RESUMO As redes sociais são lugares de exibição de fotografias amadoras e campo de experimentação artística. São também dispositivos que impactam a subjetividade e a democracia, beneficiando interesses do neoliberalismo, e que geraram um novo capítulo na história da fotografia, a selfie , cujo estudo exige uma metodologia interdisciplinar. Este artigo propõe que a selfie remete à auto-objetificação. Esta hipótese é investigada referindo-se à teoria da fotografia de Philippe Dubois, a conceitos da psicanálise e a diagnósticos de Achille Mbembe e Giorgio Agamben sobre os efeitos do capitalismo avançado na subjetividade. Por fim, analisa a selfie nas obras de Amalia Ulman, Aleta Valente e Cindy Sherman, discutindo os limites das redes sociais como lugar de circulação da obra de arte.

ABSTRACT Social networks are sites for the exhibition of amateur photography, and a field for artistic experimentation. They are also apparatus that impact subjectivity and democracy, benefiting interests of neoliberalism. Moreover, they have generated a new chapter in the history of photography, the selfie, which demands an interdisciplinary methodology to be understood. This article proposes that the selfie refers to self-objectification. It investigates this hypothesis by departing from the theory of photography developed by Philippe Dubois, concepts from psychoanalysis, and diagnostics issued by Achille Mbembe and Giorgio Agamben concerning the effects of late capitalism on subjectivity. Last, the article analyses the use of the selfie by the artists Amalia Ulman, Aleta Valente and Cindy Sherman, discussing the limits of networks as a site for art.

RESUMEN Las redes sociales son sitios de exhibición de fotografías amadoras y campo de experimentación artística. Son también dispositivos que impactan la subjetividad y la democracia, favoreciendo intereses del neoliberalismo, y han generado un nuevo capítulo en la historia de la fotografía, la selfi , cuya analice exige una metodología interdisciplinar. Este artículo propone que la selfi remete a la auto-objetificación. Esta hipótesis es investigada a partir de la teoría de la fotografía de Philippe Dubois, de conceptos de psicoanálisis y de diagnósticos de Achille Mbembe y Giorgio Agamben acerca de los efectos del capitalismo avanzado en la subjetividad. Finalmente, analiza la selfi en las obras de Amalia Ulman, Aleta Valente y Cindy Sherman, discutiendo los limites de las redes sociales como sitio de circulación de la obra del arte.

ABSTRACT Background: The impact of central venous catheter (CVC) removal on the outcome of patients with candidemia is controversial, with studies reporting discrepant results depending on the time of CVC removal (early or any time during the course of candidemia). Objective: Evaluate the effect of time to CVC removal, early (within 48 h from the diagnosis of candidemia) vs. removal at any time during the course of candidemia, on the 30-day mortality. Methods: Retrospective cohort study of 285 patients with candidemia analyzing CVC removal within 48 h (first analysis) or at any time (second analysis). Results: A CVC was in place in 212 patients and was removed in 148 (69.8%), either early (88 patients, 41.5%) or late (60 patients, 28.3%). Overall, the median time to CVC removal was one day (range 1-28) but was six days (range 3-28) for those removed later. In the first analysis, APACHE II score (odds ratio [OR] 1.111, 95% confidence interval [95% CI] 1.066-1.158), removal at any time (OR 0.079, 95% CI 0.021-0.298) and Candida parapsilosis infection (OR 0.291, 95% CI 0.133-0.638) were predictors of 30-day mortality. Early removal was not significant. In the second analysis APACHE II score (OR 1.122, 95% CI 1.071-1.175) and C. parapsilosis infection (OR 0.247, 95% CI 0.103-0.590) retained significance. Conclusions: The impact of CVC removal is dependent on whether the optimal analysis strategy is deployed and should be taken into consideration in future analyses.

ABSTRACT Background Candidemia is the most frequent invasive fungal disease in hospitalized patients, and is associated with high mortality rates. The main objective of this study was to evaluate changes in the epidemiology of candidemia at a tertiary care hospital in a 21-year period. Methods We evaluated all episodes of candidemia diagnosed between 1996 and 2016 at a University-affiliated tertiary care hospital in Brazil. We arbitrarily divided the study period in 3: 1996-2002 (period 1), 2003-2009 (period 2) and 2010-2016 (period 3). Incidence rates were calculated using hospital admissions as denominator. Results We observed 331 episodes of candidemia. The incidence was 1.30 episodes per 1000 admissions, with no significant change over time. Candida albicans (37.5%), C. tropicalis (28.1%), C. parapsilosis (18.4%) and C. glabrata (6.9%) were the most frequent species. The proportion of patients receiving treatment increased (65.5%, 79.4% and 74.7% in periods 1, 2 and 3, respectively, p= 0.04), and the median time from candidemia to treatment initiation decreased from 4 days in period 1 (range 0-32 days) to 2 days in period 2 (range 0-33 days) and 2 days in period 3 (range 0-14 days, p< 0.001). We observed a significant decrease in the use of deoxycholate amphotericin B (47.4%, 14.8% and 11.9%), and an increase in the use of echinocandins (0%, 2.8% and 49.1%; p< 0.001). The APACHE II score increased over time (median 16, 17.5, and 22, p< 0.001). The overall 30-day mortality was 58.9%, and did not change significantly over the study period. Conclusions There was an improvement in patient care, with an increase in the proportion of patients receiving treatment and a decrease in the time to treatment initiation, but no improvement in the outcome, possibly because the proportion of sicker patients increased over time.

Resumo A metafísica de artista de Hélio Oiticica parte do corpo para chegar à MÚSICA, estado de experiência e do fazer artístico que está para além do próprio corpo e da arte. No texto “O q Faço é MÚSICA”, Oiticica define o termo MÚSICA como uma totalidade-mundo, que é representada em outros textos pela imagem da galáxia, com seus pontos luminosos, e pelo conceito de Mundo-Abrigo, espaço estético preenchido por invenções de artistas de vários lugares e épocas e que, apesar de ser tratado como espaço, flutua ao redor do mundo sensível e do tempo, como uma outra dimensão. Este artigo percorre a obra de Oiticica à luz da ideia de expansão da arte rumo à MÚSICA.

Abstract The artist metaphysics of Hélio Oiticica departs from the body to arrive at MUSIC, which he defines as a form of experience and art making beyond the own body and beyond art. In the text “O q Faço é MÚSICA” (What I do is MUSIC), Oiticica defines the term, written MUSIC as a world-totality that in other texts he represents by the image of the galaxy, with its bright points, and by the concept of World-Shelter, an aesthetic space that is filled by inventions from artists from many places and eras and, despite being discussed as space, it floats around the material world and time, as if it were another dimension. This article analyses the work of Hélio Oiticica in the light of the idea of expanding art towards MUSIC.

Introduction Hypothyroidism and age impact on cardiac and renal nitric oxide (NO) production. Caveolins, which are negative modulators of NO synthase (NOS) activity, are affected by both factors. Objectives The aim of this study was to evaluate caveolin (CAV) participation in the modulation of renal and cardiac NOS activity in adult hypothyroid animals. Methods Euthyroid and hypothyroid [methimazole 0.02% (v/v) in the drinking water during 28 days] male Sprague-Dawley rats were used. Animals were sacrificed to remove the heart and kidneys. Results Right atrial NOS activity decreased with age and hypothyroi-dism. Caveolin-1 expression increased with age and hypothyroidism. Conversely, left ventricular NOS activity increased with aging and hypothyroidism and the expression of both CAV isoforms decreased in adult and hypothyroid groups. In the renal medulla, hypothyroidism reduced NOS activity in young and raised it in adult animals and CAV-1 expression decreased with age and in hypothyroid young animals. Caveolin-3 protein levels decreased in adult hypothyroid animals. Conclusions Hypothyroidism impacts on NOS activity and on that of its modulators, caveolins, in the cardiovascular and renal systems. Hypothyroidism enhances the effects of aging in both systems.

Introducción El hipotiroidismo y la edad impactan sobre la producción de óxido nítrico (NO) cardíaco y renal. Las caveolinas, moduladores negativos de la actividad enzimática de la NO sintetasa (NOS), se afectan con ambos factores. Objetivos Evaluar la implicación de las caveolinas (cav) en la modulación de la actividad de la NOS cardíaca y renal en animales hipotiroideos adultos. Material y métodos Se utilizaron ratas macho Sprague-Dawley eutiroideas e hipotiroideas [metimazol 0,02% (v/v) en el agua de bebida durante 28 días]. Los animales fueron sacrificados para extraer el corazón y los riñones. Resultados La actividad de la NOS en la aurícula derecha disminuyó con la edad y el hipotiroidismo. La expresión de cav-1 aumentó con la edad y el hipotiroidismo. La actividad de la NOS en el ventrículo izquierdo aumentó con el avance de la edad y el hipotiroidismo. La expresión de ambas caveolinas disminuyó en los grupos adulto e hipotiroideo. En la médula renal, el hipotiroidismo disminuyó la actividad de la NOS en jóvenes y la aumentó en adultos. La expresión de cav-1 disminuyó con la edad y en jóvenes hipotiroideos. Los niveles proteicos de cav-3 disminuyeron en animales adultos hipotiroideos. Conclusiones El hipotiroidismo impacta sobre la actividad de la NOS y de sus moduladores, las caveolinas, en el sistema cardiovascular y renal. El hipotiroidismo intensifica los efectos del avance de la edad en ambos sistemas.

A enurese é definida como a micção normal que ocorre durante o sono. Para o seu diagnóstico, são necessárias a idade mínima de cinco anos e frequência de pelo menos um episódio por mês. As causas mais consensuais são a poliúria noturna, dificuldades em despertar e a hiperatividade detrusora. O objetivo deste trabalho foi comparar crianças e adolescentes enuréticos que se submeteram ao tratamento com alarme, divididas entre dois protocolos de tratamento: presencial e à distância. Participaram do trabalho 61 crianças e adolescentes com idades entre seis e 17 anos e suas famílias. Todos participaram de duas sessões presenciais nas quais foram fornecidas informações sobre a enurese e o tratamento baseado no programa de espectro total. Os participantes foram alocados randomicamente entre protocolos de acompanhamento presencial (n=27) e à distância (n=34). Verificou-se que as crianças e adolescentes acompanhados à distância apresentam resultado comparável ao relatado na literatura, sendo uma alternativa viável ao acompanhamento presencial.

Nocturnal enuresis is defined as natural urination during sleep occurring at least once a month among children aged five years or older. There is a relative consensus in literature regarding possible causes: nocturnal polyuria, difficulties in waking up and a hyperactive bladder. The objective of this work was two compare two treatment protocols which used an alarm to treat enuresis: face-to-face and long distance. Sixty one enuretic children aged between 6 and 17 and their parents or caregivers participated in the study. They all attended two initial face-to-face sessions in which they received information on the treatment based on the full-spectrum programme. Participants were randomly allocated to the face-to-face (n=27) and long-distance (n=34) protocols. The long-distance protocol recorded outcome rates comparable to those cited in literature and thus offered a feasible alternative to the face-to-face protocol.

PURPOSES: To investigate the efficacy of alarm treatment in a sample of Brazilian children and adolescents with nocturnal enuresis and relate treatment success to age and type of clinical support. MATERIALS AND METHODS: During 32 weeks, 84 children and adolescents received alarm treatment together with weekly psychological support sessions for individual families or groups of 5 to 10 families. RESULTS: 71% of the participants achieved success, defined as 14 consecutive dry nights. The result was similar for children and adolescents and for individual or group support. The time until success was shorter for participants missing fewer support sessions. CONCLUSIONS: Alarm treatment was effective for the present sample, regardless of age or type of support. Missing a higher number of support sessions, which may reflect low motivation for treatment, increased the risk of failure.

Para que a utilização de frutíferas do cerrado ocorra de maneira sustentável, estudos no intuito de se conhecer suas características fazem-se necessários. Neste escopo, o presente trabalho teve como objetivo caracterizar alguns parâmetros químicos de frutos de pequizeiro coletados em três municípios do sudoeste do Estado de Goiás (Jataí, Rio Verde e Serranópolis). Em cada município foram selecionadas duas populações de pequizeiros, denominadas áreas. Em cada área, foram eleitas oito árvores para a coleta dos frutos. Nas amostras, foram determinados os teores de fósforo, potássio, cálcio, magnésio, enxofre, cobre, ferro, manganês, nitrogênio, zinco e extrato etéreo. Os resultados indicam que as diferenças entre as características químicas estudadas nos frutos coletados nas diferentes regiões não parecem variar significativamente. Comparando os teores encontrados no presente trabalho com aqueles requeridos diariamente na alimentação humana, novos estudos são recomendados objetivando utilizar o fruto do pequizeiro como uma fonte alternativa complementar de magnésio, manganês e cobre.

In order to assure that the use of cerrado fruits occur in a sustainable way, studies to investigate their characteristics are extremely relevant. In this context, the present study aims to describe some chemical parameters of pequi fruits picked in three municipalities in southwestern Goiás State (Jataí, Rio Verde, and Serranópolis). In each city, two populations of pequi trees - pequizeiros, denominated areas, were selected. In each area, eight trees were selected for the fruit to be picked. The contents of phosphorus, potassium, calcium, magnesium, nitrogen, zinc, and ether extract were determined in the samples. The results demonstrate differences between the chemical characteristics studied for the fruits picked in different areas, which does not seem to vary in a significant way. Comparing the contents obtained in the present study with those required as human daily supply, further studies are recommended aiming at using the pequi fruit as a complementary alternative source of magnesium, manganese, and copper.

O presente trabalho teve por finalidade estudar o acúmulo e os efeitos do níquel na composição mineral da levedura Saccharomyces cerevisiae Fleichmann fermentando mosto de caldo de cana com contaminações controladas, em níveis subtóxicos, do citado metal. O mosto esterelizado (120 °C/20 minutos), com 12% de açúcares redutores totais (ART) e quatro níveis de pH (3,5; 4,5; 5,5 e 6,5), foi acrescido com o sal cloreto de níquel (NiCl2.6H2O), resultando em seis níveis de contaminações (0,0; 0,1; 0,5; 1,0; 2,0 e 5,0 mmol Ni.L-1) e 24 tratamentos. A inoculação do mosto foi executada com fermento de panificação (10% p.p-1). Depois de 6 horas de fermentação, as leveduras foram obtidas por centrifugação, para posterior análise da viabilidade celular, dos teores de trealose, bem como dos teores celulares de níquel, fósforo, potássio, cálcio, magnésio, enxofre, cobre, ferro, manganês e zinco. O níquel parece influenciar nos teores intracelulares de ferro, magnésio e cálcio, sendo que a toxidade do níquel foi potencializa com o decréscimo do pH.

Sugar cane juice containing 12% (w.w -1) of total reducing sugars and 0.0 to 5.0 mmol of nickel L-1, with pH ranging from 3.5 to 6.5, was inoculated with Fleischmann’s yeast (Saccharomyces cerevisiae) (10% w.w -1). Six hours after fermentation, the yeast’s cellular viability and trehalose content were evaluated. The resulting must was centrifuged and the raw yeast was analyzed by atomic absorption spectroscopy to evaluate the intracellular levels of calcium, copper, iron, magnesium, manganese, nickel, phosphorus, potassium, sulfur and zinc. The intracellular levels of iron, magnesium and calcium were affected and the yeast’s susceptibility to nickel was enhanced by the decrease in pH. The yeast’s growth was not affected by nickel at high pH, but the toxic effects of nickel were potentiated at low pH.

Searching for information in long videos can be a time-consuming experience. In this paper, we describe OnAIR, an ontology-aided information retrieval system applied to retrieve clips from video collections. We used a video collection compiled from interviews with Ana Teixeira, a Brazilian artist. The interviews were made by Paula P. Braga, the domain expert. The interview is developed in the domain of contemporary art and the system uses a domain ontology to expand the queries with related terms. We tested the system with a battery of queries, and we veri.ed that the ontology contributes to the e.ciency improvement in terms of the relevance of retrieved documents. We designed the system to work in a domain-independent way, allowing us to move to other domains by just changing the underlying ontologies and video collections.