ABSTRACT Objective: To analyze the temporal trend of tuberculosis cure indicators in Brazil. Methods: An ecological time-series study using administrative data of reported cases of the disease nationwide between 2001 and 2022. We estimated cure indicators for each federative unit (FU) considering individuals with pulmonary tuberculosis, tuberculosis-HIV coinfection, and those in tuberculosis retreatment. We used regression models using joinpoint regression for trend analysis, reporting the annual percentage change and the average annual percentage change. Results: For the three groups analyzed, we observed heterogeneity in the annual percentage change in the Brazilian FUs, with a predominance of significantly decreasing trends in the cure indicator in most FUs, especially at the end of the time series. When considering national indicators, an average annual percentage change of −0.97% (95% CI: −1.23 to −0.74) was identified for the cure of people with pulmonary tuberculosis, of −1.11% (95% CI: −1.42 to −0.85) for the cure of people with tuberculosis-HIV coinfection, and of −1.44% (95% CI: −1.62 to −1.31) for the cure of people in tuberculosis retreatment. Conclusions: The decreasing trends of cure indicators in Brazil are concerning and underscore a warning to public authorities, as it points to the possible occurrence of other treatment outcomes, such as treatment discontinuity and death. This finding contradicts current public health care policies and requires urgent strategies aiming to promote follow-up of patients during tuberculosis treatment in Brazil. Objective Methods timeseries series 200 2022 FU (FU tuberculosisHIV HIV coinfection retreatment analysis Results analyzed FUs 097 0 97 −0.97 95% 95 (95 CI 123 1 23 −1.2 −0.74 074 74 111 11 −1.11 142 42 −1.4 −0.85 085 85 144 44 −1.44 162 62 −1.6 −1.31 131 31 Conclusions authorities outcomes death followup follow up 20 202 09 9 −0.9 (9 12 2 −1. −0.7 07 7 −1.1 14 4 −0.8 08 8 16 6 −1.3 13 3 −0. ( −1 −0 −