ABSTRACT Introduction: Mandibular advancement surgery corrects bone bases while establishing patients’ functional and aesthetic rehabilitation. However, little is known about the results of this procedure in the structures that make up the stomatognathic system, as the condyles. Objective: This study aimed to evaluate the structural and positional changes of mandibular condyles in ortho-surgical patients who underwent mandibular advancement surgery. Material and Methods: A prospective investigation was conducted with cone-beam computed tomography images. Using Dolphin Imaging® software, seven ortho-surgical patients with Angle Class II malocclusion and mandibular deficiency were evaluated. The images assessed were obtained at pre-surgical phase and after, at least, 1 year of the procedure. To study the structural and positional changes of condyles, linear and angular measurements were obtained, and the right and left sides of patients were compared. Descriptive statistical analysis was performed and, in order to verify possible significant differences, normality tests (Kolmogorov-Smirnov) were applied, followed by a paired t-test to define significance. Results: For all measures evaluated in this study, no statistically significant differences were found. Conclusion: The ortho-surgical procedure performed did not change the structure and position of the condyles of patients who underwent surgical mandibular advancement. Right and left mandibular condyles behaved similarly, suggesting stability and condylar adaptation after surgery. Introduction rehabilitation However system Objective orthosurgical ortho Methods conebeam cone beam Imaging software presurgical pre least compared KolmogorovSmirnov Kolmogorov Smirnov (Kolmogorov-Smirnov applied ttest t test significance Results found Conclusion similarly

RESUMO Introdução: A cirurgia de avanço mandibular corrige as bases ósseas e estabelece a reabilitação funcional e estética dos pacientes. Entretanto, pouco se sabe sobre os resultados desse procedimento nas estruturas que compõem o sistema estomatognático, como os côndilos. Objetivo: Este estudo teve como objetivo avaliar as alterações estruturais e posicionais dos côndilos mandibulares em pacientes ortodôntico-cirúrgicos submetidos à cirurgia de avanço mandibular. Material e Métodos: Foi realizada investigação prospectiva com imagens de tomografia computadorizada de feixe cônico. Utilizando o software Dolphin Imaging®, foram avaliados sete pacientes ortodôntico-cirúrgicos com má oclusão Classe II de Angle e deficiência mandibular. Foram avaliadas imagens da fase pré-cirúrgica e de, no mínimo, um ano após o procedimento. Para estudar as alterações estruturais e posicionais dos côndilos, foram obtidas medidas lineares e angulares e comparados os lados direito e esquerdo dos pacientes. Foi realizada análise estatística descritiva e, para verificar possíveis diferenças significativas, foram aplicados testes de normalidade (Kolmogorov-Smirnov), seguido de teste t pareado, para definição de significância. Resultados: Para nenhuma das medidas avaliadas nesse estudo foram encontradas diferenças estatisticamente significativas. Conclusão: O procedimento ortodôntico-cirúrgico realizado não alterou a estrutura e a posição dos côndilos dos pacientes submetidos à cirurgia de avanço mandibular. Os côndilos mandibulares direito e esquerdo comportaram-se de forma semelhante, sugerindo estabilidade e adaptação condilar após a cirurgia. Introdução Entretanto estomatognático Objetivo ortodônticocirúrgicos ortodôntico cirúrgicos Métodos cônico Imaging Imaging® précirúrgica pré cirúrgica mínimo significativas KolmogorovSmirnov, KolmogorovSmirnov Kolmogorov Smirnov , (Kolmogorov-Smirnov) pareado significância Resultados Conclusão ortodônticocirúrgico cirúrgico comportaramse comportaram semelhante (Kolmogorov-Smirnov

Abstract Botulinum toxin type A is effective in reducing excessive gingival display caused by hyperfunctional upper lip elevator muscles; however, this effect is transient. This study aimed to determine the duration of the effectiveness of botulinum toxin type A on a gummy smile. A systematic search was conducted using Medline (PubMed), Scopus, and Web of Science electronic databases, from 1970 to March 2017 with no language restriction; the search included studies evaluating adult patients with excessive gingival display who were treated with botulinum toxin and were followed-up for at least 3 months. OpenGrey and Clinical Trial Registry were also consulted. Quality assessment was applied to determine the level of evidence and bias, and a meta-analysis was performed. Of 2181 full texts, 71 were obtained, with 3 prospective studies meeting the selection criteria. The gingival display was significantly reduced to baseline with 2, 4, and 8 weeks of treatment. The gingival display considerably reduced at the baseline-2-week comparison (–4.44 mm using raw data and–4.05 mm using the standard difference) and increased throughout the weeks of follow-up. There is scant evidence to determine the duration of the effectiveness of toxin type A on a gummy smile. The effect tends to be stable until at least 8 weeks of follow-up, and the gingival exposure may not return to baseline within 12 weeks of follow-up. Well-designed randomized clinical trials with a minimum of 6 months of follow-up are necessary to strengthen the evidence.