RESUMO Objetivo: Caracterizar a efetividade de medicamentos antifactor de crescimento endotelial vascular na degeneração macular relacionada à idade exsudativa. Métodos: Estudo longitudinal retrospectivo em 54 pacientes com degeneração macular relacionada à idade que usaram bevacizumab ou aflibercept. Foram coletados dados demográficos, da acuidade visual e da espessura central da retina. Melhora/estabilidade da acuidade visual e redução da espessura configuraram respostas satisfatórias. Resultados: Entre 60 olhos estudados, não houve diferença (p = 0,262) de acordo com o uso de bevacizumab (48,5%) ou aflibercept (63,0%). Acuidade visual segundo Snellen, ganho de letras e espessura retiniana demonstraram melhora ou estabilidade em 55,0%, 32,8% e 78,3% dos casos, respectivamente. Entre os olhos com acuidade visual inicial < 20/400, o percentual de melhora/estabilidade foi superior (70,0% versus 40,0%; p = 0,002). Conclusão: Em pacientes com degeneração macular relacionada à idade, foi percebida uma maior proporção de melhora ou estabilização da acuidade visual e espessura macular, com melhor resposta entre os pacientes com visão pior que 20/400. Objetivo exsudativa Métodos 5 demográficos retina Melhoraestabilidade Melhora satisfatórias Resultados 6 estudados 0,262 0262 0 262 48,5% 485 48 (48,5% 63,0%. 630 63,0% . 63 (63,0%) Snellen 550 55 55,0% 328 32 8 32,8 783 78 3 78,3 casos respectivamente 20400 20 400 20/400 melhoraestabilidade 70,0% 700 70 (70,0 40,0% 40 0,002. 0002 0,002 002 0,002) Conclusão 0,26 026 26 48,5 4 (48,5 63,0 (63,0% 55,0 32, 7 78, 2040 2 20/40 70,0 (70, 40,0 000 0,00 00 0,2 02 48, (48, 63, (63,0 55, 204 20/4 70, (70 40, 0,0 0, (48 (63, 20/ (7 (4 (63 ( (6

ABSTRACT Objective: To characterize the effectiveness of anti-vascular endothelial growth factor drugs in exudative age-related macular degeneration. Methods: Retrospective longitudinal study of 54 patients with age-related macular degeneration receiving bevacizumab or aflibercept. Demographic data, visual acuity, and central retinal thickness measurements were collected. Improvement/stability of visual acuity and reduction in retinal thickness configured satisfactory responses. Results: Among the 60 eyes studied, there was no difference (p = 0.262) in satisfactory response when using bevacizumab (48.5%) or aflibercept (63.0%). Snellen’s visual acuity, letter gain, and retinal thickness showed improvement or maintenance in 55.0%, 32.8%, and 78.3% of cases, respectively. The percentage of improvement/maintenance was higher in eyes with an initial visual acuity of < Snellen 20/400 (70.0% versus 40.0%; p = 0.002). Conclusion: A higher percentage of improvement/stabilization of visual acuity and macular thickness was observed in patients with age-related macular degeneration, with better response in patients with visual acuity worse than Snellen 20/400. Objective antivascular anti vascular agerelated age related Methods 5 data collected Improvementstability Improvement stability responses Results 6 studied 0.262 0262 0 262 48.5% 485 48 (48.5% 63.0%. 630 63.0% . 63 (63.0%) Snellens s gain 550 55 55.0% 328 32 8 32.8% 783 78 3 78.3 cases respectively improvementmaintenance 20400 20 400 20/40 70.0% 700 70 (70.0 40.0% 40 0.002. 0002 0.002 002 0.002) Conclusion improvementstabilization stabilization 0.26 026 26 48.5 4 (48.5 63.0 (63.0% 55.0 32.8 7 78. 2040 2 20/4 70.0 (70. 40.0 000 0.00 00 0.2 02 48. (48. 63. (63.0 55. 32. 204 20/ 70. (70 40. 0.0 0. (48 (63. (7 (4 (63 ( (6

Abstract Background The neuropeptide Y (NPY) is one of the most abundant neurotransmitters in the nervous system. NPY acts as a potent stimulator of angiogenesis, inflammation, and adipogenesis, through the NPY 2 receptor (NPY2R). Changes in the NPY signaling pathway have been linked to Acute Coronary Syndrome (ACS). Objectives The purpose of this study is to determine the association between variants in the NPY and NPY2R genes, as well as the severity of acute coronary syndrome (ACS). Methods Approximately 221 ACS patients and 278 healthy controls were selected for this study. Four variants in NPY and two variants in NPY2R genes were genotyped using Taqman allelic discrimination and sequencing. The Chi-square and Fisher's exact tests were used to verify the genotype frequencies. The logistic regression analyses were used for the evaluation of the studied variables. Haplotype analysis was used to evaluate the linkage disequilibrium (LD) between the variants (p<0.05). Results An association of NPY c.20T>C variant was found with the ACS group when compared to the healthy group. In the analysis between variants and risk factors in the ACS group, NPY c.84G>A was associated with hypertension. The analysis between TIMI risk showed a significance for NPY c.20T>C between the low and intermediate/high TIMI risk groups. In the haplotype analysis, strong linkage disequilibrium (LD) was found between the variants NPY c.150G>A and NPY c.-485T>C. Conclusion The NPY c.20T>C variant appears to contribute to the development of ACS. The NPY2R c.-1116A>G variant may contribute to the early development of ACS and the NPY c.84G>A variant appears to contribute to the development of hypertension. In addition, the NPY c.20T>C is associated with a protective effect in ACS severity.

ABSTRACT The technology of 3D printing has been studied by different researchers, due to the possibility of producing solid objects swiftly, time reduction, labor with fewer failures the construction process. One of the challenges to be overcome is related to the development of mixtures promising. Thus, research aimed at the technology of cementitious materials is necessary to develop extrudable and sustainable mixtures. This article aimed to investigate the potential use of (FA) and (MK) in cementitious materials for application in three-dimensional printing (3D) by checking the aspects of constructibility. In the first stage, tests of normal consistency and initial and final setting time were carried out on pastes, with calcium oxide 4% and addition of (FA) and (MK) in the percentages of 8%, 10% and 15% in relation to the cement mass, in order to establish an ideal water / cement ratio. In the second stage, given a pre-determined trace of 1: 1.5, in mass, the viscosity, yield stress, extrudability and verticality tests were carried out on the cementitious materials developed in the first stage. It was observed that for the aspects related to the normal cement consistency and initial and final setting time, the paste with 15% substitution (FA) presented a longer initial setting time when compared to pastes with (MK) added. yield stress, materials with 15% substitution (FA) and without superplasticizer additive showed favorable results in the relation of the initial and final yield stress, as the mixture of 15% (MK) with 0.4% superplasticizer additive. and, therefore, they were considered promising because they were subjected to extrudability and verticality tests. Thus, it is concluded that considering the constructibility applied to prototyping, cementitious materials with 15% substitution (FA) and (MK) in relation to the cement mass present results considered relevant for the application in 3D printing. D researchers swiftly reduction process Thus FA (FA MK (MK threedimensional three dimensional (3D stage 4 8 8% 10 15 ratio predetermined pre determined 1 5 1.5 viscosity stress added 04 0 0.4 therefore prototyping 1. 0.

Resumo Objetivo O parto com idade gestacional < 37 semanas é a complicação gestacional mais associada à mortalidade e morbidade perinatal, sendo necessária a identificação de seus fatores de risco e a tentativa de sua prevenção. Os benefícios do pessário na prematuridade estão sendo investigados. Nosso objetivo foi analisar os estudos publicados sobre uso do pessário na prevenção do parto pretermo e comparar sua eficácia perante outros métodos. Métodos Foramselecionados estudos clínicos randomizados publicados entre 2010 e 2018, extraídos de bases eletrônicas de dados. Estudos de gestações múltiplas foram excluídos. Resultados Dois estudos semostraram a favor do pessário comométodo preventivo, um estudo foi contrário ao método, e outros dois não demonstraram diferença estatisticamente significativa. A meta-análise não mostrou diferença significativa no Conclusão Os dados agrupados disponíveis até o momento parecem mostrar uma falta de eficácia do pessário cervical na prevenção do parto pretermo, embora a heterogeneidade dos estudos tenha dificultado as comparações.

Abstract Objective The gestational complication most associated with perinatalmortality and morbidity is spontaneous preterm birth with gestational age < 37 weeks. Therefore, it is necessary to identify its risk factors and attempt its prevention. The benefits of the pessary in prematurity are under investigation. Our objective was to analyze the use of the pessary in the prevention of preterm births in published studies, and to compare its efficacy with other methods. Methods Randomized clinical trials published between 2010 and 2018 were selected from electronic databases. Studies on multiple gestations were excluded. Results Two studies were in favor of the pessary as a preventive method, one study was contrary to the method and another two showed no statistically significant difference. Themeta-analysis showed no statistical difference with the use of a cervical pessary in the reduction of births < 37 (odds ratio [OR]: 0.63; confidence interval [95% CI]: 0.38-1.06) and < 34 weeks (OR: 0.74; 95% CI: 0.35-1.57) Conclusion The pooled data available to date seems to show a lack of efficacy of the cervical pessary in the prevention of preterm birth, although the heterogeneity of the studies made comparisons more difficult.