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Abstract Introduction Low-Level Red-Light (LLRL) Therapy is a safe and natural way to promote healing and reduce inflammation in the body. When it comes to treating myopia in children, LLRL therapy is recent, and its efficacy and safety still are not clear. Methods A systematic review and meta-analysis of the literature for LLRL was conducted in accordance with the PRISMA guidelines on November 5, 2022. Databases, including PUBMED, Cochrane Library, Web of Science, and Embase were queried. A meta-analysis of random effects was conducted. Inclusion criteria included Randomized Controlled Trials (RCTs) or observational studies where LLRL therapy was used in children (3‒15 years old) with myopia. Exclusion criteria were studies with other ocular abnormalities. Efficacy was evaluated through the mean change in Axial Length (AL) and cycloplegic Spherical Equivalent Error (SER), while safety was evaluated by monitoring adverse effects. Results A total of 5 final studies were included (4 RCTs, and 1 observational), in which 685 total patients were analyzed. The mean age was 9.7 ± 0.66 years, with 48,2% female patients. The number of eyes in the LRLL arm is 714 and, in the control, arm is 656. LLRL showed better results in SER and AL mean change (OR = 0.58; 95% CI 0.33 to 0.83; p < 0.00001, and MD -0.33; 95% CI -0.52 to -0.13; p = 0.001, respectively), in comparison to the control group. There was no significant difference in adverse effects between groups (MD = 5.76; 95% CI 0.66 to 50.14; p = 0.11). Conclusion LLRL therapy is a non-invasive, effective, and safe short-term treatment option; however, long-term evaluation, particularly in comparison to other therapies, requires additional investigation. LowLevel Low Level RedLight Red Light (LLRL body recent clear metaanalysis meta analysis 2022 Databases PUBMED Library Science queried RCTs (RCTs 3‒15 315 3 15 (3‒1 old abnormalities (AL SER, , (SER) 4 ( observational, observational) 68 analyzed 97 9 7 9. 066 0 66 0.6 482 48 2 48,2 71 656 OR 0.58 058 58 95 033 33 0.3 0.83 083 83 000001 00001 0.00001 -0.33 0.52 052 52 -0.5 0.13 013 13 -0.13 0001 001 0.001 respectively, respectively respectively) group 5.76 576 76 50.14 5014 50 14 0.11. 011 0.11 . 11 0.11) noninvasive, noninvasive non invasive, invasive non-invasive effective shortterm short term option however longterm long evaluation therapies investigation 202 3‒1 31 (3‒ (SER 6 06 0. 48, 65 0.5 05 03 0.8 08 8 00000 0000 0.0000 -0.3 -0. 0.1 01 -0.1 000 00 0.00 5.7 57 50.1 501 20 3‒ (3 0.000 -0 0.0 5. 50. -