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Abstract To date, hydroxyurea is the only effective and safe drug that significantly reduces morbidity and mortality of individuals with Sickle cell disease. Twenty years of real-life experience has demonstrated that hydroxyurea reduces pain attacks, vaso-occlusive events, including acute chest syndrome, the number and duration of hospitalizations and the need for transfusion. The therapeutic success of hydroxyurea is directly linked to access to the drug, the dose used and adherence to treatment which, in part, is correlated to the availability of hydroxyurea. This consensus aims to reduce the number of mandatory exams needed to access the drug, prioritizing the requesting physician's report, without affecting patient safety. date disease reallife real life attacks vasoocclusive vaso occlusive events syndrome transfusion which part physicians physician s report safety

https://doi.org/10.1016/j.htct.2024.01.001

Different concentrations of fetal bovine serum affect cytokine modulation in Lipopolysaccharide-activated apical papilla cells in vitro Lipopolysaccharideactivated Lipopolysaccharide activated
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SANTOS, Letícia Martins

; CARDOSO, Patricia e Silva

; DINIZ, Elisa Abreu

; RAHHAL, Juliana Garuba

; SIPERT, Carla Renata

Journal of Applied Oral Science

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2023, Volume 31 elocation e20230020

Resumo: En | Texto: En | PDF: En

Abstract Fetal bovine serum (FBS) is the most used supplement in culture media; however, it may interfere with in vitro assays via effects on cell proliferation and cytokine production. The ideal FBS concentration for assays using apical papilla cells (APCs) remains unknown. Therefore, this study aimed to evaluate the effects of FBS on APC activation, cell viability/proliferation, and cytokine production. Methodology Human APCs were cultured, plated, and maintained in media containing increasing concentrations of FBS for 24 h, 48 h, 72 h, 7 days, and 14 days in the presence of Lipopolysaccharide (LPS - 1 µg/mL). At each time point, the cells were subjected to the MTT assay. The cytokines transforming growth factor (TGF)-β1, osteoprotegerin (OPG), and interleukin (IL)-6, along with the chemokine CCL2, were quantified using the enzyme-linked immunosorbent assay at the 24-h time-point. Statistical analysis was performed using two-way analysis of variance (ANOVA) followed by Tukey's post-hoc test (p<0.05). Results In general, APCs exhibited increasing metabolic activity in an FBS concentration-dependent fashion, regardless of the presence of LPS. In contrast, FBS interfered with the production of all the cytokines evaluated in this study, affecting the response induced by the presence of LPS. Conclusion FBS increased APC metabolism in a concentration-dependent manner and differentially affected the production of TGF-β1, OPG, IL-6, and CCL2 by APCs in vitro. (FBS however (APCs unknown Therefore activation viabilityproliferation viability viability/proliferation cultured plated 2 h 4 LPS µg/mL. µgmL µg/mL . µg mL µg/mL) point TGFβ1, TGFβ1 TGFβ TGF β1, β1 β (TGF)-β1 OPG , (OPG) IL6, IL6 IL 6, 6 (IL)-6 CCL enzymelinked enzyme linked 24h timepoint. timepoint point. time-point twoway two way ANOVA (ANOVA Tukeys Tukey s posthoc post hoc p<0.05. p005 p p<0.05 0 05 (p<0.05) general concentrationdependent dependent fashion contrast TGF-β1 IL-6 (TGF)-β (OPG (IL)- p00 p<0.0 (p<0.05 TGF-β IL- (IL) p0 p<0. (p<0.0 (IL p<0 (p<0. p< (p<0 (p< (p

https://doi.org/10.1590/1678-7757-2023-0020

Efecto repelente del aceite de las semillas de Jatropha curcas L. en larvas de Rhipicephalus (Boophilus) microplus (Canestrini, 1887) (Acari: Ixodidae)
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Rizo-Borrego, Alberto

; Soca-Pérez, Mildrey

; García-Marrero, Dany Eugenio

; Arece-García, Javier

; Cardoso, Patricia Giuponi

Pastos y Forrajes

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2022, Volume 45 elocation e1

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

ABSTRACT Objective: To evaluate the repellent activity of the oil from Jatropha curcas L. seeds with different storage periods on larvae of Rhipicephalus (Boophilus) microplus. Materials and Methods: The research was conducted in the parasitology and biotechnology laboratories of the Pastures and Forages Research Station Indio Hatuey, located in the Perico municipality, Matanzas province, Cuba. The tick strain Cayo Coco was used and oils with two storage periods were evaluated: one and three years of extraction. As positive control the acaricide Deltametrina (Butox®) was used and as negative one, distilled water. For the in vitro results the methodology for the identification of repellent substances, described by Chagas and Dias (2012), was used, where the concentrations of 0,5; 1,75; 2,5; 5 and 10 mg mL-1, were used. Results: The analysis showed significant differences (p < 0,05) between the experimental treatments in the different times, with regards to the negative control (distilled water). The repellence percentages were higher than 90 % for the J. curcas oils. The repellent activity was high, and the interval of 4-8 hours was the one with the best results, with values of 93,9 and 97,3 % for the 2014 and 2017 oil, respectively, without significant differences between both. After 8 hours, the positive control decreased its repellent activity until reaching values of 64,2 % at 16 hours. The distilled water did not show repellent activity, because its values were in an interval between 3 and 7 % during the experimental stage. Conclusions: The J. curcas oil has repellent activity, independently from the storage time, with values that exceed 90 % of efficacy.

RESUMEN Objetivo: Evaluar la actividad repelente del aceite de las semillas de Jatropha curcas L. con diferentes períodos de almacenamiento en larvas de Rhipicephalus (Boophilus) microplus. Materiales y Métodos: La investigación se desarrolló en los laboratorios de parasitología y biotecnología de la Estación Experimental de Pastos y Forrajes Indio Hatuey, ubicada en el municipio Perico, provincia de Matanzas, Cuba. Se utilizó la cepa de garrapata Cayo Coco y se evaluaron aceites con dos períodos de almacenamiento: uno y tres años de extracción. Como control positivo se utilizó el acaricida Deltametrina (Butox®) y como negativo, el agua destilada. Para los estudios in vitro se aplicó la metodología para la identificación de sustancias repelentes, descrita por Chagas y Dias (2012), donde se evaluaron las concentraciones de 0,5; 1,75; 2,5; 5 y 10 mg mL-1. Resultados: El análisis mostró diferencias significativas (p < 0,05) entre los tratamientos experimentales en los diferentes horarios, con respecto al control negativo (agua destilada). Los porcentajes de repelencia fueron superiores a 90 % para los aceites de J. curcas. La actividad repelente fue elevada, y el intervalo de 4-8 horas fue el de mejores resultados, con valores de 93,9 y 97,3 % para el aceite 2014 y 2017, respectivamente, sin diferencias significativas entre ambos. Transcurridas las 8 horas, el control positivo disminuyó su actividad repelente hasta alcanzar valores del 64,2 % a las 16 horas. El agua destilada no mostró actividad repelente, ya que sus valores estuvieron en un intervalo entre 3 y 7 % durante la etapa experimental. Conclusiones: El aceite de J. curcas posee actividad repelente, independientemente del tiempo de almacenamiento, con valores que superan 90 % de eficacia.

Seed inoculation with endophytic Induratia species on productivity of common beans
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Hayashibara, Carolina Alessandra de Almeida

; Costa, Larissa Carvalho

; Souza, Elaine Aparecida de

; Pereira, Olinto Liparini

; Cardoso, Patricia Gomes

Ciência e Agrotecnologia

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2022, Volume 46 elocation e007322

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO O feijoeiro comum (Phaseolus vulgaris L.) é uma leguminosa de grande importância econômica e nutricional em todo o mundo; portanto, o desenvolvimento de estratégias de manejo para promover o crescimento das plantas e aumentar a produtividade de grãos é de grande interesse para os agricultores. Os efeitos da promoção de crescimento por simbiose de microrganismos endofíticos com plantas têm sido explorados em várias culturas. Este estudo investigou os efeitos sobre o crescimento e a produtividade de grãos em feijoeiro por meio de fungos endofíticos Induratia inoculados em sementes. Os experimentos foram conduzidos em casa de vegetação no delineamento de blocos completos casualizados com três repetições. Foram avaliados a altura de planta, comprimento de raiz, índice foliar, número de dias para o florescimento, número de vagens por planta, número de grãos por vagem, massa de 100 grãos e produtividade de grãos. A produtividade das plantas inoculadas com Induratia coffeana (CML 4018, CML 4020) e Induratia sp. (CML 4015) aumentou 52,5%, 48,9% e 56,4%, respectivamente, em comparação com os controles. A inoculação de sementes de feijão com espécies de fungos endofíticos do gênero Induratia apresentou interação benéfica, aumentando a produtividade de grãos. Este estudo pioneiro é importante para o desenvolvimento de estratégias de manejo visando o aumento da produtividade do feijoeiro.

ABSTRACT Common bean (Phaseolus vulgaris L.) is a leguminous species of great economic and nutritional importance worldwide, and thus the development of management strategies to promote plant growth and increase grain yield of legumes is of great interest to farmers. The growth-promoting effects of the symbiosis of endophytic microorganisms in plants have been exploited in several crops. This study investigated the effects of Induratia sp. endophytic fungi on the growth and grain yield of seed-inoculated common bean plants. The experiments were conducted in a greenhouse during two growing seasons using a randomized complete block design with three replicates. Growth and yield-related parameters such as plant height, root length, leaf index, number of days for flowering, number of pods per plant, number of grains per pod, mass of 100 grains, and grain yield were evaluated. The grain yield of plants inoculated with Induratia coffeana strains CML 4018 and CML 4020 and Induratia sp. strain CML 4015 increased by 52.5%, 48.9%, and 56.4% compared to the non-inoculated control, respectively. Seed inoculation of common bean plants with endophytic fungi species of the genus Induratia showed a beneficial interaction as indicated by the recorded increase in grain yield. The present pioneering study could provide the means for developing crop management strategies for enhancing common bean crop productivity.

https://doi.org/10.1590/1413-7054202246007322

Development and application of a liquid chromatography-mass spectrometry method for the determination of sugars and organics acids in araza, ceriguela, guava, mango and pitanga
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Cardoso, Patricia Carvalho

; Sviech, Fernanda

; Reis, Marcella Fernanda Alves

; Iglesias, Amadeu Hoshi

; Oliveira, Rafael Augustus

; Ubbink, Job

; Reyes, Felix G. R.

; Prata, Ana Silvia

Brazilian Journal of Food Technology

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2021, Volume 24 elocation e2020169

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo As características intrínsecas de muitas frutas tropicais causam grandes perdas pós-colheita e impedem sua comercialização como frutas frescas. As informações sobre sua composição são cruciais para definir as condições de processamento e identificar oportunidades de desenvolvimento de produtos. No entanto, os métodos analíticos geralmente usados para quantificar açúcares e ácidos orgânicos são caros e demorados. A análise simultânea por Cromatografia Líquida-Ionização por Electrospray-Espectrometria de Massa (LC-ESI-MS/MS) é uma técnica muito sensível e reproduzível, permitindo a quantificação simultânea precisa em sistemas complexos. Assim, desenvolvemos um método LC-ESI-MS/MS de monitoramento de reações múltiplas (MRM) usando coluna de fase reversa para detectar e quantificar açúcares e alguns ácidos orgânicos em apenas quatro minutos, em frutas selecionadas: araza (Psidium cattleianum), ceriguela (Spondias purpurea), manga (Mangifera indica), goiaba (Psidium guajava) e pitanga (Eugenia uniflora L.). Todas as frutas apresentaram concentrações semelhantes de glicose e frutose, exceto a pitanga, que apresentou valores superiores. O conteúdo de ácidos cítrico, málico e tartárico foi quantificado; algumas frutas se destacaram pelo alto teor de ácidos orgânicos. Os dados gerados sobre a composição das frutas tropicais permitem estabelecer uma correlação entre o teor de carboidratos e as propriedades físicas das polpas das frutas, auxiliando no desenvolvimento de novos produtos.

Abstract The intrinsic characteristics of many tropical fruits cause high post-harvest losses and prevent their commercialization as fresh fruits. Information about their composition is crucial for defining processing conditions and identifying opportunities for product development. However, the analytical methods generally used to quantify sugars and organic acids are costly and time-consuming. Simultaneous analysis by Liquid Chromatography-Electrospray Ionization-Mass Spectrometry (LC-ESI-MS/MS) is a very sensitive and reproducible technique, allowing for accurate simultaneous multi-analyte quantitation in complex systems. Thus, a LC-ESI-MS/MS Multiple Reaction Monitoring (MRM) method was developed using reverse phase column for detecting and quantifying sugars and some organic acids in only 4 min, in selected fruits as following: araza (Psidium cattleianum L.), ciriguela (Spondias purpurea L.), mango (Mangifera indicaL.), guava (Psidium guajava L.) and pitanga (Eugenia uniflora L.). All fruits had a similar concentration of glucose and fructose, except for pitanga that presented higher values of both. The content of citric, malic and tartaric acids was quantitated; some fruits stood out by their high content of organic acids, for instance, araza was rich in citric acid. The newly generated data on the composition of tropical fruits allowed establishing a correlation between the carbohydrate content and the physical properties of the fruit pulps, assist in product development.

https://doi.org/10.1590/1981-6723.16920 359 downloads

Actividad acaricida del aceite de las semillas de Jatropha curcas L. en larvas de Rhipicephalus (Boophilus) microplus (Canestrini, 1887) (Acari: Ixodidae)
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Rizo-Borrego, Alberto

; Soca-Pérez, Mildrey

; García-Marrero, Danny E.

; Fuentes-Castillo, Alier

; Giupponi-Cardoso, Patricia

; Arece-García, Javier

; Cepero-Casas, Luis

Pastos y Forrajes

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Set 2019, Volume 42 Nº 3 Páginas 202 - 206

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Abstract In order to evaluate the acaricidal activity of the oil from Jatropha curcas L. seeds, with different storage periods, against larvae of the tick Rhipicephalus (Boophilus) microplus (Strain: Cayo Coco), this research was conducted at the Pastures and Forages Research Station Indio Hatuey. Oils with different storage periods (1 and 4 years) were evaluated. The oil was obtained from the mature, sun-dried and shelled fruits, of the Cape Verde provenance, collected in the Paraguay Farm, Guantánamo. A complete randomized experimental design was used with 17 treatments and 10 repetitions per treatment, from the different evaluated concentrations for the oils (0,5; 1,75; 2,5; 5 and 10 mg/mL), the solvent (Tween-80) and the negative (distilled water) and positive controls (Butox® Deltamethrin) used. For the in vitro studies the larval immersion techniques were applied. The negative control (distilled water) did not show acaricidal activity on the larvae (2,07 ± 0,40 %); a similar performance was observed in the solvent concentrations. The oil showed a marked larvicidal action in the two storage periods, with significant differences (p<0,05) among the experimental treatments, the negative control and the solvent, with values higher than 93 %. The best results were for the concentrations of 10 mg/mL oil 2014 (97,72 ± 0,58 %) and of 10 and 5 mg/mL oil 2017 (98,99 ± 0,33 and 98,11 ± 0,30 %, respectively), without significant differences with regards to Butox® (97,83 ± 0,45 %). The results showed that the oil from the J. curcas L. seed has acaricidal activity for the evaluated concentrations against larvae of the tick R. (B.) microplus, without significant differences between the storage periods and with values that exceeded 90 % of efficacy.

Resumen Con el objetivo de evaluar la actividad acaricida del aceite de las semillas de Jatropha curcas L., con diferentes períodos de almacenamiento, frente a larvas de la garrapata Rhipicephalus (Boophilus) microplus (Cepa: Cayo Coco), se desarrolló la presente investigación en la Estación Experimental de Pastos y Forrajes Indio Hatuey. Se evaluaron aceites con diferentes períodos de almacenamiento (1 y 4 años). El aceite se obtuvo de los frutos maduros, secados al sol y descascarados, de la procedencia Cabo Verde, colectados en la Granja Paraguay, Guantánamo. Se utilizó un diseño experimental totalmente aleatorizado con 17 tratamientos y 10 repeticiones por tratamiento, a partir de las diferentes concentraciones evaluadas para los aceites (0,5; 1,75; 2,5; 5 y 10 mg/mL), el solvente (Tween-80) y los controles negativos (agua destilada) y positivos (Butox® Deltametrina) utilizados. Para los estudios in vitro se utilizaron las técnicas de inmersión de larvas. El control negativo (agua destilada) no mostró actividad acaricida en las larvas (2,07 ± 0,40 %); un comportamiento similar se apreció en las concentraciones del solvente. El aceite presentó una marcada acción larvicida en los dos períodos de almacenamiento, con diferencias significativas (p<0,05) entre los tratamientos experimentales, el control negativo y el solvente, con valores superiores al 93 %. Los mejores resultados fueron para las concentraciones de 10 mg/mL/aceite 2014 (97,72 ± 0,58 %) y de 10 y 5 mg/mL/aceite 2017 (98,99 ± 0,33 y 98,11 ± 0,30 %, respectivamente), sin diferencias significativas con respecto al Butox® (97,83 ± 0,45 %). Los resultados mostraron que el aceite de la semilla de J. curcas L. posee actividad acaricida para las concentraciones evaluadas frente a larvas de la garrapata R. (B.) microplus, sin diferencias significativas entre los períodos de almacenamiento y con valores que superaron el 90 % de eficacia.

Un diagnóstico no pensado: toxicidad serotoninérgica secundaria a interacción medicamentosa. Caso clínico
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Cargnel, Elda G

; Cardoso, Patricia C

; Irigoyen, Julián

; García Puglisi, Sol

Archivos argentinos de pediatría

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Fev 2018, Volume 116 Nº 1 Páginas e115 - e120

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Serotonin toxicity is a potentially life-threatening condition associated with increased serotonergic activity in the central nervous system. It is seen with therapeutic medication use, intentional self-poisoning and inadvertent interactions (SSRI-isoniazid). Although this pathology is increasingly common, it is not well recognized by physicians and manifestations may be wrongly attributed to another cause. The aim of this paper is to describe the clinical picture of a patient, to collaborate on diagnosis and to improve medical care of these patients.

La toxicidad serotoninérgica es un trastorno con potencial riesgo de vida asociado con un incremento de la actividad serotoninérgica en el sistema nervioso central. Se observa con el uso terapéutico o sobredosis intencional de medicamentos e interacciones inadvertidas (inhibidores selectivos de la recaptación de serotonina-isoniacida). Aunque esta patología está incrementándose, todavía no es bien reconocida por los médicos y sus manifestaciones pueden ser erróneamente atribuidas a otras causas. El objetivo de este artículo es presentar un caso clínico, colaborar con el diagnóstico y mejorar el cuidado de estos pacientes.

https://doi.org/10.5546/aap.2018.e115 493 downloads

Occurrence of non-O157 Shiga toxin-encoding Escherichia coli in artisanal mozzarella cheese in Brazil: risk factor associated with food workers
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CARDOSO, Patricia

; MARIN, José Moacir

Food Science and Technology

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Mar 2017, Volume 37 Nº 1 Páginas 41 - 44

Resumo: En | Texto: En | PDF: En

Abstract Mozzarella cheese is considered a safe food due to the high temperature treatment used in the traditional process of stretching into hot water; however, a post-process contamination during the cheese manufacture or during the processing (before distribution) could occur. This study investigated the occurrence of Shiga toxin-encoding Escherichia coli (STEC) strains in homemade-mozzarella cheese. In total, 59 raw milk cheese samples collected at a local producer in the Jequitinhonha Valley (Northeast of Minas Gerais, Brazil) were submitted for microbiological analysis, and 38 (64.4%) tested positive for E. coli. Then, 147 strains of E. coli were isolated from positive samples and screened by polymerase chain reaction for the presence of the genes encoding the following virulence factors: stx1 and stx 2 (verotoxin types 1 and 2) and eae (intimin). All the isolates were negative for the stx 2, 14 isolates (9.5%) were positive for the stx1 gene, and 11 of them also harbored the eae gene. A food worker was probably involved in cheese contamination during the manufacture schedule. While the development of STEC infection in humans is not completely understood, all STEC- contaminated food can be considered potentially hazardous.

https://doi.org/10.1590/1678-457x.06316 1229 downloads

Prevalencia de Fasciola hepatica en vacas en pastoreo durante el periodo poco lluvioso
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Soca-Pérez, Mildrey

; Giupponi-Cardoso, Patricia

; López-Vigoa, Onel

; Sanavria, Argemiro

; Sánchez-Santana, Tania

; Labrada-Vázquez, Adela

Pastos y Forrajes

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Dez 2016, Volume 39 Nº 4 Páginas 281 - 285

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

A study was conducted in a dairy farm of the Jovellanos municipality, Matanzas province, Cuba, in order to evaluate the prevalence of Fasciola hepatica in grazing cows during the dry season. For such purpose, 100 % of the animals of the Crossbred Siboney breed belonging to the milking group, with an age between 5 and 7 years, lactation between 90 and 114 days, and average weight of 390 kg, were used. The animals were distributed in three groups depending on their body condition: BC-2,5; BC-3 and BC-3,5. After the initial diagnosis to determine the level of infestation by F. hepatica, the animals were dewormed with Labiozol®. Monthly samplings of feces were performed to determine the parasite rate of F. hepatica (FEC); in addition, the live weight, body condition and individual milk production of the animals, were determined. The prevalence of the parasite in the dairy herd was higher in February and March, with 58,3 and 62,5 % of positive animals, respectively. The highest percentages corresponded to the animals with the lowest body condition, which showed higher FEC (14,1 epg) and reached the lowest production for the period, with significant differences (p< 0,05) from the animals of groups BC-3 and BC-3,5. It is concluded that the prevalence of F. hepatica in the farm exceeded 50 % during the dry season; the group with the lowest body condition was the one with the highest parasite rate, and also had the lowest milk production.

Con el objetivo de evaluar la prevalencia de Fasciola hepatica en vacas en pastoreo durante el período poco lluvioso, se realizó una investigación en una unidad de lechería bovina en el municipio de Jovellanos, provincia de Matanzas, Cuba. Se utilizó el 100 % de los animales del racial Mestizo Siboney pertenecientes al grupo de ordeño, con una edad entre 5 y 7 años, lactancia entre 90-114 días y un peso promedio de 390 kg. Los animales fueron distribuidos en tres grupos en función de su condición corporal: CC-2,5; CC-3 y CC-3,5. Posteriormente al diagnóstico inicial para determinar el nivel de infestación por F. hepatica, los animales fueron desparasitados con Labiozol®. Se realizaron muestreos mensuales de heces para determinar la carga parasitaria de fasciola (CFH); además se determinó el peso vivo, la condición corporal y la producción de leche individual de los animales. La prevalencia del parásito en el rebaño lechero fue mayor en los meses de febrero y marzo, con 58,3 y 62,5 % de animales positivos, respectivamente. Los mayores porcentajes se correspondieron con los animales del grupo de más baja condición corporal, los cuales mostraron un mayor CFH (14,1 hpg) y alcanzaron la menor producción para el período, con diferencias significativas (p< 0,05) respecto a los animales de los grupos CC-3 y CC-3,5. Se concluye que la prevalencia de F. hepatica en la unidad superó el 50 % durante el periodo poco lluvioso; el grupo de más baja condición corporal fue el de mayor carga parasitaria, así como el de menor producción de leche.

10.

Convulsiones por isoniazida: una causa toxicológica a considerar
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Díaz, Mariano

; Lamenza, Claudia

; Trapassi, Horacio

; Cargnel, Elda

; Mandolesi, Graciela

; Cardoso, Patricia

Acta toxicológica argentina

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Set 2015, Volume 23 Nº 2 Páginas 79 - 82

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Pediatricians do not usually considered isoniazid (INH) neurotoxicity in cases of patients with severe seizure disorders. INH is one of the most suitable drugs in the treatment and chemoprophylaxis of tuberculosis. It is usually indicated to the family group, due to the epidemiological characteristics of this disease, allowing a wide availability in homes and being able to cause accidental or intentional poisoning. An acute neurotoxic picture, expressed as a convulsive syndrome or coma, which does not improve with the usual treatments, characterized severe intoxication. A case of a patient with severe intoxication with isoniazid is presented. The extended anamnesis, along with an early diagnosis and the specific antidote treatment, set the fundamental basis for the favorable evolution of the patient.

La neurotoxicidad de la isoniazida (INH) frecuentemente no es tenida en cuenta por el pediatra ante un paciente con un cuadro convulsivo agudo. La INH es uno de los fármacos más indicados en el tratamiento y quimioprofilaxis de la tuberculosis. Habitualmente se la indica al grupo familiar, debido a las características epidemiológicas de esta enfermedad, lo cual permite una amplia disponibilidad en los hogares, pudiendo originar intoxicaciones accidentales o intencionales. La intoxicación severa se caracteriza por un cuadro neurotóxico agudo, expresado en un síndrome convulsivo o coma, que no cede con el tratamiento habitual. Se presenta un caso clínico de una paciente intoxicada grave con isoniazida, habiendo sido la anamnesis dirigida ampliada junto con un diagnóstico precoz y el tratamiento específico con el antídoto, la base fundamental para la evolución favorable de la paciente.

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11.

Investigación clínica farmacológica en pediatría: consentimiento informado y asentimiento. ¿Qué lugar tiene la voluntad del paciente pediátrico? (Parte 2)
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Cardoso, Patricia C.

; Calabró, Pablo D.

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Abr 2005, Volume 103 Nº 2 Páginas 135 - 146

Resumo: Es | Texto: Es | PDF: Es

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12.

Investigación clínica farmacológica en pediatría: ¿Es ético y legal experimentar en niños? (Parte 1)
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Cardoso, Patricia C.

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Fev 2005, Volume 103 Nº 1 Páginas 46 - 50

Resumo: Es | Texto: Es | PDF: Es

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