronósticos y puede tener resolución espontánea de las quejas en el primer año después del aparecimiento. Caso clínico: los autores presentan el caso clínico de una paciente de 20 años que acudió al servicio de urgencia con lesiones nodulares, enrojecidas y dolorosas en los miembros inferiores, acompañadas de malestar general e gonalgias bilaterais com compromiso funcional. Se confirmaron linfadenopatías y hilares bilaterales y aumento de la enzima conversora de la angiotensina sérica. Conclusión: la paciente tuvo respuesta favorable a un ciclo corto de corticoterapia y analgesia con antinflamatorios, no esteroides.

Abstract Introduction: Sarcoidosis is a systemic granulomatosis of unknown etiology that can manifest acutely as Löfgren's syndrome in 20-50% of the individuals, which despite having a benign course, requires careful monitoring and follow-up of patients. This syndrome characterized by erythema nodosum, bilateral hilar lymphadenopathy and polyartralgia or polyarthritis, does not require histological evidence for the diagnosis and is more prevalent in caucasian women until the age of 30 years. It has good prognosis and may have spontaneous resolution of complaints usually occur in the first year after the onset. Case Presentation: The authors present the case of a 20-year-old female who went to the emergency department with complaints of nodular, reddish and painful lesions in the lower limbs, accompanied by general malaise and bilateral knee pain associated with functional impotence. Conclusion: Radiographic changes and elevation of the serum angiotensin converting enzyme were observed, with the patient responding well to a short course of corticosteroids and analgesia with nonsteroidal anti-inflammatory drugs.

Resumo Introdução: a sarcoidose é uma granulomatosa sistêmica de etiologia desconhecida, que se pode manifestar de forma aguda como síndrome de Löfgren em 20 %-50 % dos indivíduos, a qual, não obstante ter um curso benigno, exige uma vigilância e acompanhamento cuidadosos dos doentes. Esta síndrome caracterizada pela tríade eritema nodoso, linfadenopatias hilares bilaterais e poliartralgia ou poliartrite, não carece de confirmação histológica para o diagnóstico e é mais prevalente em mulheres caucasianas até aos 35 anos de idade. Apresenta bom prognóstico e pode ter resolução espontânea das queixas no primeiro ano após o aparecimento. Caso Clínico: os autores apresentam o caso clínico de uma doente de 20 anos que recorreu ao serviço de urgência com lesões nodulares, avermelhadas e dolorosas nos membros inferiores, acompanhadas de mal-estar geral e gonalgias bilaterais com compromisso funcional. Constataram-se linfadenopatias e hilares bilaterais e elevação da enzima conversora da angiotensina sérica. Conclusão: a doente teve resposta favorável a um ciclo curto de corticoterapia e analgesia com anti-inflamatórios não esteroides.