Resumo Esta pesquisa estuda a capacidade de absorção de água em painéis de concreto e seu processo de autocicatrização, através da incorporação de aditivo ao concreto ou aplicação na superfície. Através de ensaios de permeabilidade, absorção de água por imersão e por capilaridade, após a cura úmida dos painéis, os painéis com aditivo cristalizante aplicado superficialmente apresentaram menor capacidade de absorção, seguido pelos sem aditivo e as com o aditivo incorporado ao concreto. Através da microscopia realizada nos painéis partidos ao meio, pôde-se observar que a cristalização dos painéis com aditivo superficial estavam mais avançadas em comparação aos com o aditivo incorporado. As fissuras induzidas não atingiram o total preenchimento de poros após a cura, em ambos os tipos de aplicação.

Abstract This research studies the water absorption capacity of concrete panels and its self-healing process, using the incorporation of admixtures to the concrete or its application on the surface. Through permeability tests, water absorption by immersion and by capillarity, after the wet curing, the panels with crystalline admixtures applied superficially showed lower absorption capacity, followed by those without admixtures and those with the admixtures incorporated into the concrete, which showed greater absorption. Microscopy characterization was performed on the panels split in half, it was observed that the crystallization of the panels with superficial admixtures was more advanced compared to those with the incorporated admixtures. The induced fissures did not reach full pore filling after curing in both types of application.

Resumen Esta investigación estudia la capacidad de absorción de agua de los paneles de hormigón y su proceso de autorreparación, mediante la incorporación de aditivo al hormigón o aplicación sobre la superficie. Mediante ensayos de permeabilidad, absorción de agua por inmersión y capilaridad, después del curado en húmedo, los paneles con aditivo cristalizador aplicado superficialmente mostraron menor capacidad de absorción, seguidos de los sin aditivo y los con aditivo incorporado, que mostraron mayor absorción. A través de la microscopía, se pudo observar que la cristalización de los paneles con aditivo superficial fue más avanzada en comparación con aquellos con aditivo incorporado. Las fisuras inducidas no alcanzaron el llenado completo de los poros después del curado, en ambos tipos de aplicación.

6-Nitrodopamine is a novel catecholamine released by vascular tissues, heart, and vas deferens. The aim of this study was to investigate whether 6-nitrodopamine is released from the thoracic aorta and pulmonary artery rings of marmosets (Callithrix spp.) and to evaluate the relaxing and anti-contractile actions of this catecholamine. Release of 6-nitrodopamine, dopamine, noradrenaline, and adrenaline was assessed by liquid chromatography with tandem mass spectrometry (LC-MS/MS). The relaxations induced by 6-nitrodopamine and by the selective dopamine D2 receptor antagonist L-741,626 were evaluated on U-46619 (3 nM)-pre-contracted vessels. The effects of 6-nitrodopamine and L-741,626 on the contractions induced by electric-field stimulation (EFS), dopamine, noradrenaline, and adrenaline were also investigated. Both aorta and pulmonary artery rings exhibited endothelium-dependent release of 6-nitrodopamine, which was significantly reduced by the NO synthesis inhibitor L-NAME. Addition of 6-nitrodopamine or L-741,626 caused concentration-dependent relaxations of both vascular tissues, which were almost abolished by endothelium removal, whereas L-NAME and the soluble guanylate cyclase inhibitor ODQ had no effect on 6-nitrodopamine-induced relaxations. Additionally, pre-incubation with 6-nitrodopamine antagonized the dopamine-induced contractions, without affecting the noradrenaline- and adrenaline-induced contractions. Pre-incubation with L-741,626 antagonized the contractions induced by all catecholamines. The EFS-induced contractions were significantly increased by L-NAME, but unaffected by ODQ. Immunohistochemical assays showed no immunostaining of the neural tissue markers S-100 and calretinin in either vascular tissue. The results indicated that 6-nitrodopamine is the major catecholamine released by marmoset vascular tissues, and it acts as a potent and selective antagonist of dopamine D2-like receptors. 6-nitrodopamine release may be the major mechanism by which NO causes vasodilatation. 6Nitrodopamine Nitrodopamine 6 tissues heart deferens 6nitrodopamine nitrodopamine Callithrix spp. spp anticontractile anti contractile 6nitrodopamine, nitrodopamine, noradrenaline LCMS/MS. LCMSMS LC MS/MS . MS (LC-MS/MS) D L741,626 L741626 L 741,626 741 626 L-741,62 U46619 U 46619 U-4661 3 ( nMprecontracted nM pre contracted vessels electricfield electric field EFS, EFS , (EFS) investigated endotheliumdependent dependent LNAME. LNAME NAME. NAME concentrationdependent concentration removal 6nitrodopamineinduced nitrodopamineinduced Additionally preincubation incubation dopamineinduced adrenalineinduced Preincubation Pre catecholamines EFSinduced LNAME, NAME, S100 S 100 S-10 D2like Dlike like receptors vasodilatation LCMS LCMS/MS MSMS (LC-MS/MS L741 L741,62 L74162 741626 741,62 74 62 L-741,6 U4661 4661 U-466 (EFS S10 10 S-1 L74 L741,6 L7416 74162 741,6 7 L-741, U466 466 U-46 S1 1 S- L7 L741, 7416 741, L-741 U46 46 U-4 L-74 U4 4 U- L-7 L-

O objetivo deste estudo foi analisar o resultado do tratamento cirúrgico de aspergiloma pulmonar. Para tanto, foram avaliados 14 pacientes adultos (7 homens e 7 mulheres) e tratados no Hospital Universitário da Faculdade de Medicina de Botucatu, em Botucatu (SP), entre 1981 e 2009. Dados foram coletados dos registros médicos dos pacientes. Dez pacientes (71%) apresentaram aspergiloma pulmonar simples, e 4 (29%) apresentaram aspergiloma pulmonar complexo. O sintoma mais frequente foi hemoptise, e a pneumopatia preexistente mais prevalente foi tuberculose. Dois pacientes (14%) foram submetidos a mais de um procedimento cirúrgico. Não houve mortalidade operatória. Metade dos pacientes apresentou complicações pós-operatórias, sendo fuga aérea prolongada e empiema as mais frequentes.

The objective of this study was to analyze the outcome of surgical treatment of pulmonary aspergilloma. To that end, we evaluated 14 adult patients so treated between 1981 and 2009 at the Botucatu School of Medicine University Hospital, in the city of Botucatu, Brazil. Data were collected from the medical records of the patients. Ten patients (71%) presented with simple pulmonary aspergilloma, and 4 (29%) presented with complex pulmonary aspergilloma. Hemoptysis was the most common symptom, and tuberculosis was the most prevalent preexisting lung disease. Two patients (14%) underwent surgery on more than one occasion. There were no intraoperative deaths. Half of the patients developed postoperative complications, prolonged air leak and empyema being the most common.